GARY BAUMBACH

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Deficiency of Nox2 prevents angiotensin II-induced inward remodeling in cerebral arterioles
    Siu Lung Chan
    Department of Pathology, University of Iowa Carver College of Medicine Iowa City, IA, USA
    Front Physiol 4:133. 2013
  2. pmc Nox2 deficiency prevents hypertension-induced vascular dysfunction and hypertrophy in cerebral arterioles
    Siu Lung Chan
    Department of Pathology, University of Iowa Carver College of Medicine, 5231D RCP, 200 Hawkins Drive, Iowa City, IA 52242, USA Department of Neurological Sciences, University of Vermont, 149 Beaumont Avenue, HSRF 416, Burlington, VT 05405, USA
    Int J Hypertens 2013:793630. 2013
  3. ncbi request reprint Hypertrophy of cerebral arterioles in mice deficient in expression of the gene for CuZn superoxide dismutase
    Gary L Baumbach
    Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Stroke 37:1850-5. 2006
  4. ncbi request reprint Effects of increased pulse pressure on cerebral arterioles
    G L Baumbach
    University of Iowa College of Medicine, Department of Pathology, Iowa City 52242, USA
    Hypertension 27:159-67. 1996
  5. ncbi request reprint Structure of cerebral arterioles in mice deficient in expression of the gene for endothelial nitric oxide synthase
    Gary L Baumbach
    Department of Pathology, 5231D RCP, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Circ Res 95:822-9. 2004
  6. ncbi request reprint Cerebral arteriolar structure in mice overexpressing human renin and angiotensinogen
    Gary L Baumbach
    Department of Pathology, University of Iowa College of Medicine and Cardiovascular Center, Iowa City, Iowa 52242, USA
    Hypertension 41:50-5. 2003
  7. ncbi request reprint Effects of angiotensin-converting enzyme inhibitors on cerebral vascular structure in chronic hypertension
    G L Baumbach
    Department of Pathology, University of Iowa College of Medicine and Cardiovascular Center, Iowa City 52242, USA
    J Hypertens Suppl 18:S7-11. 2000
  8. ncbi request reprint Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice
    Gary L Baumbach
    Department of Pathology, University of Iowa College of Medicine and Cardiovascular Center, Iowa City, Iowa 52242, USA
    Circ Res 91:931-7. 2002
  9. ncbi request reprint Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen
    Sean P Didion
    Department of Internal Medicine, Cardiovascular Center, University of Iowa College of Medicine, Iowa City 52242, USA
    Am J Physiol Heart Circ Physiol 283:H1569-76. 2002
  10. pmc Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia
    Roman N Rodionov
    Department of Internal Medicine, C32 GH, The University of Iowa, Iowa City, IA 52242, USA
    Circ Res 106:551-8. 2010

Research Grants

  1. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 2005
  2. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 2004
  3. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 2003
  4. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 2001
  5. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 2000
  6. MORPHOLOGICAL EXAMINATION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 1992
  7. MORPHOLOGICAL EXAMINATION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 1991
  8. MORPHOLOGICAL EXAMINATION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 1990
  9. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 1993
  10. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 1999

Collaborators

Detail Information

Publications19

  1. pmc Deficiency of Nox2 prevents angiotensin II-induced inward remodeling in cerebral arterioles
    Siu Lung Chan
    Department of Pathology, University of Iowa Carver College of Medicine Iowa City, IA, USA
    Front Physiol 4:133. 2013
    ..This effect appears to be independent of pressure and different from that of hypertrophy. ..
  2. pmc Nox2 deficiency prevents hypertension-induced vascular dysfunction and hypertrophy in cerebral arterioles
    Siu Lung Chan
    Department of Pathology, University of Iowa Carver College of Medicine, 5231D RCP, 200 Hawkins Drive, Iowa City, IA 52242, USA Department of Neurological Sciences, University of Vermont, 149 Beaumont Avenue, HSRF 416, Burlington, VT 05405, USA
    Int J Hypertens 2013:793630. 2013
    ..In conclusion, hypertension-induced superoxide production derived from Nox2-containing NADPH oxidase promotes hypertrophy and causes endothelial dysfunction in cerebral arterioles, possibly involving interaction with nitric oxide...
  3. ncbi request reprint Hypertrophy of cerebral arterioles in mice deficient in expression of the gene for CuZn superoxide dismutase
    Gary L Baumbach
    Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Stroke 37:1850-5. 2006
    ..Reactive oxygen species are believed to be an important determinant of vascular growth. We examined effects of genetic deficiency of copper-zinc superoxide dismutase (CuZnSOD; SOD1) on structure and function of cerebral arterioles...
  4. ncbi request reprint Effects of increased pulse pressure on cerebral arterioles
    G L Baumbach
    University of Iowa College of Medicine, Department of Pathology, Iowa City 52242, USA
    Hypertension 27:159-67. 1996
    ....
  5. ncbi request reprint Structure of cerebral arterioles in mice deficient in expression of the gene for endothelial nitric oxide synthase
    Gary L Baumbach
    Department of Pathology, 5231D RCP, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Circ Res 95:822-9. 2004
    ..These findings suggest that eNOS plays a major role in regulation of cerebral vascular growth...
  6. ncbi request reprint Cerebral arteriolar structure in mice overexpressing human renin and angiotensinogen
    Gary L Baumbach
    Department of Pathology, University of Iowa College of Medicine and Cardiovascular Center, Iowa City, Iowa 52242, USA
    Hypertension 41:50-5. 2003
    ..These findings support the hypothesis that the renin-angiotensin system is an important determinant of vascular remodeling during chronic hypertension...
  7. ncbi request reprint Effects of angiotensin-converting enzyme inhibitors on cerebral vascular structure in chronic hypertension
    G L Baumbach
    Department of Pathology, University of Iowa College of Medicine and Cardiovascular Center, Iowa City 52242, USA
    J Hypertens Suppl 18:S7-11. 2000
    ..Rather, hypertrophy appears to depend in large part on increases in arterial pressure and, in particular, its pulsatile component...
  8. ncbi request reprint Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice
    Gary L Baumbach
    Department of Pathology, University of Iowa College of Medicine and Cardiovascular Center, Iowa City, Iowa 52242, USA
    Circ Res 91:931-7. 2002
    ..These findings suggest that hyperhomocysteinemia promotes cerebral vascular hypertrophy and altered cerebral vascular mechanics, both of which may contribute to the increased incidence of stroke associated with hyperhomocysteinemia...
  9. ncbi request reprint Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen
    Sean P Didion
    Department of Internal Medicine, Cardiovascular Center, University of Iowa College of Medicine, Iowa City 52242, USA
    Am J Physiol Heart Circ Physiol 283:H1569-76. 2002
    ..These results suggest that increased superoxide contributes to impaired nitric oxide-mediated relaxation in this genetic model of chronic angiotensin II-dependent hypertension...
  10. pmc Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia
    Roman N Rodionov
    Department of Internal Medicine, C32 GH, The University of Iowa, Iowa City, IA 52242, USA
    Circ Res 106:551-8. 2010
    ..Hyperhomocysteinemia is a cardiovascular risk factor that is associated with elevation of the nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA)...
  11. pmc Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension
    Carmen M Halabi
    Genetics Program, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Cell Metab 7:215-26. 2008
    ..These results identify PPARgamma as pivotal in vascular muscle as a regulator of vascular structure, vascular function, and blood pressure, potentially explaining some of the cardioprotective effects of thiazolidinediones...
  12. pmc Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling
    Andreas M Beyer
    Genetics Graduate Program, Lucille A Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    Hypertension 51:867-71. 2008
    ..These findings indicate that PPARgamma has vascular effects which are particularly profound in the cerebral circulation and provide genetic evidence that PPARgamma plays a critical role in protecting blood vessels...
  13. ncbi request reprint Spontaneous stroke in a genetic model of hypertension in mice
    Shinichiro Iida
    Cardiovascular Center, Department of Internal Medicine, University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    Stroke 36:1253-8. 2005
    ..The goal of this study was to develop a model of hemorrhagic stroke in hypertensive mice...
  14. doi request reprint Cerebral arteriolar thromboembolism in idiopathic hypereosinophilic syndrome
    Mikayel Grigoryan
    Department of Neurology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52242, USA
    Arch Neurol 66:528-31. 2009
    ..To describe imaging findings as well as postmortem brain and cardiac pathology in a patient with fulminant idiopathic hypereosinophilic syndrome...
  15. pmc Oxidative stress through activation of NAD(P)H oxidase in hypertensive mice with spontaneous intracranial hemorrhage
    Yoshinobu Wakisaka
    Cardiovascular Center and Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    J Cereb Blood Flow Metab 28:1175-85. 2008
    ..Increased NAD(P)H oxidase activity preceded signs of ICH, and increased further when R+/A+ mice developed ICH. These findings suggest that oxidative stress may contribute to spontaneous ICH in chronic hypertension...
  16. ncbi request reprint Impaired endothelium-dependent responses and enhanced influence of Rho-kinase in cerebral arterioles in type II diabetes
    Sean P Didion
    Department of Internal Medicine, University of Iowa Carver College of Medicine Iowa City, IA 52242, USA
    Stroke 36:342-7. 2005
    ..The goals of this study were to examine the role of superoxide in impaired endothelium-dependent responses and to examine the influence of Rho-kinase on vascular tone in the cerebral microcirculation in type II diabetes...
  17. ncbi request reprint Synovial chondromatosis of the cervical spine. Case illustration
    Jeremy D W Greenlee
    Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    J Neurosurg 97:150. 2002
  18. ncbi request reprint Effects of chronic nitric oxide synthase inhibition on cerebral arterioles in Wistar-Kyoto rats
    Jean Marc Chillon
    Cardiovascular Research Group, Faculté de Pharmacie de l Université Henri Poincaré Nancy I, Nancy, France
    J Hypertens 22:529-34. 2004
    ..The goal of this study was to determine whether development of vascular inward remodeling may depend on genetic factors...
  19. ncbi request reprint Effects of indapamide, a thiazide-like diuretic, on structure of cerebral arterioles in hypertensive rats
    Jean Marc Chillon
    Laboratory of Cardiovascular Pharmacology, Faculty of Pharmacy, University Henri Poincaré Nancy, France
    Hypertension 43:1092-7. 2004
    ....

Research Grants17

  1. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 2005
    ..These studies should provide important new insight into the mechanisms of vascular remodeling. ..
  2. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 2004
    ..These studies should provide important new insight into the mechanisms of vascular remodeling. ..
  3. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 2003
    ..These studies should provide important new insight into the mechanisms of vascular remodeling. ..
  4. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 2001
    ....
  5. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 2000
    ....
  6. MORPHOLOGICAL EXAMINATION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 1992
    ....
  7. MORPHOLOGICAL EXAMINATION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 1991
    ....
  8. MORPHOLOGICAL EXAMINATION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 1990
    ....
  9. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 1993
    ..In addition, the studies should provide additional insight into the interaction of structure and function in the vessel wall...
  10. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 1999
    ....
  11. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 2006
    ..These studies should provide important new insight into the mechanisms of vascular remodeling. ..