Srinivasan Beddhu

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint The body mass index paradox and an obesity, inflammation, and atherosclerosis syndrome in chronic kidney disease
    Srinivasan Beddhu
    Renal Section, Salt Lake VA Healthcare System and Division of Nephrology and Hypertension, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Semin Dial 17:229-32. 2004
  2. ncbi request reprint Inflammation and inverse associations of body mass index and serum creatinine with mortality in hemodialysis patients
    Srinivasan Beddhu
    Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah 84112, USA
    J Ren Nutr 17:372-80. 2007
  3. ncbi request reprint Effects of body size and body composition on survival in hemodialysis patients
    Srinivasan Beddhu
    Renal Section, Salt Lake VA Healthcare System, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    J Am Soc Nephrol 14:2366-72. 2003
  4. ncbi request reprint Impact of timing of initiation of dialysis on mortality
    Srinivasan Beddhu
    Renal Section, Salt Lake VA Healthcare System, Division of Nephrology and Hypertension, and Division of Clinical Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    J Am Soc Nephrol 14:2305-12. 2003
  5. pmc Associations of resting heart rate with insulin resistance, cardiovascular events and mortality in chronic kidney disease
    Srinivasan Beddhu
    Department of Medicine, VA Healthcare System, University of Utah School of Medicine, Salt Lake City, UT, USA
    Nephrol Dial Transplant 24:2482-8. 2009
  6. ncbi request reprint Associations of metabolic syndrome with inflammation in CKD: results From the Third National Health and Nutrition Examination Survey (NHANES III)
    Srinivasan Beddhu
    Medical Service, Salt Lake Veterans Affairs Healthcare System, Salt Lake City, UT, USA
    Am J Kidney Dis 46:577-86. 2005
  7. ncbi request reprint Normalization of protein intake by body weight and the associations of protein intake with nutritional status and survival
    Srinivasan Beddhu
    Renal Section, Salt Lake VA Healthcare System, Salt Lake City, UT, USA
    J Ren Nutr 15:387-97. 2005
  8. pmc Serum alkaline phosphatase and mortality in African Americans with chronic kidney disease
    Srinivasan Beddhu
    Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah, USA
    Clin J Am Soc Nephrol 4:1805-10. 2009
  9. ncbi request reprint Creatinine production, nutrition, and glomerular filtration rate estimation
    Srinivasan Beddhu
    Renal Section, Salt Lake VA Healthcare System, Salt Lake City, Utah, USA
    J Am Soc Nephrol 14:1000-5. 2003
  10. ncbi request reprint Impact of renal failure on the risk of myocardial infarction and death
    Srinivasan Beddhu
    Renal Section, Salt Lake VA Healthcare System, Salt Lake City, Utah, USA
    Kidney Int 62:1776-83. 2002

Research Grants

Detail Information

Publications52

  1. ncbi request reprint The body mass index paradox and an obesity, inflammation, and atherosclerosis syndrome in chronic kidney disease
    Srinivasan Beddhu
    Renal Section, Salt Lake VA Healthcare System and Division of Nephrology and Hypertension, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Semin Dial 17:229-32. 2004
    ..Therefore high body fat patients have intermediate survival. Thus it is postulated that an association of obesity, inflammation, and atherosclerosis (OIA syndrome) might exist in CKD...
  2. ncbi request reprint Inflammation and inverse associations of body mass index and serum creatinine with mortality in hemodialysis patients
    Srinivasan Beddhu
    Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah 84112, USA
    J Ren Nutr 17:372-80. 2007
    ..Protein-energy wasting and inflammation are common and associated with an increased risk of mortality in hemodialysis (HD) patients. We examined the extent to which they mediate the associations of each other with death in this population...
  3. ncbi request reprint Effects of body size and body composition on survival in hemodialysis patients
    Srinivasan Beddhu
    Renal Section, Salt Lake VA Healthcare System, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    J Am Soc Nephrol 14:2366-72. 2003
    ..The protective effect conferred by high BMI is limited to those patients with normal or high muscle mass. High BMI patients with inferred high body fat have increased and not decreased mortality...
  4. ncbi request reprint Impact of timing of initiation of dialysis on mortality
    Srinivasan Beddhu
    Renal Section, Salt Lake VA Healthcare System, Division of Nephrology and Hypertension, and Division of Clinical Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    J Am Soc Nephrol 14:2305-12. 2003
    ..Furthermore, these data do not support earlier initiation of dialysis. Therefore, for patients without clinical indications for initiation of dialysis, the appropriate GFR level for initiation of dialysis is unknown...
  5. pmc Associations of resting heart rate with insulin resistance, cardiovascular events and mortality in chronic kidney disease
    Srinivasan Beddhu
    Department of Medicine, VA Healthcare System, University of Utah School of Medicine, Salt Lake City, UT, USA
    Nephrol Dial Transplant 24:2482-8. 2009
    ..Resting heart rate reflects autonomic activity. Therefore, we examined the associations of resting heart rate with insulin resistance, cardiovascular events and mortality in the moderate chronic kidney disease (CKD) population...
  6. ncbi request reprint Associations of metabolic syndrome with inflammation in CKD: results From the Third National Health and Nutrition Examination Survey (NHANES III)
    Srinivasan Beddhu
    Medical Service, Salt Lake Veterans Affairs Healthcare System, Salt Lake City, UT, USA
    Am J Kidney Dis 46:577-86. 2005
    ..Although metabolic syndrome is associated with inflammation in the general population, it is unknown whether similar associations exist in patients with chronic kidney disease...
  7. ncbi request reprint Normalization of protein intake by body weight and the associations of protein intake with nutritional status and survival
    Srinivasan Beddhu
    Renal Section, Salt Lake VA Healthcare System, Salt Lake City, UT, USA
    J Ren Nutr 15:387-97. 2005
    ..To examine the associations of total protein intake (TPI) and dietary protein intake (DPI) with baseline nutrition and subsequent mortality...
  8. pmc Serum alkaline phosphatase and mortality in African Americans with chronic kidney disease
    Srinivasan Beddhu
    Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah, USA
    Clin J Am Soc Nephrol 4:1805-10. 2009
    ....
  9. ncbi request reprint Creatinine production, nutrition, and glomerular filtration rate estimation
    Srinivasan Beddhu
    Renal Section, Salt Lake VA Healthcare System, Salt Lake City, Utah, USA
    J Am Soc Nephrol 14:1000-5. 2003
    ..The fundamental assumption of the MDRD formula is invalid in patients with advanced renal failure, and the use of this formula in these patients might introduce biases...
  10. ncbi request reprint Impact of renal failure on the risk of myocardial infarction and death
    Srinivasan Beddhu
    Renal Section, Salt Lake VA Healthcare System, Salt Lake City, Utah, USA
    Kidney Int 62:1776-83. 2002
    ..We examined whether renal failure independently increases the risk of myocardial infarction and death...
  11. pmc Physical activity and mortality in chronic kidney disease (NHANES III)
    Srinivasan Beddhu
    VA Healthcare System, Salt Lake City, UT 84112, USA
    Clin J Am Soc Nephrol 4:1901-6. 2009
    ..However, it is unclear whether the associations of physical activity with mortality are modified by the presence of CKD. Therefore, we examined the effects of CKD on the associations of physical activity with mortality...
  12. ncbi request reprint Association of serum albumin and atherosclerosis in chronic hemodialysis patients
    Srinivasan Beddhu
    National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA
    Am J Kidney Dis 40:721-7. 2002
    ..Because cardiovascular disease is the leading cause of death and hypoalbuminemia predicts mortality, hypoalbuminemia may be associated with atherosclerosis...
  13. pmc Net endogenous acid production is associated with a faster decline in GFR in African Americans
    Julia J Scialla
    Department of Medicine, University of Miami, Miami, Florida 33136, USA
    Kidney Int 82:106-12. 2012
    ..10) for composite renal events per 25 mEq/day higher net endogenous acid production was not significant. Hence, our findings implicate endogenous acid production as a potential modifiable risk factor for progressive kidney disease...
  14. ncbi request reprint Association of obesity with inflammation in chronic kidney disease: a cross-sectional study
    Nirupama Ramkumar
    Division of Nephrology and Hypertension, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA
    J Ren Nutr 14:201-7. 2004
    ..We examined the cross-sectional association of body mass index (BMI) with CRP in patients with chronic kidney disease (CKD)...
  15. doi request reprint Higher serum bicarbonate levels within the normal range are associated with better survival and renal outcomes in African Americans
    Kalani L Raphael
    VA Healthcare System, Salt Lake City, Utah, USA
    Kidney Int 79:356-62. 2011
    ..Whether increasing serum bicarbonate into the high-normal range will improve kidney outcomes during interventional studies will need to be considered...
  16. pmc Associations of serum skeletal alkaline phosphatase with elevated C-reactive protein and mortality
    Rebecca Filipowicz
    Department of Medicine, University of Utah School of Medicine, 85 North Medical Drive East, Salt Lake City, UT 84112, USA
    Clin J Am Soc Nephrol 8:26-32. 2013
    ..It is unclear to what extent these associations are related to bone disease...
  17. ncbi request reprint Nutrition and racial differences in cardiovascular events and survival in elderly dialysis patients
    Donald Morris
    Renal Section, Salt Lake VA Healthcare System Division of Nephrology and Hypertension, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Am J Med 118:671-5. 2005
  18. pmc Serum bicarbonate and mortality in adults in NHANES III
    Kalani L Raphael
    Salt Lake City VA Healthcare System, Salt Lake City, UT, USA
    Nephrol Dial Transplant 28:1207-13. 2013
    ..Low serum bicarbonate concentration is a risk factor for death in people with chronic kidney disease (CKD). Whether low serum bicarbonate is a mortality risk factor for people without CKD is unknown...
  19. doi request reprint Associations of serum alkaline phosphatase with metabolic syndrome and mortality
    Vidya Raj Krishnamurthy
    VA Salt Lake City Health Care System, Utah, USA
    Am J Med 124:566.e1-7. 2011
    ..As metabolic syndrome is associated with higher serum alkaline phosphatase levels, we examined the joint association of mortality with metabolic syndrome and serum alkaline phosphatase levels in the US general population...
  20. doi request reprint Effect of donor kidney volume on recipient outcome: does the "dose" matter?
    Magdalena B Sikora
    Division of Nephrology, Transplant Program, University of Utah, 30 N 1900 E, Salt Lake City, UT 84132, USA
    Transplantation 94:1124-30. 2012
    ..The effect of donor kidney volume on recipient kidney function has not been fully evaluated...
  21. ncbi request reprint Lack of synergistic effects of metabolic syndrome and plasma fibrinogen on coronary events and mortality in moderate CKD
    Nirupama Ramkumar
    Division of Nephrology and Hypertension, University of Utah School of Medicine, Salt Lake City, UT, USA
    Am J Kidney Dis 49:356-64. 2007
    ..Metabolic syndrome and inflammation are interlinked in patients with moderate chronic kidney disease (CKD)...
  22. doi request reprint The influence of age on changes in health-related quality of life over three years in a cohort undergoing hemodialysis
    Mark L Unruh
    Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 56:1608-17. 2008
    ..To assess the extent to which persons aged 70 and older undergoing hemodialysis (HD) had greater changes in health-related quality of life (HRQOL) over 3 years than younger patients undergoing HD...
  23. ncbi request reprint Do associations with C-reactive protein and extent of coronary artery disease account for the increased cardiovascular risk of renal insufficiency?
    James S Zebrack
    Divisions of Cardiology and Nephrology, University of Utah School of Medicine, Salt Lake City, Utah, USA
    J Am Coll Cardiol 42:57-63. 2003
    ..We sought to determine whether the association of higher C-reactive protein levels (CRP) and more extensive coronary artery disease (CAD) explains the high cardiovascular risk of renal insufficiency (RI)...
  24. doi request reprint Implications and importance of skeletal muscle mass in estimating glomerular filtration rate at dialysis initiation
    Tahir Zaman
    Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    J Ren Nutr 23:233-6. 2013
    ..Until then, in those with extremes of nutrition, mean of measured urea and creatinine clearances might provide more accurate GFR estimation for initiation of dialysis than the currently available equations...
  25. pmc Dietary phosphorus intake and mortality in moderate chronic kidney disease: NHANES III
    Maureen A Murtaugh
    Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA
    Nephrol Dial Transplant 27:990-6. 2012
    ..Therefore, we examined these associations in National Health and Nutrition Examination Survey III...
  26. ncbi request reprint Malnutrition and atherosclerosis in dialysis patients
    Srinivasan Beddhu
    Renal Section, Salt Lake VA Healthcare System, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    J Am Soc Nephrol 15:733-42. 2004
    ..Further longitudinal studies are warranted to provide definitive evidence of malnutrition as a uremic risk factor for atherosclerosis...
  27. ncbi request reprint Effect of body size and body composition on survival in peritoneal dialysis patients
    Nirupama Ramkumar
    Renal Section, Salt Lake VA Healthcare System, Utah, USA
    Perit Dial Int 25:461-9. 2005
    ..We hypothesized that patients with high body mass index (BMI) and low muscle mass might be considered to have high levels of body fat...
  28. doi request reprint High dietary fiber intake is associated with decreased inflammation and all-cause mortality in patients with chronic kidney disease
    Vidya M Raj Krishnamurthy
    VA Salt Lake City Health Care System, Salt Lake City, Utah, USA
    Kidney Int 81:300-6. 2012
    ..Interventional trials are needed to establish the effects of fiber intake on inflammation and mortality in kidney disease...
  29. pmc Cognitive function and the risk of death in chronic kidney disease
    Kalani L Raphael
    VA Healthcare System, University of Utah School of Medicine, Salt Lake City, USA
    Am J Nephrol 35:49-57. 2012
    ....
  30. pmc Both low muscle mass and low fat are associated with higher all-cause mortality in hemodialysis patients
    Cindy X Huang
    Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 77:624-9. 2010
    ..These studies show that body composition in end-stage renal disease bears a complex relationship to all-cause mortality...
  31. ncbi request reprint Associations of body size with metabolic syndrome and mortality in moderate chronic kidney disease
    Bonnie C H Kwan
    Division of Nephrology and Hypertension, University of Utah School of Medicine, Salt Lake City, UT, USA
    Clin J Am Soc Nephrol 2:992-8. 2007
    ..We examined whether chronic kidney disease (CKD) modifies the association of obesity with metabolic syndrome and mortality...
  32. doi request reprint Optimal nutrition for predialysis chronic kidney disease
    Rebecca Filipowicz
    Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA
    Adv Chronic Kidney Dis 20:175-80. 2013
    ..In those with more advanced CKD, dietary calcium and phosphorus restriction could minimize vascular calcification. Dietary fiber and vitamin D supplementation might also be important to decrease inflammation in CKD...
  33. ncbi request reprint Diagnosis and therapy of coronary artery disease in renal failure, end-stage renal disease, and renal transplant populations
    Christine M Logar
    Renal Section, Salt Lake VA Healthcare System, Department of Medicine, University of Utah School of Medicine, Salt Lake City, USA
    Am J Med Sci 325:214-27. 2003
    ..Future studies need to focus on unraveling the mechanisms by which uremia leads to increased cardiovascular events to design optimal therapies targeted toward these mechanisms and improve cardiovascular outcomes...
  34. pmc Estimated net endogenous acid production and serum bicarbonate in African Americans with chronic kidney disease
    Julia J Scialla
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Clin J Am Soc Nephrol 6:1526-32. 2011
    ..We tested the association between estimated NEAP and serum bicarbonate in patients with CKD...
  35. pmc Surgical revascularization versus amputation for peripheral vascular disease in dialysis patients: a cohort study
    Christine M Logar
    Renal Section, Salt Lake VA Healthcare System, University of Utah School of Medicine, Salt Lake City, UT, USA
    BMC Nephrol 6:3. 2005
    ..Surgical treatment of peripheral vascular disease (PVD) in dialysis patients is controversial...
  36. ncbi request reprint Patient preferences for in-center intense hemodialysis
    Nirupama Ramkumar
    Division of Nephrology and Hypertension, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Hemodial Int 9:281-95. 2005
    ..Disruption of personal time, however, is an important consideration. Success of DHD program would depend on arrangements for transportation to dialysis unit...
  37. doi request reprint Serum alkaline phosphatase levels associate with elevated serum C-reactive protein in chronic kidney disease
    Sriharsha Damera
    Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Kidney Int 79:228-33. 2011
    ..Thus, associations of serum alkaline phosphatase with elevated CRP are independent of serum 25-OH vitamin D in the chronic and non-CKD populations. Hence, serum alkaline phosphatase might be a marker of the inflammatory milieu...
  38. ncbi request reprint Blood enzymes and oxidative stress in chronic kidney disease: a cross sectional study
    Kamisha L Johnson-Davis
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    Ann Clin Lab Sci 41:331-9. 2011
    ..Several studies have shown an imbalance in antioxidant activity, resulting in high oxidative stress and lipid peroxidation, in subjects undergoing hemodialysis...
  39. ncbi request reprint The effects of comorbid conditions on the outcomes of patients undergoing peritoneal dialysis
    Srinivasan Beddhu
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Med 112:696-701. 2002
    ..We examined the effects of age and comorbid conditions on technique failure (i.e., transfer to hemodialysis), death, hospital costs, and kidney transplantation in patients treated with peritoneal dialysis...
  40. ncbi request reprint The clinical and morphologic spectrum of renal cryoglobulinemia
    Srinivasan Beddhu
    Department of Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
    Medicine (Baltimore) 81:398-409. 2002
    ....
  41. ncbi request reprint Say "no" and comorbidity
    Srinivasan Beddhu
    Am J Kidney Dis 42:429-30; author reply 429. 2003
  42. ncbi request reprint Impact of dialysis dose and membrane on infection-related hospitalization and death: results of the HEMO Study
    Michael Allon
    Division of Nephrology, University of Alabama at Birmingham, Paula Building Room 226, 728 Richard Arrington Boulevard, Birmingham, AL 35233, USA
    J Am Soc Nephrol 14:1863-70. 2003
    ..However, the frequency of access-related, infection-related hospitalizations was disproportionately higher among patients with catheters compared with grafts or fistulas...
  43. ncbi request reprint Effects of hemodialysis dose and membrane flux on health-related quality of life in the HEMO Study
    Mark Unruh
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Kidney Int 66:355-66. 2004
    ....
  44. ncbi request reprint Body mass index and survival in incident dialysis patients: the answer depends on the question
    Srinivasan Beddhu
    Am J Clin Nutr 81:534-6; author reply 536. 2005
  45. ncbi request reprint The spectrum of infection-related morbidity in hospitalized haemodialysis patients
    Michael Allon
    Division of Nephrology, University of Alabama at Birmingham, AL, USA
    Nephrol Dial Transplant 20:1180-6. 2005
    ..Few prospective studies have examined the clinical consequences of infection-related hospitalizations in haemodialysis patients or the risk factors predictive of clinical outcomes...
  46. ncbi request reprint Hemodialysis timing, survival, and cardiovascular outcomes in the Hemodialysis (HEMO) Study
    Yue Harn Ng
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Kidney Dis 47:614-24. 2006
    ..This report examines the extent to which hemodialysis treatment time of day was associated with cardiovascular mortality and morbidity and all-cause mortality in a secondary analysis of the Hemodialysis Study...
  47. ncbi request reprint The paradox of the "body mass index paradox" in dialysis patients: associations of adiposity with inflammation
    Srinivasan Beddhu
    Am J Clin Nutr 82:909-10; author reply 910-11. 2005
  48. ncbi request reprint Cerebrovascular disease in maintenance hemodialysis patients: results of the HEMO Study
    James A Delmez
    Washington University, St Louis, MO, USA
    Am J Kidney Dis 47:131-8. 2006
    ....
  49. ncbi request reprint If fat is good, muscle is better
    Srinivasan Beddhu
    Am J Kidney Dis 47:193; author reply 193-4. 2006
  50. ncbi request reprint Does statin therapy improve cardiovascular outcomes in patients with type 2 diabetes receiving hemodialysis?
    Bonnie C H Kwan
    Prince of Wales Hospital, Hong Kong
    Nat Clin Pract Nephrol 2:76-7. 2006
  51. ncbi request reprint Lipoprotein metabolism and lipid management in chronic kidney disease
    Bonnie C H Kwan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    J Am Soc Nephrol 18:1246-61. 2007
  52. ncbi request reprint A story half untold: adiposity, adipokines and outcomes in dialysis population
    Bonnie C H Kwan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong BCHK
    Semin Dial 20:493-7. 2007
    ....

Research Grants8

  1. Adipokines in Hemodialysis Patients
    Srinivasan Beddhu; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: If fat cells produce harmful proteins, therapy targeted towards decreasing the production of these proteins will ultimately decrease the morbidity and mortality in obese dialysis patients. ..
  2. Protein intake, nutrition and cardiovascular disease in stage V CKD
    Srinivasan Beddhu; Fiscal Year: 2009
    ..Relevance to public health: This study will examine in HD patients the role of protein intake in malnutrition and cardiovascular disease, two of the most important problems in these patients. ..
  3. Protein intake, nutrition and cardiovascular disease in stage V CKD
    Srinivasan Beddhu; Fiscal Year: 2009
    ..Relevance to public health: This study will examine in HD patients the role of protein intake in malnutrition and cardiovascular disease, two of the most important problems in these patients. ..
  4. Adipokines in Hemodialysis Patients
    Srinivasan Beddhu; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: If fat cells produce harmful proteins, therapy targeted towards decreasing the production of these proteins will ultimately decrease the morbidity and mortality in obese dialysis patients. ..
  5. Protein intake, nutrition and cardiovascular disease in stage V CKD
    Srinivasan Beddhu; Fiscal Year: 2010
    ..Relevance to public health: This study will examine in HD patients the role of protein intake in malnutrition and cardiovascular disease, two of the most important problems in these patients. ..