L B Becker
Affiliation: University of Chicago
- New concepts in reactive oxygen species and cardiovascular reperfusion physiologyLance B Becker
Emergency Resuscitation Center, Section of Emergency Medicine, Department of Medicine MC5068, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Cardiovasc Res 61:461-70. 2004....
- Generation of superoxide in cardiomyocytes during ischemia before reperfusionL B Becker
Sections of Emergency Medicine and Pulmonary and Critical Care, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
Am J Physiol 277:H2240-6. 1999..7 +/- 0.1) and decreased with exogenous SOD (1.1 +/- 0.1). We conclude that significant superoxide generation occurs during ischemia before reperfusion from the ubisemiquinone site of the mitochondrial electron transport chain...
- The PULSE initiative: scientific priorities and strategic planning for resuscitation research and life saving therapiesLance B Becker
Department of Medicine, University of Chicago, Chicago, IL 60637, USA
Circulation 105:2562-70. 2002
- Role of reactive oxygen species in acetylcholine-induced preconditioning in cardiomyocytesZ Yao
Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois 60637, USA
Am J Physiol 277:H2504-9. 1999..07, n = 5). These results demonstrate that activation of mitochondrial K(ATP) channels and increased ROS production from mitochondria are important intracellular signals that participate in ACh-induced preconditioning in cardiomyocytes...
- Signal transduction of flumazenil-induced preconditioning in myocytesZ Yao
Department of Anesthesia and Critical Care, The University of Chicago, Chicago, Illinois 60637, USA
Am J Physiol Heart Circ Physiol 280:H1249-55. 2001..Thus flumazenil mimics preconditioning to reduce cell death in cardiomyocytes. Oxygen radicals activate mitochondrial K(ATP) channels via PKC during the process...
- Qian-Kun-Nin, a Chinese herbal medicine formulation, attenuates mitochondrial oxidant stress in cardiomyocytesZ Shao
Department of Medicine Sections of Emergency Medicine and Pulmonary Critical Care, University of Chicago, 60637, Chicago, IL, USA
J Ethnopharmacol 74:63-8. 2001....
- Cellular energy utilization and supply during hypoxia in embryonic cardiac myocytesG R Budinger
University of Chicago, Illinois 60637, USA
Am J Physiol 270:L44-53. 1996..This mechanism may represent a protective response to cellular hypoxia...
- Cytotoxicity induced by grape seed proanthocyanidins: role of nitric oxideZ H Shao
Emergency Resuscitation Center, Section of Emergency Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
Cell Biol Toxicol 22:149-58. 2006..Taken together, these results suggest that endogenous NO synthase (NOS) activation and excessive NO production play a key role in the pathogenesis of high-dose GSPE-induced cytotoxicity...
- Antioxidant effects of ginsenoside Re in cardiomyocytesJing Tian Xie
Tang Center for Herbal Medicine Research, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
Eur J Pharmacol 532:201-7. 2006....
- Therapeutic hypothermia utilization among physicians after resuscitation from cardiac arrestRaina M Merchant
Section of Emergency Medicine, University of Chicago, Chicago, IL, USA
Crit Care Med 34:1935-40. 2006..We sought to evaluate current physician use of therapeutic hypothermia after cardiac arrest, to ascertain reasons for nonadoption of this treatment, and to determine current cooling techniques employed...
- Oxidant injury occurs rapidly after cardiac arrest, cardiopulmonary resuscitation, and reperfusionAhamed H Idris
Department of Emergency Medicine, University of Florida College of Medicine, Gainesville, USA
Crit Care Med 33:2043-8. 2005..Oxidant injury may play a role in the poor outcome typical of people resuscitated from cardiac arrest. The objective of the present study was to determine the presence and timing of oxidant injury in an in vivo model of cardiac arrest...
- Transient and partial mitochondrial inhibition for the treatment of postresuscitation injury: getting it just rightTravis C Anderson
Emergency Resuscitation Center, Sections of Emergency Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, USA
Crit Care Med 34:S474-82. 2006..This study sought to further characterize the oxidant source at reperfusion and develop a strategy for therapeutic intervention by manipulation of dose, duration, and the degree of reversibility of mitochondrial inhibition...
- Induced hypothermia is underused after resuscitation from cardiac arrest: a current practice surveyBenjamin S Abella
Emergency Resuscitation Center, Section of Emergency Medicine, University of Chicago Hospitals, 5841 S Maryland Avenue, MC 5068 Chicago, IL 60637, USA
Resuscitation 64:181-6. 2005..We wished to ascertain the extent to which physicians were using this treatment, and what opinions are held by clinicians regarding its use...
- Intra-arrest cooling improves outcomes in a murine cardiac arrest modelBenjamin S Abella
Emergency Resuscitation Center, Section of Emergency Medicine, The University of Chicago, Chicago, Ill 60637, USA
Circulation 109:2786-91. 2004..We sought to determine whether cooling during cardiac arrest before ROSC (ie, "intra-arrest" hypothermia) has survival benefit over more delayed post-ROSC cooling, using a murine cardiac arrest model...
- Antioxidant effects of American ginseng berry extract in cardiomyocytes exposed to acute oxidant stressZuo Hui Shao
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, The University of Chicago, IL 60637, USA
Biochim Biophys Acta 1670:165-71. 2004..We conclude that AGBE is a potent antioxidant that protects cardiomyocytes against oxidant-mediated injury and this protection is partly mediated by its free radical scavenging properties...
- Baicalein attenuates oxidant stress in cardiomyocytesZuo Hui Shao
Section of Emergency Medicine, Department of Medicine, University of Chicago, Illinois 60637, USA
Am J Physiol Heart Circ Physiol 282:H999-H1006. 2002..We conclude that baicalein can scavenge ROS generation in cardiomyocytes and that it protects against cell death in an ischemia-reperfusion model when given only at reperfusion...
- Resuscitation of cells and systems: the PULSE research initiative. Post Resuscitative and Initial Utility of Life Saving EffortsCharles B Cairns
Colorado Emergency Medicine Research Center, University of Colorado Health Sciences Center, Denver, CO, USA
Acad Emerg Med 9:613-4. 2002
- Reperfusion, not simulated ischemia, initiates intrinsic apoptosis injury in chick cardiomyocytesTerry L Vanden Hoek
Sections of Emergency Medicine and Pulmonary Critical Care, Department of Medicine and Emergency Resuscitation Center, University of Chicago, Illinois 60637, USA
Am J Physiol Heart Circ Physiol 284:H141-50. 2003..These results suggest that reperfusion oxidants initiate cytochrome c release within minutes, and apoptosis within hours, significant enough to increase cell death and contractile dysfunction...
- Intra-arrest cooling with delayed reperfusion yields higher survival than earlier normothermic resuscitation in a mouse model of cardiac arrestDanhong Zhao
Emergency Resuscitation Center, University of Chicago Hospitals, Chicago, IL 60637, USA
Resuscitation 77:242-9. 2008..We hypothesized that a short delay in resuscitation to induce hypothermia before ROSC, even at the expense of more prolonged ischemia, may yield both physiological and survival advantages...
- Resuscitation after cardiac arrest: a 3-phase time-sensitive modelMyron L Weisfeldt
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
JAMA 288:3035-8. 2002
- Glutamine preserves cardiomyocyte viability and enhances recovery of contractile function after ischemia-reperfusion injuryPaul E Wischmeyer
Department of Anesthesiology, University of Colorado, Denver 80262, USA
JPEN J Parenter Enteral Nutr 27:116-22. 2003..We tested the hypothesis that glutamine can enhance heat shock protein 72 (HSP 72) expression, attenuate intracellular oxidant generation, and protect cardiomyocytes against ischemia/reperfusion (I/R) injury...
- Hypothermia-induced cardioprotection using extended ischemia and early reperfusion coolingZuo Hui Shao
The Emergency Resuscitation Center, Sections of Emergency Medicine, University of Chicago, Chicago, Illinois 60637, USA
Am J Physiol Heart Circ Physiol 292:H1995-2003. 2007..Such protection appears to be mediated by increased NO generation via activation of protein kinase Cepsilon; nitric oxide synthase...
- Altering CO2 during reperfusion of ischemic cardiomyocytes modifies mitochondrial oxidant injuryRomeen Lavani
Emergency Resuscitation Center, Sections of Emergency Medicine and Pulmonary Critical Care, Department of Medicine, University of Chicago, Chicago, IL, USA
Crit Care Med 35:1709-16. 2007..Acute changes in tissue CO2 and pH during reperfusion of the ischemic heart may affect ischemia/reperfusion injury. We tested whether gradual vs. acute decreases in CO2 after cardiomyocyte ischemia affect reperfusion oxidants and injury...
- Improving in-hospital cardiac arrest process and outcomes with performance debriefingDana P Edelson
Section of General Internal Medicine, University of Chicago, Chicago, Illinois, USA
Arch Intern Med 168:1063-9. 2008....
- Effects of compression depth and pre-shock pauses predict defibrillation failure during cardiac arrestDana P Edelson
Section of General Internal Medicine, University of Chicago Hospitals, Chicago, IL 60637, United States
Resuscitation 71:137-45. 2006..Specifically, the clinical effects of compression depth and pauses in chest compression prior to defibrillation (pre-shock pauses) are unknown...
- Difficulty of cardiac arrest rhythm identification does not correlate with length of chest compression pause before defibrillationBenjamin S Abella
Department of Emergency Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Crit Care Med 34:S427-31. 2006..We sought to determine whether these long pauses were due to difficulties in identifying shockable rhythms or rather due to local factors during resuscitation attempts...
- CPR quality improvement during in-hospital cardiac arrest using a real-time audiovisual feedback systemBenjamin S Abella
Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Resuscitation 73:54-61. 2007..We hypothesized that real-time feedback during CPR would improve the performance of chest compressions and ventilations during in-hospital cardiac arrest...
- Rapid cooling for saving lives: a bioengineering opportunityJoshua W Lampe
Center for Resuscitation Science, Department of Emergency Medicine, University of Pennsylvania Hospital Philadelphia, USA
Expert Rev Med Devices 4:441-6. 2007..With continuing research and investment, methods for rapid cooling can be developed and will translate into saving lives...
- Pauses in chest compression and inappropriate shocks: a comparison of manual and semi-automatic defibrillation attemptsJo Kramer-Johansen
Institute for Experimental Medical Research, Ullevaal University Hospital, N 0407 Oslo, Norway
Resuscitation 73:212-20. 2007..We hypothesised that pauses are shorter for manual defibrillation by trained rescuers, but with an increased number of inappropriate shocks given for a non-VF/VT rhythm...
- Therapeutic hypothermia after cardiac arrest: unintentional overcooling is common using ice packs and conventional cooling blanketsRaina M Merchant
Section of Emergency Medicine, University of Chicago Hospitals Emergency Resuscitation Center, Chicago, Illinois, USA
Crit Care Med 34:S490-4. 2006..We sought to measure the prevalence of overcooling (<32 degrees C) in postarrest survivors receiving primarily noninvasive cooling...
- Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytesWei Tien Chang
Emergency Resuscitation Center, Section of Emergency Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA, and Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC
Eur J Pharmacol 566:58-66. 2007..Flavonoids possess specific but differential radical scavenging capacity, which, in conjunction with the timing of treatment, affects their protective efficacy in cardiomyocytes exposed to ischemia/reperfusion...
- Controversial Topics from the 2005 International Consensus Conference on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendationsJerry P Nolan
Resuscitation 67:175-9. 2005
- Task Force on Strategic Research Direction: Basic Science Subgroup key science topics reportJoseph Loscalzo
Circulation 106:e149-61. 2002
- Grape seed proanthocyanidin extract attenuates oxidant injury in cardiomyocytesZuo Hui Shao
Department of Medicine, Section of Emergency Medicine, University of Chicago, 5841 S Maryland Avenue, MC 5068, Chicago, IL 60637, USA
Pharmacol Res 47:463-9. 2003..Its effect does not require PKC, mito K(ATP) channel, or NO synthase, presumably because it acts by reactive oxygen species scavenging and iron chelating directly...
- Grape seed proanthocyanidins induce pro-oxidant toxicity in cardiomyocytesZuo Hui Shao
Tang Center for Herbal Medicine Research, Emergency Resuscitation Research Center, and Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
Cardiovasc Toxicol 3:331-9. 2003..Consumers may take higher doses of dietary supplements in the belief that natural herbs have no major side effects. This study demonstrates that dosages of GSPE should be optimized to avoid potential harmful pro-oxidant effects...
- Caspase-dependent cytochrome c release and cell death in chick cardiomyocytes after simulated ischemia-reperfusionYimin Qin
Department of Medicine MC6076, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
Am J Physiol Heart Circ Physiol 286:H2280-6. 2004..These data suggest that active caspase-2 initiates cytochrome c release after reperfusion and that it is critical for the I/R-induced apoptosis in this model...
- Synergistic effect of Scutellaria baicalensis and grape seed proanthocyanidins on scavenging reactive oxygen species in vitroZuo Hui Shao
Tang Center for Herbal Medicine Research, Emergency Medicine and Emergency Resuscitation Center, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
Am J Chin Med 32:89-95. 2004..This has the advantage of avoiding possible side effects that may arise when higher doses of a single herb are used in an attempt to achieve a maximum degree of antioxidant activity...
- Human factors impact successful lay person automated external defibrillator use during simulated cardiac arrestSonia Callejas
University of Chicago, Section of Emergency Medicine, Chicago, IL, USA
Crit Care Med 32:S406-13. 2004..We sought to determine whether human factor differences would result in differences in parameters of successful or safe use by lay persons in the setting of simulated cardiac arrest...
- Induced hypothermia by central venous infusion: saline ice slurry versus chilled salineTerry L Vanden Hoek
University of Chicago, Section of Emergency Medicine, Chicago, IL, USA
Crit Care Med 32:S425-31. 2004..an equal volume of chilled saline. We hypothesized that slurry would achieve core hypothermia (32-34 degrees C) more consistently and at a faster rate...
- Quality of cardiopulmonary resuscitation during in-hospital cardiac arrestBenjamin S Abella
Section of Emergency Medicine, University of Chicago Hospitals, Chicago, Ill 60637, USA
JAMA 293:305-10. 2005..Recent studies have challenged the notion that CPR is uniformly performed according to established international guidelines...
- Chest compression rates during cardiopulmonary resuscitation are suboptimal: a prospective study during in-hospital cardiac arrestBenjamin S Abella
Emergency Resuscitation Center and Section of Emergency Medicine, University of Chicago Hospitals, Chicago, Ill 60637, USA
Circulation 111:428-34. 2005..We sought to measure in-hospital chest compression rates and to determine compliance with published international guidelines...
- Effectiveness of a 30-min CPR self-instruction program for lay responders: a controlled randomized studyBonnie Lynch
RMC Research Corporation, 522 SW Fifth Avenue, Suite 1407, Portland, OR 97204, USA
Resuscitation 67:31-43. 2005..The hypotheses were that VSI results in performance of basic CPR skills superior to that of untrained learners and similar to that of learners in Heartsaver classes...
- Major changes in the 2005 AHA Guidelines for CPR and ECC: reaching the tipping point for changeMary Fran Hazinski
Circulation 112:IV206-11. 2005
- Public use of automated external defibrillatorsSherry L Caffrey
City of Chicago Department of Aviation, O Hare International Airport, Chicago, IL 60666, USA
N Engl J Med 347:1242-7. 2002..We performed a two-year prospective study at three Chicago airports to assess whether random bystanders witnessing out-of-hospital cardiac arrests would retrieve and successfully use automated external defibrillators...