Douglas Bauer

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi National Bone Health Alliance Bone Turnover Marker Project: current practices and the need for US harmonization, standardization, and common reference ranges
    D Bauer
    University of California, San Francisco, USA
    Osteoporos Int 23:2425-33. 2012
  2. ncbi Biochemical markers of bone turnover and their association with bone marrow lesions
    David J Hunter
    Department of Epidemiology and Biostatistics, Boston University School of Medicine, Albany Street, Boston, Massachusetts 02118, USA
    Arthritis Res Ther 10:R102. 2008
  3. ncbi Biochemical markers of bone turnover, hip bone loss, and fracture in older men: the MrOS study
    Douglas C Bauer
    University of California, San Francisco, California 94107, USA
    J Bone Miner Res 24:2032-8. 2009
  4. ncbi Short-term changes in bone turnover markers and bone mineral density response to parathyroid hormone in postmenopausal women with osteoporosis
    D C Bauer
    Department of Medicine, University of California San Francisco Coordinating Center, 185 Berry 5700, San Francisco, CA 94107, USA
    J Clin Endocrinol Metab 91:1370-5. 2006
  5. ncbi HMG CoA reductase inhibitors and the skeleton: a comprehensive review
    D C Bauer
    Department of Medicine, Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94105, USA
    Osteoporos Int 14:273-82. 2003
  6. ncbi Quantitative ultrasound predicts hip and non-spine fracture in men: the MrOS study
    D C Bauer
    UCSF, San Francisco, CA 94107, USA
    Osteoporos Int 18:771-7. 2007
  7. ncbi Use of statins and fracture: results of 4 prospective studies and cumulative meta-analysis of observational studies and controlled trials
    Douglas C Bauer
    Department of Medicine, University of California, San Francisco 94105, USA
    Arch Intern Med 164:146-52. 2004
  8. ncbi Quantitative ultrasound and mortality: a prospective study
    D C Bauer
    Division of General Internal Medicine, Department of Epidemiology and Biostatistics, University of California, San Fransico, USA
    Osteoporos Int 13:606-12. 2002
  9. ncbi Classification of osteoarthritis biomarkers: a proposed approach
    D C Bauer
    Department of Medicine, University of California, San Francisco, CA 94107, USA
    Osteoarthritis Cartilage 14:723-7. 2006
  10. ncbi Combination and sequential therapy with PTH and bisphosphonates
    D C Bauer
    University of California, San Francisco, San Francisco, CA 94150, USA
    J Musculoskelet Neuronal Interact 4:407. 2004

Research Grants

  1. Biomarker Research in Musculoskeletal Disease
    Douglas Bauer; Fiscal Year: 2007
  2. Bone Turnover and Fracture Risk in Men
    Douglas Bauer; Fiscal Year: 2007

Collaborators

Detail Information

Publications81

  1. ncbi National Bone Health Alliance Bone Turnover Marker Project: current practices and the need for US harmonization, standardization, and common reference ranges
    D Bauer
    University of California, San Francisco, USA
    Osteoporos Int 23:2425-33. 2012
    ....
  2. ncbi Biochemical markers of bone turnover and their association with bone marrow lesions
    David J Hunter
    Department of Epidemiology and Biostatistics, Boston University School of Medicine, Albany Street, Boston, Massachusetts 02118, USA
    Arthritis Res Ther 10:R102. 2008
    ..Our objective was to determine whether markers of bone resorption and formation could serve as markers for the presence of bone marrow lesions (BMLs)...
  3. ncbi Biochemical markers of bone turnover, hip bone loss, and fracture in older men: the MrOS study
    Douglas C Bauer
    University of California, San Francisco, California 94107, USA
    J Bone Miner Res 24:2032-8. 2009
    ..We conclude that higher levels of bone turnover are associated with greater hip bone loss in older men, but increased turnover is not independently associated with the risk of hip or nonspine fracture...
  4. ncbi Short-term changes in bone turnover markers and bone mineral density response to parathyroid hormone in postmenopausal women with osteoporosis
    D C Bauer
    Department of Medicine, University of California San Francisco Coordinating Center, 185 Berry 5700, San Francisco, CA 94107, USA
    J Clin Endocrinol Metab 91:1370-5. 2006
    ..Treatment of osteoporotic women with PTH increases biochemical markers of bone turnover, increases axial bone mineral density (BMD), and reduces fracture risk...
  5. ncbi HMG CoA reductase inhibitors and the skeleton: a comprehensive review
    D C Bauer
    Department of Medicine, Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94105, USA
    Osteoporos Int 14:273-82. 2003
    ..Clinical trials with fracture endpoints are needed before statins can be recommended as therapeutic agents for osteoporosis...
  6. ncbi Quantitative ultrasound predicts hip and non-spine fracture in men: the MrOS study
    D C Bauer
    UCSF, San Francisco, CA 94107, USA
    Osteoporos Int 18:771-7. 2007
    ..We studied 5,607 older men and found that QUS predicts hip and any non-spine fracture risk nearly as well as BMD. Combined measurements of QUS and BMD are not superior to either measurement alone...
  7. ncbi Use of statins and fracture: results of 4 prospective studies and cumulative meta-analysis of observational studies and controlled trials
    Douglas C Bauer
    Department of Medicine, University of California, San Francisco 94105, USA
    Arch Intern Med 164:146-52. 2004
    ....
  8. ncbi Quantitative ultrasound and mortality: a prospective study
    D C Bauer
    Division of General Internal Medicine, Department of Epidemiology and Biostatistics, University of California, San Fransico, USA
    Osteoporos Int 13:606-12. 2002
    ..This relationship was independent of other factors associated with mortality, such as age and health status, and suggests QUS and BMD may reflect some aspect of aging not captured by these traditional factors...
  9. ncbi Classification of osteoarthritis biomarkers: a proposed approach
    D C Bauer
    Department of Medicine, University of California, San Francisco, CA 94107, USA
    Osteoarthritis Cartilage 14:723-7. 2006
    ..As effective agents for OA are developed and tested in clinical studies, biomarkers that reliably mirror or predict the progression or amelioration of OA will also be needed...
  10. ncbi Combination and sequential therapy with PTH and bisphosphonates
    D C Bauer
    University of California, San Francisco, San Francisco, CA 94150, USA
    J Musculoskelet Neuronal Interact 4:407. 2004
  11. ncbi Thyroid hormone use, hyperthyroidism and mortality in older women
    Douglas C Bauer
    Division of General Internal Medicine, University of California, San Francisco, CA 94107, USA
    Am J Med 120:343-9. 2007
    ..We performed a prospective cohort study to examine the relationship among thyroid hormone use, previous hyperthyroidism, abnormal thyroid function, and mortality...
  12. ncbi Pretreatment levels of bone turnover and the antifracture efficacy of alendronate: the fracture intervention trial
    Douglas C Bauer
    Department of Medicine, Epidemiology and Biostatistics, University of California, San Francisco, California 94107, USA
    J Bone Miner Res 21:292-9. 2006
    ..The nonspine fracture efficacy of alendronate was significantly greater among both osteoporotic and nonosteoporotic women with higher baseline levels of the bone formation marker PINP...
  13. ncbi Computed tomographic measurements of thigh muscle cross-sectional area and attenuation coefficient predict hip fracture: the health, aging, and body composition study
    Thomas Lang
    Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
    J Bone Miner Res 25:513-9. 2010
    ..This characteristic captures a physical characteristic of muscle tissue that may have importance in hip fracture etiology...
  14. ncbi Rate and circumstances of clinical vertebral fractures in older men
    S S Freitas
    Department of Medicine, Oregon Health and Science University, Portland, OR, USA
    Osteoporos Int 19:615-23. 2008
    ..Fractures were more common in the most elderly men, and were usually associated with falls and other low-energy trauma...
  15. ncbi Case-only analysis of treatment-covariate interactions in clinical trials
    E Vittinghoff
    Department of Epidemiology and Biostatistics, Division of Biostatistics, University of California, San Francisco, California 94143, USA
    Biometrics 62:769-76. 2006
    ..Case-only methods are even more efficient, and reliable under a range of circumstances...
  16. ncbi Laboratory reproducibility of biochemical markers of bone turnover in clinical practice
    A L Schafer
    Department of Medicine, University of California, San Francisco, CA, USA
    Osteoporos Int 21:439-45. 2010
    ..Longitudinal and within-run laboratory reproducibility varied substantially. Efforts to improve the reproducibility of these tests are needed...
  17. ncbi Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA
    J Bone Miner Res 23:1326-33. 2008
    ....
  18. ncbi Circadian activity rhythms and mortality: the study of osteoporotic fractures
    Gregory J Tranah
    California Pacific Medical Center Research Institute, San Francisco Coordinating Center, UCSF, 185 Berry Street, Lobby 4, Suite 5700, San Francisco, CA 94107, USA
    J Am Geriatr Soc 58:282-91. 2010
    ..To determine whether circadian activity rhythms are associated with mortality in community-dwelling older women...
  19. ncbi Warfarin use and risk for osteoporosis in elderly women. Study of Osteoporotic Fractures Research Group
    S A Jamal
    University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, USA
    Ann Intern Med 128:829-32. 1998
    ..Vitamin K deficiency may be associated with osteoporosis...
  20. ncbi Fracture risk reduction with alendronate in women with osteoporosis: the Fracture Intervention Trial. FIT Research Group
    D M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94105, USA
    J Clin Endocrinol Metab 85:4118-24. 2000
    ..Furthermore, reduction in risk is evident early in the course of treatment. This pooled analysis provides a more precise estimate of the antifracture efficacy of alendronate in women with osteoporosis than that in prior reports...
  21. ncbi Accuracy of self-reported diagnosis of hip replacement
    Neeta Parimi
    San Francisco Coordinating Center, California Pacific Medical Center, San Francisco, CA 94107 1728, USA
    Arthritis Care Res (Hoboken) 62:719-24. 2010
    ..To examine the accuracy and validity of self-report of hip replacement for osteoarthritis (OA)...
  22. ncbi Risk for fracture in women with low serum levels of thyroid-stimulating hormone
    D C Bauer
    University of California, San Francisco, 74 New Montgomery, Suite 600, San Francisco, CA 94105, USA
    Ann Intern Med 134:561-8. 2001
    ..Use of thyroid hormone itself does not increase risk for fracture if TSH levels are normal...
  23. ncbi Influence of smoking on the antiosteoporotic efficacy of raloxifene
    R D Chapurlat
    Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94105, USA
    J Clin Endocrinol Metab 86:4178-82. 2001
    ..light smokers. We conclude that smoking does not influence the antiosteoporotic effect of raloxifene. This may represent an advantage over estrogen replacement therapy...
  24. ncbi Sex hormones and frailty in older men: the osteoporotic fractures in men (MrOS) study
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107 1728, USA
    J Clin Endocrinol Metab 94:3806-15. 2009
    ..As men age, the prevalence of frailty increases whereas levels of androgens decline. Little is known about the relation between these factors...
  25. ncbi Association between endogenous hormones and sex hormone-binding globulin and bone turnover in older women: study of osteoporotic fractures
    R D Chapurlat
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
    Bone 29:381-7. 2001
    ..We conclude that older women with low endogenous hormones have somewhat higher bone turnover, but these associations are weak. Bone turnover is determined mainly by factors other than endogenous concentrations of sex hormones...
  26. ncbi Hot flushes, bone mineral density, and fractures in older postmenopausal women
    Alison Huang
    San Francisco Veterans Affairs Medical Center, University of California San Francisco, San Francisco, California 94121, USA
    Obstet Gynecol 109:841-7. 2007
    ..To assess whether greater severity of hot flushes is associated with bone loss or fracture risk in older postmenopausal women...
  27. ncbi Treatment with alendronate prevents fractures in women at highest risk: results from the Fracture Intervention Trial
    K E Ensrud
    Department of Medicine, Veterans Affairs Medical Center, and School of Public Health, University of Minnesota, Minneapolis 55417, USA
    Arch Intern Med 157:2617-24. 1997
    ..The efficacy of antiresorptive therapy in preventing fractures in women at highest fracture risk, such as very elderly women or those with severe osteoporosis, is uncertain...
  28. ncbi Changes in biochemical markers of bone turnover in women treated with raloxifene: influence of regression to the mean
    R D Chapurlat
    Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    Osteoporos Int 12:1006-14. 2001
    ....
  29. ncbi Self-reported sleep and nap habits and risk of falls and fractures in older women: the study of osteoporotic fractures
    Katie L Stone
    Research Institute, California Pacific Medical Center, San Francisco, 94107, USA
    J Am Geriatr Soc 54:1177-83. 2006
    ..To test the association between self-reported sleep and nap habits and risk of falls and fractures in a large cohort of older women...
  30. ncbi Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use
    Anthony B Hodsman
    University of Western Ontario, St Joseph s Health Care, Room 2F 15, 268, Grosvenor Street, London, Ontario N6A 4V2, Canada
    Endocr Rev 26:688-703. 2005
    ..At present, concurrent therapy with antiresorptive therapy, particularly bisphosphonates, should be avoided, although sequential therapy with such agents may consolidate the beneficial effects upon the skeleton after PTH is discontinued...
  31. ncbi Prevalence, severity, and health correlates of lower urinary tract symptoms among older men: the MrOS study
    Brent C Taylor
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    Urology 68:804-9. 2006
    ..The association of LUTS severity with poor health warrants increased clinical attention...
  32. ncbi Cost-effectiveness of bone densitometry followed by treatment of osteoporosis in older men
    John T Schousboe
    Rheumatology, Park Nicollet Health Services, Minneapolis, MN 55416, USA
    JAMA 298:629-37. 2007
    ..Osteoporotic fractures are common among elderly men...
  33. ncbi Racial variation in the relationship of anemia with mortality and mobility disability among older adults
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging NIH, Bethesda, MD 20892, USA
    Blood 109:4663-70. 2007
    ..Conversely, older blacks classified as anemic by WHO criteria were not at risk for adverse events, indicating that alternative criteria are warranted...
  34. ncbi Risk factors for mortality in middle-aged women
    Jeffrey A Tice
    Division of General Internal Medicine, Department of Medicine, University of California San Francisco, CA 94143, USA
    Arch Intern Med 166:2469-77. 2006
    ..Many factors contribute to mortality in older women, but their relative importance and independent contribution have been poorly characterized...
  35. ncbi Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial
    Dennis M Black
    San Francisco Coordinating Center, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94107, USA
    JAMA 296:2927-38. 2006
    ..The optimal duration of treatment of women with postmenopausal osteoporosis is uncertain...
  36. ncbi Alendronate treatment in women with normal to severely impaired renal function: an analysis of the fracture intervention trial
    Sophie A Jamal
    Division of Endocrinology, St Michael s Hospital and the University of Toronto, Toronto, Ont, Canada
    J Bone Miner Res 22:503-8. 2007
    ..There was no increase in adverse events among women with impaired renal function treated with alendronate. Alendronate is safe and effective among this group of women with reduced renal function...
  37. ncbi Optimal thresholds, linear or nonlinear relationships of fracture risk reduction with therapy
    Douglas C Bauer
    J Bone Miner Res 23:1349; author reply 1350. 2008
  38. ncbi Subclinical thyroid dysfunction, cardiac function, and the risk of heart failure. The Cardiovascular Health study
    Nicolas Rodondi
    Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland
    J Am Coll Cardiol 52:1152-9. 2008
    ..The goal of this study was to determine whether subclinical thyroid dysfunction was associated with incident heart failure (HF) and echocardiogram abnormalities...
  39. ncbi Associations of serum sex hormone-binding globulin and sex hormone concentrations with hip fracture risk in postmenopausal women
    Jennifer S Lee
    Division of Endocrinology, Clinical Nutrition, and Vascular Medicine, Department of Internal Medicine, University of California Davis, Sacramento, CA 95817, USA
    J Clin Endocrinol Metab 93:1796-803. 2008
    ..Endogenous estradiol, testosterone, and SHBG may influence the risk of hip fracture...
  40. ncbi Persistent hot flushes in older postmenopausal women
    Alison J Huang
    Department of Medicine, University of California San Francisco, USA
    Arch Intern Med 168:840-6. 2008
    ..To examine the prevalence, natural history, and predictors of hot flushes in older postmenopausal women...
  41. ncbi High-trauma fractures and low bone mineral density in older women and men
    Dawn C Mackey
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
    JAMA 298:2381-8. 2007
    ..It is widely believed that fractures resulting from high trauma are not osteoporotic; however, this assumption has not been studied prospectively...
  42. ncbi Quantitative ultrasound in the management of osteoporosis: the 2007 ISCD Official Positions
    Marc Antoine Krieg
    Lausanne University Hospital, Lausanne, Switzerland
    J Clin Densitom 11:163-87. 2008
    ..The ISCD Official Positions on QUS resulting from this PDC, the rationale for their establishment, and recommendations for further study are presented here...
  43. ncbi Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality
    Nicolas Ochs
    University of Lausanne, Lausanne, Switzerland
    Ann Intern Med 148:832-45. 2008
    ..Data on the association between subclinical thyroid dysfunction and coronary heart disease (CHD) and mortality are conflicting...
  44. ncbi Body mass index and mortality among older breast cancer survivors in the Study of Osteoporotic Fractures
    Katherine W Reeves
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 516A Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Cancer Epidemiol Biomarkers Prev 16:1468-73. 2007
    ..This study investigated the association between BMI and mortality after breast cancer diagnosis in a cohort of older Caucasian women enrolled in the Study of Osteoporotic Fractures...
  45. ncbi Single-point assessment of warfarin use and risk of osteoporosis in elderly men
    Claudine Woo
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA
    J Am Geriatr Soc 56:1171-6. 2008
    ..To determine whether warfarin use, assessed at a single point in time, is associated with bone mineral density (BMD), rates of bone loss, and fracture risk in older men...
  46. ncbi Cystatin-C, renal function, and incidence of hip fracture in postmenopausal women
    Andrea Z LaCroix
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Am Geriatr Soc 56:1434-41. 2008
    ..To evaluate the association between chronic kidney disease and incident hip fracture using serum cystatin-C as a biomarker of renal function calculated without reference to muscle mass...
  47. ncbi Subclinical hypothyroidism and the risk of coronary heart disease: a meta-analysis
    Nicolas Rodondi
    Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    Am J Med 119:541-51. 2006
    ..We performed a systematic review to determine whether subclinical hypothyroidism is associated with CHD in adults...
  48. ncbi Correlates of use of antifracture therapy in older women with low bone mineral density
    Kathryn M Ryder
    The University of Tennessee Health Science Center, Memphis, TN, USA
    J Gen Intern Med 21:636-41. 2006
    ..Guidelines exist for treatment of low bone mineral density (BMD). Little is known about patient characteristics associated with use of treatment...
  49. ncbi Assessing the risk/benefit profile before recommending aspirin for the primary prevention of cardiovascular events
    Nicolas Rodondi
    Am J Med 117:528-30. 2004
  50. ncbi Clinical utility of laboratory testing in women with osteoporosis
    Sophie A Jamal
    Department of Medicine, Division of Endocrinology and Metabolism, St Michael s Hospital, University of Toronto, 61 Queen Street East, Toronto, Ontario M5C 2T2, Canada
    Osteoporos Int 16:534-40. 2005
    ..4 (95% CI: 1.3-1.6). Our data suggests that when assessing healthy women with osteoporosis ordering a routine panel of laboratory tests is not useful but measuring TSH may be informative...
  51. ncbi Randomized trial of effect of alendronate continuation versus discontinuation in women with low BMD: results from the Fracture Intervention Trial long-term extension
    Kristine E Ensrud
    Department of Medicine, VA Medical Center, Minneapolis, Minnesota 55417, USA
    J Bone Miner Res 19:1259-69. 2004
    ..However, among women who discontinued alendronate and took placebo in the extension, BMD remained higher, and reduction in bone turnover was greater than values at FIT baseline, showing persistence of alendronate's effects on bone...
  52. ncbi Change in bone turnover and hip, non-spine, and vertebral fracture in alendronate-treated women: the fracture intervention trial
    Douglas C Bauer
    Department of Medicine, Epidemiology and Biostatistics, University of California, San Francisco, California 94105, USA
    J Bone Miner Res 19:1250-8. 2004
    ..In the alendronate group (n = 3105), greater reductions in one or more biochemical marker were associated with a lower risk of fracture...
  53. ncbi Effect of alendronate on bone mineral density and biochemical markers of bone turnover in type 2 diabetic women: the fracture intervention trial
    Theresa H M Keegan
    Division of Epidemiology, Stanford University School of Medicine, Stanford, CA 94305 5405, USA
    Diabetes Care 27:1547-53. 2004
    ..The objective of this project was to compare changes in BMD during 3 years of ALN treatment versus placebo in diabetic women...
  54. ncbi Diabetes is associated independently of body composition with BMD and bone volume in older white and black men and women: The Health, Aging, and Body Composition Study
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Bone Miner Res 19:1084-91. 2004
    ..01) and higher hip BMD for each race-gender group (p < or = 0.01). Type 2 diabetes was associated with a 4-5% higher total hip BMD in all race-gender groups of elderly adults, independent of body composition and fasting insulin levels...
  55. ncbi Low serum vitamin B-12 levels are associated with increased hip bone loss in older women: a prospective study
    Katie L Stone
    Department of Medicine, University of California, San Francisco, California 94105, USA
    J Clin Endocrinol Metab 89:1217-21. 2004
    ..Serum vitamin B-12 levels were not significantly associated with calcaneal bone loss. We conclude that low serum vitamin B-12 levels are associated with increased rates of hip, but not calcaneal, bone loss in older women...
  56. ncbi Association between bone mineral density and the use of nonsteroidal anti-inflammatory drugs and aspirin: impact of cyclooxygenase selectivity
    Laura D Carbone
    Department of Medicine, University of Tennessee Health Sciences Center, Memphis, Tennessee 38163, USA
    J Bone Miner Res 18:1795-802. 2003
    ..Significantly higher BMD was found in users of relative COX-2 selective NSAIDs with aspirin (COX-2/ASA) compared with nonusers. This suggests a role for COX-2/ASA in osteoporosis...
  57. ncbi Statin use, clinical fracture, and bone density in postmenopausal women: results from the Women's Health Initiative Observational Study
    Andrea Z LaCroix
    Women's Health Initiative Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP-1002, PO Box 19024, Seattle, Washington 98109-1024, USA
    Ann Intern Med 139:97-104. 2003
    ..CONCLUSION: Statin use did not improve fracture risk or bone density in the Women's Health Initiative Observational Study. The cumulative evidence does not warrant use of statins to prevent or treat osteoporosis...
  58. ncbi Relationship of changes in physical activity and mortality among older women
    Edward W Gregg
    Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    JAMA 289:2379-86. 2003
    ..Physical activity has been related to reduced mortality, but it is not clear whether changes in physical activity affect mortality among older women...
  59. ncbi Central nervous system active medications and risk for fractures in older women
    Kristine E Ensrud
    Department of Medicine and Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, MN 55417, USA
    Arch Intern Med 163:949-57. 2003
    ..Use of central nervous system (CNS) active medications may increase the risk for fractures. Prior studies are limited by incomplete control of confounders...
  60. ncbi Oral bisphosphonates and upper gastrointestinal tract problems: what is the evidence?
    Byron Cryer
    Mayo Clin Proc 77:1031-43. 2002
    ..To review and evaluate the evidence regarding possible associations of bisphosphonate use with upper gastrointestinal (GI) tract adverse events (AEs)...
  61. ncbi Central nervous system-active medications and risk for falls in older women
    Kristine E Ensrud
    Department of Medicine, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 50:1629-37. 2002
    ..To determine whether current use of central nervous system (CNS)-active medications, including benzodiazepines, antidepressants, anticonvulsants, and narcotics, increases the risk for subsequent falls...
  62. ncbi Risk factors for a first-incident radiographic vertebral fracture in women > or = 65 years of age: the study of osteoporotic fractures
    Michael C Nevitt
    Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94105, USA
    J Bone Miner Res 20:131-40. 2005
    ..Risk factors and low BMD should be useful to help focus efforts to prevent these fractures...
  63. ncbi beta-Blocker use, BMD, and fractures in the study of osteoporotic fractures
    Ian R Reid
    Department of Medicine, University of Auckland, Auckland, New Zealand
    J Bone Miner Res 20:613-8. 2005
    ..We studied the association of beta-blocker use with BMD and fractures in the Study of Osteoporotic Fractures. beta-blocker use and BMD are unrelated in this cohort, and associations with fracture risk are inconsistent...
  64. ncbi Economic comparison of diagnostic approaches for evaluating osteoporosis in older women
    Dale F Kraemer
    Department of Medical Informatics and Clinical Epidemiology and Evidence based Practice Center, Oregon Health and Science University, Portland, OR 97230, USA
    Osteoporos Int 17:68-76. 2006
    ..Compared to other approaches for diagnosing osteoporosis, sequential use of QUS followed by DXA resulted in fewer women treated and lower total costs...
  65. ncbi Statin use and breast cancer: prospective results from the Women's Health Initiative
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Natl Cancer Inst 98:700-7. 2006
    ....
  66. ncbi Metabolic syndrome and the risk of cardiovascular disease in older adults
    Javed Butler
    Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Am Coll Cardiol 47:1595-602. 2006
    ..The purpose of this study was to assess whether metabolic syndrome (MetSyn) predicts a higher risk for cardiovascular events in older adults...
  67. ncbi Cortical pQCT measures are associated with fractures in dialysis patients
    Sophie A Jamal
    Department of Medicine, Division of Endocrinology and Metabolism, St Michael s Hospital, University of Toronto, Toronto, Canada
    J Bone Miner Res 21:543-8. 2006
    ..To determine if pQCT could identify HD patients with fractures, we conducted a cross-sectional study in 52 men and women on HD. We found that cortical, but not trabecular, pQCT measures were associated with fractures...
  68. ncbi Osteoporosis and fractures in postmenopausal women using estrogen
    Heidi D Nelson
    Department of Medical Informatics and Outcomes Research, Oregon Health and Science University, Mailcode BICC 504, 3181 SW Sam Jackson Park Rd, Portland, OR 97201, USA
    Arch Intern Med 162:2278-84. 2002
    ....
  69. ncbi Subclinical hypothyroidism and the risk of heart failure, other cardiovascular events, and death
    Nicolas Rodondi
    Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    Arch Intern Med 165:2460-6. 2005
    ..Subclinical hypothyroidism has been associated with systolic and diastolic cardiac dysfunction and an elevated cholesterol level, but data on cardiovascular outcomes and death are limited...
  70. ncbi Association between thyroid dysfunction and total cholesterol level in an older biracial population: the health, aging and body composition study
    Alka M Kanaya
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, 1701 Divisadero St, Suite 554, San Francisco, CA 94143 1732, USA
    Arch Intern Med 162:773-9. 2002
    ..Thyroid dysfunction increases with age. Less is known about the prevalence of thyroid disease in older black adults and whether an association between thyroid function and serum cholesterol level exists, as in older white adults...
  71. ncbi Correlates and prevalence of prostatitis in a large community-based cohort of older men
    Nicholas A Daniels
    Division of General Internal Medicine, Department of Medicine, University of California, School of Medicine, San Francisco, California 94115, USA
    Urology 66:964-70. 2005
    ..To describe the prevalence and correlates of self-reported history of prostatitis in terms of lower urinary tract symptoms and associated dissatisfaction in community-dwelling older men...
  72. ncbi Aspirin use for the primary prevention of coronary heart disease in older adults
    Nicolas Rodondi
    Department of Epidemiology and Biostatistics, University of California, San Francisco, Calif, USA
    Am J Med 118:1288. 2005
    ..We determined the prevalence of aspirin use in relation to coronary heart disease risk and changes over time...
  73. ncbi Factors associated with the lumbar spine and proximal femur bone mineral density in older men
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, 130 DeSoto Street, Crabtree Hall A524, Pittsburgh, PA 15261, USA
    Osteoporos Int 16:1525-37. 2005
    ..Identification of these correlates could improve methods to identify men at risk for fracture and improve our understanding of fracture etiology...
  74. ncbi Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Intern Med 165:1612-7. 2005
    ..Fracture prevention needs to target specific risk factors found in older adults with DM...
  75. ncbi Daily activity energy expenditure and mortality among older adults
    Todd M Manini
    National Institute on Aging, Laboratory of Epidemiology, Demography and Biometry, Bethesda, MD 20892, USA
    JAMA 296:171-9. 2006
    ..Exercise is associated with mortality benefits but simply expending energy through any activity in an individual's free-living environment may confer survival advantages...
  76. ncbi The metabolic syndrome is associated with circulating adipokines in older adults across a wide range of adiposity
    Tongjian You
    Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY 14214, USA
    J Gerontol A Biol Sci Med Sci 63:414-9. 2008
    ..The purpose of this study was to examine the relationship of metabolic syndrome to several adipokines and the role of total and visceral adiposity in influencing this relationship in older adults...
  77. ncbi Aspirin for the primary prevention of cardiovascular disease: a comprehensive review
    Nicolas Rodondi
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
    Compr Ther 31:186-93. 2005
    ..Physicians should assess the risks and benefits of aspirin therapy for primary prevention and incorporate patient preferences...
  78. ncbi Estrogen metabolites and the risk of breast cancer in older women
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Epidemiology 14:740-4. 2003
    ..The objective of this study was to test the hypothesis that serum concentrations of 2-hydroxyestrone (2-OHE1) and 16alpha-hydroxyestrone (16alpha-OHE1), as well as their ratio, predict the risk of breast cancer in older women...
  79. ncbi Prognostic value of usual gait speed in well-functioning older people--results from the Health, Aging and Body Composition Study
    Matteo Cesari
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, Florida 32608, USA
    J Am Geriatr Soc 53:1675-80. 2005
    ..To define clinically relevant cutpoints for usual gait speed and to investigate their predictive value for health-related events in older persons...
  80. ncbi Circulating levels of inflammatory markers and cancer risk in the health aging and body composition cohort
    Dora Il'yasova
    Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Cancer Epidemiol Biomarkers Prev 14:2413-8. 2005
    ..This study examined the relationships between circulating levels of the inflammatory markers interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-alpha) and total as well as site-specific cancer incidence...
  81. ncbi Lipid-lowering drug use and breast cancer in older women: a prospective study
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Womens Health (Larchmt) 12:749-56. 2003
    ..To test the hypothesis that use of lipid-lowering drugs reduces the risk of breast cancer in older women...

Research Grants5

  1. Biomarker Research in Musculoskeletal Disease
    Douglas Bauer; Fiscal Year: 2007
    ..Funding of this K24 will allow Dr. Bauer to reduce his clinical and administrative responsibilities, and focus his efforts on promoting and teaching patient-oriented research. ..
  2. Bone Turnover and Fracture Risk in Men
    Douglas Bauer; Fiscal Year: 2007
    ..These analyses will address critical questions about the pathogenesis of spine and non-spine fracture in men, and will determine the clinical utility of bone turnover measurements in this population. ..