Jill Becker

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis
    Jill B Becker
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, 48109, USA
    Biol Sex Differ 3:14. 2012
  2. pmc Effects of a selectively bred novelty-seeking phenotype on the motivation to take cocaine in male and female rats
    Jennifer A Cummings
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Biol Sex Differ 2:3. 2011
  3. pmc Sexual differentiation of motivation: a novel mechanism?
    Jill B Becker
    Department of Psychology, Molecular and Behavioral Neuroscience Institute, Neuroscience Program, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI, 48109, USA
    Horm Behav 55:646-54. 2009
  4. pmc Sex differences in drug abuse
    Jill B Becker
    Psychology Department, University of Michigan, Ann Arbor, MI 48109, USA
    Front Neuroendocrinol 29:36-47. 2008
  5. ncbi request reprint Strategies and methods for research on sex differences in brain and behavior
    Jill B Becker
    Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109, USA
    Endocrinology 146:1650-73. 2005
  6. ncbi request reprint The role of dopamine in the nucleus accumbens and striatum during sexual behavior in the female rat
    J B Becker
    Psychology Department, and Reproductive Sciences Program and Neuroscience Program, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 21:3236-41. 2001
  7. ncbi request reprint Gender differences in the behavioral responses to cocaine and amphetamine. Implications for mechanisms mediating gender differences in drug abuse
    J B Becker
    Psychology Department, Reproductive Sciences Program, and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Ann N Y Acad Sci 937:172-87. 2001
  8. ncbi request reprint Effects of sex and estrogen on behavioral sensitization to cocaine in rats
    Ming Hu
    Psychology Department, Neuroscience Program and Reproductive Sciences Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 23:693-9. 2003
  9. doi request reprint Perspective: sex matters: gonadal steroids and the brain
    Elizabeth A Young
    Department of Psychiatry, Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Neuropsychopharmacology 34:537-8. 2009
  10. pmc Acquisition of cocaine self-administration in ovariectomized female rats: effect of estradiol dose or chronic estradiol administration
    Ming Hu
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, United States
    Drug Alcohol Depend 94:56-62. 2008

Research Grants

  1. Rapid Effects of Estradiol in the Brain
    Jill Becker; Fiscal Year: 2007
  2. GENDER DIFFERENCES IN DRUG ABUSE
    Jill B Becker; Fiscal Year: 2010
  3. 2007 Catecholamines Gordon Research Conference
    Jill Becker; Fiscal Year: 2007
  4. GENDER DIFFERENCES IN DRUG ABUSE
    Jill Becker; Fiscal Year: 2007
  5. GENDER DIFFERENCES IN DRUG ABUSE
    Jill Becker; Fiscal Year: 2002
  6. Drug Abuse: Sex differences in developmental and environmental influences
    Jill B Becker; Fiscal Year: 2010

Collaborators

Detail Information

Publications23

  1. pmc Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis
    Jill B Becker
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, 48109, USA
    Biol Sex Differ 3:14. 2012
    ..In the current review we discuss historical, cultural, social and biological bases for sex differences in addiction with an emphasis on sex differences in the neurotransmitter systems that are implicated...
  2. pmc Effects of a selectively bred novelty-seeking phenotype on the motivation to take cocaine in male and female rats
    Jennifer A Cummings
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Biol Sex Differ 2:3. 2011
    ..abstract:..
  3. pmc Sexual differentiation of motivation: a novel mechanism?
    Jill B Becker
    Department of Psychology, Molecular and Behavioral Neuroscience Institute, Neuroscience Program, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI, 48109, USA
    Horm Behav 55:646-54. 2009
    ..Here it is proposed that sexual differentiation of motivation is mediated, at least in part, by a novel mechanism in which ovarian hormones secreted at puberty in the female actively feminize the DA system...
  4. pmc Sex differences in drug abuse
    Jill B Becker
    Psychology Department, University of Michigan, Ann Arbor, MI 48109, USA
    Front Neuroendocrinol 29:36-47. 2008
    ..In this review, sex differences in drug abuse are discussed for humans and in animal models. The possible neuroendocrine mechanisms mediating these sex differences are discussed...
  5. ncbi request reprint Strategies and methods for research on sex differences in brain and behavior
    Jill B Becker
    Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109, USA
    Endocrinology 146:1650-73. 2005
    ..This article describes methods and procedures to assist scientists new to the field in designing and conducting experiments to investigate sex differences in research involving both laboratory animals and humans...
  6. ncbi request reprint The role of dopamine in the nucleus accumbens and striatum during sexual behavior in the female rat
    J B Becker
    Psychology Department, and Reproductive Sciences Program and Neuroscience Program, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 21:3236-41. 2001
    ..Sexual behavior in the female rat is proposed as a model to determine the role of dopamine in motivated behavior...
  7. ncbi request reprint Gender differences in the behavioral responses to cocaine and amphetamine. Implications for mechanisms mediating gender differences in drug abuse
    J B Becker
    Psychology Department, Reproductive Sciences Program, and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Ann N Y Acad Sci 937:172-87. 2001
    ..Results also indicate gender differences in sensitization independent of gonadal hormones, suggesting that the neural systems that undergo sensitization are sexually dimorphic...
  8. ncbi request reprint Effects of sex and estrogen on behavioral sensitization to cocaine in rats
    Ming Hu
    Psychology Department, Neuroscience Program and Reproductive Sciences Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 23:693-9. 2003
    ..Thus, estrogen enhances sensitization to cocaine, there are sex differences in behavioral sensitization, and sensitization that develops under conditions with estrogen persists even when estrogen levels are low...
  9. doi request reprint Perspective: sex matters: gonadal steroids and the brain
    Elizabeth A Young
    Department of Psychiatry, Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Neuropsychopharmacology 34:537-8. 2009
    ..This body of work challenges all of neuropsychopharmacology to consider the importance of sex and gonadal steroids in future studies...
  10. pmc Acquisition of cocaine self-administration in ovariectomized female rats: effect of estradiol dose or chronic estradiol administration
    Ming Hu
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, United States
    Drug Alcohol Depend 94:56-62. 2008
    ..These results suggest an inverted U-shaped dose-response curve for the effect of E on acquisition of cocaine self-administration...
  11. pmc Viral vector-mediated overexpression of estrogen receptor-alpha in striatum enhances the estradiol-induced motor activity in female rats and estradiol-modulated GABA release
    Kristin N Schultz
    Molecular and Behavioral Neuroscience Institute and Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 29:1897-903. 2009
    ..ERalpha overexpression also enhanced the inhibitory effect of estradiol on K(+)-evoked GABA release suggesting that disinhibition of dopamine release from terminals in the striatum resulted in the enhanced rotational behavior...
  12. pmc Sensitization enhances acquisition of cocaine self-administration in female rats: estradiol further enhances cocaine intake after acquisition
    Wei Zhao
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
    Horm Behav 58:8-12. 2010
    ..Furthermore, prior cocaine experience is more powerful than estradiol at enhancing acquisition, while estradiol enhances intake of cocaine after acquisition of self-administration...
  13. pmc The effects of novelty-seeking phenotypes and sex differences on acquisition of cocaine self-administration in selectively bred High-Responder and Low-Responder rats
    Brooke A Davis
    Molecular and Behavioral Neuroscience Institute, University of Michigan, MI 48109, United States
    Pharmacol Biochem Behav 90:331-8. 2008
    ..In conclusion, female rats, like males, exhibit HR-LR phenotypes that predict rapidity of acquiring cocaine self-administration. Moreover, HR females self-administer more cocaine than HR males and both LR groups...
  14. ncbi request reprint Biological basis of sex differences in the propensity to self-administer cocaine
    Ming Hu
    Psychology Department, University of Michigan, Ann Arbor, MI 48109 1109, USA
    Neuropsychopharmacology 29:81-5. 2004
    ..These data demonstrate that both intrinsic sex differences in brain organization and the actions of circulating estradiol contribute to increased vulnerability for cocaine use in female subjects...
  15. ncbi request reprint The effect of estradiol in the striatum is blocked by ICI 182,780 but not tamoxifen: pharmacological and behavioral evidence
    Li Xiao
    Department of Psychology, The University of Michigan, Ann Arbor, Mich, USA
    Neuroendocrinology 77:239-45. 2003
    ..The specific effects of ICI, but not TAM, on striatal DA release and pacing behavior provide further information about the binding site for estradiol in the striatum...
  16. pmc Interactions among ovarian hormones and time of testing on behavioral sensitization and cocaine self-administration
    Hongyan Yang
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Behav Brain Res 184:174-84. 2007
    ..Concurrent administration of progesterone with estradiol counteracted the effect of estradiol on cocaine intake at 0.75 mg/kg/infusion, while progesterone alone did not enhance cocaine self-administration...
  17. ncbi request reprint Female rats develop conditioned place preferences for sex at their preferred interval
    William J Jenkins
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1109, USA
    Horm Behav 43:503-7. 2003
    ..This suggests that sexual behavior is reinforcing to female rats when their preferred interval is achieved, whether or not they are actively controlling the rate of copulation...
  18. ncbi request reprint Sex differences and hormonal influences on acquisition of cocaine self-administration in rats
    Lisa R Jackson
    Department of Psychiatry, The University of Michigan, Ann Arbor, MI 48109 1109, USA
    Neuropsychopharmacology 31:129-38. 2006
    ....
  19. doi request reprint Sex-specific susceptibility to cocaine in rats with a history of prenatal stress
    Mark B Thomas
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
    Physiol Behav 97:270-7. 2009
    ..Thus, these results suggest that gestational stress is a sex-specific risk factor for different aspects of substance abuse...
  20. ncbi request reprint Estradiol attenuates the K+-induced increase in extracellular GABA in rat striatum
    Ming Hu
    Psychology Department, University of Michigan, Ann Arbor, Michigan 48109, USA
    Synapse 59:122-4. 2006
    ..In support of our hypothesis, the K+-evoked increase in GABA, but not taurine or glutamate, was significantly attenuated 30 min after treatment with estradiol...
  21. ncbi request reprint Stress and disease: is being female a predisposing factor?
    Jill B Becker
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 27:11851-5. 2007
  22. pmc Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding
    Gina M Leinninger
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Metab 10:89-98. 2009
    ..Thus, these findings reveal that LHA LepRb neurons link anorexic leptin action to the mesolimbic DA system...
  23. ncbi request reprint Dynamic increases in dopamine during paced copulation in the female rat
    William J Jenkins
    Department of Psychology, Reproductive Sciences Program, and Neuroscience Program, University of Michigan, 525 E University, Ann Arbor, MI 48109 1109 USA
    Eur J Neurosci 18:1997-2001. 2003
    ..We conclude that increases in dopamine in the nucleus accumbens are involved in anticipation, not consummation, of sexual behaviour in the female rat...

Research Grants18

  1. Rapid Effects of Estradiol in the Brain
    Jill Becker; Fiscal Year: 2007
    ..It may also be important for our understanding and treatment of a number of neurological disorders including stroke, Alzheimer's disease and Parkinson's disease where estradiol may be neuroprotective. ..
  2. GENDER DIFFERENCES IN DRUG ABUSE
    Jill B Becker; Fiscal Year: 2010
    ..The long-term goal of this project is to develop better intervention and treatment protocols for both men and women based on an improved understanding of neural basis of vulnerability to addiction. ..
  3. 2007 Catecholamines Gordon Research Conference
    Jill Becker; Fiscal Year: 2007
    ..Bridging the gap among these different aspects of catecholamine research is one of the main benefits of a conference focusing on the entire field of catecholamine research. ..
  4. GENDER DIFFERENCES IN DRUG ABUSE
    Jill Becker; Fiscal Year: 2007
    ..5) To determine if progesterone can reverse the effects of estrogen on cocaine self-administration. ..
  5. GENDER DIFFERENCES IN DRUG ABUSE
    Jill Becker; Fiscal Year: 2002
    ..abstract_text> ..
  6. Drug Abuse: Sex differences in developmental and environmental influences
    Jill B Becker; Fiscal Year: 2010
    ..Results from these experiments will have implications for treatment and prevention of drug abuse using non-pharmacological interventions. ..