Mary Behan

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Sex steroid hormones and the neural control of breathing
    Mary Behan
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Respir Physiol Neurobiol 136:249-63. 2003
  2. doi request reprint Neuronal control of breathing: sex and stress hormones
    Mary Behan
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin, USA
    Compr Physiol 1:2101-39. 2011
  3. ncbi request reprint Sex hormone receptors are expressed in identified respiratory motoneurons in male and female rats
    M Behan
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706 1102, USA
    Neuroscience 130:725-34. 2005
  4. ncbi request reprint Chemoarchitecture of GABAergic neurons in the ferret superior colliculus
    Mary Behan
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706 1102, USA
    J Comp Neurol 452:334-59. 2002
  5. pmc Sex steroidal hormones and respiratory control
    Mary Behan
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706 1102, USA
    Respir Physiol Neurobiol 164:213-21. 2008
  6. ncbi request reprint Age and gender effects on serotonin-dependent plasticity in respiratory motor control
    M Behan
    Department of Comparative Biosciences, School of Veterinary Medicine, 2015 Linden Drive, University of Wisconsin, Madison, WI 53706, USA
    Respir Physiol Neurobiol 131:65-77. 2002
  7. ncbi request reprint Spatial distribution of tectotectal connections in the cat
    M Behan
    Department of Comparative Biosciences, University of Wisconsin, Madison 53706, USA
    Prog Brain Res 112:131-42. 1996
  8. ncbi request reprint Age-related changes in serotonin in the hypoglossal nucleus of rat: implications for sleep-disordered breathing
    M Behan
    Department of Comparative Biosciences, University of Wisconsin, Madison 53706, USA
    Neurosci Lett 267:133-6. 1999
  9. ncbi request reprint Intrinsic and efferent connections of the endopiriform nucleus in rat
    M Behan
    Department of Comparative Biosciences, University of Wisconsin, Madison 53706, USA
    J Comp Neurol 408:532-48. 1999
  10. pmc Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy
    Keith B Hengen
    Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 7:e30608. 2012

Research Grants

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Sex steroid hormones and the neural control of breathing
    Mary Behan
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Respir Physiol Neurobiol 136:249-63. 2003
    ....
  2. doi request reprint Neuronal control of breathing: sex and stress hormones
    Mary Behan
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin, USA
    Compr Physiol 1:2101-39. 2011
    ..Finally, the impact of stress on the development of neural circuits involved in breathing is evaluated in animal models, and the consequences of early stress on respiratory health and disease is discussed...
  3. ncbi request reprint Sex hormone receptors are expressed in identified respiratory motoneurons in male and female rats
    M Behan
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706 1102, USA
    Neuroscience 130:725-34. 2005
    ..These data suggest that in male and female rats, sex hormones can modulate the output of respiratory motoneurons directly...
  4. ncbi request reprint Chemoarchitecture of GABAergic neurons in the ferret superior colliculus
    Mary Behan
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706 1102, USA
    J Comp Neurol 452:334-59. 2002
    ..Thus, the arrangement of GABAergic neurons in the ferret superior colliculus is broadly distributed and is distinct from other recognized organizational patterns in the superior colliculus...
  5. pmc Sex steroidal hormones and respiratory control
    Mary Behan
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706 1102, USA
    Respir Physiol Neurobiol 164:213-21. 2008
    ....
  6. ncbi request reprint Age and gender effects on serotonin-dependent plasticity in respiratory motor control
    M Behan
    Department of Comparative Biosciences, School of Veterinary Medicine, 2015 Linden Drive, University of Wisconsin, Madison, WI 53706, USA
    Respir Physiol Neurobiol 131:65-77. 2002
    ..We speculate about a possible relationship between age and gender effects on serotonin-dependent plasticity in upper airway motoneuron pools and the prevalence of obstructive sleep apnea...
  7. ncbi request reprint Spatial distribution of tectotectal connections in the cat
    M Behan
    Department of Comparative Biosciences, University of Wisconsin, Madison 53706, USA
    Prog Brain Res 112:131-42. 1996
    ..At this time it is not clear whether specific commissural terminals contain excitatory or inhibitory neurotransmitters, and our ongoing studies are addressing this question...
  8. ncbi request reprint Age-related changes in serotonin in the hypoglossal nucleus of rat: implications for sleep-disordered breathing
    M Behan
    Department of Comparative Biosciences, University of Wisconsin, Madison 53706, USA
    Neurosci Lett 267:133-6. 1999
    ..These data suggest that normal aging may result in a change in the availability of serotonin that results in decreased facilitation of hypoglossal motoneurons...
  9. ncbi request reprint Intrinsic and efferent connections of the endopiriform nucleus in rat
    M Behan
    Department of Comparative Biosciences, University of Wisconsin, Madison 53706, USA
    J Comp Neurol 408:532-48. 1999
    ..The significance of these findings for the triggering of generalized seizures from the deep piriform region are discussed. An hypothesis for a role of the endopiriform nucleus in memory storage is presented...
  10. pmc Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy
    Keith B Hengen
    Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 7:e30608. 2012
    ..Increased ε subunit expression may be critical to preserve respiratory function (and life) despite increased neurosteroid levels during pregnancy...
  11. pmc Functional adaptation in female rats: the role of estrogen signaling
    Susannah J Sample
    Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 7:e43215. 2012
    ..GPER is distributed throughout the nervous system, but little is known about its effects on bone. In male rats, adaptation to loading is neuronally regulated, but this has not been studied in females...
  12. pmc Serotonergic projections from the caudal raphe nuclei to the hypoglossal nucleus in male and female rats
    Jessica R Barker
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706 1102, United States
    Respir Physiol Neurobiol 165:175-84. 2009
    ....
  13. pmc Conversion from testosterone to oestradiol is required to modulate respiratory long-term facilitation in male rats
    A G Zabka
    Department of Comparative Biosciences, School of Veterinary Medicine, 2015 Linden Drive, Madison, WI 53706, USA
    J Physiol 576:903-12. 2006
    ..In contrast, LTF was not restored in T + ADT or DHT-treated gonadectomized rats. We conclude that the conversion of testosterone to oestradiol modulates phrenic and XII LTF in male F344 rats...
  14. pmc Mechanical loading of a long bone induces plasticity in sensory input to the central nervous system
    Qiang Wu
    Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    Neurosci Lett 463:254-7. 2009
    ....
  15. pmc Systemic effects of ulna loading in male rats during functional adaptation
    Susannah J Sample
    Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    J Bone Miner Res 25:2016-28. 2010
    ..In young, growing male rats we conclude that ulna loading induced increased bone formation in multiple bones. Systemic adaptation effects were, at least in part, neuronally regulated...
  16. pmc The effects of aging on hypoglossal motoneurons in rats
    Emilie C Schwarz
    Department of Comparative Biosciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Dysphagia 24:40-8. 2009
    ..Loss of primary dendrites could reduce the number of synaptic inputs and thereby impair function...
  17. pmc Long term facilitation of respiratory motor output decreases with age in male rats
    A G Zabka
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    J Physiol 531:509-14. 2001
    ..05). Decreased phrenic and XII LTF suggests that serotonergic modulation of respiratory motor output decreases in ageing male rats. We speculate that decreased serotonergic modulation may contribute to age-related breathing disorders...
  18. pmc Age and sex differences in the ventilatory response to hypoxia and hypercapnia in awake neonatal, pre-pubertal and young adult rats
    Heidi S Holley
    University of Wisconsin Madison School of Veterinary Medicine, Department of Comparative Biosciences, 2015 Linden Drive, Madison, WI 53706, United States
    Respir Physiol Neurobiol 180:79-87. 2012
    ..Estradiol and ventilatory responses to hypoxia and hypercapnia were negatively correlated in neonatal male, but not female rats. Our results suggest that P10-15 includes a critical developmental period in male but not female rats...
  19. pmc Hypoxic and hypercapnic ventilatory responses in aging male vs. aging female rats
    J M Wenninger
    Department of Comparative Biosciences, School of Veterinary Medicine, 2015 Linden Dr, Madison, WI 53706, USA
    J Appl Physiol 106:1522-8. 2009
    ..Thus it is critical to take sex, age, estrous cycle stage, and systemic hormone levels into consideration when conducting and reporting studies on respiratory control...
  20. pmc Differential expression of respiratory long-term facilitation among inbred rat strains
    T L Baker-Herman
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Respir Physiol Neurobiol 170:260-7. 2010
    ..BN had higher 5-HT(7) and TrkB mRNA versus F344; BN and Lewis had higher BDNF mRNA levels versus F344. Genetic variations in serotonergic function may underlie strain differences in AIH-induced pLTF...
  21. ncbi request reprint Expression of hypoglossal long-term facilitation differs between substrains of Sprague-Dawley rat
    D D Fuller
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Physiol Genomics 4:175-81. 2001
    ..We conclude that the expression of hypoglossal LTF differs between SD rat substrains, indicating a difference in their genetic predisposition to neural plasticity...
  22. pmc Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling
    R G Gregg
    Waisman Center, University of Wisconsin, Madison 53705, USA
    Proc Natl Acad Sci U S A 93:13961-6. 1996
    ....
  23. pmc Ageing and gonadectomy have similar effects on hypoglossal long-term facilitation in male Fischer rats
    A G Zabka
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    J Physiol 563:557-68. 2005
    ..Furthermore, LTF is similarly impaired in middle-aged and gonadectomized male rats, suggesting that gonadal hormones play an important role in modulating the capacity for neuroplasticity in upper airway motor control...
  24. ncbi request reprint Selected contribution: chronic intermittent hypoxia enhances respiratory long-term facilitation in geriatric female rats
    A G Zabka
    Department of Comparative Biosciences, School of Veterinary Medicine, Madison, WI 53706, USA
    J Appl Physiol 95:2614-23; discussion 2604. 2003
    ..05). The magnitude of phrenic and XII LTF in all groups was inversely related to the ratio of progesterone to estradiol serum levels (P < 0.05). Thus CIH and sex hormones influence the magnitude of LTF in geriatric female rats...
  25. ncbi request reprint Selected contribution: Time-dependent hypoxic respiratory responses in female rats are influenced by age and by the estrus cycle
    A G Zabka
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Dr West, Madison, WI 53706, USA
    J Appl Physiol 91:2831-8. 2001
    ..05), whereas XII LTF increased in middle-aged female rats during diestrus only. Age and gender influence time-dependent hypoxic phrenic and XII responses in a complex manner...
  26. pmc The effect of age and tongue exercise on BDNF and TrkB in the hypoglossal nucleus of rats
    Allison J Schaser
    Department of Surgery, University of Wisconsin Madison, WI 53706, USA
    Behav Brain Res 226:235-41. 2012
    ....
  27. pmc Age-related changes in the serotonin 2A receptor in the hypoglossal nucleus of male and female rats
    Benjamin R Seebart
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706 1102, United States
    Respir Physiol Neurobiol 158:14-21. 2007
    ..Data from the present study suggest that aging male rats fail to compensate adequately for reduced 5HT in the hypoglossal nucleus by upregulating the expression of the 5HT(2A) receptor...
  28. ncbi request reprint A new subdivision of anterior piriform cortex and associated deep nucleus with novel features of interest for olfaction and epilepsy
    J J Ekstrand
    Department of Anatomy, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Comp Neurol 434:289-307. 2001
    ..Normal functions of the APC(VR)-pEn may require a shaping of neuronal activity by inhibitory processes in a fashion that renders this region susceptible to pathological behavior...
  29. ncbi request reprint Age-associated changes in the serotonergic system in rat superior colliculus and pretectum
    M J Parsons
    Department of Psychiatry, University of Wisconsin, Madison, WI, USA
    Brain Res Bull 55:435-44. 2001
    ..These data suggest that the age-related changes in the serotonergic system in the superior colliculus and pretectum may account for some of the alterations in light-mediated behaviors with aging...
  30. pmc Atypical protein kinase C expression in phrenic motor neurons of the rat
    C H Guenther
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706, USA
    Neuroscience 169:787-93. 2010
    ..Documenting the expression of atypical PKCs in phrenic motor neurons provides a framework within which to assess their role in respiratory motor control, including novel forms of respiratory plasticity known to occur in this region...
  31. pmc Hibernation induces pentobarbital insensitivity in medulla but not cortex
    Keith B Hengen
    School of Veterinary Medicine, University of Wisconsin, Madison, Madison, Wisconsin 53706, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1028-36. 2009
    ..We hypothesize that GABA(A) receptors undergo a seasonal modification in subunit composition, such that cardiorespiratory neurons are uniquely unaffected by surges of an endogenous positive allosteric modulator...
  32. pmc Functional adaptation to loading of a single bone is neuronally regulated and involves multiple bones
    Susannah J Sample
    Comparative Orthopaedic Research Laboratory, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Bone Miner Res 23:1372-81. 2008
    ..Persistent changes in bone neuropeptide concentrations after a single loading period suggest that plasticity exists in the innervation of bone...
  33. pmc Retinal projections to the subcortical visual system in congenic albino and pigmented rats
    M D Fleming
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706 1102, USA
    Neuroscience 143:895-904. 2006
    ..These findings raise the possibility that enhanced retinofugal projections to subcortical visual nuclei in albinos may underlie some light-mediated behaviors that differ between albino and pigmented mammals...
  34. pmc Changes in ventral respiratory column GABAaR ε- and δ-subunits during hibernation mediate resistance to depression by EtOH and pentobarbital
    K B Hengen
    Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin, USA
    Am J Physiol Regul Integr Comp Physiol 300:R272-83. 2011
    ..Synaptic input from adjacent inhibitory interneurons that express δ-subunit-containing GABA(A)Rs is responsible for the excitatory effects of EtOH on VRC neurons during hibernation...
  35. pmc Testosterone restores respiratory long term facilitation in old male rats by an aromatase-dependent mechanism
    N R Nelson
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706 1102, USA
    J Physiol 589:409-21. 2011
    ..Our findings suggest that testosterone supplementation could potentially be used to enhance upper airway control in the elderly...
  36. ncbi request reprint Fos immunoreactivity in rat subcortical visual shell in response to illuminance changes
    J R Prichard
    Neuroscience Training Program, University of Wisconsin Madison, 1300 University Avenue, Madison, WI 53706, USA
    Neuroscience 114:781-93. 2002
    ....
  37. ncbi request reprint Comparison of hypocretin/orexin and melanin-concentrating hormone neurons and axonal projections in the embryonic and postnatal rat brain
    Teresa L Steininger
    Molecular Neurobiology Laboratory, SRI International, Menlo Park, CA 94025, USA
    J Chem Neuroanat 27:165-81. 2004
    ..The present results demonstrate developmental differences and similarities between the MCH and H/O systems that may relate to their respective roles in feeding and sleep regulation...
  38. ncbi request reprint Light-dependent retinal innervation of the rat superior colliculus
    J Roxanne Prichard
    Behavioral Neuroscience Program, University of St Thomas, St Paul, Minnesota 55105, USA
    Anat Rec (Hoboken) 290:341-8. 2007
    ....

Research Grants9

  1. Age,Gender, Serotonin and Respiratory Control
    Mary Behan; Fiscal Year: 2005
    ..An understanding of these mechanisms may lead to therapeutic strategies for intervention in age-related breathing disorders that affect both men and women such as obstructive sleep apnea. ..
  2. Age, Gender, Serotonin and Respiratory Control
    Mary Behan; Fiscal Year: 2007
    ..Ultimately, these studies may enable us to identify age- and gender-appropriate pharmacological interventions for breathing disorders. ..
  3. Age, Gender, Serotonin and Respiratory Control
    Mary Behan; Fiscal Year: 2010
    ..Ultimately, these studies may enable us to identify age- and gender-appropriate pharmacological interventions for breathing disorders. ..