L B Becker

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint New concepts in reactive oxygen species and cardiovascular reperfusion physiology
    Lance B Becker
    Emergency Resuscitation Center, Section of Emergency Medicine, Department of Medicine MC5068, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Cardiovasc Res 61:461-70. 2004
  2. ncbi request reprint Generation of superoxide in cardiomyocytes during ischemia before reperfusion
    L B Becker
    Sections of Emergency Medicine and Pulmonary and Critical Care, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol 277:H2240-6. 1999
  3. ncbi request reprint The PULSE initiative: scientific priorities and strategic planning for resuscitation research and life saving therapies
    Lance B Becker
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Circulation 105:2562-70. 2002
  4. ncbi request reprint Role of reactive oxygen species in acetylcholine-induced preconditioning in cardiomyocytes
    Z Yao
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol 277:H2504-9. 1999
  5. ncbi request reprint Signal transduction of flumazenil-induced preconditioning in myocytes
    Z Yao
    Department of Anesthesia and Critical Care, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Heart Circ Physiol 280:H1249-55. 2001
  6. ncbi request reprint Qian-Kun-Nin, a Chinese herbal medicine formulation, attenuates mitochondrial oxidant stress in cardiomyocytes
    Z Shao
    Department of Medicine Sections of Emergency Medicine and Pulmonary Critical Care, University of Chicago, 60637, Chicago, IL, USA
    J Ethnopharmacol 74:63-8. 2001
  7. ncbi request reprint Cellular energy utilization and supply during hypoxia in embryonic cardiac myocytes
    G R Budinger
    University of Chicago, Illinois 60637, USA
    Am J Physiol 270:L44-53. 1996
  8. ncbi request reprint Cytotoxicity induced by grape seed proanthocyanidins: role of nitric oxide
    Z H Shao
    Emergency Resuscitation Center, Section of Emergency Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Cell Biol Toxicol 22:149-58. 2006
  9. ncbi request reprint Antioxidant effects of ginsenoside Re in cardiomyocytes
    Jing Tian Xie
    Tang Center for Herbal Medicine Research, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Eur J Pharmacol 532:201-7. 2006
  10. ncbi request reprint Therapeutic hypothermia utilization among physicians after resuscitation from cardiac arrest
    Raina M Merchant
    Section of Emergency Medicine, University of Chicago, Chicago, IL, USA
    Crit Care Med 34:1935-40. 2006

Research Grants

Collaborators

Detail Information

Publications44

  1. ncbi request reprint New concepts in reactive oxygen species and cardiovascular reperfusion physiology
    Lance B Becker
    Emergency Resuscitation Center, Section of Emergency Medicine, Department of Medicine MC5068, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Cardiovasc Res 61:461-70. 2004
    ....
  2. ncbi request reprint Generation of superoxide in cardiomyocytes during ischemia before reperfusion
    L B Becker
    Sections of Emergency Medicine and Pulmonary and Critical Care, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol 277:H2240-6. 1999
    ..7 +/- 0.1) and decreased with exogenous SOD (1.1 +/- 0.1). We conclude that significant superoxide generation occurs during ischemia before reperfusion from the ubisemiquinone site of the mitochondrial electron transport chain...
  3. ncbi request reprint The PULSE initiative: scientific priorities and strategic planning for resuscitation research and life saving therapies
    Lance B Becker
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Circulation 105:2562-70. 2002
  4. ncbi request reprint Role of reactive oxygen species in acetylcholine-induced preconditioning in cardiomyocytes
    Z Yao
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol 277:H2504-9. 1999
    ..07, n = 5). These results demonstrate that activation of mitochondrial K(ATP) channels and increased ROS production from mitochondria are important intracellular signals that participate in ACh-induced preconditioning in cardiomyocytes...
  5. ncbi request reprint Signal transduction of flumazenil-induced preconditioning in myocytes
    Z Yao
    Department of Anesthesia and Critical Care, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Heart Circ Physiol 280:H1249-55. 2001
    ..Thus flumazenil mimics preconditioning to reduce cell death in cardiomyocytes. Oxygen radicals activate mitochondrial K(ATP) channels via PKC during the process...
  6. ncbi request reprint Qian-Kun-Nin, a Chinese herbal medicine formulation, attenuates mitochondrial oxidant stress in cardiomyocytes
    Z Shao
    Department of Medicine Sections of Emergency Medicine and Pulmonary Critical Care, University of Chicago, 60637, Chicago, IL, USA
    J Ethnopharmacol 74:63-8. 2001
    ....
  7. ncbi request reprint Cellular energy utilization and supply during hypoxia in embryonic cardiac myocytes
    G R Budinger
    University of Chicago, Illinois 60637, USA
    Am J Physiol 270:L44-53. 1996
    ..This mechanism may represent a protective response to cellular hypoxia...
  8. ncbi request reprint Cytotoxicity induced by grape seed proanthocyanidins: role of nitric oxide
    Z H Shao
    Emergency Resuscitation Center, Section of Emergency Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Cell Biol Toxicol 22:149-58. 2006
    ..Taken together, these results suggest that endogenous NO synthase (NOS) activation and excessive NO production play a key role in the pathogenesis of high-dose GSPE-induced cytotoxicity...
  9. ncbi request reprint Antioxidant effects of ginsenoside Re in cardiomyocytes
    Jing Tian Xie
    Tang Center for Herbal Medicine Research, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Eur J Pharmacol 532:201-7. 2006
    ....
  10. ncbi request reprint Therapeutic hypothermia utilization among physicians after resuscitation from cardiac arrest
    Raina M Merchant
    Section of Emergency Medicine, University of Chicago, Chicago, IL, USA
    Crit Care Med 34:1935-40. 2006
    ..We sought to evaluate current physician use of therapeutic hypothermia after cardiac arrest, to ascertain reasons for nonadoption of this treatment, and to determine current cooling techniques employed...
  11. ncbi request reprint Oxidant injury occurs rapidly after cardiac arrest, cardiopulmonary resuscitation, and reperfusion
    Ahamed H Idris
    Department of Emergency Medicine, University of Florida College of Medicine, Gainesville, USA
    Crit Care Med 33:2043-8. 2005
    ..Oxidant injury may play a role in the poor outcome typical of people resuscitated from cardiac arrest. The objective of the present study was to determine the presence and timing of oxidant injury in an in vivo model of cardiac arrest...
  12. ncbi request reprint Transient and partial mitochondrial inhibition for the treatment of postresuscitation injury: getting it just right
    Travis C Anderson
    Emergency Resuscitation Center, Sections of Emergency Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Crit Care Med 34:S474-82. 2006
    ..This study sought to further characterize the oxidant source at reperfusion and develop a strategy for therapeutic intervention by manipulation of dose, duration, and the degree of reversibility of mitochondrial inhibition...
  13. ncbi request reprint Induced hypothermia is underused after resuscitation from cardiac arrest: a current practice survey
    Benjamin S Abella
    Emergency Resuscitation Center, Section of Emergency Medicine, University of Chicago Hospitals, 5841 S Maryland Avenue, MC 5068 Chicago, IL 60637, USA
    Resuscitation 64:181-6. 2005
    ..We wished to ascertain the extent to which physicians were using this treatment, and what opinions are held by clinicians regarding its use...
  14. ncbi request reprint Intra-arrest cooling improves outcomes in a murine cardiac arrest model
    Benjamin S Abella
    Emergency Resuscitation Center, Section of Emergency Medicine, The University of Chicago, Chicago, Ill 60637, USA
    Circulation 109:2786-91. 2004
    ..We sought to determine whether cooling during cardiac arrest before ROSC (ie, "intra-arrest" hypothermia) has survival benefit over more delayed post-ROSC cooling, using a murine cardiac arrest model...
  15. ncbi request reprint Antioxidant effects of American ginseng berry extract in cardiomyocytes exposed to acute oxidant stress
    Zuo Hui Shao
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, The University of Chicago, IL 60637, USA
    Biochim Biophys Acta 1670:165-71. 2004
    ..We conclude that AGBE is a potent antioxidant that protects cardiomyocytes against oxidant-mediated injury and this protection is partly mediated by its free radical scavenging properties...
  16. ncbi request reprint Baicalein attenuates oxidant stress in cardiomyocytes
    Zuo Hui Shao
    Section of Emergency Medicine, Department of Medicine, University of Chicago, Illinois 60637, USA
    Am J Physiol Heart Circ Physiol 282:H999-H1006. 2002
    ..We conclude that baicalein can scavenge ROS generation in cardiomyocytes and that it protects against cell death in an ischemia-reperfusion model when given only at reperfusion...
  17. ncbi request reprint Resuscitation of cells and systems: the PULSE research initiative. Post Resuscitative and Initial Utility of Life Saving Efforts
    Charles B Cairns
    Colorado Emergency Medicine Research Center, University of Colorado Health Sciences Center, Denver, CO, USA
    Acad Emerg Med 9:613-4. 2002
  18. ncbi request reprint Reperfusion, not simulated ischemia, initiates intrinsic apoptosis injury in chick cardiomyocytes
    Terry L Vanden Hoek
    Sections of Emergency Medicine and Pulmonary Critical Care, Department of Medicine and Emergency Resuscitation Center, University of Chicago, Illinois 60637, USA
    Am J Physiol Heart Circ Physiol 284:H141-50. 2003
    ..These results suggest that reperfusion oxidants initiate cytochrome c release within minutes, and apoptosis within hours, significant enough to increase cell death and contractile dysfunction...
  19. pmc Intra-arrest cooling with delayed reperfusion yields higher survival than earlier normothermic resuscitation in a mouse model of cardiac arrest
    Danhong Zhao
    Emergency Resuscitation Center, University of Chicago Hospitals, Chicago, IL 60637, USA
    Resuscitation 77:242-9. 2008
    ..We hypothesized that a short delay in resuscitation to induce hypothermia before ROSC, even at the expense of more prolonged ischemia, may yield both physiological and survival advantages...
  20. ncbi request reprint Resuscitation after cardiac arrest: a 3-phase time-sensitive model
    Myron L Weisfeldt
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    JAMA 288:3035-8. 2002
  21. ncbi request reprint Glutamine preserves cardiomyocyte viability and enhances recovery of contractile function after ischemia-reperfusion injury
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado, Denver 80262, USA
    JPEN J Parenter Enteral Nutr 27:116-22. 2003
    ..We tested the hypothesis that glutamine can enhance heat shock protein 72 (HSP 72) expression, attenuate intracellular oxidant generation, and protect cardiomyocytes against ischemia/reperfusion (I/R) injury...
  22. ncbi request reprint Hypothermia-induced cardioprotection using extended ischemia and early reperfusion cooling
    Zuo Hui Shao
    The Emergency Resuscitation Center, Sections of Emergency Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Heart Circ Physiol 292:H1995-2003. 2007
    ..Such protection appears to be mediated by increased NO generation via activation of protein kinase Cepsilon; nitric oxide synthase...
  23. ncbi request reprint Altering CO2 during reperfusion of ischemic cardiomyocytes modifies mitochondrial oxidant injury
    Romeen Lavani
    Emergency Resuscitation Center, Sections of Emergency Medicine and Pulmonary Critical Care, Department of Medicine, University of Chicago, Chicago, IL, USA
    Crit Care Med 35:1709-16. 2007
    ..Acute changes in tissue CO2 and pH during reperfusion of the ischemic heart may affect ischemia/reperfusion injury. We tested whether gradual vs. acute decreases in CO2 after cardiomyocyte ischemia affect reperfusion oxidants and injury...
  24. doi request reprint Improving in-hospital cardiac arrest process and outcomes with performance debriefing
    Dana P Edelson
    Section of General Internal Medicine, University of Chicago, Chicago, Illinois, USA
    Arch Intern Med 168:1063-9. 2008
    ....
  25. ncbi request reprint Effects of compression depth and pre-shock pauses predict defibrillation failure during cardiac arrest
    Dana P Edelson
    Section of General Internal Medicine, University of Chicago Hospitals, Chicago, IL 60637, United States
    Resuscitation 71:137-45. 2006
    ..Specifically, the clinical effects of compression depth and pauses in chest compression prior to defibrillation (pre-shock pauses) are unknown...
  26. ncbi request reprint Difficulty of cardiac arrest rhythm identification does not correlate with length of chest compression pause before defibrillation
    Benjamin S Abella
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Crit Care Med 34:S427-31. 2006
    ..We sought to determine whether these long pauses were due to difficulties in identifying shockable rhythms or rather due to local factors during resuscitation attempts...
  27. ncbi request reprint CPR quality improvement during in-hospital cardiac arrest using a real-time audiovisual feedback system
    Benjamin S Abella
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Resuscitation 73:54-61. 2007
    ..We hypothesized that real-time feedback during CPR would improve the performance of chest compressions and ventilations during in-hospital cardiac arrest...
  28. ncbi request reprint Rapid cooling for saving lives: a bioengineering opportunity
    Joshua W Lampe
    Center for Resuscitation Science, Department of Emergency Medicine, University of Pennsylvania Hospital Philadelphia, USA
    Expert Rev Med Devices 4:441-6. 2007
    ..With continuing research and investment, methods for rapid cooling can be developed and will translate into saving lives...
  29. ncbi request reprint Pauses in chest compression and inappropriate shocks: a comparison of manual and semi-automatic defibrillation attempts
    Jo Kramer-Johansen
    Institute for Experimental Medical Research, Ullevaal University Hospital, N 0407 Oslo, Norway
    Resuscitation 73:212-20. 2007
    ..We hypothesised that pauses are shorter for manual defibrillation by trained rescuers, but with an increased number of inappropriate shocks given for a non-VF/VT rhythm...
  30. ncbi request reprint Therapeutic hypothermia after cardiac arrest: unintentional overcooling is common using ice packs and conventional cooling blankets
    Raina M Merchant
    Section of Emergency Medicine, University of Chicago Hospitals Emergency Resuscitation Center, Chicago, Illinois, USA
    Crit Care Med 34:S490-4. 2006
    ..We sought to measure the prevalence of overcooling (<32 degrees C) in postarrest survivors receiving primarily noninvasive cooling...
  31. pmc Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes
    Wei Tien Chang
    Emergency Resuscitation Center, Section of Emergency Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA, and Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC
    Eur J Pharmacol 566:58-66. 2007
    ..Flavonoids possess specific but differential radical scavenging capacity, which, in conjunction with the timing of treatment, affects their protective efficacy in cardiomyocytes exposed to ischemia/reperfusion...
  32. ncbi request reprint Controversial Topics from the 2005 International Consensus Conference on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations
    Jerry P Nolan
    Resuscitation 67:175-9. 2005
  33. ncbi request reprint Task Force on Strategic Research Direction: Basic Science Subgroup key science topics report
    Joseph Loscalzo
    Circulation 106:e149-61. 2002
  34. ncbi request reprint Grape seed proanthocyanidin extract attenuates oxidant injury in cardiomyocytes
    Zuo Hui Shao
    Department of Medicine, Section of Emergency Medicine, University of Chicago, 5841 S Maryland Avenue, MC 5068, Chicago, IL 60637, USA
    Pharmacol Res 47:463-9. 2003
    ..Its effect does not require PKC, mito K(ATP) channel, or NO synthase, presumably because it acts by reactive oxygen species scavenging and iron chelating directly...
  35. ncbi request reprint Grape seed proanthocyanidins induce pro-oxidant toxicity in cardiomyocytes
    Zuo Hui Shao
    Tang Center for Herbal Medicine Research, Emergency Resuscitation Research Center, and Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
    Cardiovasc Toxicol 3:331-9. 2003
    ..Consumers may take higher doses of dietary supplements in the belief that natural herbs have no major side effects. This study demonstrates that dosages of GSPE should be optimized to avoid potential harmful pro-oxidant effects...
  36. ncbi request reprint Caspase-dependent cytochrome c release and cell death in chick cardiomyocytes after simulated ischemia-reperfusion
    Yimin Qin
    Department of Medicine MC6076, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Heart Circ Physiol 286:H2280-6. 2004
    ..These data suggest that active caspase-2 initiates cytochrome c release after reperfusion and that it is critical for the I/R-induced apoptosis in this model...
  37. ncbi request reprint Synergistic effect of Scutellaria baicalensis and grape seed proanthocyanidins on scavenging reactive oxygen species in vitro
    Zuo Hui Shao
    Tang Center for Herbal Medicine Research, Emergency Medicine and Emergency Resuscitation Center, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
    Am J Chin Med 32:89-95. 2004
    ..This has the advantage of avoiding possible side effects that may arise when higher doses of a single herb are used in an attempt to achieve a maximum degree of antioxidant activity...
  38. ncbi request reprint Human factors impact successful lay person automated external defibrillator use during simulated cardiac arrest
    Sonia Callejas
    University of Chicago, Section of Emergency Medicine, Chicago, IL, USA
    Crit Care Med 32:S406-13. 2004
    ..We sought to determine whether human factor differences would result in differences in parameters of successful or safe use by lay persons in the setting of simulated cardiac arrest...
  39. ncbi request reprint Induced hypothermia by central venous infusion: saline ice slurry versus chilled saline
    Terry L Vanden Hoek
    University of Chicago, Section of Emergency Medicine, Chicago, IL, USA
    Crit Care Med 32:S425-31. 2004
    ..an equal volume of chilled saline. We hypothesized that slurry would achieve core hypothermia (32-34 degrees C) more consistently and at a faster rate...
  40. ncbi request reprint Quality of cardiopulmonary resuscitation during in-hospital cardiac arrest
    Benjamin S Abella
    Section of Emergency Medicine, University of Chicago Hospitals, Chicago, Ill 60637, USA
    JAMA 293:305-10. 2005
    ..Recent studies have challenged the notion that CPR is uniformly performed according to established international guidelines...
  41. ncbi request reprint Chest compression rates during cardiopulmonary resuscitation are suboptimal: a prospective study during in-hospital cardiac arrest
    Benjamin S Abella
    Emergency Resuscitation Center and Section of Emergency Medicine, University of Chicago Hospitals, Chicago, Ill 60637, USA
    Circulation 111:428-34. 2005
    ..We sought to measure in-hospital chest compression rates and to determine compliance with published international guidelines...
  42. ncbi request reprint Effectiveness of a 30-min CPR self-instruction program for lay responders: a controlled randomized study
    Bonnie Lynch
    RMC Research Corporation, 522 SW Fifth Avenue, Suite 1407, Portland, OR 97204, USA
    Resuscitation 67:31-43. 2005
    ..The hypotheses were that VSI results in performance of basic CPR skills superior to that of untrained learners and similar to that of learners in Heartsaver classes...
  43. ncbi request reprint Major changes in the 2005 AHA Guidelines for CPR and ECC: reaching the tipping point for change
    Mary Fran Hazinski
    Circulation 112:IV206-11. 2005
  44. ncbi request reprint Public use of automated external defibrillators
    Sherry L Caffrey
    City of Chicago Department of Aviation, O Hare International Airport, Chicago, IL 60666, USA
    N Engl J Med 347:1242-7. 2002
    ..We performed a two-year prospective study at three Chicago airports to assess whether random bystanders witnessing out-of-hospital cardiac arrests would retrieve and successfully use automated external defibrillators...

Research Grants2

  1. Optimizing Heart and Brain Cooling during Cardiac Arrest
    Lance Becker; Fiscal Year: 2006
    ..abstract_text> ..