K J Becker

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. doi request reprint Autoimmune responses to brain following stroke
    Kyra Becker
    School of Medicine, University of Washington, Box 359775 HMC, 325 9th Ave, Seattle, WA, 98104 2499, USA
    Transl Stroke Res 3:310-7. 2012
  2. ncbi request reprint Ischemic stroke during sexual intercourse: a report of 4 cases in persons with patent foramen ovale
    Kyra Becker
    Department of Neurology, Harborview Medical Center, University of Washington School of Medicine, 325 9th Avenue, Seattle, WA 98104 2499, USA
    Arch Neurol 61:1114-6. 2004
  3. pmc Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia
    K J Becker
    Stroke Branch, National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:10873-8. 1997
  4. ncbi request reprint Approval of the MERCI clot retriever: a critical view
    Kyra J Becker
    University of Washington School of Medicine, Harborview Medical Center, Box 359775, 325 9th Ave, Seattle, WA 98104 2499, USA
    Stroke 36:400-3. 2005
  5. ncbi request reprint Endovascular treatment of acute stroke
    Kyra Becker
    Kyra Becker, MD University of Washington, Box 359775 HMC, 325 9th Avenue, Seattle, WA 98104, USA
    Curr Treat Options Neurol 9:463-9. 2007
  6. pmc Sensitization and tolerization to brain antigens in stroke
    K J Becker
    University of Washington School of Medicine, Harborview Medical Center, Box 359775, 325 9th Avenue, Seattle, WA 98104 2499, USA
    Neuroscience 158:1090-7. 2009
  7. doi request reprint Stroke. 'Spotting' patients at the highest risk of hematoma growth
    Kyra Becker
    University of Washington School of Medicine, Harborview Medical Center, 325 9th Avenue, Seattle, WA 98104, USA
    Nat Rev Neurol 5:526-8. 2009
  8. pmc Modulation of the postischemic immune response to improve stroke outcome
    Kyra J Becker
    University of Washington School of Medicine, Seattle, Wash, USA
    Stroke 41:S75-8. 2010
  9. pmc Autoimmune responses to the brain after stroke are associated with worse outcome
    Kyra J Becker
    Department of Neurology, University of Washington School of Medicine, Box 359775, Harborview Medical Center, 325 9th Avenue, Seattle, WA 98104 2499, USA
    Stroke 42:2763-9. 2011
  10. ncbi request reprint Adoptive transfer of myelin basic protein-tolerized splenocytes to naive animals reduces infarct size: a role for lymphocytes in ischemic brain injury?
    Kyra Becker
    Department of Neurology, University of Washington School of Medicine, Harborview Medical Center, Seattle, WA 98104 2499, USA
    Stroke 34:1809-15. 2003

Research Grants

  1. Sensitization to brain antigens following stroke.
    Kyra Becker; Fiscal Year: 2007
  2. Sensitization to brain antigens following stroke.
    Kyra J Becker; Fiscal Year: 2010
  3. CNS antigen sensitization in stroke.
    Kyra Becker; Fiscal Year: 2009
  4. THE ROLE OF LYMPHOCYTES IN CEREBRAL ISCHEMIC INJURY
    Kyra Becker; Fiscal Year: 2004
  5. Sensitization to brain antigens following stroke.
    Kyra Becker; Fiscal Year: 2009
  6. CNS antigen sensitization in stroke.
    Kyra Becker; Fiscal Year: 2007
  7. CNS antigen sensitization in stroke.
    Kyra Becker; Fiscal Year: 2006
  8. Sensitization to brain antigens following stroke.
    Kyra Becker; Fiscal Year: 2006
  9. CNS antigen sensitization in stroke.
    Kyra Becker; Fiscal Year: 2005

Collaborators

Detail Information

Publications30

  1. doi request reprint Autoimmune responses to brain following stroke
    Kyra Becker
    School of Medicine, University of Washington, Box 359775 HMC, 325 9th Ave, Seattle, WA, 98104 2499, USA
    Transl Stroke Res 3:310-7. 2012
    ....
  2. ncbi request reprint Ischemic stroke during sexual intercourse: a report of 4 cases in persons with patent foramen ovale
    Kyra Becker
    Department of Neurology, Harborview Medical Center, University of Washington School of Medicine, 325 9th Avenue, Seattle, WA 98104 2499, USA
    Arch Neurol 61:1114-6. 2004
    ..The association between patent foramen ovale (PFO) and stroke risk in young adults is controversial and poorly understood. Paradoxical embolization through a PFO represents a possible mechanism by which PFO might predispose to stroke...
  3. pmc Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia
    K J Becker
    Stroke Branch, National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:10873-8. 1997
    ..These results demonstrate that antigen-specific modulation of the immune response decreases infarct size after focal cerebral ischemia and that sensitization to the same antigen may actually worsen outcome...
  4. ncbi request reprint Approval of the MERCI clot retriever: a critical view
    Kyra J Becker
    University of Washington School of Medicine, Harborview Medical Center, Box 359775, 325 9th Ave, Seattle, WA 98104 2499, USA
    Stroke 36:400-3. 2005
  5. ncbi request reprint Endovascular treatment of acute stroke
    Kyra Becker
    Kyra Becker, MD University of Washington, Box 359775 HMC, 325 9th Avenue, Seattle, WA 98104, USA
    Curr Treat Options Neurol 9:463-9. 2007
    ..Endovascular therapy should be considered for patients with large-vessel occlusions who are not candidates for intravenous thrombolysis or who do not recanalize after intravenous thrombolysis...
  6. pmc Sensitization and tolerization to brain antigens in stroke
    K J Becker
    University of Washington School of Medicine, Harborview Medical Center, Box 359775, 325 9th Avenue, Seattle, WA 98104 2499, USA
    Neuroscience 158:1090-7. 2009
    ..Together these data argue that the nature of the post-ischemic immune response influences neurological recovery from stroke...
  7. doi request reprint Stroke. 'Spotting' patients at the highest risk of hematoma growth
    Kyra Becker
    University of Washington School of Medicine, Harborview Medical Center, 325 9th Avenue, Seattle, WA 98104, USA
    Nat Rev Neurol 5:526-8. 2009
    ..novel methods for identifying those patients at the highest risk of hemorrhage growth might enable better patient selection and, hence, increase the chance of demonstrating an improvement in clinical outcome...
  8. pmc Modulation of the postischemic immune response to improve stroke outcome
    Kyra J Becker
    University of Washington School of Medicine, Seattle, Wash, USA
    Stroke 41:S75-8. 2010
    ..In particular, the potential of modulating the postischemic immune response to improve stroke outcome is explored...
  9. pmc Autoimmune responses to the brain after stroke are associated with worse outcome
    Kyra J Becker
    Department of Neurology, University of Washington School of Medicine, Box 359775, Harborview Medical Center, 325 9th Avenue, Seattle, WA 98104 2499, USA
    Stroke 42:2763-9. 2011
    ..The aim of this study was to determine if patients who developed infection in the poststroke period would be similarly predisposed to develop autoimmune responses to central nervous system antigens...
  10. ncbi request reprint Adoptive transfer of myelin basic protein-tolerized splenocytes to naive animals reduces infarct size: a role for lymphocytes in ischemic brain injury?
    Kyra Becker
    Department of Neurology, University of Washington School of Medicine, Harborview Medical Center, Seattle, WA 98104 2499, USA
    Stroke 34:1809-15. 2003
    ..Encounter of central nervous system antigens by the peripheral immune system can be capitalized on to modulate the postischemic inflammatory response and potentially improve outcome from stroke...
  11. ncbi request reprint Anti-leukocyte antibodies: LeukArrest (Hu23F2G) and Enlimomab (R6.5) in acute stroke
    Kyra J Becker
    University of Washington School of Medicine, Seattle, USA
    Curr Med Res Opin 18:s18-22. 2002
    ..The potential reasons for the failure of these trials are discussed...
  12. ncbi request reprint Antibody to the alpha4 integrin decreases infarct size in transient focal cerebral ischemia in rats
    K Becker
    University of Washington School of Medicine, Seattle, USA
    Stroke 32:206-11. 2001
    ..Blockade of neutrophil adhesion to endothelium improves outcome after experimental stroke. In this study we sought to assess the contribution of lymphocytes and monocytes to ischemic brain injury...
  13. ncbi request reprint Intensive care unit management of the stroke patient
    K Becker
    Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA
    Neurol Clin 18:439-54. 2000
    ....
  14. ncbi request reprint Thrombolysis for acute ischemic stroke
    K J Becker
    Department of Neurology, University of Washington School of Medicine, Seattle, USA
    Phys Med Rehabil Clin N Am 10:773-85, vii. 1999
    ..Important considerations for treating patients with thrombolysis are explored, and theoretic and practical differences in the approach to patients with anterior and posterior circulation disease are highlighted...
  15. ncbi request reprint Extravasation of radiographic contrast is an independent predictor of death in primary intracerebral hemorrhage
    K J Becker
    Department of Neurology University of Washington School of Medicine, Harborview Medical Center, Seattle, Washington, USA
    Stroke 30:2025-32. 1999
    ....
  16. ncbi request reprint Inflammation and acute stroke
    K J Becker
    Harborview Medical Center, Seattle, WA 98104 2499, USA
    Curr Opin Neurol 11:45-9. 1998
    ..This review will highlight the most recent advances in our knowledge as well as the early experience of using anti-inflammatory strategies to treat acute stroke...
  17. ncbi request reprint Community-based education improves stroke knowledge
    K Becker
    University of Washington School of Medicine, Harborview Medical Center, Seattle, Wash, USA
    Cerebrovasc Dis 11:34-43. 2001
    ..Health education campaigns can increase community awareness and may decrease time to hospital presentation among stroke patients...
  18. ncbi request reprint Withdrawal of support in intracerebral hemorrhage may lead to self-fulfilling prophecies
    K J Becker
    Department of Neurology, Harborview Medical Center, University of Washington School of Medicine, Seattle 98104 2499, USA
    Neurology 56:766-72. 2001
    ....
  19. ncbi request reprint Targeting the central nervous system inflammatory response in ischemic stroke
    K J Becker
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA
    Curr Opin Neurol 14:349-53. 2001
    ..These clinical failures probably reflect the fact that there has been insufficient preclinical data and inadequate trial design, rather than provide evidence against a role for inflammation in ischemic brain injury...
  20. ncbi request reprint Intra-arterial urokinase for acute ischemic stroke: factors associated with complications
    D L Tirschwell
    Department of Neurology, University of Washington, Seattle 98104 2499, USA
    Neurology 57:1100-3. 2001
    ..Although urokinase is no longer manufactured, these findings identify patients at risk for complications from other intra-arterial thrombolytics...
  21. ncbi request reprint Seizures after decompressive hemicraniectomy for ischaemic stroke
    C J Creutzfeldt
    Department of Neurology and Neurosurgery, University of Washington, Seattle, Washington, USA
    J Neurol Neurosurg Psychiatry 85:721-5. 2014
    ..The risk of seizures after malignant middle cerebral artery (MCA) infarction with decompressive hemicraniectomy (DHC) is uncertain. Also unknown is how this complication influences survivors' recovery and quality of life...
  22. pmc Induction of immunologic tolerance to myelin basic protein prevents central nervous system autoimmunity and improves outcome after stroke
    J Michael Gee
    Department of Neurology, University of Washington School of Medicine, Harborview Medical Center, Seattle, WA, USA
    Stroke 39:1575-82. 2008
    ....
  23. ncbi request reprint Shortening the NIH Stroke scale for use in the prehospital setting
    David L Tirschwell
    Department of Neurology, Harborview Medical Center, University of Washington School of Medicine, Seattle
    Stroke 33:2801-6. 2002
    ..The goal of this study was to identify a subset of the 15 items in the National Institutes of Health Stroke Scale (NIHSS-15) that measures stroke severity and predicts outcomes...
  24. ncbi request reprint Treatment of hyperglycemia in ischemic stroke (THIS): a randomized pilot trial
    Askiel Bruno
    Department of Neurology, Indiana University School of Medicine, Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
    Stroke 39:384-9. 2008
    ..Hyperglycemia may worsen brain injury during acute cerebral infarction. We tested the feasibility and tolerability of aggressive hyperglycemia correction with intravenous insulin compared with usual care during acute cerebral infarction...
  25. ncbi request reprint Transesophageal echocardiography: not for everyone?
    Edward A Gill
    Stroke 38:e78; author reply e79. 2007
  26. ncbi request reprint Lymphocytes: potential mediators of postischemic injury and neuroprotection
    J Michael Gee
    Harborview Medical Center, University of Washington School of Medicine, Seattle, WA 98104 2499, USA
    Stroke 38:783-8. 2007
    ..We present data to support this hypothesis and to show that the breach in the blood-brain barrier can also be capitalized on to modulate the immune response to create a neuroprotective environment after stroke...
  27. ncbi request reprint Immunology of ischemic vascular disease: plaque to attack
    John M Hallenbeck
    Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg 49 Room 2A10, 49 Convent Drive MSC 4476, Bethesda, MD 20892 4476, USA
    Trends Immunol 26:550-6. 2005
    ..Antigen-targeted and other forms of focused immunomodulation that can suppress vessel activation and protect ischemic tissue might ultimately find a niche in the prevention and treatment of vascular disease...
  28. pmc Sensitization to brain antigens after stroke is augmented by lipopolysaccharide
    Kyra J Becker
    Department of Neurology, University of Washington School of Medicine, Seattle, WA 98104 2499, USA
    J Cereb Blood Flow Metab 25:1634-44. 2005
    ..These data may partially explain why patients who become infected after stroke experience increased morbidity...
  29. ncbi request reprint Patent foramen ovale and recurrent stroke: closure is the best option: no
    David C Tong
    Department of Neurology and Neurological Sciences, Stanford Medical Center, Palo Alto, Calif 94304, USA
    Stroke 35:804-5. 2004
  30. ncbi request reprint Myocardial infarction following brief convulsive seizures
    Peter S Chin
    Department of Neurology, University of Washington and Harborview Medical Centers, Seattle, WA 98104, USA
    Neurology 63:2453-4. 2004

Research Grants11

  1. Sensitization to brain antigens following stroke.
    Kyra Becker; Fiscal Year: 2007
    ..End of Abstract) ..
  2. Sensitization to brain antigens following stroke.
    Kyra J Becker; Fiscal Year: 2010
    ..abstract_text> ..
  3. CNS antigen sensitization in stroke.
    Kyra Becker; Fiscal Year: 2009
    ..Data derived from this study will be used to plan future trials of immunomodulation in patients with stroke. ..
  4. THE ROLE OF LYMPHOCYTES IN CEREBRAL ISCHEMIC INJURY
    Kyra Becker; Fiscal Year: 2004
    ....
  5. Sensitization to brain antigens following stroke.
    Kyra Becker; Fiscal Year: 2009
    ..abstract_text> ..
  6. CNS antigen sensitization in stroke.
    Kyra Becker; Fiscal Year: 2007
    ..Data derived from this study will be used to plan future trials of immunomodulation in patients with stroke. ..
  7. CNS antigen sensitization in stroke.
    Kyra Becker; Fiscal Year: 2006
    ..Data derived from this study will be used to plan future trials of immunomodulation in patients with stroke. ..
  8. Sensitization to brain antigens following stroke.
    Kyra Becker; Fiscal Year: 2006
    ..End of Abstract) ..
  9. CNS antigen sensitization in stroke.
    Kyra Becker; Fiscal Year: 2005
    ..Data derived from this study will be used to plan future trials of immunomodulation in patients with stroke. ..