Pamela Becker

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Retrospective comparison of clofarabine versus fludarabine in combination with high-dose cytarabine with or without granulocyte colony-stimulating factor as salvage therapies for acute myeloid leukemia
    Pamela S Becker
    Divisions of Hematology and Medical Oncology, University of Washington, USA
    Haematologica 98:114-8. 2013
  2. ncbi Dependence of acute myeloid leukemia on adhesion within the bone marrow microenvironment
    Pamela S Becker
    Division of Hematology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Campus Box 358056, 815 Mercer Street N415, Seattle, WA 98109, USA
    ScientificWorldJournal 2012:856467. 2012
  3. ncbi Clofarabine with high dose cytarabine and granulocyte colony-stimulating factor (G-CSF) priming for relapsed and refractory acute myeloid leukaemia
    Pamela S Becker
    Division of Hematology and Medical Oncology, University of Washington, Seattle, WA 98109, USA
    Br J Haematol 155:182-9. 2011
  4. ncbi Preclinical correction of human Fanconi anemia complementation group A bone marrow cells using a safety-modified lentiviral vector
    P S Becker
    Division of Hematology, Department of Medicine, University of Washington, 815 Mercer Street, Seattle, WA 98109, USA
    Gene Ther 17:1244-52. 2010
  5. ncbi Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia
    Pamela S Becker
    Division of Hematology, University of Washington, Seattle, WA 98109, USA
    Blood 113:866-74. 2009
  6. ncbi Growth factor priming in therapy of acute myelogenous leukemia
    Pamela S Becker
    Division of Hematology, 1959 NE Pacific St, University of Washington, Seattle, WA 98195, USA
    Curr Hematol Rep 3:413-8. 2004
  7. ncbi The current status of gene therapy in autologous transplantation
    Pamela S Becker
    University of Washington, Seattle, WA 98195, USA
    Acta Haematol 114:188-97. 2005
  8. ncbi Hematopoietic stem cell gene therapy for inherited bone marrow disorders: past accomplishments and continued challenges
    Pamela S Becker
    Department of Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    J Cell Biochem Suppl 38:55-64. 2002
  9. ncbi A specific heptapeptide from a phage display peptide library homes to bone marrow and binds to primitive hematopoietic stem cells
    Grzegorz S Nowakowski
    Division of Gene Therapy, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Stem Cells 22:1030-8. 2004
  10. ncbi Adhesion receptor expression by CD34+ cells from peripheral blood or bone marrow grafts: correlation with time to engraftment
    Jack Gold
    Department of Mathematics, University of Massachusetts, Amherst, MA, USA
    Exp Hematol 34:680-7. 2006

Research Grants

  1. RETROVIRAL TRANSFER OF ANKYRIN FOR SPHEROCYTOSIS
    Pamela Becker; Fiscal Year: 2002
  2. Core--National Cell Procuremen
    Pamela Becker; Fiscal Year: 2005

Collaborators

Detail Information

Publications15

  1. ncbi Retrospective comparison of clofarabine versus fludarabine in combination with high-dose cytarabine with or without granulocyte colony-stimulating factor as salvage therapies for acute myeloid leukemia
    Pamela S Becker
    Divisions of Hematology and Medical Oncology, University of Washington, USA
    Haematologica 98:114-8. 2013
    ..43, P=0.0002). Despite the retrospective nature of the analyses, GCLAC may be superior to FA/FLAG, particularly in patients with short duration of first complete remission or unfavorable cytogenetics...
  2. ncbi Dependence of acute myeloid leukemia on adhesion within the bone marrow microenvironment
    Pamela S Becker
    Division of Hematology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Campus Box 358056, 815 Mercer Street N415, Seattle, WA 98109, USA
    ScientificWorldJournal 2012:856467. 2012
    ..Detachment of these cells from the bone marrow in combination with chemotherapy may improve the outcome of therapy for AML...
  3. ncbi Clofarabine with high dose cytarabine and granulocyte colony-stimulating factor (G-CSF) priming for relapsed and refractory acute myeloid leukaemia
    Pamela S Becker
    Division of Hematology and Medical Oncology, University of Washington, Seattle, WA 98109, USA
    Br J Haematol 155:182-9. 2011
    ..GCLAC is highly active in relapsed and refractory AML and warrants prospective comparison to other regimens, as well as study in untreated patients...
  4. ncbi Preclinical correction of human Fanconi anemia complementation group A bone marrow cells using a safety-modified lentiviral vector
    P S Becker
    Division of Hematology, Department of Medicine, University of Washington, 815 Mercer Street, Seattle, WA 98109, USA
    Gene Ther 17:1244-52. 2010
    ..007), and increased survival. Thus, combining short transduction and reducing oxidative stress may enhance the viability and engraftment of gene-corrected cells in patients with FANCA...
  5. ncbi Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia
    Pamela S Becker
    Division of Hematology, University of Washington, Seattle, WA 98109, USA
    Blood 113:866-74. 2009
    ..Adhesion and migratory properties of AML blasts thus appear to influence chemosensitivity and therefore may be therapeutic targets...
  6. ncbi Growth factor priming in therapy of acute myelogenous leukemia
    Pamela S Becker
    Division of Hematology, 1959 NE Pacific St, University of Washington, Seattle, WA 98195, USA
    Curr Hematol Rep 3:413-8. 2004
    ....
  7. ncbi The current status of gene therapy in autologous transplantation
    Pamela S Becker
    University of Washington, Seattle, WA 98195, USA
    Acta Haematol 114:188-97. 2005
    ..Despite the slow progress of the field to date, there is extraordinary promise for gene therapy in the future...
  8. ncbi Hematopoietic stem cell gene therapy for inherited bone marrow disorders: past accomplishments and continued challenges
    Pamela S Becker
    Department of Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    J Cell Biochem Suppl 38:55-64. 2002
    ....
  9. ncbi A specific heptapeptide from a phage display peptide library homes to bone marrow and binds to primitive hematopoietic stem cells
    Grzegorz S Nowakowski
    Division of Gene Therapy, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Stem Cells 22:1030-8. 2004
    ....
  10. ncbi Adhesion receptor expression by CD34+ cells from peripheral blood or bone marrow grafts: correlation with time to engraftment
    Jack Gold
    Department of Mathematics, University of Massachusetts, Amherst, MA, USA
    Exp Hematol 34:680-7. 2006
    ..05). CONCLUSION: These data suggest that upregulation of specific adhesion receptors or selection of certain cell populations could result in earlier blood cell recovery after transplant...
  11. ncbi Autologous stem-cell transplantation can be performed safely without the use of blood-product support
    Karen K Ballen
    Division of Hematology Oncology, Massachusetts General Hospital, 100 Blossom St, Cox 640, Boston, MA 02114, USA
    J Clin Oncol 22:4087-94. 2004
    ..Most transplants require RBC and platelet support. We report the ability to perform autologous transplantation without blood-product support...
  12. ncbi Stem cells and prenatal origin of breast cancer
    Inkyung Baik
    Cancer Research Center and Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cancer Causes Control 15:517-30. 2004
    ..We conclude by outlining a feasible population-based study that measures stem cell potential to explore mechanisms mediating the relation between in utero exposure to pregnancy hormones and breast cancer risk in the offspring...
  13. ncbi Marrow stem cells shift gene expression and engraftment phenotype with cell cycle transit
    Jean-Francois Lambert
    Department of Research, Roger Williams Medical Center, 825 Chalkstone Ave, Providence, RI 02908, USA
    J Exp Med 197:1563-72. 2003
    ..These observations suggest stem cell gene expression shifts through cell cycle in relation to cell cycle related alterations of stem cell phenotype. The engraftment defect is related to a major phenotypic change of the stem cell...
  14. ncbi Low-dose total body irradiation followed by allogeneic lymphocyte infusion may induce remission in patients with refractory hematologic malignancy
    Karen K Ballen
    Cancer Center and Department of Medicine, University of Massachusetts Memorial Health Care, Worcester, MA, USA
    Blood 100:442-50. 2002
    ..Low-dose TBI and allogeneic lymphocyte infusion may induce remission in patients with refractory hematologic malignancy...
  15. ncbi Association of fetal hormone levels with stem cell potential: evidence for early life roots of human cancer
    Inkyung Baik
    Cancer Research Center and Department of Cancer Biology, ILAT Steroid RIA Laboratory, University of Massachusetts Medical School, Worchester, MA 01605, USA
    Cancer Res 65:358-63. 2005
    ....

Research Grants5

  1. RETROVIRAL TRANSFER OF ANKYRIN FOR SPHEROCYTOSIS
    Pamela Becker; Fiscal Year: 2002
    ..abstract_text> ..
  2. Core--National Cell Procuremen
    Pamela Becker; Fiscal Year: 2005
    ..abstract_text> ..