STEPHEN BAYLOR

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Simulation of Ca2+ movements within the sarcomere of fast-twitch mouse fibers stimulated by action potentials
    Stephen M Baylor
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Gen Physiol 130:283-302. 2007
  2. pmc Effects of tetracaine on voltage-activated calcium sparks in frog intact skeletal muscle fibers
    Stephen Hollingworth
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Gen Physiol 127:291-307. 2006
  3. pmc Comparison of myoplasmic calcium movements during excitation-contraction coupling in frog twitch and mouse fast-twitch muscle fibers
    Stephen Hollingworth
    Department of Physiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Gen Physiol 141:567-83. 2013
  4. pmc Intracellular calcium movements during excitation-contraction coupling in mammalian slow-twitch and fast-twitch muscle fibers
    Stephen M Baylor
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Gen Physiol 139:261-72. 2012
  5. pmc Simulation of calcium sparks in cut skeletal muscle fibers of the frog
    W K Chandler
    Department of Cellular and Molecular Physiology, Yale Universtiy School of Medicine, New Haven, CT 06520, USA
    J Gen Physiol 121:311-24. 2003
  6. pmc Measurement and simulation of myoplasmic calcium transients in mouse slow-twitch muscle fibres
    Stephen Hollingworth
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6085, USA
    J Physiol 590:575-94. 2012
  7. pmc Calcium sparks in intact skeletal muscle fibers of the frog
    S Hollingworth
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6085, USA
    J Gen Physiol 118:653-78. 2001
  8. pmc Calcium indicators and calcium signalling in skeletal muscle fibres during excitation-contraction coupling
    Stephen M Baylor
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6085, USA
    Prog Biophys Mol Biol 105:162-79. 2011
  9. ncbi request reprint Calcium sparks in skeletal muscle fibers
    Stephen M Baylor
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, 19104 6085, USA
    Cell Calcium 37:513-30. 2005
  10. pmc Sarcoplasmic reticulum calcium release compared in slow-twitch and fast-twitch fibres of mouse muscle
    S M Baylor
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6085, USA
    J Physiol 551:125-38. 2003

Collaborators

  • Stephen Hollingworth
  • W K Chandler
  • S Hollingworth
  • Myungsa Kang
  • Michele M Kim
  • W Knox Chandler
  • Sanjay A Desai
  • Godfrey Lisk
  • J Peet

Detail Information

Publications13

  1. pmc Simulation of Ca2+ movements within the sarcomere of fast-twitch mouse fibers stimulated by action potentials
    Stephen M Baylor
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Gen Physiol 130:283-302. 2007
    ..Overall, the simulations indicate that this reaction-diffusion model, which was originally developed for Ca(2+) sparks in frog fibers, works well when adapted to mouse fast-twitch fibers stimulated by APs...
  2. pmc Effects of tetracaine on voltage-activated calcium sparks in frog intact skeletal muscle fibers
    Stephen Hollingworth
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Gen Physiol 127:291-307. 2006
    ..e., in the absence of tetracaine) are produced by two or more active RyR Ca(2+) channels. The question of how the activation of multiple RyRs is coordinated is discussed...
  3. pmc Comparison of myoplasmic calcium movements during excitation-contraction coupling in frog twitch and mouse fast-twitch muscle fibers
    Stephen Hollingworth
    Department of Physiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Gen Physiol 141:567-83. 2013
    ..We speculate that, in general, parajunctional RyRs permit increased myofilament activation in fibers whose triadic junctions are located at the z-line...
  4. pmc Intracellular calcium movements during excitation-contraction coupling in mammalian slow-twitch and fast-twitch muscle fibers
    Stephen M Baylor
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Gen Physiol 139:261-72. 2012
    ....
  5. pmc Simulation of calcium sparks in cut skeletal muscle fibers of the frog
    W K Chandler
    Department of Cellular and Molecular Physiology, Yale Universtiy School of Medicine, New Haven, CT 06520, USA
    J Gen Physiol 121:311-24. 2003
    ..These results indicate that the gating of RYRs, or their apparent single channel Ca2+ flux, is different in frog cut fibers--and, perhaps, in other disrupted preparations--than in intact fibers...
  6. pmc Measurement and simulation of myoplasmic calcium transients in mouse slow-twitch muscle fibres
    Stephen Hollingworth
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6085, USA
    J Physiol 590:575-94. 2012
    ..4 × 10(8) m(-1) s(-1) and 26 s(-1), respectively, were found to be consistent with the ΔF measurements...
  7. pmc Calcium sparks in intact skeletal muscle fibers of the frog
    S Hollingworth
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6085, USA
    J Gen Physiol 118:653-78. 2001
    ..Possible explanations for the increase in mass in cut fibers are a reduction in the Ca(2+) buffering power of myoplasm in cut fibers and an increase in the flux of Ca(2+) during release...
  8. pmc Calcium indicators and calcium signalling in skeletal muscle fibres during excitation-contraction coupling
    Stephen M Baylor
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6085, USA
    Prog Biophys Mol Biol 105:162-79. 2011
    ..The simulations are quantitatively consistent with the measurements and appear to provide a satisfactory picture of the underlying Ca(2+) movements...
  9. ncbi request reprint Calcium sparks in skeletal muscle fibers
    Stephen M Baylor
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, 19104 6085, USA
    Cell Calcium 37:513-30. 2005
    ..A major goal of future experiments is to estimate this number more precisely and, if it is two or more, to investigate the communication mechanism that allows multiple RYRs to be co-activated in a rapid but self-limited fashion...
  10. pmc Sarcoplasmic reticulum calcium release compared in slow-twitch and fast-twitch fibres of mouse muscle
    S M Baylor
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6085, USA
    J Physiol 551:125-38. 2003
    ..2-0.3; fast-twitch, 0.1-0.3). The results support the conclusion that individual SR Ca2+ release units function similarly in slow-twitch and fast-twitch mammalian fibres...
  11. pmc Comparison of simulated and measured calcium sparks in intact skeletal muscle fibers of the frog
    S M Baylor
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Gen Physiol 120:349-68. 2002
    ..Under the assumption that the single channel Ca(2+) current of a ryanodine receptor (RYR) is 0.5-2 pA, the results suggest that 1-5 active RYRs generate an average Ca(2+) spark in a frog intact muscle fiber...
  12. pmc Model of sarcomeric Ca2+ movements, including ATP Ca2+ binding and diffusion, during activation of frog skeletal muscle
    S M Baylor
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6085, USA
    J Gen Physiol 112:297-316. 1998
    ..We conclude that Ca2+ binding by ATP and diffusion of CaATP make important contributions to the determination of the amplitude and the time course of Delta[Ca2+]...
  13. ncbi request reprint Malaria parasites are rapidly killed by dantrolene derivatives specific for the plasmodial surface anion channel
    Myungsa Kang
    The Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Mol Pharmacol 68:34-40. 2005
    ..Because, as a class, these derivatives fulfil the requirements for drug leads and can be studied with simple screening technology, more extensive medicinal chemistry is warranted to explore antimalarial development...

Research Grants26

  1. EXCITATION - CONTRACTION COUPLING IN STRIATED MUSCLE
    STEPHEN BAYLOR; Fiscal Year: 1993
    ....
  2. EXCITATION-CONTRACTION COUPLING IN STRIATED MUSCLE
    STEPHEN BAYLOR; Fiscal Year: 2003
    ..Overall, the knowledge obtained will contribute importantly to understanding the mechanisms of intracellular Ca signaling and the mechanisms by which specific drugs and diseases affect muscle performance. ..
  3. EXCITATION-CONTRACTION COUPLING IN STRIATED MUSCLE
    STEPHEN BAYLOR; Fiscal Year: 2004
    ..Overall, the knowledge obtained will contribute importantly to understanding the mechanisms of intracellular Ca signaling and the mechanisms by which specific drugs and diseases affect muscle performance. ..
  4. Intracellular calcium signaling in normal and diseased mammalian skeletal muscle
    STEPHEN BAYLOR; Fiscal Year: 2009
    ..Treatments of muscle conditions involving alterations in Ca signaling will likely improve with increased understanding of the underlying Ca movements. ..
  5. EXCITATION - CONTRACTION COUPLING IN STRIATED MUSCLE
    STEPHEN BAYLOR; Fiscal Year: 1992
    ....
  6. EXCITATION - CONTRACTION COUPLING IN STRIATED MUSCLE
    STEPHEN BAYLOR; Fiscal Year: 1991
    ....
  7. Intracellular calcium signaling in normal and diseased mammalian skeletal muscle
    Stephen M Baylor; Fiscal Year: 2010
    ..Treatments of muscle conditions involving alterations in Ca signaling will likely improve with increased understanding of the underlying Ca movements. ..
  8. EXCITATION - CONTRACTION COUPLING IN STRIATED MUSCLE
    STEPHEN BAYLOR; Fiscal Year: 1990
    ....
  9. EXCITATION-CONTRACTION COUPLING IN STRIATED MUSCLE
    STEPHEN BAYLOR; Fiscal Year: 2005
    ..Overall, the knowledge obtained will contribute importantly to understanding the mechanisms of intracellular Ca signaling and the mechanisms by which specific drugs and diseases affect muscle performance. ..
  10. EXCITATION-CONTRACTION COUPLING IN STRIATED MUSCLE
    STEPHEN BAYLOR; Fiscal Year: 2002
    ..Overall, the knowledge obtained will contribute importantly to understanding the mechanisms of intracellular Ca signaling and the mechanisms by which specific drugs and diseases affect muscle performance. ..
  11. EXCITATION-CONTRACTION COUPLING IN STRIATED MUSCLE
    STEPHEN BAYLOR; Fiscal Year: 2000
    ..The information obtained should contribute importantly to an understanding of how drugs and diseases alter specific events that determine muscle performance. ..
  12. EXCITATION-CONTRACTION COUPLING IN STRIATED MUSCLE
    STEPHEN BAYLOR; Fiscal Year: 1999
    ..The information obtained should contribute importantly to an understanding of how drugs and diseases alter specific events that determine muscle performance. ..