Trevor Bedford

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Optimization of gene expression by natural selection
    Trevor Bedford
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 106:1133-8. 2009
  2. pmc Global migration dynamics underlie evolution and persistence of human influenza A (H3N2)
    Trevor Bedford
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Pathog 6:e1000918. 2010
  3. pmc Strength and tempo of selection revealed in viral gene genealogies
    Trevor Bedford
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, USA
    BMC Evol Biol 11:220. 2011
  4. pmc Overdispersion of the molecular clock varies between yeast, Drosophila and mammals
    Trevor Bedford
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 179:977-84. 2008
  5. pmc Adaptive impact of the chimeric gene Quetzalcoatl in Drosophila melanogaster
    Rebekah L Rogers
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 107:10943-8. 2010
  6. pmc Overdispersion of the molecular clock: temporal variation of gene-specific substitution rates in Drosophila
    Trevor Bedford
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA
    Mol Biol Evol 25:1631-8. 2008
  7. pmc Formation and longevity of chimeric and duplicate genes in Drosophila melanogaster
    Rebekah L Rogers
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 181:313-22. 2009
  8. pmc The roles of competition and mutation in shaping antigenic and genetic diversity in influenza
    Daniel Zinder
    University of Michigan, Department of Computational Medicine and Bioinformatics, Department of Ecology and Evolutionary Biology, Ann Arbor, MI, USA
    PLoS Pathog 9:e1003104. 2013
  9. pmc Viral phylodynamics
    Erik M Volz
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Comput Biol 9:e1002947. 2013
  10. pmc Canalization of the evolutionary trajectory of the human influenza virus
    Trevor Bedford
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Biol 10:38. 2012

Detail Information

Publications12

  1. pmc Optimization of gene expression by natural selection
    Trevor Bedford
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 106:1133-8. 2009
    ..These findings highlight the power of natural selection to shape phenotype, even when the fitness effects of mutations are in the nearly neutral range...
  2. pmc Global migration dynamics underlie evolution and persistence of human influenza A (H3N2)
    Trevor Bedford
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Pathog 6:e1000918. 2010
    ..Our results might also aid the design of surveillance efforts and of vaccines better tailored to different geographic regions...
  3. pmc Strength and tempo of selection revealed in viral gene genealogies
    Trevor Bedford
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, USA
    BMC Evol Biol 11:220. 2011
    ..Understanding the process of adaptation in these viral systems is essential to our efforts to combat infectious disease...
  4. pmc Overdispersion of the molecular clock varies between yeast, Drosophila and mammals
    Trevor Bedford
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 179:977-84. 2008
    ..Our research suggests that mutational robustness is more pervasive in organisms with large population sizes and that robustness acts to stabilize the molecular evolutionary clock of sequence change...
  5. pmc Adaptive impact of the chimeric gene Quetzalcoatl in Drosophila melanogaster
    Rebekah L Rogers
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 107:10943-8. 2010
    ..Together, these results show that chimeric genes can produce structural and regulatory changes in a single mutational step and may be a major factor in adaptive evolution...
  6. pmc Overdispersion of the molecular clock: temporal variation of gene-specific substitution rates in Drosophila
    Trevor Bedford
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA
    Mol Biol Evol 25:1631-8. 2008
    ..Also, the presence of substantial variation in gene-specific substitution rates has broad implications for work in phylogeny reconstruction and evolutionary rate estimation...
  7. pmc Formation and longevity of chimeric and duplicate genes in Drosophila melanogaster
    Rebekah L Rogers
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 181:313-22. 2009
    ..Our results paint a dynamic picture of both chimeras and duplicate genes within the genome and suggest that chimeric genes contribute substantially to genomic novelty...
  8. pmc The roles of competition and mutation in shaping antigenic and genetic diversity in influenza
    Daniel Zinder
    University of Michigan, Department of Computational Medicine and Bioinformatics, Department of Ecology and Evolutionary Biology, Ann Arbor, MI, USA
    PLoS Pathog 9:e1003104. 2013
    ....
  9. pmc Viral phylodynamics
    Erik M Volz
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Comput Biol 9:e1002947. 2013
    ..The quantitative investigation of these processes through the consideration of viral phylogenies is the central aim of viral phylodynamics...
  10. pmc Canalization of the evolutionary trajectory of the human influenza virus
    Trevor Bedford
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Biol 10:38. 2012
    ..Here, we propose a simple model of antigenic evolution in the influenza virus that accounts for this apparent discrepancy...
  11. pmc Spatial guilds in the Serengeti food web revealed by a Bayesian group model
    Edward B Baskerville
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Comput Biol 7:e1002321. 2011
    ..Furthermore, our Bayesian approach provides a powerful, flexible framework for the study of network structure, and we believe it will prove instrumental in a variety of biological contexts...
  12. ncbi request reprint Gene conversion as a source of nucleotide diversity in Plasmodium falciparum
    Kaare M Nielsen
    Department of Organismic and Evolutionary Biology, Harvard University, USA
    Mol Biol Evol 20:726-34. 2003
    ..The 5' and 3' flanking regions differ in 47.7% and 39.8% of the nucleotide sites, respectively. Hence synonymous sites and flanking regions are not conserved in sequence in spite of their high AT content and T skew...