T Mark Beasley

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Validity and power of missing data imputation for extreme sampling and terminal measures designs in mediation analysis
    Robert Makowsky
    Department of Biostatistics, University of Alabama at Birmingham Birmingham, AL, USA
    Front Genet 2:75. 2011
  2. pmc Rank-based inverse normal transformations are increasingly used, but are they merited?
    T Mark Beasley
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Ryals Public Health Building, Suite 327, Birmingham, AL, 35294, USA
    Behav Genet 39:580-95. 2009
  3. pmc Joint tests for quantitative trait loci in experimental crosses
    T Mark Beasley
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL, USA
    Genet Sel Evol 36:601-19. 2004
  4. pmc Warfarin dosing in patients with impaired kidney function
    Nita A Limdi
    Department of Neurology, University of Alabama at Birmingham, AL 35294 0021, USA
    Am J Kidney Dis 56:823-31. 2010
  5. pmc Body fat and racial genetic admixture are associated with aerobic fitness levels in a multiethnic pediatric population
    Amanda L Willig
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Obesity (Silver Spring) 19:2222-7. 2011
  6. pmc VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans
    Nita A Limdi
    Department of Neurology, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC 312, Birmingham AL 35294 0021, USA
    Pharmacogenomics 9:1445-58. 2008
  7. pmc Ancestry-informative markers on chromosomes 2, 8 and 15 are associated with insulin-related traits in a racially diverse sample of children
    Yann C Klimentidis
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
    Hum Genomics 5:79-89. 2011
  8. pmc Parental feeding practices and socioeconomic status are associated with child adiposity in a multi-ethnic sample of children
    Michelle Cardel
    Department of Nutrition Sciences, Clinical Nutrition Research Center, University of Alabama at Birmingham, 1675 University Blvd, WEBB 415, Birmingham, AL 35294 3360, USA
    Appetite 58:347-53. 2012
  9. ncbi request reprint Empirical bayes method for incorporating data from multiple genome scans
    T Mark Beasley
    Department of Biostatistics, Section of Statistical Genetics, The University of Alabama at Birmingham, 35294, USA
    Hum Hered 60:36-42. 2005
  10. pmc Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear model
    David T Redden
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS Genet 2:e137. 2006

Detail Information

Publications31

  1. pmc Validity and power of missing data imputation for extreme sampling and terminal measures designs in mediation analysis
    Robert Makowsky
    Department of Biostatistics, University of Alabama at Birmingham Birmingham, AL, USA
    Front Genet 2:75. 2011
    ..Yet, the use of extreme sampling designs and methods to handle the resultant missing data presents a viable research strategy...
  2. pmc Rank-based inverse normal transformations are increasingly used, but are they merited?
    T Mark Beasley
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Ryals Public Health Building, Suite 327, Birmingham, AL, 35294, USA
    Behav Genet 39:580-95. 2009
    ..Rigorous research evaluating the utility of INTs seems warranted...
  3. pmc Joint tests for quantitative trait loci in experimental crosses
    T Mark Beasley
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL, USA
    Genet Sel Evol 36:601-19. 2004
    ..Joint tests were generally more powerful for one-tailed selection under both backcross and F2 intercross situations. However, joint tests cannot be recommended for one-tailed selective genotyping if segregation distortion is suspected...
  4. pmc Warfarin dosing in patients with impaired kidney function
    Nita A Limdi
    Department of Neurology, University of Alabama at Birmingham, AL 35294 0021, USA
    Am J Kidney Dis 56:823-31. 2010
    ..Unfortunately, few data exist to guide dose adjustment in patients with decreased kidney function. Here, we determine the degree of warfarin dose reduction associated with kidney impairment and make recommendations for warfarin dosing...
  5. pmc Body fat and racial genetic admixture are associated with aerobic fitness levels in a multiethnic pediatric population
    Amanda L Willig
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Obesity (Silver Spring) 19:2222-7. 2011
    ..01). In conclusion, aerobic fitness levels differ by percent body fat and genetic admixture irrespective of BMI classification, and such differences should be taken into account when evaluating outcomes of health interventions...
  6. pmc VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans
    Nita A Limdi
    Department of Neurology, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC 312, Birmingham AL 35294 0021, USA
    Pharmacogenomics 9:1445-58. 2008
    ..However, the inadequate representation of African-Americans and the assessment of a few VKORC1 polymorphisms have hindered this effort...
  7. pmc Ancestry-informative markers on chromosomes 2, 8 and 15 are associated with insulin-related traits in a racially diverse sample of children
    Yann C Klimentidis
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
    Hum Genomics 5:79-89. 2011
    ..Importantly, we have implicated this region in the early development of diabetes-related phenotypes, and in the genetic aetiology of population differences in these phenotypes...
  8. pmc Parental feeding practices and socioeconomic status are associated with child adiposity in a multi-ethnic sample of children
    Michelle Cardel
    Department of Nutrition Sciences, Clinical Nutrition Research Center, University of Alabama at Birmingham, 1675 University Blvd, WEBB 415, Birmingham, AL 35294 3360, USA
    Appetite 58:347-53. 2012
    ..Thus, parental feeding practices differ across racial/ethnic groups and SES and may contribute to population differences in child adiposity...
  9. ncbi request reprint Empirical bayes method for incorporating data from multiple genome scans
    T Mark Beasley
    Department of Biostatistics, Section of Statistical Genetics, The University of Alabama at Birmingham, 35294, USA
    Hum Hered 60:36-42. 2005
    ..This EB method for incorporating data from multiple studies into genome scan analyses seems promising...
  10. pmc Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear model
    David T Redden
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS Genet 2:e137. 2006
    ....
  11. pmc Intramyocellular lipid and insulin resistance: differential relationships in European and African Americans
    Katherine H Ingram
    Department of Biostatistics, University of Alabama, Birmingham, Alabama, USA
    Obesity (Silver Spring) 19:1469-75. 2011
    ..These results highlight ethnic differences in the determinants of insulin sensitivity and in the pathogenesis of the metabolic syndrome trait cluster...
  12. pmc A proposed metric for assessing the measurement quality of individual microarrays
    Kyoungmi Kim
    Department of Biostatistics, University of Alabama, Birmingham, Alabama, USA
    BMC Bioinformatics 7:35. 2006
    ..In some cases this may be manifested as systematic spatial variation on the surface of microarray in which expression measurements within an individual array may vary as a function of geographic position on the array surface...
  13. pmc Kidney function influences warfarin responsiveness and hemorrhagic complications
    Nita A Limdi
    Department of Neurology, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC 312, Birmingham, Alabama 35294 0021, USA
    J Am Soc Nephrol 20:912-21. 2009
    ..Diminished renal function may have implications for a larger proportion of warfarin users than previously estimated...
  14. ncbi request reprint Association of African genetic admixture with resting metabolic rate and obesity among women
    Jose R Fernandez
    Department of Nutrition Sciences and the Clinical Nutrition Research Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Obes Res 11:904-11. 2003
    ....
  15. ncbi request reprint New joint covariance- and marginal-based tests for association and linkage for quantitative traits for random and non-random sampling
    Hemant K Tiwari
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Genet Epidemiol 28:48-57. 2005
    ..Both random sampling and extreme sampling schemes were investigated. A multinomial logistic joint test provides the highest overall power irrespective of sample size, allele frequency, heritability, and modes of inheritance...
  16. pmc Beyond thriftiness: independent and interactive effects of genetic and dietary factors on variations in fat deposition and distribution across populations
    Krista Casazza
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
    Am J Phys Anthropol 145:181-91. 2011
    ..Interactive effects of genetic and non-genetic factors alter metabolic pathways and underlie some of the present population-based differences in fat storage...
  17. pmc Canaries in the coal mine: a cross-species analysis of the plurality of obesity epidemics
    Yann C Klimentidis
    Department of Biostatistics, University of Alabama, Birmingham, AL, USA
    Proc Biol Sci 278:1626-32. 2011
    ..g. viral pathogens, epigenetic factors). This finding may eventually enhance the discovery and fuller elucidation of other factors that have contributed to the recent rise in obesity rates...
  18. pmc Bias in estimates of quantitative-trait-locus effect in genome scans: demonstration of the phenomenon and a method-of-moments procedure for reducing bias
    David B Allison
    Department of Biostatistics and Center for Research on Clinical Nutrition, University of Alabama at Birmingham, 35294 0022, USA
    Am J Hum Genet 70:575-85. 2002
    ..Finally, limitations of the MOM approach are noted, and we discuss some alternative procedures that may also reduce bias...
  19. doi request reprint Randomized controlled trial of chewing gum for weight loss
    James M Shikany
    Division of Preventive Medicine, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Obesity (Silver Spring) 20:547-52. 2012
    ..Analyses including completers only produced essentially the same results. We conclude that chewing gum on a regular schedule for 8 weeks did not facilitate weight loss in these overweight and obese adults...
  20. pmc Associations among calcium intake, resting energy expenditure, and body fat in a multiethnic sample of children
    Lynae J Hanks
    Department of Nutrition Sciences and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
    J Pediatr 157:473-8. 2010
    ..The objective was to determine if calcium intake was associated with resting energy expenditure (REE) and body fat in children after accounting for ancestral genetic background...
  21. pmc A pilot assessment of parental practices and attitudes regarding risk disclosure and clinical research involving children in Huntington disease families
    Leon S Dure
    Department of Pediatrics, The University of Alabama at Birmingham School of Medicine, Alabama, USA
    Genet Med 10:811-9. 2008
    ..To characterize parental practices of informing children of risk for Huntington disease (HD), and to understand the attitudes of parents concerning childhood participation in HD research...
  22. ncbi request reprint Improving the power of sib pair quantitative trait loci detection by phenotype winsorization
    Jose R Fernandez
    Department of Nutrition Sciences, Division of Physiology and Metabolism, The University of Alabama at Birmingham, 35294 3360, USA
    Hum Hered 53:59-67. 2002
    ..We evaluated the robustness and power of reducing the influence of subjects with extreme phenotypic values by Winsorizing non-normal distributions in three versions of Haseman-Elston regression-based methods of QTL linkage analysis...
  23. ncbi request reprint Using genetic admixture to explain racial differences in insulin-related phenotypes
    Barbara A Gower
    Department of Nutrition Sciences, The University of Alabama at Birmingham, Birmingham, Alabama 35294 3360, USA
    Diabetes 52:1047-51. 2003
    ....
  24. ncbi request reprint Comparison of linear weighting schemes for perfect match and mismatch gene expression levels from microarray data
    T Mark Beasley
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Am J Pharmacogenomics 5:197-205. 2005
    ....
  25. ncbi request reprint The effect of gender and respirator brand on the association of respirator fit with facial dimensions
    R Kent Oestenstad
    Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    J Occup Environ Hyg 4:923-30. 2007
    ....
  26. ncbi request reprint Effectiveness evaluation of the N-O-T smoking cessation program for adolescents
    Connie L Kohler
    Department of Health Behavior, University of Alabama at Birmingham, 1530 3rd Avenue South, RPHB 227, Birmingham, AL 35294 0022, USA
    Am J Health Behav 32:368-79. 2008
    ..To evaluate the effectiveness of the Not-On-Tobacco Program...
  27. pmc Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz
    Brandon F Keele
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nature 460:515-9. 2009
    ..These findings challenge the prevailing view that all natural SIV infections are non-pathogenic and suggest that SIVcpz has a substantial negative impact on the health, reproduction and lifespan of chimpanzees in the wild...
  28. pmc Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans
    Nita A Limdi
    University of Alabama at Birmingham, Department of Neurology, 1719 6th Avenue South, CIRC 312, Birmingham, AL 35294 0021, USA
    Pharmacogenomics 9:511-26. 2008
    ....
  29. ncbi request reprint Effect of winsorization on power and type 1 error of variance components and related methods of QTL detection
    Sanjay Shete
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Behav Genet 34:153-9. 2004
    ..A robust version of the LRT that adjusts for sample kurtosis showed the best power for nonnormal data. Finally, phenotype winsorization of nonnormal data reduces the bias in estimation of the major gene variance component...
  30. doi request reprint Tympanometry in rhesus monkeys: effects of aging and caloric restriction
    Cynthia G Fowler
    Department of Communicative Disorders, University of Wisconsin Madison, WI 53706, USA
    Int J Audiol 47:209-14. 2008
    ..These results parallel many findings in middle-ear function in aging humans. Longitudinal studies are planned...
  31. pmc Attenuation of sarcopenia by dietary restriction in rhesus monkeys
    Ricki J Colman
    Wisconsin National Primate Research Center, University of Wisconsin Madison, 1220 Capitol Ct, Madison, WI 53715, USA
    J Gerontol A Biol Sci Med Sci 63:556-9. 2008
    ..Body weight-adjusted skeletal muscle mass declined somewhat in both groups but was far more rapid in the control group. We have shown that moderate, adult-onset DR can attenuate sarcopenia in a nonhuman primate model...