N Baumgarth

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc How specific is too specific? B-cell responses to viral infections reveal the importance of breadth over depth
    Nicole Baumgarth
    Center for Comparative Medicine and the Department of Pathology, Microbiology and Immunology, University of California, Davis, Davis, CA 95616, USA
    Immunol Rev 255:82-94. 2013
  2. doi request reprint Innate-like B cells and their rules of engagement
    Nicole Baumgarth
    Center for Comparative Medicine, University of California, Davis, CA 95616, USA
    Adv Exp Med Biol 785:57-66. 2013
  3. ncbi request reprint B cell lineage contributions to antiviral host responses
    N Baumgarth
    Center for Comparative Medicine, University of California, Davis, County Rd 98 and Hutchison Drive, Davis, CA 95616, USA
    Curr Top Microbiol Immunol 319:41-61. 2008
  4. doi request reprint The double life of a B-1 cell: self-reactivity selects for protective effector functions
    Nicole Baumgarth
    Center for Comparative Medicine, University of California, Davis, California 95616, USA
    Nat Rev Immunol 11:34-46. 2011
  5. pmc B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection
    N Baumgarth
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA
    J Exp Med 192:271-80. 2000
  6. pmc Highly tissue substructure-specific effects of human papilloma virus in mucosa of HIV-infected patients revealed by laser-dissection microscopy-assisted gene expression profiling
    Nicole Baumgarth
    Center for Comparative Medicine, University of California, Davis, CA, USA
    Am J Pathol 165:707-18. 2004
  7. pmc Innate and acquired humoral immunities to influenza virus are mediated by distinct arms of the immune system
    N Baumgarth
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 96:2250-5. 1999
  8. pmc CD4+ T cells derived from B cell-deficient mice inhibit the establishment of peripheral B cell pools
    N Baumgarth
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 97:4766-71. 2000
  9. ncbi request reprint Nine color eleven parameter immunophenotyping using three laser flow cytometry
    M Bigos
    Department of Genetics, Stanford University School of Medicine, California 94305 5318, USA
    Cytometry 36:36-45. 1999
  10. ncbi request reprint CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation
    C Pan
    Department of Medicine, Stanford University School of Medicine, California 94305, USA
    Immunity 11:495-506. 1999

Research Grants

  1. Long-lived B cell Immunity in the Respiratory Tract
    Nicole Baumgarth; Fiscal Year: 2010
  2. Regulation of Humoral Immunity to Influenza Virus
    Nicole Baumgarth; Fiscal Year: 2010
  3. Regulation of Humoral Immunity to Influenza Virus
    Nicole Baumgarth; Fiscal Year: 2011
  4. Early Regulation of Immunity in the Respiratory Tract
    Nicole Baumgarth; Fiscal Year: 2007
  5. Regulation of Humoral Immunity to Influenza Virus
    Nicole Baumgarth; Fiscal Year: 2005
  6. Regulation of Humoral Immunity to Influenza Virus
    Nicole Baumgarth; Fiscal Year: 2010

Collaborators

Detail Information

Publications30

  1. pmc How specific is too specific? B-cell responses to viral infections reveal the importance of breadth over depth
    Nicole Baumgarth
    Center for Comparative Medicine and the Department of Pathology, Microbiology and Immunology, University of California, Davis, Davis, CA 95616, USA
    Immunol Rev 255:82-94. 2013
    ..As outlined, the pathogenesis of influenza virus and the nature of the antiviral B-cell response seem to emphasize repertoire diversity over affinity maturation as driving forces behind the influenza-specific B-cell immunity. ..
  2. doi request reprint Innate-like B cells and their rules of engagement
    Nicole Baumgarth
    Center for Comparative Medicine, University of California, Davis, CA 95616, USA
    Adv Exp Med Biol 785:57-66. 2013
    ....
  3. ncbi request reprint B cell lineage contributions to antiviral host responses
    N Baumgarth
    Center for Comparative Medicine, University of California, Davis, County Rd 98 and Hutchison Drive, Davis, CA 95616, USA
    Curr Top Microbiol Immunol 319:41-61. 2008
    ....
  4. doi request reprint The double life of a B-1 cell: self-reactivity selects for protective effector functions
    Nicole Baumgarth
    Center for Comparative Medicine, University of California, Davis, California 95616, USA
    Nat Rev Immunol 11:34-46. 2011
    ....
  5. pmc B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection
    N Baumgarth
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA
    J Exp Med 192:271-80. 2000
    ....
  6. pmc Highly tissue substructure-specific effects of human papilloma virus in mucosa of HIV-infected patients revealed by laser-dissection microscopy-assisted gene expression profiling
    Nicole Baumgarth
    Center for Comparative Medicine, University of California, Davis, CA, USA
    Am J Pathol 165:707-18. 2004
    ..Because of its large dynamic measurement range it could also become a method of choice to confirm and better quantify results obtained by microarray analysis...
  7. pmc Innate and acquired humoral immunities to influenza virus are mediated by distinct arms of the immune system
    N Baumgarth
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 96:2250-5. 1999
    ....
  8. pmc CD4+ T cells derived from B cell-deficient mice inhibit the establishment of peripheral B cell pools
    N Baumgarth
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 97:4766-71. 2000
    ..Thus, we conclude that the presence of B cells in the neonate conditions the CD4(+) T-cell population to permit the establishment and maintenance of normal B cell pools throughout life...
  9. ncbi request reprint Nine color eleven parameter immunophenotyping using three laser flow cytometry
    M Bigos
    Department of Genetics, Stanford University School of Medicine, California 94305 5318, USA
    Cytometry 36:36-45. 1999
    ..An application characterizing low frequency murine B cell subpopulations is given...
  10. ncbi request reprint CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation
    C Pan
    Department of Medicine, Stanford University School of Medicine, California 94305, USA
    Immunity 11:495-506. 1999
    ..In addition, CD72 is a negative regulator of B cell activation, as CD72-/- B cells were hyperproliferative in response to various stimuli and showed enhanced kinetics in their intracellular Ca2+ response following IgM cross-linking...
  11. ncbi request reprint A population of murine gammadelta T cells that recognize an inducible MHC class Ib molecule
    M P Crowley
    Program in Immunology, Department of Microbiology and Immunology, and Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 287:314-6. 2000
    ..Furthermore, the fast on-rates and slow off-rates that characterize this receptor/ligand interaction would compensate for the low ligand stability and suggest a high threshold for gammadelta T cell activation...
  12. ncbi request reprint A two-phase model of B-cell activation
    N Baumgarth
    Department of Genetics, Stanford University Medical School, Beckman Center, CA 94305 5318, USA
    Immunol Rev 176:171-80. 2000
    ..Hence, this model provides an explanation of how B-cell responses are induced rapidly in vivo at a time when T-cell help is rare...
  13. ncbi request reprint CD1 expression defines subsets of follicular and marginal zone B cells in the spleen: beta 2-microglobulin-dependent and independent forms
    M Amano
    Department of Medicine, Stanford University School of Medicine, CA 94305 5111, USA
    J Immunol 161:1710-7. 1998
    ..They further suggest that a beta 2m-independent form of CD1 is expressed on B cells that can stimulate T cells; however, this form is not easily visualized with the anti-CD1 mAb used here...
  14. ncbi request reprint A practical approach to multicolor flow cytometry for immunophenotyping
    N Baumgarth
    Department of Genetics, Stanford University Medical School, Beckman Center B 007, 94305 5318, Stanford, CA, USA
    J Immunol Methods 243:77-97. 2000
    ..While inspired by the 11-color technology that we currently use, these principles apply to all flow cytometric experiments in which more than one fluorescent dye is used...
  15. pmc Rigid interferon-alpha subtype responses of human plasmacytoid dendritic cells
    Richard Szubin
    Center for Comparative Medicine, University of California, Davis, California 95616, USA
    J Interferon Cytokine Res 28:749-63. 2008
    ..These data are most consistent with the induction of optimized ratios of IFN-alpha subtypes, each of which may have differing signaling properties or alternatively, a great degree of redundancy in the IFN-alpha response...
  16. pmc Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality
    W L William Chang
    Center for Comparative Medicine, University of California, Davis, County Road 98 and Hutchison Drive, Davis, CA 95616, USA
    J Virol 78:8720-31. 2004
    ..Collectively, we show that cmvIL-10 causes long-term functional alterations at all stages of DC activation...
  17. pmc Human cytomegalovirus suppresses type I interferon secretion by plasmacytoid dendritic cells through its interleukin 10 homolog
    W L William Chang
    Center for Comparative Medicine, University of California, Davis, CA 95616, USA
    Virology 390:330-7. 2009
    ..These results suggest that HCMV subverts innate immunity by suppressing type I IFN production of PDCs during primary viral infection via its IL-10 homolog...
  18. ncbi request reprint Exposure of myeloid dendritic cells to exogenous or endogenous IL-10 during maturation determines their longevity
    W L William Chang
    Center for Comparative Medicine, University of California Davis, County Road 98 and Hutchison Drive, Davis, CA 95616, USA
    J Immunol 178:7794-804. 2007
    ..This regulatory mechanism of IL-10 is associated with the dynamic control of antiapoptotic Bcl-2 proteins...
  19. doi request reprint Analysis of immune cells within the healthy oral mucosa of specific pathogen-free cats
    B Arzi
    William R Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Anat Histol Embryol 40:1-10. 2011
    ..We describe the topographical distribution of various leucocyte subsets in the normal healthy feline oral mucosa, and demonstrate regional differences in the distribution of these cells...
  20. pmc Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma
    Kirk D C Jensen
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    Immunity 29:90-100. 2008
    ..The swift IL-17 response mounted by antigen-naive gammadelta T cells suggests a critical role for these cells at the onset of an acute inflammatory response to novel antigens...
  21. ncbi request reprint Type I IFN receptor signals directly stimulate local B cells early following influenza virus infection
    Elizabeth S Coro
    Center for Comparative Medicine, University of California, Davis, 95616, USA
    J Immunol 176:4343-51. 2006
    ..Thus, ligand(s) of the type I IFNR are direct nonredundant early innate signals that regulate local antiviral B cell responses...
  22. pmc Identification of a germ-line pro-B cell subset that distinguishes the fetal/neonatal from the adult B cell development pathway
    Li Sheng Lu
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5318, USA
    Proc Natl Acad Sci U S A 99:3007-12. 2002
    ....
  23. pmc Dual role for B-1a cells in immunity to influenza virus infection
    Youn Soo Choi
    Graduate Group in Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    J Exp Med 205:3053-64. 2008
    ..With that, our data reveal fundamental differences in the response regulation of B-1 and B-2 cells during an infection...
  24. ncbi request reprint B-cell immunophenotyping
    Nicole Baumgarth
    Center for Comparative Medicine, University of California, Davis, Davis, California 95616, USA
    Methods Cell Biol 75:643-62. 2004
  25. pmc An early CD4+ T cell-dependent immunoglobulin A response to influenza infection in the absence of key cognate T-B interactions
    Mark Y Sangster
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Exp Med 198:1011-21. 2003
    ..Our study demonstrates a CD4+ T cell-dependent, antiviral IgA response that is generated in the absence of B cell signaling via MHC II or CD40, and is restricted exclusively to virus-specific B cells...
  26. ncbi request reprint Influenza virus infection causes global respiratory tract B cell response modulation via innate immune signals
    W L William Chang
    Center for Comparative Medicine and
    J Immunol 178:1457-67. 2007
    ....
  27. ncbi request reprint Autoimmune disease: skin deep but complex
    Nicole Baumgarth
    Nature 449:551-3. 2007
  28. pmc Evaluation of intranuclear BrdU detection procedures for use in multicolor flow cytometry
    Kristina Rothaeusler
    Center for Comparative Medicine, University of California, Davis, USA
    Cytometry A 69:249-59. 2006
    ..However, the extent to which the often harsh cell preparation procedures required affect the staining quality of more recently developed fluorescent dyes has not been assessed...
  29. ncbi request reprint Inherent specificities in natural antibodies: a key to immune defense against pathogen invasion
    Nicole Baumgarth
    Center for Comparative Medicine, University of California, Davis, Davis, CA 95616, USA
    Springer Semin Immunopathol 26:347-62. 2005
    ....
  30. ncbi request reprint Enumeration and characterization of virus-specific B cells by multicolor flow cytometry
    Virginia P Doucett
    Center for Comparative Medicine, University of California, Davis, County Rd 98, CA 95616, USA
    J Immunol Methods 303:40-52. 2005
    ..We conclude that viral HA can be used in conjunction with cell surface and intracytoplasmic stains in multicolor flow cytometry to provide detailed phenotypic and functional information on virus HA-specific B cells...

Research Grants15

  1. Long-lived B cell Immunity in the Respiratory Tract
    Nicole Baumgarth; Fiscal Year: 2010
    ..This basic information will provide potential avenues for rational vaccine design that aims to boost local/mucosal immune responses. ..
  2. Regulation of Humoral Immunity to Influenza Virus
    Nicole Baumgarth; Fiscal Year: 2010
    ..Completion of these studies will contribute to a better understanding of the processes that regulate the induction of protective antiviral B cell responses to influenza virus. ..
  3. Regulation of Humoral Immunity to Influenza Virus
    Nicole Baumgarth; Fiscal Year: 2011
    ..Completion of these studies will contribute to a better understanding of the processes that regulate the induction of protective antiviral B cell responses to influenza virus. ..
  4. Early Regulation of Immunity in the Respiratory Tract
    Nicole Baumgarth; Fiscal Year: 2007
    ..This information could help the development of novel interventions that utilize early respiratory tract defenses for immune protection. ..
  5. Regulation of Humoral Immunity to Influenza Virus
    Nicole Baumgarth; Fiscal Year: 2005
    ..It would also form the basis for defining the precise molecular mechanisms of early virus-specific B cell activation, thus for identifying possible new targets for rationale vaccine design. ..
  6. Regulation of Humoral Immunity to Influenza Virus
    Nicole Baumgarth; Fiscal Year: 2010
    ..Completion of these studies will contribute to a better understanding of the processes that regulate the induction of protective antiviral B cell responses to influenza virus. Project Description Page 6 ..