Carlton M Bates
Affiliation: University of Pittsburgh
Walker K, Sims Lucas S, Bates C. Fibroblast growth factor receptor signaling in kidney and lower urinary tract development. Pediatr Nephrol. 2016;31:885-95 pubmed publisher
..Finally, many studies have shown how FGFR signaling is critical for kidney and lower urinary tract patterning in humans. ..
Di Giovanni V, Walker K, Bushnell D, Schaefer C, Sims Lucas S, Puri P, et al
. Fibroblast growth factor receptor-Frs2Î± signaling is critical for nephron progenitors. Dev Biol. 2015;400:82-93 pubmed publisher
..Thus, Fgfr1 and Fgfr2 have synergistic roles in maintaining nephron progenitors; furthermore, Fgfr signaling in nephron progenitors appears to be mediated predominantly by Frs2Î±. ..
Bebee T, Sims Lucas S, Park J, Bushnell D, Cieply B, Xing Y, et al
. Ablation of the epithelial-specific splicing factor Esrp1 results in ureteric branching defects and reduced nephron number. Dev Dyn. 2016;245:991-1000 pubmed publisher
..Developmental Dynamics 245:991-1000, 2016. © 2016 The Authors. Developmental Dynamics published by Wiley Periodicals, Inc. on behalf of American Association of Anatomists. ..
Ikeda Y, Zabbarova I, Schaefer C, Bushnell D, de Groat W, Kanai A, et al
. Fgfr2 is integral for bladder mesenchyme patterning and function. Am J Physiol Renal Physiol. 2017;312:F607-F618 pubmed publisher
..i>Fgfr2 is critical for bladder mesenchyme patterning by virtue of its role in modulation of hedgehog signaling. ..
Puri P, Schaefer C, Bushnell D, Taglienti M, Kreidberg J, Yoder B, et al
. Ectopic Phosphorylated Creb Marks Dedifferentiated Proximal Tubules in Cystic Kidney Disease. Am J Pathol. 2018;188:84-94 pubmed publisher
..Moreover, ectopic p-Creb expression/cAMP signaling marks dedifferentiated proximal tubular cystic segments. Furthermore, proximal tubules are predisposed to become cystic after cAMP stimulation. ..