Leigh Beglinger

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint Neuropsychological test performance in healthy volunteers before and after donepezil administration
    Leigh J Beglinger
    Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Psychopharmacol 18:102-8. 2004
  2. pmc Risperidone and the treatment of psychiatric, motor, and cognitive symptoms in Huntington's disease
    Kevin Duff
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242 1000, USA
    Ann Clin Psychiatry 20:1-3. 2008
  3. pmc Clinical predictors of driving status in Huntington's disease
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Mov Disord 27:1146-52. 2012
  4. pmc The Indiana faces in places test: preliminary findings on a new visuospatial memory test in patients with mild cognitive impairment
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242 1000, USA
    Arch Clin Neuropsychol 24:607-18. 2009
  5. pmc An updated version of the Weigl discriminates adults with dementia from those with mild impairment and healthy controls
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa College of Medicine, MEB 1 321, Iowa City, IA 52242 1000, USA
    Arch Clin Neuropsychol 23:149-56. 2008
  6. pmc Randomized controlled trial of atomoxetine for cognitive dysfunction in early Huntington disease
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242 1000, USA
    J Clin Psychopharmacol 29:484-7. 2009
  7. pmc Cognitive change in patients with Huntington disease on the Repeatable Battery for the Assessment of Neuropsychological Status
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242 1000, USA
    J Clin Exp Neuropsychol 32:573-8. 2010
  8. pmc The neuropsychological course of acute delirium in adult hematopoietic stem cell transplantation patients
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, 52242 1000, USA
    Arch Clin Neuropsychol 26:98-109. 2011
  9. ncbi request reprint Neuropsychological and psychiatric functioning pre- and posthematopoietic stem cell transplantation in adult cancer patients: a preliminary study
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 1000, USA
    J Int Neuropsychol Soc 13:172-7. 2007
  10. ncbi request reprint Incidence of delirium and associated mortality in hematopoietic stem cell transplantation patients
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa
    Biol Blood Marrow Transplant 12:928-35. 2006

Research Grants

Detail Information

Publications39

  1. ncbi request reprint Neuropsychological test performance in healthy volunteers before and after donepezil administration
    Leigh J Beglinger
    Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Psychopharmacol 18:102-8. 2004
    ..While the results are counter to expectations, some tests in the battery did detect a cognitive change (transient mild worsening during drug administration) in healthy volunteers...
  2. pmc Risperidone and the treatment of psychiatric, motor, and cognitive symptoms in Huntington's disease
    Kevin Duff
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242 1000, USA
    Ann Clin Psychiatry 20:1-3. 2008
    ..Huntington's disease (HD) is a progressive, neuropsychiatric disorder, and limited reports indicate that risperidone might improve motor and psychiatric functioning for these patients...
  3. pmc Clinical predictors of driving status in Huntington's disease
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Mov Disord 27:1146-52. 2012
    ..A detailed cognitive evaluation is an important component of multidisciplinary clinical assessment in patients with HD who are driving...
  4. pmc The Indiana faces in places test: preliminary findings on a new visuospatial memory test in patients with mild cognitive impairment
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242 1000, USA
    Arch Clin Neuropsychol 24:607-18. 2009
    ..64 and 0.66). Preliminary psychometric analyses support further study of the IFIPT. The measure showed evidence of clinical utility by demonstrating group differences between this sample of healthy adults and those with MCI...
  5. pmc An updated version of the Weigl discriminates adults with dementia from those with mild impairment and healthy controls
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa College of Medicine, MEB 1 321, Iowa City, IA 52242 1000, USA
    Arch Clin Neuropsychol 23:149-56. 2008
    ..The new measure discriminated well between healthy controls and older adults with either cognitive impairment without dementia, or dementia. The Weigl-R may be a useful adjunct to brief dementia batteries but requires further validation...
  6. pmc Randomized controlled trial of atomoxetine for cognitive dysfunction in early Huntington disease
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242 1000, USA
    J Clin Psychopharmacol 29:484-7. 2009
    ..Atomoxetine is a norepinephrine reuptake inhibitor approved for treatment of attention-deficit/hyperactivity disorder...
  7. pmc Cognitive change in patients with Huntington disease on the Repeatable Battery for the Assessment of Neuropsychological Status
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242 1000, USA
    J Clin Exp Neuropsychol 32:573-8. 2010
    ..The RBANS provided additional information about other cognitive domains affected (e.g., memory) and may be a useful measure for tracking longitudinal change...
  8. pmc The neuropsychological course of acute delirium in adult hematopoietic stem cell transplantation patients
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, 52242 1000, USA
    Arch Clin Neuropsychol 26:98-109. 2011
    ....
  9. ncbi request reprint Neuropsychological and psychiatric functioning pre- and posthematopoietic stem cell transplantation in adult cancer patients: a preliminary study
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 1000, USA
    J Int Neuropsychol Soc 13:172-7. 2007
    ..Education about these possible pretransplant sequelae and the potential for rebound may be helpful to patients and families as they prepare for this treatment and the recovery period...
  10. ncbi request reprint Incidence of delirium and associated mortality in hematopoietic stem cell transplantation patients
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa
    Biol Blood Marrow Transplant 12:928-35. 2006
    ..Studies to determine the factors that connect delerium soon after transplantation to mortality are highly warranted...
  11. ncbi request reprint Probability of obsessive and compulsive symptoms in Huntington's disease
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa, Iowa City, Iowa 52242 1000, USA
    Biol Psychiatry 61:415-8. 2007
    ..The purpose of this study was to examine the probability of obsessive and compulsive (OC) symptoms across stages of Huntington's disease (HD) with both cross sectional and longitudinal data...
  12. ncbi request reprint Neuropsychological test performance in healthy elderly volunteers before and after donepezil administration: a randomized, controlled study
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Psychopharmacol 25:159-65. 2005
    ....
  13. ncbi request reprint Practice effects and the use of alternate forms in serial neuropsychological testing
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa College of Medicine, 1 321 MEB, 200 Hawkins Dr, Iowa City, Iowa 52242, USA
    Arch Clin Neuropsychol 20:517-29. 2005
    ..Alternate forms and baseline practice sessions may help control early, rapid improvements in clinical trials...
  14. ncbi request reprint White matter volume and cognitive dysfunction in early Huntington's disease
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, Iowa 52242, USA
    Cogn Behav Neurol 18:102-7. 2005
    ..Fewer studies have examined other cerebral structures in early HD and potential associations with cognition...
  15. pmc Obsessive and compulsive symptoms in prediagnosed Huntington's disease
    Leigh J Beglinger
    University of Iowa, Department of Psychiatry, MEB 1 321, Iowa City, IA 52242 1000, USA
    J Clin Psychiatry 69:1758-65. 2008
    ..Although psychiatric symptoms have been reported in individuals with the HD gene expansion prior to clinical diagnosis (pre-HD), little is known about OCS in this phase of disease...
  16. ncbi request reprint Concurrent validity of social subtype and IQ after early intensive behavioral intervention in children with autism: a preliminary investigation
    Leigh Beglinger
    Washington State University, USA
    J Autism Dev Disord 35:295-303. 2005
    ..Participants classified as aloof had significantly lower IQ scores and changes in IQ after EIBI than other children. Future studies should extend these findings by examining whether social subtype at pretreatment predicts EIBI outcome...
  17. pmc Challenges assessing clinical endpoints in early Huntington disease
    Jane S Paulsen
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 1000, USA
    Mov Disord 25:2595-603. 2010
    ..We conclude that future clinical trials designed for very early disease will require the development of new and more sensitive measures of real-life function...
  18. pmc Comorbidities of obsessive and compulsive symptoms in Huntington's disease
    Karen E Anderson
    Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    J Nerv Ment Dis 198:334-8. 2010
    ..Clinicians should be aware that patients with HD and O/Cs might have a somewhat different clinical picture from those without, and may require a specialized treatment plan...
  19. pmc Earliest functional declines in Huntington disease
    Leigh J Beglinger
    Department of Psychiatry, The University of Iowa, Iowa City, IA, USA
    Psychiatry Res 178:414-8. 2010
    ..These are also important areas for clinical monitoring and treatment planning as up to 65% experienced loss in at least one area prior to diagnosis...
  20. pmc "Frontal" behaviors before the diagnosis of Huntington's disease and their relationship to markers of disease progression: evidence of early lack of awareness
    Kevin Duff
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, USA
    J Neuropsychiatry Clin Neurosci 22:196-207. 2010
    ..Participant/companion discrepancies, especially closest to Huntington's disease diagnosis, might suggest early lack of awareness in these individuals...
  21. pmc A longitudinal community-based study of chronic illness, cognitive and physical function, and depression
    Carolyn L Turvey
    Department of Psychiatry, University of Iowa, 500 Newton Road, Iowa City, IA 52242 1000, USA
    Am J Geriatr Psychiatry 17:632-41. 2009
    ..This study examines the relative contribution of cognitive function, physical function, and chronic illness to depression 2 years later in a nationwide sample of elders aged 70 and older...
  22. pmc Cognitive deficits in Huntington's disease on the Repeatable Battery for the Assessment of Neuropsychological Status
    Kevin Duff
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242 1000, USA
    J Clin Exp Neuropsychol 32:231-8. 2010
    ..Although additional research is needed, the current study supports the clinical applicability of the RBANS in patients with HD...
  23. doi request reprint Premorbid intellect and current RBANS performance: discrepancy scores in three geriatric samples
    Kevin Duff
    Department of Psychiatry, University of Iowa, Iowa City, Iowa 52242, USA
    Appl Neuropsychol 15:241-9. 2008
    ....
  24. pmc Neuropsychological outcomes of older breast cancer survivors: cognitive features ten or more years after chemotherapy
    Torricia H Yamada
    Department of Neurology, University of Iowa Carver College of Medicine, USA
    J Neuropsychiatry Clin Neurosci 22:48-54. 2010
    ..Our findings suggest that among breast cancer survivors who remain disease-free for more than a decade, the previous cancer treatment may further augment cognitive dysfunction associated with age-related brain changes...
  25. pmc Validation of the modified telephone interview for cognitive status in amnestic mild cognitive impairment and intact elders
    Kevin Duff
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242 1000, USA
    Alzheimer Dis Assoc Disord 23:38-43. 2009
    ..Overall, these results provide additional validation of the mTICS as a valuable screening instrument for cognition in individuals with milder cognitive impairments...
  26. ncbi request reprint Test-retest stability and practice effects of the RBANS in a community dwelling elderly sample
    Kevin Duff
    University of Iowa, Department of Psychiatry, Iowa City, Iowa 52242, USA
    J Clin Exp Neuropsychol 27:565-75. 2005
    ..A case example is provided that demonstrates the use of the current findings in conjunction with existing change formulas...
  27. pmc Using a brief intervention to improve decisional capacity in schizophrenia research
    David J Moser
    Department of Psychiatry MEB 1 328, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Schizophr Bull 32:116-20. 2006
    ..The use of such interventions will enable a larger number of people with schizophrenia to make informed decisions regarding research participation...
  28. pmc Practice effects in the prediction of long-term cognitive outcome in three patient samples: a novel prognostic index
    Kevin Duff
    University of Iowa, Department of Psychiatry, MEB 1 308, Iowa City, IA 52242 1000, United States
    Arch Clin Neuropsychol 22:15-24. 2007
    ..Additionally, this prognostic index could be used to offer interventions to patients who are in the earliest stages of progressive neurodegenerative disorders...
  29. ncbi request reprint Pre- and post-right middle cerebral artery stroke in a young adult: a case study examining the sensitivity of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)
    Kevin Duff
    University of Iowa, Department of Psychiatry, MEB 1 308, Iowa City, IA 52242 1000, USA
    Appl Neuropsychol 13:194-200. 2006
    ..Line Orientation fell from normal to defective levels; these findings were associated with decline in related standard neuropsychological measures...
  30. ncbi request reprint Psychiatric symptoms in Huntington's disease before diagnosis: the predict-HD study
    Kevin Duff
    Department of Psychiatry, University of Iowa, Iowa City, Iowa 52242 1000, USA
    Biol Psychiatry 62:1341-6. 2007
    ..Psychiatric disturbances are relatively common in manifest Huntington's disease (HD), but less is known about these symptoms in the earliest phase of the illness...
  31. pmc Cerebral cortex structure in prodromal Huntington disease
    Peggy C Nopoulos
    Department of Psychiatry, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, IA 52242, USA
    Neurobiol Dis 40:544-54. 2010
    ..Early in the course of HD, the cortex shows changes that are manifest as cortical thinning and are most robust in the posterior and superior regions of the cerebrum...
  32. pmc Short-term practice effects in amnestic mild cognitive impairment: implications for diagnosis and treatment
    Kevin Duff
    Department of Psychiatry, College of Medicine, University of Iowa, Iowa City, IA 52242 1000, USA
    Int Psychogeriatr 20:986-99. 2008
    ..Practice effects have been widely reported in healthy older adults, but these improvements due to repeat exposure to test materials have been more equivocal in individuals with mild cognitive impairment (MCI)...
  33. pmc Self-paced timing detects and tracks change in prodromal Huntington disease
    Kelly C Rowe
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Neuropsychology 24:435-42. 2010
    ..This study compares self-paced timing performance (cross-sectionally and longitudinally) between participants with prodromal Huntington's disease (pr-HD) and a comparison group of gene non-expanded participants from affected families (NC)...
  34. pmc CAG-repeat length and the age of onset in Huntington disease (HD): a review and validation study of statistical approaches
    Douglas R Langbehn
    Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1000, USA
    Am J Med Genet B Neuropsychiatr Genet 153:397-408. 2010
    ..The Langbehn et al. model appears accurate enough to have substantial utility in various research contexts. We also emphasize remaining caveats, many of which are relevant for any direct application to genetic counseling...
  35. doi request reprint Predictors of neuropsychological recovery in treatment for anorexia nervosa
    Ekaterina Keifer
    Department of Counseling Psychology, University of Iowa, Iowa City, Iowa, USA
    Eat Disord 18:302-17. 2010
    ..Information about cognitive reserve and AN subtype may provide clinicians with valuable prognostic information and help guide treatment...
  36. doi request reprint Emotional and motivational changes after bilateral lesions of the globus pallidus
    Lavanya Vijayaraghavan
    Department of Psychiatry, University of Iowa Hospitals and Clinics, IA, USA
    Neuropsychology 22:412-8. 2008
    ..Active withdrawal from liked stimuli could constitute the basic mechanism underlying poor motivation and social withdrawal associated with globus pallidus damage...
  37. pmc Perceptions of discrimination among persons who have undergone predictive testing for Huntington's disease
    Elizabeth Penziner
    Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA
    Am J Med Genet B Neuropsychiatr Genet 147:320-5. 2008
    ..Discrimination concerns remain high in this sample and point to the need for more information to determine the extent and scope of the problem...
  38. doi request reprint Retention rates on RBANS memory subtests in elderly adults
    Mike R Schoenberg
    American Board of Clinical Neuropsychology, Department of Neurology, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    J Geriatr Psychiatry Neurol 21:26-33. 2008
    ..These preliminary data suggest that retention rates of the RBANS memory subtests may add to the clinical utility of this test as a neuropsychological diagnostic and research tool...
  39. pmc LA allelic heterozygosity of the 5HTTLPR polymorphism is associated with higher cognitive function and lower interpersonal sensitivity
    Jess G Fiedorowicz
    Psychiatr Genet 17:3-4. 2007

Research Grants2

  1. Cognition in Clinical Trials for Huntington's Disease
    Leigh Beglinger; Fiscal Year: 2007
    ..Identifying means of improving cognitive and psychiatric symptoms in early HD clearly fits with the mission of NINDS, in that it could provide information about reducing the burden of this neurological disease to the patient and family. ..