Michel Baum

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Proximal tubule Na+/H+ exchanger activity in adult NHE8-/-, NHE3-/-, and NHE3-/-/NHE8-/- mice
    Michel Baum
    Dept of Pediatrics, Univ of Texas Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Am J Physiol Renal Physiol 303:F1495-502. 2012
  2. ncbi Ontogeny of renal sodium transport
    Michel Baum
    Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX 75235 9063, USA
    Semin Perinatol 28:91-6. 2004
  3. ncbi Phosphatonin washout in Hyp mice proximal tubules: evidence for posttranscriptional regulation
    Michel Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9063, USA
    Am J Physiol Renal Physiol 288:F363-70. 2005
  4. ncbi Thyroid hormone modulates rabbit proximal straight tubule paracellular permeability
    Michel Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235 9063, USA
    Am J Physiol Renal Physiol 286:F477-82. 2004
  5. doi Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea
    Michel Baum
    Department of Pediatrics, Mattel Children s Hospital, David Geffen School of Medicine at the University of California, Los Angeles, USA
    J Pediatr Gastroenterol Nutr 53:474-7. 2011
  6. pmc Correction of proximal tubule phosphate transport defect in Hyp mice in vivo and in vitro with indomethacin
    Michel Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75235 9063, USA
    Proc Natl Acad Sci U S A 100:11098-103. 2003
  7. ncbi Effect of fibroblast growth factor-23 on phosphate transport in proximal tubules
    Michel Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9063, USA
    Kidney Int 68:1148-53. 2005
  8. ncbi Cystinuria presenting with acute renal failure and hyperkalemia
    Michel Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, 75235 9063, USA
    Pediatr Nephrol 21:759; quiz 760. 2006
  9. ncbi Fetal origins of cardiovascular disease
    Michel Baum
    Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, Texas 75235 9063, USA
    Curr Opin Pediatr 15:166-70. 2003
  10. ncbi Role of prostaglandins in the pathogenesis of X-linked hypophosphatemia
    Michel Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9063, USA
    Pediatr Nephrol 21:1067-74. 2006

Research Grants

  1. Neonatal Proximal Tubule Acidification
    Michel Baum; Fiscal Year: 2005
  2. PEDIATRIC NEPHROLOGY TRAINING
    Michel Baum; Fiscal Year: 2005
  3. Proximal Tubule Transport Defect in Hyp Mice
    Michel Baum; Fiscal Year: 2007
  4. Effect of Prenatal Programming on Renal Tubular Transport
    Michel Baum; Fiscal Year: 2009
  5. Neonatal Proximal Tubule Acidification
    Orson W Moe; Fiscal Year: 2010
  6. NEONATAL PROXIMAL TUBULAR ACIDIFICATION
    Michel Baum; Fiscal Year: 1999
  7. NEONATAL PROXIMAL TUBULAR ACIDIFICATION
    Michel Baum; Fiscal Year: 1993
  8. Effect of Prenatal Programming on Renal Tubular Transport
    Michel G Baum; Fiscal Year: 2010

Collaborators

Detail Information

Publications61

  1. pmc Proximal tubule Na+/H+ exchanger activity in adult NHE8-/-, NHE3-/-, and NHE3-/-/NHE8-/- mice
    Michel Baum
    Dept of Pediatrics, Univ of Texas Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Am J Physiol Renal Physiol 303:F1495-502. 2012
    ..In conclusion, NHE3 is the predominant Na(+)/H(+) exchanger in adult mice. NHE8 may play a compensatory role in renal acidification and blood pressure regulation in NHE3(-/-) mice...
  2. ncbi Ontogeny of renal sodium transport
    Michel Baum
    Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX 75235 9063, USA
    Semin Perinatol 28:91-6. 2004
    ..This review focuses on how the neonatal kidney reabsorbs NaCl with a special emphasis on the differences between the neonatal and adult kidney...
  3. ncbi Phosphatonin washout in Hyp mice proximal tubules: evidence for posttranscriptional regulation
    Michel Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9063, USA
    Am J Physiol Renal Physiol 288:F363-70. 2005
    ..These data are consistent with a rapidly reversible posttranscriptional defect in Hyp mice causing a reduction in phosphate transport...
  4. ncbi Thyroid hormone modulates rabbit proximal straight tubule paracellular permeability
    Michel Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235 9063, USA
    Am J Physiol Renal Physiol 286:F477-82. 2004
    ..cm(2), or 7.0 +/- 0.7 Omega.cm(2) in hypothyroid animals that received thyroid replacement. Therefore, the maturational increase in thyroid hormone levels does not fully explain the developmental changes in the paracellular pathway...
  5. doi Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea
    Michel Baum
    Department of Pediatrics, Mattel Children s Hospital, David Geffen School of Medicine at the University of California, Los Angeles, USA
    J Pediatr Gastroenterol Nutr 53:474-7. 2011
    ..Although brush border membrane Na/H exchange activity may be decreased, exonic mutations in NHE8 cannot account for this disorder in these subjects...
  6. pmc Correction of proximal tubule phosphate transport defect in Hyp mice in vivo and in vitro with indomethacin
    Michel Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75235 9063, USA
    Proc Natl Acad Sci U S A 100:11098-103. 2003
    ..In conclusion, there is dysregulation of renal PG metabolism in Hyp mice, and indomethacin treatment normalizes the urinary excretion of phosphate by a direct tubular effect...
  7. ncbi Effect of fibroblast growth factor-23 on phosphate transport in proximal tubules
    Michel Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9063, USA
    Kidney Int 68:1148-53. 2005
    ..Fibroblast growth factor-23 (FGF-23) has been implicated in the renal phosphate wasting in tumor-induced osteomalacia, X-linked hypophosphatemia, and autosomal-dominant hypophosphatemic rickets...
  8. ncbi Cystinuria presenting with acute renal failure and hyperkalemia
    Michel Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, 75235 9063, USA
    Pediatr Nephrol 21:759; quiz 760. 2006
  9. ncbi Fetal origins of cardiovascular disease
    Michel Baum
    Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, Texas 75235 9063, USA
    Curr Opin Pediatr 15:166-70. 2003
    ..These studies suggest that at critical times during fetal development fetal injury programs the development of cardiovascular disease and diabetes in later life...
  10. ncbi Role of prostaglandins in the pathogenesis of X-linked hypophosphatemia
    Michel Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9063, USA
    Pediatr Nephrol 21:1067-74. 2006
    ..In Hyp mice, indomethacin improves the phosphate transport defect in vitro and in vivo. Whether indomethacin has the same effect in patients with X-linked hypophosphatemia is unknown...
  11. pmc Effect of catecholamines on rat medullary thick ascending limb chloride transport: interaction with angiotensin II
    Michel Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Am J Physiol Regul Integr Comp Physiol 298:R954-8. 2010
    ..These data are consistent with an interaction of both alpha- and beta-catecholamines and ANG II on net chloride transport in the mTAL...
  12. pmc Role of the kidney in the prenatal and early postnatal programming of hypertension
    Michel Baum
    Department of Pediatrics and Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Physiol Renal Physiol 298:F235-47. 2010
    ..Understanding the mechanism for the increase in blood pressure and renal injury resulting from prenatal insults may lead to therapies that prevent hypertension and the development of chronic kidney and cardiovascular disease...
  13. ncbi Postnatal developmental renal physiology: a study of historic significance
    Michel Baum
    Department of Pediatrics, Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9063
    Am J Physiol Renal Physiol 296:F667-8. 2009
    ..the-aps.org/publications/classics/) that is freely available online: Falk G. Maturation of renal function in infant rats. Am J Physiol 181: 157-170, 1955 (http://ajplegacy.physiology.org/cgi/reprint/181/1/157)...
  14. ncbi Maturation of rat proximal tubule chloride permeability
    Michel Baum
    Dept of Pediatrics, Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75235 9063, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1659-64. 2005
    ..2 +/- 0.8 vs. 4.6 +/- 0.1 ohms x cm2, P < 0.05). These studies demonstrate there are maturational changes in the rat paracellular pathway that impact net NaCl transport during development...
  15. pmc Prenatal programming of rat thick ascending limb chloride transport by low-protein diet and dexamethasone
    Amit Dagan
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Physiol Regul Integr Comp Physiol 297:R93-9. 2009
    ..This study demonstrates that insults administered to the fetus can program altered sodium transport. Increased tubular sodium transport is a likely cause for the hypertension by prenatal programming...
  16. ncbi Glucocorticoids increase osmotic water permeability (Pf) of neonatal rabbit renal brush border membrane vesicles
    Jaap Mulder
    Dept of Pediatrics, U T Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1417-21. 2005
    ..This mimics the maturational changes and suggests a physiological role for glucocorticoids in maturation of proximal tubule water transport...
  17. pmc Effect of metabolic acidosis on neonatal proximal tubule acidification
    Katherine Twombley
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1360-8. 2010
    ..A comparable increase in NHE3 and NHE8 was found in neonatal rats with acidosis. In conclusion, the neonatal proximal tubule can adapt to metabolic acidosis with an increase in Na(+)/H(+) exchanger activity...
  18. ncbi Fibroblast growth factor-23 increases mouse PGE2 production in vivo and in vitro
    Ashu Syal
    Department of Pediatrics, U T Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235 9063, USA
    Am J Physiol Renal Physiol 290:F450-5. 2006
    ..In conclusion, FGF-23 increases urinary and renal tubular PGE2 production via the MAP kinase pathway and PGE2 inhibits proximal tubule phosphate transport...
  19. ncbi Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteins
    Ghazala Abuazza
    Deptartment of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Am J Physiol Renal Physiol 291:F1132-41. 2006
    ..In summary, we have identified developmentally expressed claudin isoforms, claudin 6, claudin 9, and claudin 13. These paracellular proteins may play a role in the maturational changes in paracellular permeability...
  20. ncbi Ontogeny of NHE8 in the rat proximal tubule
    Amy M Becker
    Dept of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Am J Physiol Renal Physiol 293:F255-61. 2007
    ..These data demonstrate that NHE8 does undergo maturational changes on the apical membrane of the rat proximal tubule and may account for the Na(+)-dependent proton flux in neonatal proximal tubules...
  21. pmc FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Physiol Renal Physiol 297:F282-91. 2009
    ..6 +/- 0.3 vs. 5.2 +/- 0.5 mg/dl) or BBM NaPi-2a and NaPi-2c expression. These data show that FGFR1 is the predominant receptor for the hypophosphatemic action of FGF23 in vivo, with FGFR4 likely playing a minor role...
  22. ncbi Developmental changes in rabbit proximal straight tubule paracellular permeability
    Raymond Quigley
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 75235 9063, USA
    Am J Physiol Renal Physiol 283:F525-31. 2002
    ..3 +/- 1.4 Omega x cm(2) in neonatal PST (P < 0.01). In conclusion, there are significant maturational changes in the characteristics of the PST paracellular pathway affecting transport in this nephron segment...
  23. ncbi Prenatal programming of rat proximal tubule Na+/H+ exchanger by dexamethasone
    Amit Dagan
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1230-5. 2007
    ..The increase in proximal tubule transport may be a factor mediating the hypertension by prenatal programming with dexamethasone...
  24. pmc Regulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4
    Jyothsna Gattineni
    Dept of Pediatrics, U T Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Am J Physiol Renal Physiol 301:F371-7. 2011
    ..In addition, when 1,25(OH)(2)Vitamin D(3) levels are not affected by FGF23, as in FGFR3(-/-)FGFR4(-/-) mice, a reduction in PTH can override the effects of FGF23 on renal phosphate transport...
  25. pmc Evidence that prenatal programming of hypertension by dietary protein deprivation is mediated by fetal glucocorticoid exposure
    Sabeen Habib
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, USA
    Am J Hypertens 24:96-101. 2011
    ..Prenatal programming by maternal dietary protein deprivation and prenatal dexamethasone result in a reduction in nephron number and hypertension when the offspring are studied as adults...
  26. pmc Regulation of phosphate transport by fibroblast growth factor 23 (FGF23): implications for disorders of phosphate metabolism
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
    Pediatr Nephrol 25:591-601. 2010
    ..Here, we also discuss new potentially clinically important data pointing to the receptor(s) that mediate the binding and action of FGF23 and Klotho...
  27. ncbi Effect of thyroid hormone on the postnatal renal expression of NHE8
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75235 9063, USA
    Am J Physiol Renal Physiol 294:F198-204. 2008
    ..In conclusion, thyroid hormone plays a potential role in the developmental isoform change from NHE8 to NHE3 and decreases NHE8 activity...
  28. doi Effect of renal denervation on prenatal programming of hypertension and renal tubular transporter abundance
    Amit Dagan
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Am J Physiol Renal Physiol 295:F29-34. 2008
    ..This study is consistent with renal nerves playing a role in mediating the hypertension by prenatal programming by dexamethasone...
  29. ncbi Prenatal dexamethasone programs hypertension and renal injury in the rat
    Luis A Ortiz
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75235 9063, USA
    Hypertension 41:328-34. 2003
    ....
  30. ncbi Developmental changes in proximal tubule NaCl transport
    Michel Baum
    Department of Pediatrics, U T Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75235 9063, USA, Michael
    Pediatr Nephrol 23:185-94. 2008
    ..The causes for these postnatal changes in proximal tubular transport and developmental isoform changes are also discussed in this review...
  31. pmc Effect of claudins 6 and 9 on paracellular permeability in MDCK II cells
    David Sas
    Dept of Pediatrics, U T Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1713-9. 2008
    ....
  32. ncbi Maturation of the Na+/H+ antiporter (NHE3) in the proximal tubule of the hypothyroid adrenalectomized rat
    Neena Gupta
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Physiol Renal Physiol 287:F521-7. 2004
    ..05). We conclude that combined deficiency of both hormones totally prevents the maturational increase in NHE3 mRNA and protein abundance and Na(+)/H(+) antiporter activity...
  33. doi Effect of prenatal dexamethasone on postnatal serum and urinary angiotensin II levels
    Amit Dagan
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, TX, USA
    Am J Hypertens 23:420-4. 2010
    ..Prenatal programming of hypertension has been described in humans and in animal models that receive a prenatal insult, but the mechanism for the increase in blood pressure remains elusive...
  34. ncbi Ontogeny of water transport in the rabbit proximal tubule
    Raymond Quigley
    Department of Pediatrics, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9063 USA
    Pediatr Nephrol 18:1089-94. 2003
    ..This review will discuss postnatal maturation of proximal tubule water transport...
  35. pmc Glucocorticoids acutely increase cell surface Na+/H+ exchanger-3 (NHE3) by activation of NHE3 exocytosis
    I Alexandru Bobulescu
    Univ of Texas Southwestern Medical Ctr, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 289:F685-91. 2005
    ....
  36. pmc Prenatal programming of rat cortical collecting tubule sodium transport
    Chih Jen Cheng
    Dept of Pediatrics, U T Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Am J Physiol Renal Physiol 302:F674-8. 2012
    ..Thus we directly demonstrate that there is prenatal programming of cortical collecting duct sodium transport...
  37. ncbi Hypothyroidism increases osmotic water permeability (Pf) in the developing renal brush border membrane
    Jaap Mulder
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Texas 75390 9063, USA
    Pediatr Res 53:1001-7. 2003
    ..The higher Pf in hypothyroid adult rabbits is due to a higher expression of AQP1 protein as well as a greater membrane fluidity than in euthyroid rabbits...
  38. pmc Acid increases NHE8 surface expression and activity in NRK cells
    Catherine Joseph
    Dept of Pediatrics, U T Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Am J Physiol Renal Physiol 302:F495-503. 2012
    ..In conclusion, NHE8 surface expression and activity are regulated by acid media by increasing the rate of trafficking to the apical membrane...
  39. ncbi Water transport in neonatal and adult rabbit proximal tubules
    Raymond Quigley
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Physiol Renal Physiol 283:F280-5. 2002
    ..01 vs. 40.49 +/- 13.89 microm/s, P < 0.05). Thus the intracellular compartment of the neonatal PCT has a lower resistance for water transport than the adult PCT and is responsible for the higher than expected P(f) in the neonatal PCT...
  40. pmc Kidney-specific WNK1 regulates sodium reabsorption and potassium secretion in mouse cortical collecting duct
    Chih Jen Cheng
    Department of Medicine, Division of Nephrology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Am J Physiol Renal Physiol 304:F397-402. 2013
    ..In addition, KS-WNK1 plays a role in regulating Na(+) transport in the CCD...
  41. pmc Prenatal programming of hypertension induces sympathetic overactivity in response to physical stress
    Masaki Mizuno
    Departments of Health Care Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Hypertension 61:180-6. 2013
    ..The data demonstrate that the sympathetic response to physical stress is markedly exaggerated in PPH and may play a significant role in the development of hypertension in adults born small for gestational age...
  42. ncbi Antidiuretic hormone resistance in the neonatal cortical collecting tubule is mediated in part by elevated phosphodiesterase activity
    Raymond Quigley
    Department of Pediatrics, Univeristy of Texas Southwestern Medical Center, Dallas, TX 75235 9063, USA
    Am J Physiol Renal Physiol 286:F317-22. 2004
    ..Hence, one of the key factors in the decreased ability of neonates to concentrate their urine is overactivity of phosphodiesterase in the cortical collecting duct that blunts the neonatal collecting duct Pf response to ADH...
  43. ncbi Renal nerve stimulation augments effect of intraluminal angiotensin II on proximal tubule transport
    Albert Quan
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Am J Physiol Renal Physiol 282:F1043-8. 2002
    ..Renal nerve stimulation augments the stimulatory effect of intraluminal angiotensin II. The sympathetic renal nerves modulate the proximal tubule renin-angiotensin system and thereby regulate proximal tubule transport...
  44. doi Enalapril attenuates the exaggerated sympathetic response to physical stress in prenatally programmed hypertensive rats
    Masaki Mizuno
    University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9174
    Hypertension 63:324-9. 2014
    ..The results suggest that the renin-angiotensin system contributes to the enhancement of the renal sympathetic and pressor responses to physical stress in PPH rats. ..
  45. pmc Kidney-specific WNK1 inhibits sodium reabsorption in the cortical thick ascending limb
    Chih Jen Cheng
    Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 303:F667-73. 2012
    ..Thus KS-WNK1 inhibits Na(+) reabsorption in cTAL and mediates the inhibition of Na(+) reabsorption in the segment by a high-K diet...
  46. ncbi Developmental changes in proximal tubule tight junction proteins
    Maha Haddad
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, TX 75235, USA
    Pediatr Res 57:453-7. 2005
    ..In conclusion, there are postnatal maturational changes in tight junction proteins. The factors that cause these maturational changes are unknown but unlikely to be due solely to the maturational increase in thyroid hormone...
  47. ncbi Peritoneal protein losses in children with steroid-resistant nephrotic syndrome on continuous-cycler peritoneal dialysis
    Sashikala Kopanati
    Department of Pediatrics, Division of Pediatric Nephrology, University of TX Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Pediatr Nephrol 21:1013-9. 2006
    ..These results are consistent with the systemic effect of a "circulating factor" in SRNS and underscore the importance of adequate protein intake in patients on peritoneal dialysis...
  48. doi Urinary prostaglandins and the effect of indomethacin on phosphate excretion in children with hypophosphatemic rickets
    Mouin G Seikaly
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Pediatr Res 64:210-2. 2008
    ..In conclusion, urinary prostaglandin excretion is similar in children with HPR compared with controls. Indomethacin had no significant effect on serum phosphorus or urinary phosphate excretion in children with HPR...
  49. pmc Genetic disorders of phosphate regulation
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9063, USA
    Pediatr Nephrol 27:1477-87. 2012
    ..The main focus of this educational review article is to discuss the genetic and clinical features of phosphate regulation disorders and provide understanding and treatment options...
  50. pmc The Drosophila NKCC Ncc69 is required for normal renal tubule function
    Aylin R Rodan
    Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, USA
    Am J Physiol Cell Physiol 303:C883-94. 2012
    ..Thus, Ncc69 plays an important role in transepithelial ion and fluid transport in the fly renal tubule and is a target for regulation in antidiuretic states...
  51. pmc Prenatal programming of hypertension in the rat: effect of postnatal rearing
    Sabeen Habib
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Tex, USA
    Nephron Extra 1:157-65. 2011
    ..This study examined if postnatal rearing had an effect on blood pressure and glomerular number in male rats whose mothers were fed either a control diet or a low protein diet...
  52. ncbi Maturational changes in renal tubular transport
    Michel Baum
    Departments of Pediatrics and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9063, USA
    Curr Opin Nephrol Hypertens 12:521-6. 2003
    ..This review examines the maturational changes that occur in renal tubules during postnatal development...
  53. ncbi Primary renal lymphoma presenting with hypertension
    Amy M Becker
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Pediatr Blood Cancer 48:711-3. 2007
    ..PRL is more diagnosed in adults than children. We describe an asymptomatic child who presented with hypertension and was subsequently diagnosed with primary renal lymphoma. This case represents an atypical presentation for PRL...
  54. doi Accidental and iatrogenic causes of acute kidney injury
    Katherine Twombley
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Curr Opin Pediatr 23:208-14. 2011
    ..Ingestions and iatrogenic administration of drugs are all too common causes of acute kidney injury. This review will discuss these preventable causes of acute kidney injury...
  55. ncbi Mercury intoxication: lack of correlation between symptoms and levels
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9063, USA
    Clin Pediatr (Phila) 46:844-6. 2007
    ..This case highlights the fact that urinary mercury levels do not necessarily correlate with the severity of clinical signs and symptoms of mercury intoxication...
  56. ncbi Bone mineral density in children with myelomeningocele: effect of hydrochlorothiazide
    Albert Quan
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9063, USA
    Pediatr Nephrol 18:929-33. 2003
    ..95+/-0.98 to -5.86+/-0.92) and placebo (-7.19+/-0.69 to -6.67+/-0.63) groups. While use of HCTZ for 1 year did not affect BMD, it reduced urinary calcium excretion in non-ambulatory children with myelomeningocele...
  57. ncbi Obstructive uropathy
    Amy Becker
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, 5323 Harry Hines Blvd, Texas 75390 9063, USA
    Early Hum Dev 82:15-22. 2006
    ....
  58. ncbi Neonatal acid base balance and disturbances
    Raymond Quigley
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
    Semin Perinatol 28:97-102. 2004
    ..This review discusses the mechanisms by which the kidney is capable of excreting acid as well as the developmental regulation of these processes and the basis of inherited disorders of acidification...
  59. ncbi Association of hypocalcemia with a change in gentamicin administration in neonates
    Gregory L Jackson
    Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9063, USA
    Pediatr Nephrol 18:653-6. 2003
    ..The possible association with a higher gentamicin dose and longer dosing interval is described...
  60. pmc Regulation of fibroblast growth factor-23 signaling by klotho
    Hiroshi Kurosu
    Department of Pathology, Pediatrics, and Internal Medicine and Applied Genomics, Genzyme Corporation, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 281:6120-3. 2006
    ..Thus, Klotho functions as a cofactor essential for activation of FGF signaling by FGF23...
  61. pmc Characterization of Na+/H+ exchanger NHE8 in cultured renal epithelial cells
    Jianning Zhang
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 293:F761-6. 2007
    ..NHE8 activity is Na+ dependent, displaying a cooperative sigmoidal relationship, and is highly sensitive to 5-(N-ethyl-n-isopropyl)-amiloride (EIPA). NRK cells provide a useful system where NHE8 can be studied in its native environment...

Research Grants20

  1. Neonatal Proximal Tubule Acidification
    Michel Baum; Fiscal Year: 2005
    ..abstract_text> ..
  2. PEDIATRIC NEPHROLOGY TRAINING
    Michel Baum; Fiscal Year: 2005
    ..Fellows also attend seminars in basic science departments. The research mentor, as well as the program director, closely supervise trainees to ensure that the goals of the training program are achieved. ..
  3. Proximal Tubule Transport Defect in Hyp Mice
    Michel Baum; Fiscal Year: 2007
    ..These studies will not only examine the pathogenesis of this disorder, but will directly examine if indomethacin potentially represents a novel therapy for this disease. ..
  4. Effect of Prenatal Programming on Renal Tubular Transport
    Michel Baum; Fiscal Year: 2009
    ..We show that prenatal dexamethasone can result in the development of hypertension when administered during specific times during fetal development. This proposal aims to determine how prenatal dexamethasone causes hypertension. ..
  5. Neonatal Proximal Tubule Acidification
    Orson W Moe; Fiscal Year: 2010
    ..This proposal will characterize a neonatal transporter that likely plays an important role in neonatal kidney acidification and salt transport. ..
  6. NEONATAL PROXIMAL TUBULAR ACIDIFICATION
    Michel Baum; Fiscal Year: 1999
    ..The reason, for this block in signal transduction is unknown. We will examine why the response to PTH and dopamine are attenuated in the neonate and if glucocorticoids affect the maturation of signal transduction. ..
  7. NEONATAL PROXIMAL TUBULAR ACIDIFICATION
    Michel Baum; Fiscal Year: 1993
    ..Finally, I will examine if the intrinsic rate of development and maturation of proximal tubular acidification can be altered by imposing environmental stresses on newborn rabbits which frequently affect premature infants...
  8. Effect of Prenatal Programming on Renal Tubular Transport
    Michel G Baum; Fiscal Year: 2010
    ..We show that prenatal dexamethasone can result in the development of hypertension when administered during specific times during fetal development. This proposal aims to determine how prenatal dexamethasone causes hypertension. ..