James Becker

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Three-dimensional patterns of hippocampal atrophy in mild cognitive impairment
    James T Becker
    Alzheimer s Disease Research Center, University of Pittsburgh, PA 15213, USA
    Arch Neurol 63:97-101. 2006
  2. pmc Magnetoencephalography as a putative biomarker for Alzheimer's disease
    Edward Zamrini
    Department of Neurology, University of Utah, Salt Lake City, UT 84112, USA
    Int J Alzheimers Dis 2011:280289. 2011
  3. pmc Brain structural and functional recovery following initiation of combination antiretroviral therapy
    James T Becker
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    J Neurovirol 18:423-7. 2012
  4. pmc Functional connectivity measured with magnetoencephalography identifies persons with HIV disease
    James T Becker
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Imaging Behav 6:366-73. 2012
  5. pmc Cross-validation of brain structural biomarkers and cognitive aging in a community-based study
    James T Becker
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Int Psychogeriatr 24:1065-75. 2012
  6. pmc Factors affecting brain structure in men with HIV disease in the post-HAART era
    James T Becker
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neuroradiology 54:113-21. 2012
  7. pmc The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease
    Carmen Antunez
    Department of Structural Genomics, Neocodex, Avda, Charles Darwin, Sevilla, s n 41092, Spain
    Genome Med 3:33. 2011
  8. pmc Vascular risk factors, HIV serostatus, and cognitive dysfunction in gay and bisexual men
    J T Becker
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neurology 73:1292-9. 2009
  9. pmc Depressed mood is not a risk factor for incident dementia in a community-based cohort
    James T Becker
    Department of Psychiatry, School of Medicine, Graduate School of Public Health, University of Pittsburgh, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 17:653-63. 2009
  10. pmc Subcortical brain atrophy persists even in HAART-regulated HIV disease
    James T Becker
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Brain Imaging Behav 5:77-85. 2011

Detail Information

Publications69

  1. ncbi request reprint Three-dimensional patterns of hippocampal atrophy in mild cognitive impairment
    James T Becker
    Alzheimer s Disease Research Center, University of Pittsburgh, PA 15213, USA
    Arch Neurol 63:97-101. 2006
    ....
  2. pmc Magnetoencephalography as a putative biomarker for Alzheimer's disease
    Edward Zamrini
    Department of Neurology, University of Utah, Salt Lake City, UT 84112, USA
    Int J Alzheimers Dis 2011:280289. 2011
    ..This paper presents a framework for using MEG in dementia research, and for short-term research priorities...
  3. pmc Brain structural and functional recovery following initiation of combination antiretroviral therapy
    James T Becker
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    J Neurovirol 18:423-7. 2012
    ..These data suggest that at least some of the effects of HIV on the brain can be fully reversed with treatment...
  4. pmc Functional connectivity measured with magnetoencephalography identifies persons with HIV disease
    James T Becker
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Imaging Behav 6:366-73. 2012
    ....
  5. pmc Cross-validation of brain structural biomarkers and cognitive aging in a community-based study
    James T Becker
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Int Psychogeriatr 24:1065-75. 2012
    ..We examined the feasibility of acquiring state-of-the-art brain MRI images at a community hospital, and attempted to cross-validate two independent approaches to image analysis...
  6. pmc Factors affecting brain structure in men with HIV disease in the post-HAART era
    James T Becker
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neuroradiology 54:113-21. 2012
    ..The purpose of this study was to characterize brain volumetric differences in HIV seropositive and seronegative men and to determine effects of age, cardiovascular risk, and HIV infection on structural integrity...
  7. pmc The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease
    Carmen Antunez
    Department of Structural Genomics, Neocodex, Avda, Charles Darwin, Sevilla, s n 41092, Spain
    Genome Med 3:33. 2011
    ..In order to identify novel loci associated with Alzheimer's disease (AD), we conducted a genome-wide association study (GWAS) in the Spanish population...
  8. pmc Vascular risk factors, HIV serostatus, and cognitive dysfunction in gay and bisexual men
    J T Becker
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neurology 73:1292-9. 2009
    ..The purpose of this study was to evaluate the relationship between cognitive performance, risk factors for cardiovascular and cerebrovascular disease (CVD), and HIV infection in the era of highly active antiretroviral therapy...
  9. pmc Depressed mood is not a risk factor for incident dementia in a community-based cohort
    James T Becker
    Department of Psychiatry, School of Medicine, Graduate School of Public Health, University of Pittsburgh, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 17:653-63. 2009
    ..To determine the relationship between depressed mood and the development of Alzheimer disease in cognitively normal individuals...
  10. pmc Subcortical brain atrophy persists even in HAART-regulated HIV disease
    James T Becker
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Brain Imaging Behav 5:77-85. 2011
    ....
  11. pmc Three-dimensional surface mapping of the caudate nucleus in late-life depression
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 17:4-12. 2009
    ....
  12. ncbi request reprint Persistence of neuropsychologic deficits in the remitted state of late-life depression
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 14:419-27. 2006
    ..Cognitive impairment in late-life depression (LLD) is prevalent, disabling, and persists despite the remission of depressive symptoms. This article characterizes neuropsychologic functioning during remission in LLD...
  13. ncbi request reprint Psychiatric and neurocognitive disorders among HIV-positive and negative veterans in care: Veterans Aging Cohort Five-Site Study
    Amy C Justice
    Veterans Aging Cohort Study Center, VA Pittsburgh Healthcare System, and University of Pittsburgh Center for Research on Health Care, School of Medicine, Division of General Internal Medicine, Pennsylvania, USA
    AIDS 18:S49-59. 2004
    ..The risk for psychiatric and neurocognitive disorders among middle-aged and older individuals with HIV infection has not been well characterized...
  14. ncbi request reprint The nature and determinants of neuropsychological functioning in late-life depression
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 61:587-95. 2004
    ..Cognitive impairment in late-life depression (LLD) is highly prevalent, disabling, poorly understood, and likely related to long-term outcome...
  15. pmc Patterns of mild cognitive impairment after treatment of depression in the elderly
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 17:308-16. 2009
    ....
  16. ncbi request reprint Prevalence of cognitive disorders differs as a function of age in HIV virus infection
    James T Becker
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    AIDS 18:S11-8. 2004
    ..The purpose of this report is to describe the prevalence and incidence of cognitive impairment in HIV-infected individuals enrolled in a community-based study...
  17. ncbi request reprint Evaluation of dementia in the cardiovascular health cognition study
    Oscar L Lopez
    Department of Neurology, University of Pittsburgh School of Medicine, PA 15261, USA
    Neuroepidemiology 22:1-12. 2003
    ..To describe a methodology to evaluate dementia and frequency of different types of dementia and prevalence of the Cardiovascular Health Study (CHS)...
  18. pmc Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative
    Owen Carmichael
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Arch Neurol 67:1370-8. 2010
    ....
  19. pmc [New perspectives on Alzheimer's disease from neuroimaging]
    James T Becker
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Rev Neurol 50:S23-6. 2010
    ....
  20. ncbi request reprint Incidence of dementia in mild cognitive impairment in the cardiovascular health study cognition study
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, 3501 Forbes Ave, Suite 830, Oxford Bldg, Pittsburgh, PA 15213 3323, USA
    Arch Neurol 64:416-20. 2007
    ..To examine the incidence of dementia in subjects with mild cognitive impairment (MCI) in the Cardiovascular Health Study Cognition Study...
  21. ncbi request reprint Focal atrophy and cerebrovascular disease increase dementia risk among cognitively normal older adults
    Caterina Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, Pennysylvania, USA
    J Neuroimaging 17:148-55. 2007
    ....
  22. ncbi request reprint Alterations in the hemodynamic response function in cognitively impaired HIV/AIDS subjects
    Shannon B Juengst
    Department of Psychiatry, University of Pittsburgh School of Medicine, United States
    J Neurosci Methods 163:208-12. 2007
    ..The HRF of MNCD/HAD subjects did not return to baseline after 16s, suggesting subtle alterations in neuronal function, which may affect event-related fMRI studies...
  23. ncbi request reprint Functional brain abnormalities are related to clinical recovery and time to return-to-play in athletes
    Mark R Lovell
    Department of Orthopedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15203, USA
    Neurosurgery 61:352-9; discussion 359-60. 2007
    ..The relationship between athlete reports of symptoms, neurophysiological activation, and neuropsychological functioning is investigated in a sample of high school athletes...
  24. pmc Frequency and correlates of advance planning among cognitively impaired older adults
    Jennifer Hagerty Lingler
    Department of Health and Community Systems, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:643-9. 2008
    ..To examine the prevalence and sociodemographic correlates of written advance planning among patients with or at risk for dementia-imposed decisional incapacity...
  25. pmc Pathways linking late-life depression to persistent cognitive impairment and dementia
    Meryl A Butters
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    Dialogues Clin Neurosci 10:345-57. 2008
    ....
  26. pmc Imaging cerebral blood flow in the cognitively normal aging brain with arterial spin labeling: implications for imaging of neurodegenerative disease
    Charles Lee
    Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
    J Neuroimaging 19:344-52. 2009
    ..The purpose of this article is to present ASL imaging features of 38 elderly cognitively normals (CN) with their rCBF values and an averaged profile of targeted anatomic regions rCBF values...
  27. ncbi request reprint Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 60:1385-9. 2003
    ..To examine the prevalence of mild cognitive impairment (MCI) and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study...
  28. ncbi request reprint Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment
    Clayton A Wiley
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurovirol 12:262-71. 2006
    ....
  29. ncbi request reprint Executive functioning, illness course, and relapse/recurrence in continuation and maintenance treatment of late-life depression: is there a relationship?
    Meryl A Butters
    Intervention Research Center for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh Medical Center, USA
    Am J Geriatr Psychiatry 12:387-94. 2004
    ..The authors tested the hypothesis that impaired executive functioning leads to high rates of relapse and recurrence in late-life depression...
  30. ncbi request reprint Positron emission tomography imaging of the aging brain
    Carolyn Cidis Meltzer
    Department of Radiology, University of Pittsburgh School of Medicine, CHP MT 3972, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Neuroimaging Clin N Am 13:759-67. 2003
    ..Recognition of inherent potential confounds in the use of PET in aging studies is essential to the proper interpretation of these data...
  31. ncbi request reprint Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimer's disease: correlation with cognitive impairment
    Steven T DeKosky
    Department of Neurology and the Alzheimer s Disease Research Center, University of Pittsburgh, PA, USA
    Ann Neurol 53:81-90. 2003
    ....
  32. ncbi request reprint Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 60:1394-9. 2003
    ..To examine the risk factors for mild cognitive impairment (MCI) in a longitudinal population study-the Cardiovascular Health Study Cognition Study...
  33. ncbi request reprint Psychiatric symptoms vary with the severity of dementia in probable Alzheimer's disease
    Oscar L Lopez
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 15:346-53. 2003
    ..Education and race were independently associated with psychosis. However, while education was associated with psychosis in mild/moderate stages, race was associated with psychosis in moderate/severe stages...
  34. ncbi request reprint Patterns of change in the treatment of psychiatric symptoms in patients with probable Alzheimer's disease from 1983 to 2000
    Oscar L Lopez
    Alzheimer s Disease Research Center, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 15:67-73. 2003
    ..g., aggression, agitation) and sleep disorders in AD. Although the use of SHA has a proven deleterious effect on patients with AD, their use has increased over the past two decades...
  35. ncbi request reprint Non-cognitive symptoms in mild cognitive impairment subjects
    Oscar L Lopez
    Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurocase 11:65-71. 2005
    ....
  36. ncbi request reprint Diagnosis, risk factors, and treatment of vascular dementia
    Oscar L Lopez
    Department of Neurology, 3501 Forbes Avenue, Suite 830, Pittsburgh, PA 15213, USA
    Curr Neurol Neurosci Rep 4:358-67. 2004
    ..Therefore, there is a need for a better definition of VaD. This is extremely important to better understand its risk factors, as well as to create homogenous cohorts suitable for drug trials...
  37. ncbi request reprint Alteration of a clinically meaningful outcome in the natural history of Alzheimer's disease by cholinesterase inhibition
    Oscar L Lopez
    Alzheimer s Disease Research Center and Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 53:83-7. 2005
    ..To describe the effect of cholinesterase inhibitors (CEIs) on the natural course of Alzheimer's disease (AD) using clinically meaningful outcomes...
  38. pmc Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer's disease with Pittsburgh Compound B
    Cyrus A Raji
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2593, United States
    J Neurosci Methods 172:277-82. 2008
    ..02, p=0.01) and anterior ventral striatum [t(9)=2.37, p=0.04] in AD. No group differences (AD versus MCI) were detected in laterality [F (1, 15)=0.15, p=0.7] or asymmetry [F (1, 15)=0.7, p=0.42]...
  39. ncbi request reprint Incident physical disability in people with lower extremity peripheral arterial disease: the role of cardiovascular disease
    Jennifer S Brach
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Am Geriatr Soc 56:1037-44. 2008
    ..To evaluate the risk of incident physical disability and the decline in gait speed over a 6-year follow-up associated with a low ankle-arm index (AAI) in older adults...
  40. ncbi request reprint Normative data for determining significance of test-retest differences on eight common neuropsychological instruments
    Andrew J Levine
    Department of Psychiatry, UCLA School of Medicine, Los Angeles, CA 90024 1759, USA
    Clin Neuropsychol 18:373-84. 2004
    ..Limitations are discussed regarding the applicability of the data. Those with a need to factor out the effects of practice, test-retest reliability and other statistical confounds will find the information within this article useful...
  41. pmc Altered functioning of the executive control circuit in late-life depression: episodic and persistent phenomena
    Howard J Aizenstein
    Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 17:30-42. 2009
    ..To characterize the functional neuroanatomy of late-life depression (LLD) by probing for both episodic and persistent alterations in the executive-control circuit of elderly adults...
  42. ncbi request reprint Differential cortical atrophy in subgroups of mild cognitive impairment
    Sandra Bell-McGinty
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Neurol 62:1393-7. 2005
    ..To compare gray matter brain volumes in patients diagnosed with subtypes of mild cognitive impairment (MCI) (those with a focal amnestic disorder and those with more diffuse cognitive dysfunction) with those of elderly controls...
  43. pmc Atlas-based hippocampus segmentation in Alzheimer's disease and mild cognitive impairment
    Owen T Carmichael
    Radiology Department, University of Pittsburgh, B 938 PUH, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Neuroimage 27:979-90. 2005
    ..The use of fully deformable registration methods, cohort atlases, and user-defined manual tracings are recommended for highest performance in fully automated hippocampus segmentation...
  44. ncbi request reprint Research evaluation and prospective diagnosis of dementia with Lewy bodies
    Oscar L Lopez
    Alzheimer s Disease Research Center, University of Pittsburgh, PA, USA
    Arch Neurol 59:43-6. 2002
    ..To evaluate the relative merits of recently developed criteria for dementia with Lewy bodies (DLBs) in a longitudinal study of dementia...
  45. ncbi request reprint Brain morphometric abnormalities in geriatric depression: long-term neurobiological effects of illness duration
    Sandra Bell-McGinty
    Neuropsychology Research Program, Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    Am J Psychiatry 159:1424-7. 2002
    ..The authors' goal was to compare regional brain volumes in depressed elderly subjects with those of nondepressed elderly subjects by using voxel-based morphometry...
  46. pmc The associative deficit in older adult memory: Recognition of pairs is not improved by repetition
    Amy A Overman
    Department of Psychology and Center for the Neural Basis of Cognition, University of Pittsburgh, USA
    Psychol Aging 24:501-6. 2009
    ..This provides converging evidence that older adults do not form associative links between items within pairs and supports the hypothesis that an associative deficit contributes to age-related memory decline...
  47. pmc Cognitive and affective predictors of rehabilitation participation after stroke
    Elizabeth R Skidmore
    Department of Occupational Therapy, University of Pittsburgh, Pittsburgh, PA, USA
    Arch Phys Med Rehabil 91:203-7. 2010
    ..To examine associations between cognitive and affective impairments and rehabilitation participation during stroke rehabilitation...
  48. pmc Effects of image normalization on the statistical analysis of perfusion MRI in elderly brains
    Weiying Dai
    Department of Computer Science, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Magn Reson Imaging 28:1351-60. 2008
    ..To fully understand the effects of an image processing methodology on the comparisons of regional patterns of brain perfusion over time and between subject groups...
  49. pmc Basal forebrain atrophy is a presymptomatic marker for Alzheimer's disease
    Andrew M Hall
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Alzheimers Dement 4:271-9. 2008
    ....
  50. pmc Abnormal regional cerebral blood flow in cognitively normal elderly subjects with hypertension
    Weiying Dai
    Department of Computer Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Stroke 39:349-54. 2008
    ..This is a noninvasive technique that does not require either injections or ionizing radiation and can measure absolute rCBF rates over the entire brain...
  51. pmc Factors contributing to impaired self-awareness of cognitive functioning in an HIV positive and at-risk population
    Shannon Juengst
    Department of Rehabilitation Sciences and Technology, University of Pittsburgh, Pittsburgh, PA, USA
    Disabil Rehabil 34:19-25. 2012
    ..To examine the association between self-awareness of cognitive impairment and age, selected mood disorders, and type and severity of cognitive impairment in a sample of individuals with HIV/AIDS and at risk for HIV...
  52. ncbi request reprint Functional dissociations within the inferior parietal cortex in verbal working memory
    Susan M Ravizza
    Department of Psychology, University of Pittsburgh, PA 15260, USA
    Neuroimage 22:562-73. 2004
    ..Instead, we hypothesize that the DIPC may support domain-general executive processes, while the VIPC may support phonological encoding-recoding processes central to a variety of language tasks...
  53. ncbi request reprint Prospective study of attitudinal and relationship predictors of sexual risk in the multicenter AIDS cohort study
    David G Ostrow
    David Ostrow and Associates, Chicago MACS Howard Brown Health Center and Northwestern University School of Medicine, 5455 N Sheridan Rd, Suite 1207, Chicago, IL 60640, USA
    AIDS Behav 12:127-38. 2008
    ..We conclude that HIV prevention efforts should target modifiable attitudes (reduced concern about HIV and safer sex fatigue) and increases in sexual risk-taking of MSM, particularly among HIV+ men having sex with serodiscordant partners...
  54. ncbi request reprint Psychosocial risk factors of HIV morbidity and mortality: findings from the Multicenter AIDS Cohort Study (MACS)
    Roxanna Farinpour
    UCLA Neuropsychiatric Institute, Los Angeles, CA 90095, USA
    J Clin Exp Neuropsychol 25:654-70. 2003
    ....
  55. pmc Tracking Alzheimer's disease
    Paul M Thompson
    Department of Neurology, Laboratory of Neuro Imaging, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
    Ann N Y Acad Sci 1097:183-214. 2007
    ..Strengths and weaknesses of these different imaging measures for basic neuroscience and drug trials are discussed...
  56. pmc Ventricular volume and dementia progression in the Cardiovascular Health Study
    Owen T Carmichael
    Neurology Department, University of California, Davis, CA 95616, USA
    Neurobiol Aging 28:389-97. 2007
    ..Larger ventricles in healthy subjects may indicate susceptibility to, or progression of, dementia-related pathology...
  57. pmc Cerebral ventricular changes associated with transitions between normal cognitive function, mild cognitive impairment, and dementia
    Owen T Carmichael
    Neurology and Computer Science Departments, Center for Neuroscience, University of California Davis, 1544 Newton Court, Davis, CA 95616, USA
    Alzheimer Dis Assoc Disord 21:14-24. 2007
    ..Patients with diabetes had faster VBR change. Ventricular expansion may accelerate late in the progression from normal cognitive function to dementia, and may be modulated by diabetes...
  58. ncbi request reprint 3D mapping of ventricular and corpus callosum abnormalities in HIV/AIDS
    Paul M Thompson
    Laboratory of Neuro Imaging, Dept of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
    Neuroimage 31:12-23. 2006
    ..We (1) identified regions with greatest differences between AIDS patients and healthy controls and (2) correlated specific 3D patterns of structural differences with measures of immune system deterioration and cognitive decline...
  59. pmc 3D pattern of brain atrophy in HIV/AIDS visualized using tensor-based morphometry
    Ming Chang Chiang
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
    Neuroimage 34:44-60. 2007
    ..To perform TBM, we developed a new MRI-based analysis technique that uses fluid image warping, and a new alpha-entropy-based information-theoretic measure of image correspondence, called the Jensen-RĂ©nyi divergence (JRD)...
  60. ncbi request reprint Gene-environment interactions with cognition in late life and compression of morbidity
    James T Becker
    Am J Psychiatry 164:849-52. 2007
  61. pmc Incidence and epidemiology of anal cancer in the multicenter AIDS cohort study
    Gypsyamber D'Souza
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 48:491-9. 2008
    ..To examine the incidence and risk factors for anal cancer in a multicenter cohort of human immunodeficiency virus (HIV) positive and HIV-negative men who have sex with men followed between 1984 and 2006 (Multicenter AIDS Cohort Study)...
  62. pmc The generalizability of neurocognitive test/retest data derived from a nonclinical sample for detecting change among two HIV+ cohorts
    Andrew J Levine
    Department of Neurology, National Neurological AIDS Bank, UCLA David Geffen School of Medicine, Los Angeles, CA, USA
    J Clin Exp Neuropsychol 29:669-78. 2007
    ..Thus, the accuracy of the two methods examined for determining clinically significant change among HIV+ cohorts differs depending upon their similarity with the normative sample...
  63. pmc Automated ventricular mapping with multi-atlas fluid image alignment reveals genetic effects in Alzheimer's disease
    Yi Yu Chou
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA, USA
    Neuroimage 40:615-30. 2008
    ..This high-throughput method for morphometric studies further motivates the combination of genetic and neuroimaging strategies in predicting AD progression and treatment response...
  64. ncbi request reprint Recovery of replication-competent HIV type 1-infected circulating monocytes from individuals receiving antiretroviral therapy
    Sharon M Harrold
    Department of Pathology, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    AIDS Res Hum Retroviruses 18:427-34. 2002
    ..These studies demonstrate that HIV-infected individuals on ART with breakthrough viremia have significantly higher levels of circulating infected monocytes, the precursors of tissue macrophages...
  65. ncbi request reprint Mean template for tensor-based morphometry using deformation tensors
    Natasha Lepore
    Laboratory of Neuro Imaging, UCLA, Los Angeles, CA 90095, USA
    Med Image Comput Comput Assist Interv 10:826-33. 2007
    ..These results are compared to the ones found using the 'best' control, B. Statistics on both shapes are evaluated using cumulative distribution functions of the p-values in maps of inter-group differences...
  66. pmc Effect of tuberculosis on the survival of HIV-infected men in a country with low tuberculosis incidence
    Hugo Lopez-Gatell
    Directorate of Epidemiology, Ministry of Health, Mexico, Mexico
    AIDS 22:1869-73. 2008
    ..2-4.7). Results underscore the importance of avoiding TB by using preventive interventions such as treatment of latent TB infection, particularly in populations with a large prevalence of HIV/TB co-infected individuals...
  67. ncbi request reprint Multivariate statistics of the Jacobian matrices in tensor based morphometry and their application to HIV/AIDS
    Natasha Lepore
    Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Med Image Comput Comput Assist Interv 9:191-8. 2006
    ..We apply a manifold version of Hotelling's T2 test to the strain matrices. Our results complement those found from the determinants of the Jacobians alone and provide greater power in detecting group differences in brain structure...
  68. ncbi request reprint Statistical properties of Jacobian maps and the realization of unbiased large-deformation nonlinear image registration
    Alex D Leow
    Neuropsychiatric Hospital and the Laboratory of Neuro Imaging, Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA
    IEEE Trans Med Imaging 26:822-32. 2007
    ..Using permutation tests, we show that the symmetrization of image registration statistically reduces skewness in the log-Jacobian map...
  69. pmc Thinning of the cerebral cortex visualized in HIV/AIDS reflects CD4+ T lymphocyte decline
    Paul M Thompson
    Laboratory of Neuro Imaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095 1769, USA
    Proc Natl Acad Sci U S A 102:15647-52. 2005
    ..They provide an approach to gauge the impact of AIDS on the living brain and show that the brain is still vulnerable to infection even when patients are receiving antiretroviral therapy...

Research Grants21

  1. HIV1 RELATED NEUROPSYCHOLOGICAL ABNORMALITIES
    James Becker; Fiscal Year: 2000
    ..By studying MCMD in detail, and the factors that predict transition to MCMD and HAD, it may be possible to provide information useful to the development of rational treatment strategies directed at cognitive dysfunction. ..
  2. Age Moderates HIV-Related CNS Dysfunction
    James Becker; Fiscal Year: 2004
    ..By carefully characterizing the neuropsychological deficits (including those identified using brain imaging technology) we will be better able to understand the interactive effects of agingand HIVIAIDS. ..
  3. Pilot Study of an Internet-based Cognitive Stimulation Program in AIDS
    James Becker; Fiscal Year: 2008
    ..If this is true, then it means that people with mild forms of cognitive impairment may be able to help themselves to get better. [unreadable] [unreadable] [unreadable] [unreadable]..
  4. HIV1 RELATED NEUROPSYCHOLOGICAL ABNORMALITIES
    James Becker; Fiscal Year: 2001
    ..By studying MCMD in detail, and the factors that predict transition to MCMD and HAD, it may be possible to provide information useful to the development of rational treatment strategies directed at cognitive dysfunction. ..
  5. Pilot Study of the Utility of MEG Imaging in HIV/AIDS
    James Becker; Fiscal Year: 2008
    ..This is important because without this information it is difficult to know how reliable (reproducible) study results are, and this can have a major impact in terms of the interpretation (understanding) of any future studies. ..
  6. Cerebral Blood Flow in HIV/AIDS and Drug Abuse Detected by CASL MRI
    James Becker; Fiscal Year: 2008
    ..We are interested in knowing whether changes in their circulation may be responsible for some of the changes in their ability to think. ..
  7. HIV-1 RELATED NEUROPSYCHOLOGICAL ABNORMALITIES
    James Becker; Fiscal Year: 1991
    ....
  8. HIV-1 RELATED NEUROPSYCHOLOGICAL ABNORMALITIES
    James Becker; Fiscal Year: 1990
    ....
  9. Age Moderates HIV-Related CNS Dysfunction
    James Becker; Fiscal Year: 2005
    ..By carefully characterizing the neuropsychological deficits (including those identified using brain imaging technology) we will be better able to understand the interactive effects of agingand HIVIAIDS. ..
  10. HIV1 RELATED NEUROPSYCHOLOGICAL ABNORMALITIES
    James Becker; Fiscal Year: 1999
    ..By studying MCMD in detail, and the factors that predict transition to MCMD and HAD, it may be possible to provide information useful to the development of rational treatment strategies directed at cognitive dysfunction. ..
  11. HIV-1 RELATED NEUROPSYCHOLOGICAL ABNORMALITIES
    James Becker; Fiscal Year: 1993
    ....
  12. Age Moderates HIV-Related CNS Dysfunction
    James Becker; Fiscal Year: 2003
    ..By carefully characterizing the neuropsychological deficits (including those identified using brain imaging technology) we will be better able to understand the interactive effects of agingand HIVIAIDS. ..
  13. HIV1 RELATED NEUROPSYCHOLOGICAL ABNORMALITIES
    James Becker; Fiscal Year: 2002
    ..By studying MCMD in detail, and the factors that predict transition to MCMD and HAD, it may be possible to provide information useful to the development of rational treatment strategies directed at cognitive dysfunction. ..
  14. Age Moderates HIV-Related CNS Dysfunction
    James Becker; Fiscal Year: 2002
    ..By carefully characterizing the neuropsychological deficits (including those identified using brain imaging technology) we will be better able to understand the interactive effects of agingand HIVIAIDS. ..
  15. HIV-1 RELATED NEUROPSYCHOLOGICAL ABNORMALITIES
    James Becker; Fiscal Year: 1992
    ....
  16. Cardiovascular and HIV/AIDS Effects on Brain Structure/Function and Cognition
    James T Becker; Fiscal Year: 2010
    ....