Research Topics
Species | Melinda BeckSummaryAffiliation: University of North Carolina Country: USA Publications
Research Grants
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Detail Information
Publications
Diesel exhaust enhances influenza virus infections in respiratory epithelial cellsIlona Jaspers
Center for Environmental Medicine, Asthma, and Lung Biology, Department of Pediatrics, Division of Infectious Diseases and Host Defense, University of North Carolina at Chapel Hill, North Carolina 27599 7310, USA
Toxicol Sci 85:990-1002. 2005....- Dietary oxidative stress and the potentiation of viral infectionM A Beck
Frank Porter Graham Child Development Center, University of North Carolina, Chapel Hill 27599 8180, USA
Annu Rev Nutr 18:93-116. 1998..Further research is needed to determine whether poor host nutrition plays any role in the emergence of new viral diseases via alterations in he genotype of an infectious agent... - Selenium and vitamin E status: impact on viral pathogenicityMelinda A Beck
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599 7461, USA
J Nutr 137:1338-40. 2007..Thus, host nutritional status should be considered a driving force for the emergence of new viral strains or newly pathogenic strains of known viruses... - Benign coxsackievirus damages heart muscle in iron-loaded vitamin E-deficient miceMelinda A Beck
University of North Carolina, 3312 Medical Bio Molecular Research Building, CB 7224, Chapel Hill, NC 27599 7224, USA
Free Radic Biol Med 38:112-6. 2005..Further research is needed to clarify the role of oxidative stress and iron overload in determining the course of viral infection... - Host nutritional status: the neglected virulence factorMelinda A Beck
Department of Pediatrics and Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, NC 27599, USA
Trends Microbiol 12:417-23. 2004..This latter finding markedly changes our concept of host-pathogen interactions and creates a new paradigm for the study of such phenomena... - Selenium deficiency and viral infectionMelinda A Beck
Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Nutr 133:1463S-7S. 2003..Further research, both basic and applied, is needed to assess properly the possible role of malnutrition in contributing to the emergence of novel viral diseases... - Coxsackievirus B3-resistant mice become susceptible in Se/vitamin E deficiencyMelinda A Beck
Departments of Nutrition and Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7220, USA
Free Radic Biol Med 34:1263-70. 2003.... - Antioxidants and viral infections: host immune response and viral pathogenicityM A Beck
Department of Pediatrics, University of North Carolina at Chapel Hill, 27599 7220, USA
J Am Coll Nutr 20:384S-388S; discussion 396S-397S. 2001..This work points to the importance of host nutrition in not only optimizing the host immune response, but also in preventing viral mutations which could increase the viral pathogenicity... - The role of oxidative stress in viral infectionsM A Beck
Department of Pediatrics, 535 Burnett Womack, CB 7220, University of NC at Chapel Hill, Chapel Hill, NC 27599 7220, USA
Ann N Y Acad Sci 917:906-12. 2000..A coxsackie-like virus was isolated from the cerebrospinal fluid from 84% of patients cultured. Thus, oxidative stress can have profound effects, not only on the host, but on the pathogen as well... - Micronutrients and host resistance to viral infectionM A Beck
Department of Nutrition, CB 7220, University of NC at Chapel Hill, Chapel Hill, NC 27599 7220, USA
Proc Nutr Soc 59:581-5. 2000..Thus, a deficiency in Se can have profound effects on the host as well as on the virus itself. How the alteration of the immune response of the Se-deficient animal affects the development of the virulent genotype remains to be answered... - Host nutritional status and its effect on a viral pathogenM A Beck
Departments of Pediatrics and Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7220, USA
J Infect Dis 182:S93-6. 2000..Once these mutations occurred, even mice with normal nutriture developed disease from the mutated virus. These results suggest that the oxidative stress status of the host can have a profound influence on a viral pathogen... - Selenium and host defence towards virusesM A Beck
University of North Carolina at Chapel Hill 27599 7220, USA
Proc Nutr Soc 58:707-11. 1999..Our work points to the importance of host nutrition during a viral disease, not only from the perspective of the host, but from the perspective of the viral pathogen as well... - Glutathione peroxidase protects mice from viral-induced myocarditisM A Beck
Frank Porter Graham Child Development Center, University of North Carolina at Chapel Hill, 27599 8180, USA
FASEB J 12:1143-9. 1998..No changes were found in virus isolated from Gpx1+/+ mice. These results demonstrate that GPX-1 provides protection against viral-induced damage in vivo due to mutations in the viral genome of a benign virus... - Selenium deficiency induced an altered immune response and increased survival following influenza A/Puerto Rico/8/34 infectionWei Li
Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
Exp Biol Med (Maywood) 232:412-9. 2007..This altered immune response was beneficial for protecting the mice from influenza virus-induced mortality... 
Fish oil-fed mice have impaired resistance to influenza infectionNicole M J Schwerbrock
Department of Nutrition, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Nutr 139:1588-94. 2009..These results suggest that the antiinflammatory properties of fish oil feeding can alter the immune response to influenza infection, resulting in increased morbidity and mortality...- Diet-induced obese mice have increased mortality and altered immune responses when infected with influenza virusAlexia G Smith
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
J Nutr 137:1236-43. 2007..These data indicate that obesity inhibits the ability of the immune system to appropriately respond to influenza infection and suggests that obesity may lead to increased morbidity and mortality from viral infections... - Selective impairment in dendritic cell function and altered antigen-specific CD8+ T-cell responses in diet-induced obese mice infected with influenza virusAlexia G Smith
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599 7461, USA
Immunology 126:268-79. 2009..Thus, obesity interferes with cellular responses during influenza infection, leading to alterations in the T-cell population that ultimately may be detrimental to the host... - Glycerol-3-phosphate acyltransferase 1 is essential for the immune response to infection with coxsackievirus B3 in miceErik A Karlsson
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
J Nutr 139:779-83. 2009..Innate mechanisms may be affected by altered membrane composition or host redox status, whereas the adaptive response may require GPAT1 activity itself... - The immune response to herpes simplex virus encephalitis in mice is modulated by dietary vitamin EPatricia A Sheridan
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
J Nutr 138:130-7. 2008..We demonstrated that adequate levels of VE are important in limiting HSE pathology and that 10x supplementation does not enhance protection... - The dendritic and T cell responses to herpes simplex virus-1 are modulated by dietary vitamin EPatricia A Sheridan
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
Free Radic Biol Med 46:1581-8. 2009..Our results demonstrate that adequate levels of VE are important for trafficking antigen-specific T cells to the brain, and dietary VE levels modulate T regulatory and dendritic cells in the periphery... - Activation of superoxide dismutase in selenium-deficient mice infected with influenza virusMiroslav Styblo
Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
J Trace Elem Med Biol 21:52-62. 2007..However, SOD activation that leads to increased production of H(2)O(2) may also contribute to pathogenesis and to influenza virus mutation in lungs of Se-deficient mice... - Diet-induced obesity in mice reduces the maintenance of influenza-specific CD8+ memory T cellsErik A Karlsson
Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599 7461, USA
J Nutr 140:1691-7. 2010..It is imperative to understand how the obese state alters memory T cells, because impairment in maintenance of functional memory responses has important implications for vaccine efficacy in an obese population... - Vitamin C deficiency increases the lung pathology of influenza virus-infected gulo-/- miceWei Li
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
J Nutr 136:2611-6. 2006..These data suggest that vitamin C is required for an adequate immune response in limiting lung pathology after influenza virus infection... - Decreased selenoprotein expression alters the immune response during influenza virus infection in micePatricia A Sheridan
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
J Nutr 137:1466-71. 2007..These results suggest that although selenoproteins are important for immune function, there is a threshold of GPX-1 activity that can prevent an increase in lung pathology during influenza infection... 
Diet-induced obesity impairs the T cell memory response to influenza virus infectionErik A Karlsson
Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
J Immunol 184:3127-33. 2010..Moreover, impairment of memory responses has significant implications for vaccine efficacy in an obese population...- A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosolShan Lin
Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Biol Chem 277:10795-803. 2002..Because methylation of arsenic is a critical feature of its metabolism, characterization of this enzyme will improve our understanding of this metalloid's metabolism and its actions as a toxin and a carcinogen... - Unexpected hazard of illegal immigration: Outbreak of viral myocarditis exacerbated by confinement and deprivation in a shipboard cargo containerMelissa K Li
University of Florida, Gainesville, Florida, USA
Am J Forensic Med Pathol 25:117-24. 2004..In summary, these cases represent a potential infectious disease hazard of illegal immigration... - An aged host promotes the evolution of avirulent coxsackievirus into a virulent strainRaina T Gay
Nutritional Immunology Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 103:13825-30. 2006..These results demonstrate that the aged host promotes rapid selection of a pathogenic variant of CVB3 from an avirulent strain and introduces a host-virus paradigm for studies of viral infection in the aged...
Research Grants
- The Role of Nutrition in Virus-Induced Optic NeuropathyMelinda Beck; Fiscal Year: 2006....
- Nutrition, Viral Mutation and Host DefenseMelinda Beck; Fiscal Year: 2007..abstract_text> ..
- Risk of Influenza Infection In A Vaccinated Obese PopulationMelinda A Beck; Fiscal Year: 2010....
- Viral Adaptation to Host Selenium StatusMelinda A Beck; Fiscal Year: 2010..This project is designed to understand how selenium nutritional status can impact changes in viral adaptation. The goal is to develop tools to predict outbreaks of emerging infectious diseases. ..
- The Influence of Nutrition on Influenza Virus InfectionMelinda Beck; Fiscal Year: 2004..abstract_text> ..
- NUTRITION AND VIRUS INDUCED OPTIC NEUROPATHYMelinda Beck; Fiscal Year: 2002..abstract_text> ..
- Risk of Influenza Infection In A Vaccinated Obese PopulationMelinda A Beck; Fiscal Year: 2011....