M Margarita Behrens

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase
    M Margarita Behrens
    Department of Medicine, Division of Geriatric Medicine, University of California San Diego, La Jolla, CA 92093 0746, USA
    Science 318:1645-7. 2007
  2. pmc Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia
    M Margarita Behrens
    Department of Medicine, Division of Geriatric Medicine, University of California, San Diego, La Jolla, California 92093 0746, USA
    J Neurosci 28:13957-66. 2008
  3. pmc IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase
    Laura L Dugan
    Division of Geriatric Medicine, Department of Medicine, University of California San Diego, La Jolla, California, USA
    PLoS ONE 4:e5518. 2009
  4. ncbi request reprint IL-1beta induces a MyD88-dependent and ceramide-mediated activation of Src in anterior hypothalamic neurons
    Christopher N Davis
    The Harold L Dorris Neurological Research Institute and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurochem 98:1379-89. 2006
  5. pmc Does schizophrenia arise from oxidative dysregulation of parvalbumin-interneurons in the developing cortex?
    M Margarita Behrens
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Neuropharmacology 57:193-200. 2009
  6. pmc How Nox2-containing NADPH oxidase affects cortical circuits in the NMDA receptor antagonist model of schizophrenia
    Xin Wang
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Antioxid Redox Signal 18:1444-62. 2013
  7. pmc Behavioral and neurochemical consequences of cortical oxidative stress on parvalbumin-interneuron maturation in rodent models of schizophrenia
    Susan B Powell
    Department of Psychiatry, University of California, San Diego, MC0804, La Jolla, CA 92093 0804, USA
    Neuropharmacology 62:1322-31. 2012
  8. ncbi request reprint Gender differences in free radical homeostasis during aging: shorter-lived female C57BL6 mice have increased oxidative stress
    Sameh S Ali
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Aging Cell 5:565-74. 2006
  9. pmc Downregulation of parvalbumin at cortical GABA synapses reduces network gamma oscillatory activity
    Vladislav Volman
    Howard Hughes Medical Institute, Computational Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 31:18137-48. 2011
  10. pmc MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics
    Christopher N Davis
    The Harold L Dorris Neurological Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:2953-8. 2006

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase
    M Margarita Behrens
    Department of Medicine, Division of Geriatric Medicine, University of California San Diego, La Jolla, CA 92093 0746, USA
    Science 318:1645-7. 2007
    ..These results suggest that NADPH oxidase may represent a novel target for the treatment of ketamine-induced psychosis...
  2. pmc Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia
    M Margarita Behrens
    Department of Medicine, Division of Geriatric Medicine, University of California, San Diego, La Jolla, California 92093 0746, USA
    J Neurosci 28:13957-66. 2008
    ....
  3. pmc IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase
    Laura L Dugan
    Division of Geriatric Medicine, Department of Medicine, University of California San Diego, La Jolla, California, USA
    PLoS ONE 4:e5518. 2009
    ..However, the mechanisms underlying this association between IL-6 and cognitive vulnerability remain unclear...
  4. ncbi request reprint IL-1beta induces a MyD88-dependent and ceramide-mediated activation of Src in anterior hypothalamic neurons
    Christopher N Davis
    The Harold L Dorris Neurological Research Institute and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurochem 98:1379-89. 2006
    ....
  5. pmc Does schizophrenia arise from oxidative dysregulation of parvalbumin-interneurons in the developing cortex?
    M Margarita Behrens
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Neuropharmacology 57:193-200. 2009
    ..Thus, in individuals with genetic predisposition, the persistent activation of the IL-6/Nox2 pathway may be an environmental factor that tips the redox balance leading to schizophrenia symptoms in late adolescence and early adulthood...
  6. pmc How Nox2-containing NADPH oxidase affects cortical circuits in the NMDA receptor antagonist model of schizophrenia
    Xin Wang
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Antioxid Redox Signal 18:1444-62. 2013
    ....
  7. pmc Behavioral and neurochemical consequences of cortical oxidative stress on parvalbumin-interneuron maturation in rodent models of schizophrenia
    Susan B Powell
    Department of Psychiatry, University of California, San Diego, MC0804, La Jolla, CA 92093 0804, USA
    Neuropharmacology 62:1322-31. 2012
    ..Thus, oxidative stress during the maturation window for PV+ interneurons by alteration of normal brain development, leads to the emergence of schizophrenia-like behavioral dysfunctions when subjects reach early adulthood...
  8. ncbi request reprint Gender differences in free radical homeostasis during aging: shorter-lived female C57BL6 mice have increased oxidative stress
    Sameh S Ali
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Aging Cell 5:565-74. 2006
    ..Our results indicate that differences in ROS homeostasis contribute to gender divergence in survival, but also suggest that mitochondrial superoxide production may not be primarily responsible for gender differences in lifespan...
  9. pmc Downregulation of parvalbumin at cortical GABA synapses reduces network gamma oscillatory activity
    Vladislav Volman
    Howard Hughes Medical Institute, Computational Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 31:18137-48. 2011
    ..Our results suggest a mechanism by which reduced GAD67 and PV in fast-spiking interneurons may contribute to cortical dysfunction in schizophrenia and related psychiatric disorders...
  10. pmc MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics
    Christopher N Davis
    The Harold L Dorris Neurological Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:2953-8. 2006
    ....
  11. ncbi request reprint A specific role for NR2A-containing NMDA receptors in the maintenance of parvalbumin and GAD67 immunoreactivity in cultured interneurons
    Jefferson W Kinney
    The Harold L Dorris Neurological Research Center, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 26:1604-15. 2006
    ..These results suggest that the activity of NR2A-containing NMDA receptors play a pivotal role in the maintenance of the GABAergic function of PV interneurons...
  12. pmc Pregnenolone sulfate and cortisol induce secretion of acyl-CoA-binding protein and its conversion into endozepines from astrocytes
    William F Loomis
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0368, USA
    J Biol Chem 285:21359-65. 2010
    ..These effects of steroids in neurons will be reinforced by the release of endozepines from astrocytes shown here, and suggest an orchestrated astrocyte-neuron cross-talk that can affect a broad spectrum of behavioral functions...
  13. pmc Repeated phencyclidine administration alters glutamate release and decreases GABA markers in the prefrontal cortex of rats
    Nurith Amitai
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Neuropharmacology 62:1422-31. 2012
    ..A better understanding of glutamate and GABA dysregulation in schizophrenia may uncover new treatment targets for schizophrenia-related cognitive dysfunction...
  14. pmc Ceramide mediates the rapid phase of febrile response to IL-1beta
    Manuel Sanchez-Alavez
    Harold L Dorris Neurological Research Center, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:2904-8. 2006
    ..These in vivo and in vitro data suggest that ceramide fulfills the criteria for an endogenous pyrogen...
  15. pmc Global epigenomic reconfiguration during mammalian brain development
    Ryan Lister
    Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 341:1237905. 2013
    ....
  16. ncbi request reprint Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity
    Bruno Conti
    Harold L Dorris Neurological Research Center, Scripps Research Institute, La Jolla, California 92037, USA
    J Neurochem 93:493-501. 2005
    ..Our data suggest that UCP2 may represent a drug target for slowing the progression of Parkinson's disease...
  17. pmc Prostaglandin E2-increased thermosensitivity of anterior hypothalamic neurons is associated with depressed inhibition
    Iustin V Tabarean
    Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:2590-5. 2004
    ....
  18. pmc A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses
    Tamas Bartfai
    Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:7971-6. 2003
    ..p.). Inhibition of the TIR domain-mediated MyD88/IL1-RI interaction by a low molecular weight, cell-penetrating TIR domain mimic suggests an intracellular site for antiinflammatory drug action...
  19. pmc Prolonged exposure to NMDAR antagonist suppresses inhibitory synaptic transmission in prefrontal cortex
    Yuchun Zhang
    Department of Biology and Volen Center for Complex Systems, Brandeis University, MS 008, 415 South Street, Waltham, MA 02454, USA
    J Neurophysiol 100:959-65. 2008
    ..Our results show that NMDAR antagonist produces biochemical changes in the GABA system that lead to a functional disinhibition. Such disinhibition would be expected to decrease gamma oscillations, which are reduced in schizophrenia...
  20. ncbi request reprint TrkB mediates BDNF-induced potentiation of neuronal necrosis in cortical culture
    Hyun Jung Kim
    National Creative Research Initiative Center for the Study of CNS Zinc, University of Ulsan College of Medicine, Seoul 138 736, Korea
    Neurobiol Dis 14:110-9. 2003
    ..Furthermore, BDNF did not potentiate neuronal necrosis in cortical cultures prepared from embryonic TrkB-null mice. These results suggest that TrkB plays an important role in BDNF-mediated neuronal necrosis...
  21. ncbi request reprint Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons
    Valerie Heidinger
    Department of Neurology and Center for the Study of the Nervous System Injury, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 22:5452-61. 2002
    ....