Sabrina Bedard

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc The foldon substructure of staphylococcal nuclease
    Sabrina Bedard
    Johnson Research Foundation, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6059, USA
    J Mol Biol 376:1142-54. 2008
  2. pmc Protein folding: independent unrelated pathways or predetermined pathway with optional errors
    Sabrina Bedard
    Johnson Research Foundation, Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:7182-7. 2008
  3. pmc Protein hydrogen exchange: testing current models
    John J Skinner
    Johnson Research Foundation, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6059, USA
    Protein Sci 21:987-95. 2012
  4. pmc Protein dynamics viewed by hydrogen exchange
    John J Skinner
    Johnson Research Foundation, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6059, USA
    Protein Sci 21:996-1005. 2012
  5. pmc Cytochrome c folding pathway: kinetic native-state hydrogen exchange
    Linh Hoang
    The Johnson Research Foundation, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6059, USA
    Proc Natl Acad Sci U S A 99:12173-8. 2002
  6. pmc Dynamic and thermodynamic response of the Ras protein Cdc42Hs upon association with the effector domain of PAK3
    Veronica R Moorman
    Graduate Group in Biochemistry and Molecular Biophysics, Johnson Research Foundation and Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6059, USA
    J Mol Biol 426:3520-38. 2014
  7. pmc Reverse micelles as a platform for dynamic nuclear polarization in solution NMR of proteins
    Kathleen G Valentine
    Johnson Research Foundation and Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6059
    J Am Chem Soc 136:2800-7. 2014
  8. pmc Optimization of NMR spectroscopy of encapsulated proteins dissolved in low viscosity fluids
    Nathaniel V Nucci
    Graduate Group in Biochemistry and Molecular Biophysics and Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104 6059, USA
    J Biomol NMR 50:421-30. 2011

Collaborators

Detail Information

Publications8

  1. pmc The foldon substructure of staphylococcal nuclease
    Sabrina Bedard
    Johnson Research Foundation, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6059, USA
    J Mol Biol 376:1142-54. 2008
    ..Because the unfolding parameters of many other residues are not determined, it seems likely that the concerted foldon units are more extensive than is shown by the 34 residues actually observed...
  2. pmc Protein folding: independent unrelated pathways or predetermined pathway with optional errors
    Sabrina Bedard
    Johnson Research Foundation, Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:7182-7. 2008
    ..Structural, kinetic, and thermodynamic information for the folding intermediates and pathways of many proteins is consistent with the predetermined pathway-optional error (PPOE) model but contrary to the properties implied in IUP models...
  3. pmc Protein hydrogen exchange: testing current models
    John J Skinner
    Johnson Research Foundation, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6059, USA
    Protein Sci 21:987-95. 2012
    ..Protein Sci 2012;21:996-1005)...
  4. pmc Protein dynamics viewed by hydrogen exchange
    John J Skinner
    Johnson Research Foundation, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6059, USA
    Protein Sci 21:996-1005. 2012
    ..Many of these motions occur over time scales that are appropriate for biochemical function...
  5. pmc Cytochrome c folding pathway: kinetic native-state hydrogen exchange
    Linh Hoang
    The Johnson Research Foundation, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6059, USA
    Proc Natl Acad Sci U S A 99:12173-8. 2002
    ..Four distinct unfolding steps are found to be kinetically ordered in the same pathway sequence inferred before...
  6. pmc Dynamic and thermodynamic response of the Ras protein Cdc42Hs upon association with the effector domain of PAK3
    Veronica R Moorman
    Graduate Group in Biochemistry and Molecular Biophysics, Johnson Research Foundation and Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6059, USA
    J Mol Biol 426:3520-38. 2014
    ..In addition, the Rho insert helix, which is located at a site remote from the PBD46 binding interface, shows a significant dynamic response to PBD46 binding. ..
  7. pmc Reverse micelles as a platform for dynamic nuclear polarization in solution NMR of proteins
    Kathleen G Valentine
    Johnson Research Foundation and Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6059
    J Am Chem Soc 136:2800-7. 2014
    ..These and other observations suggest that merging reverse micelle encapsulation technology with DNP offers a route to a significant increase in the sensitivity of solution NMR spectroscopy of proteins and other biomolecules. ..
  8. pmc Optimization of NMR spectroscopy of encapsulated proteins dissolved in low viscosity fluids
    Nathaniel V Nucci
    Graduate Group in Biochemistry and Molecular Biophysics and Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104 6059, USA
    J Biomol NMR 50:421-30. 2011
    ....