Srinivasan Beddhu

..Therefore high body fat patients have intermediate survival. Thus it is postulated that an association of obesity, inflammation, and atherosclerosis (OIA syndrome) might exist in CKD...

..Protein-energy wasting and inflammation are common and associated with an increased risk of mortality in hemodialysis (HD) patients. We examined the extent to which they mediate the associations of each other with death in this population...

..Although metabolic syndrome is associated with inflammation in the general population, it is unknown whether similar associations exist in patients with chronic kidney disease...

..To examine the associations of total protein intake (TPI) and dietary protein intake (DPI) with baseline nutrition and subsequent mortality...

..The protective effect conferred by high BMI is limited to those patients with normal or high muscle mass. High BMI patients with inferred high body fat have increased and not decreased mortality...

..Furthermore, these data do not support earlier initiation of dialysis. Therefore, for patients without clinical indications for initiation of dialysis, the appropriate GFR level for initiation of dialysis is unknown...

..However, it is unclear whether the associations of physical activity with mortality are modified by the presence of CKD. Therefore, we examined the effects of CKD on the associations of physical activity with mortality...

..Because cardiovascular disease is the leading cause of death and hypoalbuminemia predicts mortality, hypoalbuminemia may be associated with atherosclerosis...

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..The fundamental assumption of the MDRD formula is invalid in patients with advanced renal failure, and the use of this formula in these patients might introduce biases...

..Resting heart rate reflects autonomic activity. Therefore, we examined the associations of resting heart rate with insulin resistance, cardiovascular events and mortality in the moderate chronic kidney disease (CKD) population...

..We examined whether renal failure independently increases the risk of myocardial infarction and death...

..10) for composite renal events per 25 mEq/day higher net endogenous acid production was not significant. Hence, our findings implicate endogenous acid production as a potential modifiable risk factor for progressive kidney disease...

..CONCLUSION: These data suggest that as in the general population, in CKD patients, obesity, a traditional risk factor for atherosclerosis, is associated with inflammation, a novel risk factor for atherosclerosis...

..Whether increasing serum bicarbonate into the high-normal range will improve kidney outcomes during interventional studies will need to be considered...

..As metabolic syndrome is associated with higher serum alkaline phosphatase levels, we examined the joint association of mortality with metabolic syndrome and serum alkaline phosphatase levels in the US general population...

..The effect of donor kidney volume on recipient kidney function has not been fully evaluated...

..Metabolic syndrome and inflammation are interlinked in patients with moderate chronic kidney disease (CKD)...

..To assess the extent to which persons aged 70 and older undergoing hemodialysis (HD) had greater changes in health-related quality of life (HRQOL) over 3 years than younger patients undergoing HD...

..We sought to determine whether the association of higher C-reactive protein levels (CRP) and more extensive coronary artery disease (CAD) explains the high cardiovascular risk of renal insufficiency (RI)...

..Therefore, we examined these associations in National Health and Nutrition Examination Survey III...

..As incident PD patients with high BMI and normal or high muscle mass have the best survival, PD patients should be encouraged to gain muscle mass rather than fat mass...

..Further longitudinal studies are warranted to provide definitive evidence of malnutrition as a uremic risk factor for atherosclerosis...

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..Interventional trials are needed to establish the effects of fiber intake on inflammation and mortality in kidney disease...

..These studies show that body composition in end-stage renal disease bears a complex relationship to all-cause mortality...

..We examined whether chronic kidney disease (CKD) modifies the association of obesity with metabolic syndrome and mortality...

..It is unclear to what extent these associations are related to bone disease...

..We tested the association between estimated NEAP and serum bicarbonate in patients with CKD...

..Future studies need to focus on unraveling the mechanisms by which uremia leads to increased cardiovascular events to design optimal therapies targeted toward these mechanisms and improve cardiovascular outcomes...

..Surgical treatment of peripheral vascular disease (PVD) in dialysis patients is controversial...

..Disruption of personal time, however, is an important consideration. Success of DHD program would depend on arrangements for transportation to dialysis unit...

..Thus, associations of serum alkaline phosphatase with elevated CRP are independent of serum 25-OH vitamin D in the chronic and non-CKD populations. Hence, serum alkaline phosphatase might be a marker of the inflammatory milieu...

..Several studies have shown an imbalance in antioxidant activity, resulting in high oxidative stress and lipid peroxidation, in subjects undergoing hemodialysis...

..CONCLUSION: Patients who are older and more ill have a greater risk of death and of transfer to hemodialysis from peritoneal dialysis...

..Until then, in those with extremes of nutrition, mean of measured urea and creatinine clearances might provide more accurate GFR estimation for initiation of dialysis than the currently available equations...

..In those with more advanced CKD, dietary calcium and phosphorus restriction could minimize vascular calcification. Dietary fiber and vitamin D supplementation might also be important to decrease inflammation in CKD...

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..However, the frequency of access-related, infection-related hospitalizations was disproportionately higher among patients with catheters compared with grafts or fistulas...

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..Few prospective studies have examined the clinical consequences of infection-related hospitalizations in haemodialysis patients or the risk factors predictive of clinical outcomes...

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..89 to 1.22; P = 0.64). CONCLUSION: Making extensive adjustment for patient characteristics, this report does not support the association of lower all-cause mortality with morning hemodialysis or a particular benefit for older patients...

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..PUBLIC HEALTH RELEVANCE: If fat cells produce harmful proteins, therapy targeted towards decreasing the production of these proteins will ultimately decrease the morbidity and mortality in obese dialysis patients. ..

..Relevance to public health: This study will examine in HD patients the role of protein intake in malnutrition and cardiovascular disease, two of the most important problems in these patients. ..

..Relevance to public health: This study will examine in HD patients the role of protein intake in malnutrition and cardiovascular disease, two of the most important problems in these patients. ..

..PUBLIC HEALTH RELEVANCE: If fat cells produce harmful proteins, therapy targeted towards decreasing the production of these proteins will ultimately decrease the morbidity and mortality in obese dialysis patients. ..

..Relevance to public health: This study will examine in HD patients the role of protein intake in malnutrition and cardiovascular disease, two of the most important problems in these patients. ..