Joseph A Baur

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Control of gluconeogenesis by metformin: does redox trump energy charge?
    Joseph A Baur
    Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Electronic address
    Cell Metab 20:197-9. 2014
  2. pmc Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance
    Lan Ye
    State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
    Aging (Albany NY) 5:539-50. 2013
  3. pmc Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
    Lan Ye
    Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA, USA
    Front Genet 3:177. 2012
  4. ncbi request reprint Are sirtuins viable targets for improving healthspan and lifespan?
    Joseph A Baur
    Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Drug Discov 11:443-61. 2012
  5. pmc Mitochondrial genome sequence analysis: a custom bioinformatics pipeline substantially improves Affymetrix MitoChip v2.0 call rate and accuracy
    Hongbo M Xie
    Center for Biomedical Informatics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    BMC Bioinformatics 12:402. 2011
  6. pmc Challenges of translating basic research into therapeutics: resveratrol as an example
    James M Smoliga
    Department of Health and Physical Education, Human Physiology Laboratory, Marywood University, Scranton, Pennsylvania, USA
    J Gerontol A Biol Sci Med Sci 67:158-67. 2012
  7. pmc Resveratrol, sirtuins, and the promise of a DR mimetic
    Joseph A Baur
    Institute for Diabetes, Obesity, and Metabolism, Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mech Ageing Dev 131:261-9. 2010
  8. pmc Biochemical effects of SIRT1 activators
    Joseph A Baur
    Institute for Diabetes, Obesity, and Metabolism, and Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Biochim Biophys Acta 1804:1626-34. 2010
  9. doi request reprint Resveratrol and life extension
    Beamon Agarwal
    Institute for Diabetes, Obesity, and Metabolism, Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Ann N Y Acad Sci 1215:138-43. 2011
  10. pmc Extended wakefulness: compromised metabolics in and degeneration of locus ceruleus neurons
    Jing Zhang
    Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing 100034, China, Center for Sleep and Circadian Neurobiology, Department of Medicine, Institute for Diabetes, Obesity and Metabolism, and Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
    J Neurosci 34:4418-31. 2014

Collaborators

  • Jing Zhang
  • Nirinjini Naidoo
  • David G Le Couteur
  • James M Smoliga
  • Lan Ye
  • David M Sabatini
  • Dudley W Lamming
  • Hongbo M Xie
  • Beamon Agarwal
  • Carrie A Sims
  • Ole Vang
  • James G Davis
  • Yuxia Guan
  • Anne L Widlund
  • David E Harrison
  • Behzad Varamini
  • Colleen Clarke
  • Xiaowu Gai
  • Sergey I Zhadanov
  • Anthony Albano
  • Michael Grauer
  • Michael P King
  • Marni J Falk
  • Cecilia Kim
  • Hakon Hakonarson
  • Jonathan Schug
  • Vincent Procaccio
  • Avni Santani
  • Emily Place
  • Matthew C Dulik
  • Juan C Perin
  • Theodore G Schurr

Detail Information

Publications11

  1. ncbi request reprint Control of gluconeogenesis by metformin: does redox trump energy charge?
    Joseph A Baur
    Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Electronic address
    Cell Metab 20:197-9. 2014
    ..2014). ..
  2. pmc Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance
    Lan Ye
    State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
    Aging (Albany NY) 5:539-50. 2013
    ..We conclude that the doses of rapamycin required to extend life do not cause overt mitochondrial dysfunction in skeletal muscle. ..
  3. pmc Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
    Lan Ye
    Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA, USA
    Front Genet 3:177. 2012
    ..Thus, mTORC2 disruption, rather than inhibition of mitochondria, causes insulin resistance in rapamycin-treated myotubes, and this system may serve as a useful model to understand the effects of rapamycin on mTOR signaling in vivo...
  4. ncbi request reprint Are sirtuins viable targets for improving healthspan and lifespan?
    Joseph A Baur
    Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Drug Discov 11:443-61. 2012
    ..This Review covers the current status and controversies surrounding the potential of sirtuins as novel pharmacological targets, with a focus on SIRT1...
  5. pmc Mitochondrial genome sequence analysis: a custom bioinformatics pipeline substantially improves Affymetrix MitoChip v2.0 call rate and accuracy
    Hongbo M Xie
    Center for Biomedical Informatics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    BMC Bioinformatics 12:402. 2011
    ....
  6. pmc Challenges of translating basic research into therapeutics: resveratrol as an example
    James M Smoliga
    Department of Health and Physical Education, Human Physiology Laboratory, Marywood University, Scranton, Pennsylvania, USA
    J Gerontol A Biol Sci Med Sci 67:158-67. 2012
    ..The evidence for benefits of resveratrol in humans remains too sparse to be conclusive; yet, the limited data that are available, combined with a growing list of animal studies, provide a strong justification for further study...
  7. pmc Resveratrol, sirtuins, and the promise of a DR mimetic
    Joseph A Baur
    Institute for Diabetes, Obesity, and Metabolism, Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mech Ageing Dev 131:261-9. 2010
    ..This review summarizes recent work on resveratrol, sirtuins, and their potential to mimic beneficial effects of DR...
  8. pmc Biochemical effects of SIRT1 activators
    Joseph A Baur
    Institute for Diabetes, Obesity, and Metabolism, and Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Biochim Biophys Acta 1804:1626-34. 2010
    ..These efforts are especially important in light of the fact that SIRT1 activators are entering clinical trials in humans, and "nutraceutical" formulations containing resveratrol are already widely available...
  9. doi request reprint Resveratrol and life extension
    Beamon Agarwal
    Institute for Diabetes, Obesity, and Metabolism, Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Ann N Y Acad Sci 1215:138-43. 2011
    ..However, the poor phenotype of SIRT1 null mice has thus far precluded a more definitive test...
  10. pmc Extended wakefulness: compromised metabolics in and degeneration of locus ceruleus neurons
    Jing Zhang
    Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing 100034, China, Center for Sleep and Circadian Neurobiology, Department of Medicine, Institute for Diabetes, Obesity and Metabolism, and Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
    J Neurosci 34:4418-31. 2014
    ....
  11. pmc Aging and sleep deprivation induce the unfolded protein response in the pancreas: implications for metabolism
    Nirinjini Naidoo
    Division of Sleep Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Aging Cell 13:131-41. 2014
    ....