Research Topics
| Carrie E BeardenSummaryAffiliation: University of California Country: USA Publications
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Publications
Neurocognitive and neuroimaging predictors of clinical outcome in bipolar disorderCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA 90095, USA
Curr Psychiatry Rep 12:499-504. 2010..A better understanding of the relationship between neurocognitive and neuroimaging assays and functional outcome has the potential to improve current treatment options and provide targets for new treatment strategies in bipolar disorder...- Greater cortical gray matter density in lithium-treated patients with bipolar disorderCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
Biol Psychiatry 62:7-16. 2007..Previous neuroimaging findings have been inconsistent; however, new methods for three-dimensional (3-D) computational image analysis may better characterize neuroanatomic changes than standard volumetric measures... 
Sources of declarative memory impairment in bipolar disorder: mnemonic processes and clinical featuresCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 Building Medical Plaza, Suite 2265, Los Angeles, CA 90095, USA
J Psychiatr Res 40:47-58. 2006..This study seeks to: (i) better characterize the nature of declarative memory impairment in bipolar disorder, and (ii) determine the relationship between clinical variables and memory function in bipolar disorder...- Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorderCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA 90095, USA
Bipolar Disord 9:145-59. 2007..Systematic parsing of executive function processes is critical for the development of more specific models of neurobiological processes mediating disturbed cognition in youth with bipolar disorder (BPD)... - Cortical mapping of genotype-phenotype relationships in schizophreniaCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095, USA
Hum Brain Mapp 28:519-32. 2007.... - Thought disorder and communication deviance as predictors of outcome in youth at clinical high risk for psychosisCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA
J Am Acad Child Adolesc Psychiatry 50:669-80. 2011..Here we examined the contribution of thought and communication disturbance to the prediction of outcome in adolescents identified as putatively prodromal for psychosis... - Mapping corpus callosum morphology in twin pairs discordant for bipolar disorderCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA
Cereb Cortex 21:2415-24. 2011..However, findings of callosal thinning appear to be disease related, rather than reflecting genetic vulnerability to bipolar illness... - Three-dimensional mapping of hippocampal anatomy in unmedicated and lithium-treated patients with bipolar disorderCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
Neuropsychopharmacology 33:1229-38. 2008..Moreover, increased hippocampal volume in lithium-treated bipolar patients may reflect postulated neurotrophic effects of this agent, a possibility warranting further study in longitudinal investigations... - Patterns of memory impairment in bipolar disorder and unipolar major depressionCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 90095, USA
Psychiatry Res 142:139-50. 2006..These impairments do not appear to be secondary to clinical state, but rather suggest a similar underlying pathophysiology involving medial temporal dysfunction... - Endophenotypes for psychiatric disorders: ready for primetime?Carrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90095, USA
Trends Genet 22:306-13. 2006..Gene expression studies and non-human primate models are recent developments in which an endophenotype approach might prove particularly valuable... - The impact of neurocognitive impairment on occupational recovery of clinically stable patients with bipolar disorder: a prospective studyCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Bipolar Disord 13:323-33. 2011..The reasons for this are not well understood. We evaluated the relationship between neurocognition and occupational function in bipolar disorder patients, following symptomatic recovery... - Effects of COMT genotype on behavioral symptomatology in the 22q11.2 Deletion SyndromeCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
Child Neuropsychol 11:109-17. 2005.... - Three-dimensional mapping of hippocampal anatomy in adolescents with bipolar disorderCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, UCLA, 300 Building Medical Plaza, Suite 2265, Los Angeles, CA 90095, USA
J Am Acad Child Adolesc Psychiatry 47:515-25. 2008..Using the same three-dimensional mapping methods, we sought to investigate whether a similar pattern exists in adolescents with bipolar disorder... - Neural phenotypes of common and rare genetic variantsCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, United States
Biol Psychol 79:43-57. 2008..Finally, we discuss the contribution of behavioral neurogenetics research to our understanding of the genetic basis of neuropsychiatric disorders in the broader population... 
Methodological issues in molecular genetic studies of mental disordersCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, CA 90095, USA
Annu Rev Clin Psychol 5:49-69. 2009..Here we discuss the methodologies employed for genetic investigation of mental disorders, including phenotyping strategies, approaches to genetic mapping, and use of animal models of psychopathology...- Regional brain abnormalities in 22q11.2 deletion syndrome: association with cognitive abilities and behavioral symptomsCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA 90095, USA
Neurocase 10:198-206. 2004..Although preliminary,these findings suggest a possible underlying pathophysiology of the cognitive deficits seen in this syndrome,and provide insight into complex gene-brain-behavior relationships... - Alterations in midline cortical thickness and gyrification patterns mapped in children with 22q11.2 deletionsCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90024, USA
Cereb Cortex 19:115-26. 2009.... - Why genetic investigation of psychiatric disorders is so difficultCarrie E Bearden
Departments of Psychology, University of California, Los Angeles, 300 Medical Plaza, Room 2265, Los Angeles, California 90095, USA
Curr Opin Genet Dev 14:280-6. 2004..At the same time, movement toward large-scale, collaborative efforts is increasing the effectiveness of traditional genetic mapping approaches... - Effects of a functional COMT polymorphism on prefrontal cognitive function in patients with 22q11.2 deletion syndromeCarrie E Bearden
Children s Hospital of Philadelphia, Department of Child Development, USA
Am J Psychiatry 161:1700-2. 2004..The goal of the present study was to examine COMT genotype as a predictor of prefrontal cognitive function in patients with 22q11.2 deletion syndrome... - Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophreniaKatherine H Karlsgodt
Department of Psychology, University of California, Los Angeles, California 90095 1563, USA
Biol Psychiatry 63:512-8. 2008.... - The course of neurocognition and social functioning in individuals at ultra high risk for psychosisTara A Niendam
Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
Schizophr Bull 33:772-81. 2007..This study evaluates longitudinal neuropsychological performance and its association with clinical symptomatology and psychosocial outcome in individuals identified as ultra high risk (UHR) for psychosis... - Neurocognitive performance and functional disability in the psychosis prodromeTara A Niendam
Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
Schizophr Res 84:100-11. 2006..This study evaluates the pattern of neuropsychological deficits and their association with clinical symptomatology and social functioning in individuals identified as ultra-high-risk (UHR) for psychosis... - Family problem solving interactions and 6-month symptomatic and functional outcomes in youth at ultra-high risk for psychosis and with recent onset psychotic symptoms: a longitudinal studyMary P O'Brien
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, United States
Schizophr Res 107:198-205. 2009.... - Elucidating a magnetic resonance imaging-based neuroanatomic biomarker for psychosis: classification analysis using probabilistic brain atlas and machine learning algorithmsDaqiang Sun
Department of Psychology, University of California at Los Angeles, 90095, USA
Biol Psychiatry 66:1055-60. 2009..Recently, efforts have been made to discriminate psychotic patients from healthy individuals using machine-learning-based pattern classification methods on MRI data... - Language network dysfunction as a predictor of outcome in youth at clinical high risk for psychosisFred W Sabb
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Box 956968, Rm 2265, 300 Medical Plaza, Los Angeles, CA 90095 6968, USA
Schizophr Res 116:173-83. 2010..Yet, no study to date has investigated underlying neural networks associated with discourse processing in adolescents at clinical high risk (CHR) for developing psychosis(1)... - Ecological assessment of executive dysfunction in the psychosis prodrome: a pilot studyTara A Niendam
Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, United States
Schizophr Res 93:350-4. 2007..The BRIEF appears to capture unique aspects of executive dysfunction, possibly associated with illness progression and functioning in the psychosis prodrome... - Mapping cortical thickness in children with 22q11.2 deletionsCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
Cereb Cortex 17:1889-98. 2007..These brain maps reveal how haploinsufficiency for such genes can affect cortical development and suggest a possible underlying pathophysiology of the neurobehavioral phenotype... - Symptomatic and functional correlates of regional brain physiology during working memory processing in patients with recent onset schizophreniaJacqueline H Sanz
Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095, United States
Psychiatry Res 173:177-82. 2009.... - White matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosisKatherine H Karlsgodt
Department of Psychology, University of California, Los Angeles UCLA, California 90095 1563, USA
Biol Psychiatry 66:562-9. 2009.... - Social cognition in 22q11.2 microdeletion syndrome: relevance to psychosis?Maria Jalbrzikowski
Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, United States
Schizophr Res 142:99-107. 2012..Given that ToM was a robust predictor of positive symptoms in our sample, these findings suggest that social cognition may be a valuable intermediate trait for predicting the development of psychosis... - Processing speed and neurodevelopment in adolescent-onset psychosis: cognitive slowing predicts social functionPeter Bachman
Semel Institute of Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA 90095 1759, USA
J Abnorm Child Psychol 40:645-54. 2012..This pattern is consistent with the view that adolescent brain developmental processes, such as myelination, may be disrupted in these patients... - Gender differences in symptoms, functioning and social support in patients at ultra-high risk for developing a psychotic disorderRachael K Willhite
University of California, Los Angeles, Department of Psychology, Los Angeles, CA 90095, United States
Schizophr Res 104:237-45. 2008..Follow-up studies should examine the relationship between symptoms, functioning and social support in this population... - A relationship between neurocognitive impairment and functional impairment in bipolar disorder: a pilot studyLori L Altshuler
Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Medical Center, Los Angeles, CA, USA
Psychiatry Res 157:289-93. 2008..Poor verbal memory and executive function were associated with functional impairment, suggesting that functional disability may be restricted to a subgroup of cognitively impaired bipolar patients... - Integrity of emotional and motivational states during the prodromal, first-episode, and chronic phases of schizophreniaCindy M Yee
Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
J Abnorm Psychol 119:71-82. 2010.... - Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophreniaKatherine H Karlsgodt
Department of Psychology, UCLA, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
Schizophr Res 108:143-50. 2009.... - Genetic architecture of declarative memory: implications for complex illnessesCarrie E Bearden
Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA
Neuroscientist 18:516-32. 2012..And finally we review evidence from both complex and single-gene disorders, which provide insight into the molecular mechanisms underlying the genetic basis of human memory function... - Remember and know judgments during recognition in chronic schizophreniaTheo G M van Erp
Department of Psychology, UCLA, Los Angeles, CA 90095, USA
Schizophr Res 100:181-90. 2008..Taken together, these findings are consistent with a deficit in recollection and increased reliance on familiarity in making recognition memory judgments in chronic schizophrenia... - Predicting the longitudinal effects of the family environment on prodromal symptoms and functioning in patients at-risk for psychosisDanielle A Schlosser
University of California at Los Angeles, 300 Medical Plaza, Box 666824, Los Angeles, CA 90095, United States
Schizophr Res 118:69-75. 2010..These results suggest that the family environment should be a specific target of treatment for individuals at risk for psychosis... - Markers of basal ganglia dysfunction and conversion to psychosis: neurocognitive deficits and dyskinesias in the prodromal periodVijay A Mittal
Department of Psychology, University of California Los Angeles, Los Angeles, California, USA
Biol Psychiatry 68:93-9. 2010.... - Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: a preliminary studyDylan G Gee
University of California, Los Angeles, Department of Psychology, Los Angeles, CA 90095 1563, USA
Schizophr Res 134:1-9. 2012..Longitudinal data are needed to confirm aberrant developmental trajectories intra-individually and to examine whether these abnormalities are predictive of conversion to psychosis, and of later deficits in socioemotional functioning... - Early and late neurodevelopmental influences in the prodrome to schizophrenia: contributions of genes, environment, and their interactionsTyrone D Cannon
Department of Psychology, University of California, Los Angeles, 90095, USA
Schizophr Bull 29:653-69. 2003.... - A multilevel analysis of cognitive dysfunction and psychopathology associated with chromosome 22q11.2 deletion syndrome in childrenTony J Simon
University of California, Davis, Sacramento 95817, USA
Dev Psychopathol 17:753-84. 2005..Beyond that, we introduce the idea that variation in other genes may further explain the phenotypic variation in cognitive function and possibly the anomalies in brain development... - Psychoeducational multi-family group treatment with adolescents at high risk for developing psychosisMary P O'Brien
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
Early Interv Psychiatry 1:325-32. 2007..In this study, we investigate the feasibility and acceptability of a 9-month psychoeducational multi-family group (PMFG) intervention for adolescents who are at ultra-high-risk (UHR) for developing psychosis... - Alterations in white matter microstructure in neurofibromatosis-1Katherine H Karlsgodt
Semel Institute for Neuroscience and Behavior, University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 7:e47854. 2012..Further, this indicates that axial and radial diffusivity can uniquely contribute as markers of NF1-associated brain pathology in conjunction with the typically investigated measures... - Social cognition in schizophrenia, Part 1: performance across phase of illnessMichael F Green
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095 6968, USA
Schizophr Bull 38:854-64. 2012..An accompanying article prospectively examines the longitudinal stability of social cognition and prediction of functional outcome in the first-episode sample... - Obsessive compulsive symptoms in the psychosis prodrome: correlates of clinical and functional outcomeTara A Niendam
Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
Schizophr Res 108:170-5. 2009..However, the prevalence of obsessive compulsive symptomatology (OCS) and its relationship to outcome has not been evaluated in adolescents at ultra high-risk for psychosis (UHR)... - Identification and treatment of a pineal region tumor in an adolescent with prodromal psychotic symptomsVijay A Mittal
Department of Psychology, University of California Los Angeles, USA
Am J Psychiatry 167:1033-7. 2010..Etiological pathways that may have played a role in symptom development are of particular interest, as understanding these mechanisms may shed light on the pathophysiology of psychotic disorders more generally... - The psychosis prodrome in adolescent patients viewed through the lens of DSM-IVStephanie E Meyer
Division of Child and Adolescent Psychiatry, Neuropsychiatric Institute and Hospital, University of California Los Angeles, CA 90024, USA
J Child Adolesc Psychopharmacol 15:434-51. 2005..However, the array of symptomatology in these patients is broad and has not yet been systematically characterized using established diagnostic and assessment tools... - Positive family environment predicts improvement in symptoms and social functioning among adolescents at imminent risk for onset of psychosisMary P O'Brien
Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA
Schizophr Res 81:269-75. 2006.... - Parent attitudes and parent adolescent interaction in families of youth at risk for psychosis and with recent-onset psychotic symptomsMary P O'Brien
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, University of California, Los Angeles, CA, USA
Early Interv Psychiatry 2:268-76. 2008..This study investigated the behavioural correlates of caregiver attitudes among parents of youth at risk for psychosis and with recent-onset psychotic symptoms... - Prefrontal and paralimbic metabolic dysregulation related to sustained attention in euthymic older adults with bipolar disorderJohn O Brooks
Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, Los Angeles, CA 90024, USA
Bipolar Disord 12:866-74. 2010..In the present study, we evaluated relationships between cognitive performance deficits and resting cerebral metabolism in euthymic older adults with bipolar disorder... - The prodromal questionnaire (PQ): preliminary validation of a self-report screening measure for prodromal and psychotic syndromesRachel L Loewy
Department of Psychology, University of California, Los Angeles, 1285 Franz Hall Box 951563, Los Angeles, CA 90095 1563, USA
Schizophr Res 79:117-25. 2005..The PQ shows good preliminary validity in detecting individuals with an interview-diagnosed prodromal or psychotic syndrome, but it is less sensitive to the threshold between prodromal and full-blown psychosis... - Obstetric complications and risk for conversion to psychosis among individuals at high clinical riskVijay A Mittal
Department of Psychology, University of California Los Angeles, Los Angeles, California 90095 1563, USA
Early Interv Psychiatry 3:226-30. 2009..Despite substantial evidence implicating the incidence of obstetric complications (OCs) as a risk factor for schizophrenia, little is known about the relationship between OCs and risk for conversion among high-risk individuals... - Genetic influence on the working memory circuitry: behavior, structure, function and extensions to illnessKatherine H Karlsgodt
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA
Behav Brain Res 225:610-22. 2011..This has implications for our understanding of the transmission of working memory deficits in both healthy and disordered populations... - A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblingsTara A Niendam
Department of Psychology, University of California-Los Angeles, Los Angeles, CA 90095, USA
Am J Psychiatry 160:2060-2. 2003..However, the probands exhibited more severe deficits in perceptual-motor speed and speeded processes of working memory than their unaffected siblings... - Recovery from an at-risk state: clinical and functional outcomes of putatively prodromal youth who do not develop psychosisDanielle A Schlosser
Department of Psychiatry, University of California, 401 Parnassus Avenue, Box 0984, San Francisco, CA 94143, USA
Schizophr Bull 38:1225-33. 2012..However, most individuals identified as CHR do not convert to psychosis, and it is unknown whether these nonconverting individuals actually recover from an at-risk state... - Neurofibromin regulates corticostriatal inhibitory networks during working memory performanceCarrie Shilyansky
Department of Neurobiology, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 107:13141-6. 2010..Collectively, these integrative mouse and human studies reveal molecular and cellular mechanisms contributing to working memory deficits in NF1... - The prodromal questionnaire (PQ): preliminary validation of a self-report screening measure for prodromal and psychotic syndromesRachel L Loewy
Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
Schizophr Res 77:141-9. 2005..The PQ shows good preliminary validity in detecting individuals with an interview-diagnosed prodromal or psychotic syndrome, but it is less sensitive to the threshold between prodromal and full-blown psychosis... - Three-dimensional mapping of hippocampal and amygdalar structure in euthymic adults with bipolar disorder not treated with lithiumLara C Foland-Ross
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
Psychiatry Res 211:195-201. 2013..Future studies, nevertheless, that further elucidate the impact of age, course of illness, and medication on amygdala structure in bipolar disorder are warranted... - Trait impulsivity as an endophenotype for bipolar I disorderLauren E Lombardo
Department of Psychology, Temple University, Philadelphia, PA, USA
Bipolar Disord 14:565-70. 2012..Familial risk for bipolar disorder is known to affect inhibitory control but its impact on the attentional and planning dimensions of impulsivity is still unclear... - Converging levels of analysis on a genomic hotspot for psychosis: insights from 22q11.2 deletion syndromeMatthew J Schreiner
Interdepartmental Neuroscience Program, University of California, Los Angeles, USA
Neuropharmacology 68:157-73. 2013..This article is part of the Special Issue entitled 'Neurodevelopmental Disorders'... - Deficits in mental state attributions in individuals with 22q11.2 deletion syndrome (velo-cardio-facial syndrome)Jennifer S Ho
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA
Autism Res 5:407-18. 2012..A better understanding of the social deficits in VCFS is essential for the development of targeted behavioral interventions... - The neurocognitive signature of psychotic bipolar disorderDavid C Glahn
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
Biol Psychiatry 62:910-6. 2007..We sought to ascertain the profile of cognitive impairment in patients with bipolar disorder and to determine whether a distinct profile of cognitive deficits characterizes bipolar patients with a history of psychosis... - Visuospatial and numerical cognitive deficits in children with chromosome 22q11.2 deletion syndromeTony J Simon
University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
Cortex 41:145-55. 2005..Instead, our findings are supportive of the hypothesis that visuospatial and numerical deficits in children with the chromosome 22q11.2 deletion are due, at least in part, to posterior parietal dysfunction... - Attention deficits in bipolar disorder: a comparison based on the Continuous Performance TestPablo Najt
South Texas Veterans Health Care System, Audie L. Murphy Division, San Antonio, TX, USA
Neurosci Lett 379:122-6. 2005..Our findings suggest that attentional dysfunction may be a trait deficit associated with bipolar illness. However, within-subjects longitudinal studies examining fluctuations in performance over time are needed... - Preliminary findings for two new measures of social and role functioning in the prodromal phase of schizophreniaBarbara A Cornblatt
Recognition and Prevention Program, Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
Schizophr Bull 33:688-702. 2007.... - Dissociable mechanisms for memory impairment in bipolar disorder and schizophreniaDavid C Glahn
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
Psychol Med 36:1085-95. 2006..Clarifying the nature and degree of overlap in memory deficits between the two illnesses could help to distinguish brain systems disrupted in these illnesses, and indicate cognitive remediation strategies to improve patient outcomes... - Declarative memory impairment in pediatric bipolar disorderDavid C Glahn
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Bipolar Disord 7:546-54. 2005..However, similar impairments in juvenile-onset bipolar disorder have not been yet documented. Here, we assessed declarative memory in a large sample of clinically well-characterized children with bipolar disorder... - Differential working memory impairment in bipolar disorder and schizophrenia: effects of lifetime history of psychosisDavid C Glahn
Division of Schizophrenia and Related Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
Bipolar Disord 8:117-23. 2006..Although working memory dysfunction has been proposed to be central to the pathophysiology of schizophrenia, it has received less attention in studies of bipolar disorder... - The feasibility of neuropsychological endophenotypes in the search for genes associated with bipolar affective disorderDavid C Glahn
Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78229 3900, USA
Bipolar Disord 6:171-82. 2004..We reviewed the literature to determine if neuropsychological measures could be used as effective endophenotypes to aid molecular genetic studies searching for genes predisposing to BPD... - Williams syndrome cognitive profile also characterizes Velocardiofacial/DiGeorge syndromeCarrie E Bearden
Am J Med Genet 114:689-92. 2002 - Reduced educational attainment in bipolar disorderDavid C Glahn
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 78229, USA
J Affect Disord 92:309-12. 2006..To document educational attainment in relation to IQ in patients with bipolar disorder, in order to establish guidelines for matching patients with appropriate comparison subjects... - Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophreniaDavid C Glahn
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
Hum Brain Mapp 25:60-9. 2005....
Research Grants
- Identification of endophenotypes for bipolar disorderCarrie Bearden; Fiscal Year: 2007....
- Neurodevelopment and Psychosis in the 22q11.2 Deletion SyndromeCarrie E Bearden; Fiscal Year: 2010..These findings will also shed light on genetic influences on brain development and psychosis in the broader population. ..
- Neurodevelopment and Psychosis in the 22q11.2 Deletion SyndromeCarrie E Bearden; Fiscal Year: 2011..These findings will also shed light on genetic influences on brain development and psychosis in the broader population. ..