Carrie E Bearden

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Patterns of memory impairment in bipolar disorder and unipolar major depression
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 90095, USA
    Psychiatry Res 142:139-50. 2006
  2. ncbi request reprint Endophenotypes for psychiatric disorders: ready for primetime?
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90095, USA
    Trends Genet 22:306-13. 2006
  3. pmc Greater cortical gray matter density in lithium-treated patients with bipolar disorder
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
    Biol Psychiatry 62:7-16. 2007
  4. pmc Cortical mapping of genotype-phenotype relationships in schizophrenia
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095, USA
    Hum Brain Mapp 28:519-32. 2007
  5. pmc Three-dimensional mapping of hippocampal anatomy in adolescents with bipolar disorder
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, UCLA, 300 Building Medical Plaza, Suite 2265, Los Angeles, CA 90095, USA
    J Am Acad Child Adolesc Psychiatry 47:515-25. 2008
  6. ncbi request reprint Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Bipolar Disord 9:145-59. 2007
  7. pmc Thought disorder and communication deviance as predictors of outcome in youth at clinical high risk for psychosis
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Am Acad Child Adolesc Psychiatry 50:669-80. 2011
  8. ncbi request reprint Three-dimensional mapping of hippocampal anatomy in unmedicated and lithium-treated patients with bipolar disorder
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
    Neuropsychopharmacology 33:1229-38. 2008
  9. pmc Neural phenotypes of common and rare genetic variants
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, United States
    Biol Psychol 79:43-57. 2008
  10. pmc Alterations in midline cortical thickness and gyrification patterns mapped in children with 22q11.2 deletions
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90024, USA
    Cereb Cortex 19:115-26. 2009

Detail Information

Publications78

  1. ncbi request reprint Patterns of memory impairment in bipolar disorder and unipolar major depression
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 90095, USA
    Psychiatry Res 142:139-50. 2006
    ..These impairments do not appear to be secondary to clinical state, but rather suggest a similar underlying pathophysiology involving medial temporal dysfunction...
  2. ncbi request reprint Endophenotypes for psychiatric disorders: ready for primetime?
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90095, USA
    Trends Genet 22:306-13. 2006
    ..Gene expression studies and non-human primate models are recent developments in which an endophenotype approach might prove particularly valuable...
  3. pmc Greater cortical gray matter density in lithium-treated patients with bipolar disorder
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
    Biol Psychiatry 62:7-16. 2007
    ..Previous neuroimaging findings have been inconsistent; however, new methods for three-dimensional (3-D) computational image analysis may better characterize neuroanatomic changes than standard volumetric measures...
  4. pmc Cortical mapping of genotype-phenotype relationships in schizophrenia
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095, USA
    Hum Brain Mapp 28:519-32. 2007
    ....
  5. pmc Three-dimensional mapping of hippocampal anatomy in adolescents with bipolar disorder
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, UCLA, 300 Building Medical Plaza, Suite 2265, Los Angeles, CA 90095, USA
    J Am Acad Child Adolesc Psychiatry 47:515-25. 2008
    ..Using the same three-dimensional mapping methods, we sought to investigate whether a similar pattern exists in adolescents with bipolar disorder...
  6. ncbi request reprint Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Bipolar Disord 9:145-59. 2007
    ..Systematic parsing of executive function processes is critical for the development of more specific models of neurobiological processes mediating disturbed cognition in youth with bipolar disorder (BPD)...
  7. pmc Thought disorder and communication deviance as predictors of outcome in youth at clinical high risk for psychosis
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Am Acad Child Adolesc Psychiatry 50:669-80. 2011
    ..Here we examined the contribution of thought and communication disturbance to the prediction of outcome in adolescents identified as putatively prodromal for psychosis...
  8. ncbi request reprint Three-dimensional mapping of hippocampal anatomy in unmedicated and lithium-treated patients with bipolar disorder
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
    Neuropsychopharmacology 33:1229-38. 2008
    ..Moreover, increased hippocampal volume in lithium-treated bipolar patients may reflect postulated neurotrophic effects of this agent, a possibility warranting further study in longitudinal investigations...
  9. pmc Neural phenotypes of common and rare genetic variants
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, United States
    Biol Psychol 79:43-57. 2008
    ..Finally, we discuss the contribution of behavioral neurogenetics research to our understanding of the genetic basis of neuropsychiatric disorders in the broader population...
  10. pmc Alterations in midline cortical thickness and gyrification patterns mapped in children with 22q11.2 deletions
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90024, USA
    Cereb Cortex 19:115-26. 2009
    ....
  11. pmc Mapping corpus callosum morphology in twin pairs discordant for bipolar disorder
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA
    Cereb Cortex 21:2415-24. 2011
    ..However, findings of callosal thinning appear to be disease related, rather than reflecting genetic vulnerability to bipolar illness...
  12. doi request reprint Methodological issues in molecular genetic studies of mental disorders
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, CA 90095, USA
    Annu Rev Clin Psychol 5:49-69. 2009
    ..Here we discuss the methodologies employed for genetic investigation of mental disorders, including phenotyping strategies, approaches to genetic mapping, and use of animal models of psychopathology...
  13. pmc Neurocognitive and neuroimaging predictors of clinical outcome in bipolar disorder
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA 90095, USA
    Curr Psychiatry Rep 12:499-504. 2010
    ..A better understanding of the relationship between neurocognitive and neuroimaging assays and functional outcome has the potential to improve current treatment options and provide targets for new treatment strategies in bipolar disorder...
  14. pmc The impact of neurocognitive impairment on occupational recovery of clinically stable patients with bipolar disorder: a prospective study
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Bipolar Disord 13:323-33. 2011
    ..The reasons for this are not well understood. We evaluated the relationship between neurocognition and occupational function in bipolar disorder patients, following symptomatic recovery...
  15. pmc Effects of COMT genotype on behavioral symptomatology in the 22q11.2 Deletion Syndrome
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Child Neuropsychol 11:109-17. 2005
    ....
  16. ncbi request reprint Regional brain abnormalities in 22q11.2 deletion syndrome: association with cognitive abilities and behavioral symptoms
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA 90095, USA
    Neurocase 10:198-206. 2004
    ..Although preliminary,these findings suggest a possible underlying pathophysiology of the cognitive deficits seen in this syndrome,and provide insight into complex gene-brain-behavior relationships...
  17. ncbi request reprint Effects of a functional COMT polymorphism on prefrontal cognitive function in patients with 22q11.2 deletion syndrome
    Carrie E Bearden
    Children s Hospital of Philadelphia, Department of Child Development, USA
    Am J Psychiatry 161:1700-2. 2004
    ..The goal of the present study was to examine COMT genotype as a predictor of prefrontal cognitive function in patients with 22q11.2 deletion syndrome...
  18. ncbi request reprint Sources of declarative memory impairment in bipolar disorder: mnemonic processes and clinical features
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 Building Medical Plaza, Suite 2265, Los Angeles, CA 90095, USA
    J Psychiatr Res 40:47-58. 2006
    ..This study seeks to: (i) better characterize the nature of declarative memory impairment in bipolar disorder, and (ii) determine the relationship between clinical variables and memory function in bipolar disorder...
  19. ncbi request reprint Why genetic investigation of psychiatric disorders is so difficult
    Carrie E Bearden
    Departments of Psychology, University of California, Los Angeles, 300 Medical Plaza, Room 2265, Los Angeles, California 90095, USA
    Curr Opin Genet Dev 14:280-6. 2004
    ..At the same time, movement toward large-scale, collaborative efforts is increasing the effectiveness of traditional genetic mapping approaches...
  20. ncbi request reprint Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophrenia
    Katherine H Karlsgodt
    Department of Psychology, University of California, Los Angeles, California 90095 1563, USA
    Biol Psychiatry 63:512-8. 2008
    ....
  21. pmc The course of neurocognition and social functioning in individuals at ultra high risk for psychosis
    Tara A Niendam
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    Schizophr Bull 33:772-81. 2007
    ..This study evaluates longitudinal neuropsychological performance and its association with clinical symptomatology and psychosocial outcome in individuals identified as ultra high risk (UHR) for psychosis...
  22. ncbi request reprint Neurocognitive performance and functional disability in the psychosis prodrome
    Tara A Niendam
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    Schizophr Res 84:100-11. 2006
    ..This study evaluates the pattern of neuropsychological deficits and their association with clinical symptomatology and social functioning in individuals identified as ultra-high-risk (UHR) for psychosis...
  23. pmc Family problem solving interactions and 6-month symptomatic and functional outcomes in youth at ultra-high risk for psychosis and with recent onset psychotic symptoms: a longitudinal study
    Mary P O'Brien
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, United States
    Schizophr Res 107:198-205. 2009
    ....
  24. pmc Elucidating a magnetic resonance imaging-based neuroanatomic biomarker for psychosis: classification analysis using probabilistic brain atlas and machine learning algorithms
    Daqiang Sun
    Department of Psychology, University of California at Los Angeles, 90095, USA
    Biol Psychiatry 66:1055-60. 2009
    ..Recently, efforts have been made to discriminate psychotic patients from healthy individuals using machine-learning-based pattern classification methods on MRI data...
  25. pmc Ecological assessment of executive dysfunction in the psychosis prodrome: a pilot study
    Tara A Niendam
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, United States
    Schizophr Res 93:350-4. 2007
    ..The BRIEF appears to capture unique aspects of executive dysfunction, possibly associated with illness progression and functioning in the psychosis prodrome...
  26. pmc Language network dysfunction as a predictor of outcome in youth at clinical high risk for psychosis
    Fred W Sabb
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Box 956968, Rm 2265, 300 Medical Plaza, Los Angeles, CA 90095 6968, USA
    Schizophr Res 116:173-83. 2010
    ..Yet, no study to date has investigated underlying neural networks associated with discourse processing in adolescents at clinical high risk (CHR) for developing psychosis(1)...
  27. pmc White matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosis
    Katherine H Karlsgodt
    Department of Psychology, University of California, Los Angeles UCLA, California 90095 1563, USA
    Biol Psychiatry 66:562-9. 2009
    ....
  28. pmc Symptomatic and functional correlates of regional brain physiology during working memory processing in patients with recent onset schizophrenia
    Jacqueline H Sanz
    Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095, United States
    Psychiatry Res 173:177-82. 2009
    ....
  29. pmc Mapping cortical thickness in children with 22q11.2 deletions
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
    Cereb Cortex 17:1889-98. 2007
    ..These brain maps reveal how haploinsufficiency for such genes can affect cortical development and suggest a possible underlying pathophysiology of the neurobehavioral phenotype...
  30. pmc Social cognition in 22q11.2 microdeletion syndrome: relevance to psychosis?
    Maria Jalbrzikowski
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, United States
    Schizophr Res 142:99-107. 2012
    ..Given that ToM was a robust predictor of positive symptoms in our sample, these findings suggest that social cognition may be a valuable intermediate trait for predicting the development of psychosis...
  31. pmc Processing speed and neurodevelopment in adolescent-onset psychosis: cognitive slowing predicts social function
    Peter Bachman
    Semel Institute of Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA 90095 1759, USA
    J Abnorm Child Psychol 40:645-54. 2012
    ..This pattern is consistent with the view that adolescent brain developmental processes, such as myelination, may be disrupted in these patients...
  32. pmc Integrity of emotional and motivational states during the prodromal, first-episode, and chronic phases of schizophrenia
    Cindy M Yee
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    J Abnorm Psychol 119:71-82. 2010
    ....
  33. pmc Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophrenia
    Katherine H Karlsgodt
    Department of Psychology, UCLA, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    Schizophr Res 108:143-50. 2009
    ....
  34. pmc Gender differences in symptoms, functioning and social support in patients at ultra-high risk for developing a psychotic disorder
    Rachael K Willhite
    University of California, Los Angeles, Department of Psychology, Los Angeles, CA 90095, United States
    Schizophr Res 104:237-45. 2008
    ..Follow-up studies should examine the relationship between symptoms, functioning and social support in this population...
  35. ncbi request reprint A relationship between neurocognitive impairment and functional impairment in bipolar disorder: a pilot study
    Lori L Altshuler
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Medical Center, Los Angeles, CA, USA
    Psychiatry Res 157:289-93. 2008
    ..Poor verbal memory and executive function were associated with functional impairment, suggesting that functional disability may be restricted to a subgroup of cognitively impaired bipolar patients...
  36. ncbi request reprint Reciprocal social behavior in youths with psychotic illness and those at clinical high risk
    Maria Jalbrzikowski
    University of California, Los Angeles
    Dev Psychopathol 25:1187-97. 2013
    ..Further, the SRS predicts subsequent real-world social functioning in CHR youth, suggesting that this measure may be useful for identifying targets of treatment in psychosocial interventions. ..
  37. pmc Three-dimensional mapping of hippocampal and amygdalar structure in euthymic adults with bipolar disorder not treated with lithium
    Lara C Foland-Ross
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
    Psychiatry Res 211:195-201. 2013
    ..Future studies, nevertheless, that further elucidate the impact of age, course of illness, and medication on amygdala structure in bipolar disorder are warranted...
  38. pmc Genetic architecture of declarative memory: implications for complex illnesses
    Carrie E Bearden
    Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA
    Neuroscientist 18:516-32. 2012
    ..And finally we review evidence from both complex and single-gene disorders, which provide insight into the molecular mechanisms underlying the genetic basis of human memory function...
  39. pmc Predicting the longitudinal effects of the family environment on prodromal symptoms and functioning in patients at-risk for psychosis
    Danielle A Schlosser
    University of California at Los Angeles, 300 Medical Plaza, Box 666824, Los Angeles, CA 90095, United States
    Schizophr Res 118:69-75. 2010
    ..These results suggest that the family environment should be a specific target of treatment for individuals at risk for psychosis...
  40. pmc Markers of basal ganglia dysfunction and conversion to psychosis: neurocognitive deficits and dyskinesias in the prodromal period
    Vijay A Mittal
    Department of Psychology, University of California Los Angeles, Los Angeles, California, USA
    Biol Psychiatry 68:93-9. 2010
    ....
  41. pmc Remember and know judgments during recognition in chronic schizophrenia
    Theo G M van Erp
    Department of Psychology, UCLA, Los Angeles, CA 90095, USA
    Schizophr Res 100:181-90. 2008
    ..Taken together, these findings are consistent with a deficit in recollection and increased reliance on familiarity in making recognition memory judgments in chronic schizophrenia...
  42. pmc Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: a preliminary study
    Dylan G Gee
    University of California, Los Angeles, Department of Psychology, Los Angeles, CA 90095 1563, USA
    Schizophr Res 134:1-9. 2012
    ..Longitudinal data are needed to confirm aberrant developmental trajectories intra-individually and to examine whether these abnormalities are predictive of conversion to psychosis, and of later deficits in socioemotional functioning...
  43. doi request reprint Psychoeducational multi-family group treatment with adolescents at high risk for developing psychosis
    Mary P O'Brien
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
    Early Interv Psychiatry 1:325-32. 2007
    ..In this study, we investigate the feasibility and acceptability of a 9-month psychoeducational multi-family group (PMFG) intervention for adolescents who are at ultra-high-risk (UHR) for developing psychosis...
  44. ncbi request reprint Early and late neurodevelopmental influences in the prodrome to schizophrenia: contributions of genes, environment, and their interactions
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles, 90095, USA
    Schizophr Bull 29:653-69. 2003
    ....
  45. pmc A multilevel analysis of cognitive dysfunction and psychopathology associated with chromosome 22q11.2 deletion syndrome in children
    Tony J Simon
    University of California, Davis, Sacramento 95817, USA
    Dev Psychopathol 17:753-84. 2005
    ..Beyond that, we introduce the idea that variation in other genes may further explain the phenotypic variation in cognitive function and possibly the anomalies in brain development...
  46. pmc Recovery from an at-risk state: clinical and functional outcomes of putatively prodromal youth who do not develop psychosis
    Danielle A Schlosser
    Department of Psychiatry, University of California, 401 Parnassus Avenue, Box 0984, San Francisco, CA 94143, USA
    Schizophr Bull 38:1225-33. 2012
    ..However, most individuals identified as CHR do not convert to psychosis, and it is unknown whether these nonconverting individuals actually recover from an at-risk state...
  47. pmc Alterations in white matter microstructure in neurofibromatosis-1
    Katherine H Karlsgodt
    Semel Institute for Neuroscience and Behavior, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e47854. 2012
    ..Further, this indicates that axial and radial diffusivity can uniquely contribute as markers of NF1-associated brain pathology in conjunction with the typically investigated measures...
  48. pmc Social cognition in schizophrenia, Part 1: performance across phase of illness
    Michael F Green
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095 6968, USA
    Schizophr Bull 38:854-64. 2012
    ..An accompanying article prospectively examines the longitudinal stability of social cognition and prediction of functional outcome in the first-episode sample...
  49. pmc Obsessive compulsive symptoms in the psychosis prodrome: correlates of clinical and functional outcome
    Tara A Niendam
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    Schizophr Res 108:170-5. 2009
    ..However, the prevalence of obsessive compulsive symptomatology (OCS) and its relationship to outcome has not been evaluated in adolescents at ultra high-risk for psychosis (UHR)...
  50. ncbi request reprint Identification and treatment of a pineal region tumor in an adolescent with prodromal psychotic symptoms
    Vijay A Mittal
    Department of Psychology, University of California Los Angeles, USA
    Am J Psychiatry 167:1033-7. 2010
    ..Etiological pathways that may have played a role in symptom development are of particular interest, as understanding these mechanisms may shed light on the pathophysiology of psychotic disorders more generally...
  51. ncbi request reprint The psychosis prodrome in adolescent patients viewed through the lens of DSM-IV
    Stephanie E Meyer
    Division of Child and Adolescent Psychiatry, Neuropsychiatric Institute and Hospital, University of California Los Angeles, CA 90024, USA
    J Child Adolesc Psychopharmacol 15:434-51. 2005
    ..However, the array of symptomatology in these patients is broad and has not yet been systematically characterized using established diagnostic and assessment tools...
  52. ncbi request reprint Positive family environment predicts improvement in symptoms and social functioning among adolescents at imminent risk for onset of psychosis
    Mary P O'Brien
    Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA
    Schizophr Res 81:269-75. 2006
    ....
  53. doi request reprint Parent attitudes and parent adolescent interaction in families of youth at risk for psychosis and with recent-onset psychotic symptoms
    Mary P O'Brien
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, University of California, Los Angeles, CA, USA
    Early Interv Psychiatry 2:268-76. 2008
    ..This study investigated the behavioural correlates of caregiver attitudes among parents of youth at risk for psychosis and with recent-onset psychotic symptoms...
  54. pmc Deficits in mental state attributions in individuals with 22q11.2 deletion syndrome (velo-cardio-facial syndrome)
    Jennifer S Ho
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA
    Autism Res 5:407-18. 2012
    ..A better understanding of the social deficits in VCFS is essential for the development of targeted behavioral interventions...
  55. ncbi request reprint The prodromal questionnaire (PQ): preliminary validation of a self-report screening measure for prodromal and psychotic syndromes
    Rachel L Loewy
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall Box 951563, Los Angeles, CA 90095 1563, USA
    Schizophr Res 79:117-25. 2005
    ..The PQ shows good preliminary validity in detecting individuals with an interview-diagnosed prodromal or psychotic syndrome, but it is less sensitive to the threshold between prodromal and full-blown psychosis...
  56. doi request reprint Prefrontal and paralimbic metabolic dysregulation related to sustained attention in euthymic older adults with bipolar disorder
    John O Brooks
    Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Bipolar Disord 12:866-74. 2010
    ..In the present study, we evaluated relationships between cognitive performance deficits and resting cerebral metabolism in euthymic older adults with bipolar disorder...
  57. pmc Multisystem component phenotypes of bipolar disorder for genetic investigations of extended pedigrees
    Scott C Fears
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles
    JAMA Psychiatry 71:375-87. 2014
    ..Together, these phenotypes provide a basis for identifying loci contributing to BP-I risk and for genetic dissection of the disorder. ..
  58. pmc Coping styles of individuals at clinical high risk for developing psychosis
    Maria Jalbrzikowski
    Department of Psychology, University of California, Los Angeles, California, USA
    Early Interv Psychiatry 8:68-76. 2014
    ..However, the contribution of coping strategies to outcome in youth at clinical high risk (CHR) for developing psychosis has not been investigated...
  59. pmc Converging levels of analysis on a genomic hotspot for psychosis: insights from 22q11.2 deletion syndrome
    Matthew J Schreiner
    Interdepartmental Neuroscience Program, University of California, Los Angeles, USA
    Neuropharmacology 68:157-73. 2013
    ..This article is part of the Special Issue entitled 'Neurodevelopmental Disorders'...
  60. pmc Obstetric complications and risk for conversion to psychosis among individuals at high clinical risk
    Vijay A Mittal
    Department of Psychology, University of California Los Angeles, Los Angeles, California 90095 1563, USA
    Early Interv Psychiatry 3:226-30. 2009
    ..Despite substantial evidence implicating the incidence of obstetric complications (OCs) as a risk factor for schizophrenia, little is known about the relationship between OCs and risk for conversion among high-risk individuals...
  61. pmc Genetic influence on the working memory circuitry: behavior, structure, function and extensions to illness
    Katherine H Karlsgodt
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA
    Behav Brain Res 225:610-22. 2011
    ..This has implications for our understanding of the transmission of working memory deficits in both healthy and disordered populations...
  62. ncbi request reprint A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings
    Tara A Niendam
    Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:2060-2. 2003
    ..This study evaluated childhood cognitive functioning in individuals who later developed schizophrenia and in their unaffected siblings...
  63. pmc Neurofibromin regulates corticostriatal inhibitory networks during working memory performance
    Carrie Shilyansky
    Department of Neurobiology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:13141-6. 2010
    ..Collectively, these integrative mouse and human studies reveal molecular and cellular mechanisms contributing to working memory deficits in NF1...
  64. ncbi request reprint The prodromal questionnaire (PQ): preliminary validation of a self-report screening measure for prodromal and psychotic syndromes
    Rachel L Loewy
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    Schizophr Res 77:141-9. 2005
    ..The PQ shows good preliminary validity in detecting individuals with an interview-diagnosed prodromal or psychotic syndrome, but it is less sensitive to the threshold between prodromal and full-blown psychosis...
  65. pmc Trait impulsivity as an endophenotype for bipolar I disorder
    Lauren E Lombardo
    Department of Psychology, Temple University, Philadelphia, PA, USA
    Bipolar Disord 14:565-70. 2012
    ..Familial risk for bipolar disorder is known to affect inhibitory control but its impact on the attentional and planning dimensions of impulsivity is still unclear...
  66. ncbi request reprint Declarative memory impairment in pediatric bipolar disorder
    David C Glahn
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Bipolar Disord 7:546-54. 2005
    ..However, similar impairments in juvenile-onset bipolar disorder have not been yet documented. Here, we assessed declarative memory in a large sample of clinically well-characterized children with bipolar disorder...
  67. ncbi request reprint The neurocognitive signature of psychotic bipolar disorder
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Biol Psychiatry 62:910-6. 2007
    ..We sought to ascertain the profile of cognitive impairment in patients with bipolar disorder and to determine whether a distinct profile of cognitive deficits characterizes bipolar patients with a history of psychosis...
  68. pmc Preliminary findings for two new measures of social and role functioning in the prodromal phase of schizophrenia
    Barbara A Cornblatt
    Recognition and Prevention Program, Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Schizophr Bull 33:688-702. 2007
    ....
  69. ncbi request reprint The feasibility of neuropsychological endophenotypes in the search for genes associated with bipolar affective disorder
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Bipolar Disord 6:171-82. 2004
    ..We reviewed the literature to determine if neuropsychological measures could be used as effective endophenotypes to aid molecular genetic studies searching for genes predisposing to BPD...
  70. ncbi request reprint Visuospatial and numerical cognitive deficits in children with chromosome 22q11.2 deletion syndrome
    Tony J Simon
    University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Cortex 41:145-55. 2005
    ..Instead, our findings are supportive of the hypothesis that visuospatial and numerical deficits in children with the chromosome 22q11.2 deletion are due, at least in part, to posterior parietal dysfunction...
  71. ncbi request reprint Dissociable mechanisms for memory impairment in bipolar disorder and schizophrenia
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Psychol Med 36:1085-95. 2006
    ..Clarifying the nature and degree of overlap in memory deficits between the two illnesses could help to distinguish brain systems disrupted in these illnesses, and indicate cognitive remediation strategies to improve patient outcomes...
  72. ncbi request reprint Attention deficits in bipolar disorder: a comparison based on the Continuous Performance Test
    Pablo Najt
    South Texas Veterans Health Care System, Audie L Murphy Division, San Antonio, TX, USA
    Neurosci Lett 379:122-6. 2005
    ..Our findings suggest that attentional dysfunction may be a trait deficit associated with bipolar illness. However, within-subjects longitudinal studies examining fluctuations in performance over time are needed...
  73. ncbi request reprint Differential working memory impairment in bipolar disorder and schizophrenia: effects of lifetime history of psychosis
    David C Glahn
    Division of Schizophrenia and Related Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Bipolar Disord 8:117-23. 2006
    ..Although working memory dysfunction has been proposed to be central to the pathophysiology of schizophrenia, it has received less attention in studies of bipolar disorder...
  74. ncbi request reprint Reduced educational attainment in bipolar disorder
    David C Glahn
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 78229, USA
    J Affect Disord 92:309-12. 2006
    ..To document educational attainment in relation to IQ in patients with bipolar disorder, in order to establish guidelines for matching patients with appropriate comparison subjects...
  75. ncbi request reprint Williams syndrome cognitive profile also characterizes Velocardiofacial/DiGeorge syndrome
    Carrie E Bearden
    Am J Med Genet 114:689-92. 2002
  76. ncbi request reprint Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Hum Brain Mapp 25:60-9. 2005
    ....

Research Grants4

  1. Identification of endophenotypes for bipolar disorder
    Carrie Bearden; Fiscal Year: 2007
    ....
  2. Identification of endophenotypes for bipolar disorder
    Carrie Bearden; Fiscal Year: 2008
    ....
  3. Neurodevelopment and Psychosis in the 22q11.2 Deletion Syndrome
    Carrie E Bearden; Fiscal Year: 2010
    ..These findings will also shed light on genetic influences on brain development and psychosis in the broader population. ..
  4. Neurodevelopment and Psychosis in the 22q11.2 Deletion Syndrome
    Carrie E Bearden; Fiscal Year: 2011
    ..These findings will also shed light on genetic influences on brain development and psychosis in the broader population. ..