Research Topics
Genomes and GenesSpecies | David Wc BeasleySummaryAffiliation: University of Texas Medical Branch Country: USA Publications
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Publications
Safety and immunogenicity of a chimeric vaccine for West Nile virus in aged subjectsDavid W C Beasley
Department of Microbiology and Immunology, Sealy Center for Vaccine Development, Center for Biodefense and Emerging Infectious Disease, Institute for Human Infections and Immunity, Galveston, TX, USA
Expert Rev Vaccines 10:601-4. 2011..The apparent safety and immunogenicity of ChimeriVax-WN02 in this population indicates that further development and clinical testing are justified...
Genome sequence and attenuating mutations in West Nile virus isolate from MexicoDavid W C Beasley
University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
Emerg Infect Dis 10:2221-4. 2004..11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation...- Envelope protein glycosylation status influences mouse neuroinvasion phenotype of genetic lineage 1 West Nile virus strainsDavid W C Beasley
Department of Pathology, Cancer Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555 0609, USA
J Virol 79:8339-47. 2005..Therefore, the enhanced virulence of North American WNV strains compared with other Old World lineage 1 strains is at least partly mediated by envelope protein glycosylation... - Protection against Japanese encephalitis virus strains representing four genotypes by passive transfer of sera raised against ChimeriVax-JE experimental vaccineDavid W C Beasley
Department of Pathology, Sealy Center for Vaccine Development, and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0609, USA
Vaccine 22:3722-6. 2004..ChimeriVax-JE stimulated protection that was comparable or superior to the JE-VAX control... - Recent advances in the molecular biology of west nile virusDavid W C Beasley
Department of Microbiology and Immunology, and Institute for Human Infections and Immunity, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0609, USA
Curr Mol Med 5:835-50. 2005..This review addresses the most recent results from studies investigating the molecular biology and evolution of WNV, as well as progress in the development of diagnostic and therapeutic reagents... 
Vaccines and immunotherapeutics for the prevention and treatment of infections with West Nile virusDavid W C Beasley
Department of Microbiology and Immunology, Sealy Center for Vaccine Development, Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, and Galveston National Laboratory, The University of Texas Medical Branch, Galveston, TX 77555 0609, USA
Immunotherapy 3:269-85. 2011..This article focuses on progress in development and evaluation of vaccines and immunotherapeutics for the prevention and treatment of WNV disease in humans and animals...- Development and characterization of non-glycosylated E and NS1 mutant viruses as a potential candidate vaccine for West Nile virusMelissa C Whiteman
Sealy Center for Vaccine Development, Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections, Immunity and Department of Pathology, TX 77555 0609, USA
Vaccine 28:1075-83. 2010.... - A mutation in the envelope protein fusion loop attenuates mouse neuroinvasiveness of the NY99 strain of West Nile virusShuliu Zhang
Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0609, USA
Virology 353:35-40. 2006..MAb 3D9 was subsequently shown to be broadly cross-reactive with other flaviviruses, consistent with binding near the highly conserved fusion loop... - Differential expression of domain III neutralizing epitopes on the envelope proteins of West Nile virus strainsLi Li
Center for Biodefense and Emerging Infectious Diseases, Sealy Center for Vaccine Development, and Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0609, USA
Virology 335:99-105. 2005..Mutations of residue 332 had the most significant effects on variation of domain III neutralizing epitopes among strains... - Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotypeDavid W C Beasley
Department of Pathology, The University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
Virology 296:17-23. 2002..Virus isolated in North America was found to be highly neuroinvasive with a lack of age-related resistance to infection in mice normally associated with mosquito-borne flaviviruses... - Solution structure and antibody binding studies of the envelope protein domain III from the New York strain of West Nile virusDavid E Volk
Sealy Center for Structural Biology, University of Texas Medical Branch, Galveston, Texas 77555 1147, USA
J Biol Chem 279:38755-61. 2004.... - Long range communication in the envelope protein domain III and its effect on the resistance of West Nile virus to antibody-mediated neutralizationRodrigo A Maillard
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 1055, USA
J Biol Chem 283:613-22. 2008..This hypothesis is consistent with reported mutations in other flaviviruses whose surfaces are not exposed for the interaction with other macromolecules, yet they confer mAb neutralization resistance... - West Nile virus in Mexico: evidence of widespread circulation since July 2002Jose G Estrada-Franco
University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
Emerg Infect Dis 9:1604-7. 2003..Phylogenetic studies indicate that this isolate, the first from Mexico, is related to strains from the central United States but has a relatively high degree of sequence divergence... - NMR assignments of the sylvatic dengue 1 virus envelope protein domain IIIDavid E Volk
Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX 77555 1157, USA
Biomol NMR Assign 2:155-7. 2008.... - Development pathway for biodefense vaccinesAlan D T Barrett
Sealy Center for Vaccine Development, Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555 0436, USA
Vaccine 27:D2-7. 2009..Nonetheless, the vaccine pathway still requires the same fundamental components of basic science/discovery, preclinical development, clinical trials, registration/licensure, and a plan for implementation... - Role of BC loop residues in structure, function and antigenicity of the West Nile virus envelope protein receptor-binding domain IIIShuliu Zhang
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA
Virology 403:85-91. 2010.... - Identification of neutralizing epitopes within structural domain III of the West Nile virus envelope proteinDavid W C Beasley
WHO Collaborating Center for Tropical Diseases, Sealy Center for Vaccine Development, Department of Pathology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0609, USA
J Virol 76:13097-100. 2002.... - Development of resistance to passive therapy with a potently neutralizing humanized monoclonal antibody against West Nile virusShuliu Zhang
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA
J Infect Dis 200:202-5. 2009..Moreover, the emergence of resistant variants after infection with fully sensitive virus occurred but was relatively rare, even in highly immunocompromised B and T cell-deficient RAG mice... - Current use and development of vaccines for Japanese encephalitisDavid W C Beasley
University of Texas Medical Branch, Department of Microbiology and Immunology, Galveston, TX 77555 0609, USA
Expert Opin Biol Ther 8:95-106. 2008.... - Solution structure of the envelope protein domain III of dengue-4 virusDavid E Volk
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 1157, USA
Virology 364:147-54. 2007..Important structural differences between DEN4-rED3 and ED3 domains of DEN2, DEN3 and other flaviviruses are discussed... - Introductions of West Nile virus strains to MexicoEleanor Deardorff
University of Texas Medical Branch, Galveston, Texas 77555-0609, USA
Emerg Infect Dis 12:314-8. 2006.... - A single amino acid substitution in the central portion of the West Nile virus NS4B protein confers a highly attenuated phenotype in miceJason A Wicker
Department of Microbiology and Immunology, Sealy Center for Vaccine Development, Center for Biodefense and Emerging Infectious Diseases, and Institute for Human Infections and Immunity, University of Texas Medical Branch at Galveston, TX 77555 0609, USA
Virology 349:245-53. 2006.... - Phylogenetic analysis of North American West Nile virus isolates, 2001-2004: evidence for the emergence of a dominant genotypeC Todd Davis
Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, and Sealy Center for Vaccine Development, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77550-0609, USA
Virology 342:252-65. 2005..The implications of these findings are discussed as they relate to transmission and spread of the virus in the Western Hemisphere... - Limited evolution of West Nile virus has occurred during its southwesterly spread in the United StatesDavid W C Beasley
WHO Collaborating Center for Tropical Diseases, Galveston, TX 77555-0609, USA
Virology 309:190-5. 2003..The presence of unique patterns of small numbers of mutations in North American West Nile strains studied to date may suggest the absence of a strong selective pressure to drive the emergence of dominant variants... - Use of a recombinant envelope protein subunit antigen for specific serological diagnosis of West Nile virus infectionDavid W C Beasley
Department of Pathology, UTMB, 301 University Blvd, Galveston, TX 77555-0609, USA
J Clin Microbiol 42:2759-65. 2004.... - Characterization of a West Nile virus isolate from a human on the Gulf Coast of TexasBruno P Granwehr
Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555-0609, USA
J Clin Microbiol 42:5375-7. 2004.... - Structure of the envelope protein domain III of Omsk hemorrhagic fever virusDavid E Volk
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555-1157, USA
Virology 351:188-95. 2006..Important structural differences between tick-borne flaviviruses, such as OHFV and TBE, and mosquito-borne flaviviruses, such as West Nile virus, are discussed... - Structure of yellow fever virus envelope protein domain IIIDavid E Volk
Departments of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 1157, USA
Virology 394:12-8. 2009..Variations in the structure and surface chemistry of ED3 between flaviviruses affect neutralization sites and may affect host cell receptor interactions and play a role in the observed variations in viral pathogenesis and tissue tropism... - Genetic variation among temporally and geographically distinct West Nile virus isolates, United States, 2001, 2002C Todd Davis
Center for Biodefense and Emerging Diseases, Galveston, Texas 77555-0609, USA
Emerg Infect Dis 9:1423-9. 2003..35% (mean = 0.18%). These results show the geographic clustering of genetically similar WNV isolates and the possible emergence of a dominant variant circulating across much of the United States during 2002... - Natural and nosocomial infection in a patient with West Nile encephalitis and extrapyramidal movement disordersTom Solomon
Department of Pathology, University Texas Medical Branch, Galveston, TX, USA and Departments of Neurological Science and Medical Microbiology, University of Liverpool, United Kingdom
Clin Infect Dis 36:E140-5. 2003..Detailed molecular analysis suggested that, although our patient received a blood transfusion infected with WNV, the virus that caused his initial infection and encephalitis was probably acquired naturally from a mosquito... - Genetic variation of St. Louis encephalitis virusFiona J May
Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
J Gen Virol 89:1901-10. 2008..Finally, SLEV has much lower nucleotide (10.1 %) and amino acid variation (2.8 %) than other members of the Japanese encephalitis virus complex (maximum variation 24.6 % nucleotide and 11.8 % amino acid)... - Emergence of attenuated West Nile virus variants in Texas, 2003C Todd Davis
Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, USA
Virology 330:342-50. 2004..These data indicate microevolution of WNV and the emergence of isolates exhibiting phenotypic variation... - Origin and evolution of Japanese encephalitis virus in southeast AsiaTom Solomon
Department of Neurological Science, University of Liverpool, Liverpool L9 7LJ, United Kingdom
J Virol 77:3091-8. 2003..Our data, together with recent evidence on the origins of other emerging viruses, including dengue virus and Nipah virus, imply that tropical southeast Asia may be an important zone for emerging pathogens... - Experimental infection of rhesus macaques with West Nile virus: level and duration of viremia and kinetics of the antibody response after infectionMarion S Ratterree
Division of Veterinary Medicine, Tulane National Primate Research Center, Tulane University, Covington, Louisiana, USA
J Infect Dis 189:669-76. 2004..Our results suggest that both nucleic acid and serological testing may be needed to determine exposure to WNV and to identify potentially infected blood donors... - Short report: serological evidence of West Nile virus activity in El SalvadorLilian Cruz
Field Epidemiology Training Program, Ministry of Public Health and Social Welfare, San Salvador, El Salvador
Am J Trop Med Hyg 72:612-5. 2005..Ten of these infections were confirmed by plaque reduction neutralization tests, suggesting West Nile virus has extended its range and spread to Central America... - Selection of thioaptamers for diagnostics and therapeuticsXianbin Yang
Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology, University of Texas Medical Branch at Galveston, Texas 77555-1157, USA
Ann N Y Acad Sci 1082:116-9. 2006..Moreover, some promising thioaptamers have been shown in preliminary animal therapeutic dosing to increase survival in animal models of infection with West Nile virus... - 1H, 13C and 15N resonance assignments for domain III of the West Nile virus envelope proteinDavid E Volk
J Biomol NMR 29:445-6. 2004 - West Nile encephalitisTom Solomon
Department of Neurological Science, University of Liverpool, Liverpool L9 7LJ, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia
BMJ 326:865-9. 2003