Hirak S Basu

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model
    Hirak S Basu
    University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, WI 53792 5669, USA
    Cancer Res 69:7689-95. 2009
  2. doi request reprint Pretreatment with anti-oxidants sensitizes oxidatively stressed human cancer cells to growth inhibitory effect of suberoylanilide hydroxamic acid (SAHA)
    Hirak S Basu
    Wisconsin Institutes for Medical Research, University of Wisconsin Carbone Comprehensive Cancer Center, Madison, WI 53705, USA
    Cancer Chemother Pharmacol 67:705-15. 2011
  3. ncbi request reprint Cyclopropane-containing polyamine analogues are efficient growth inhibitors of a human prostate tumor xenograft in nude mice
    Benjamin Frydman
    SLIL Biomedical Corporation, 535 Science Drive, Suite C, Madison, WI 53711 1066, USA
    J Med Chem 46:4586-600. 2003
  4. doi request reprint JunD mediates androgen-induced oxidative stress in androgen dependent LNCaP human prostate cancer cells
    Farideh Mehraein-Ghomi
    University of Wisconsin Paul P Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, USA
    Prostate 68:924-34. 2008
  5. pmc Androgen receptor requires JunD as a coactivator to switch on an oxidative stress generation pathway in prostate cancer cells
    Farideh Mehraein-Ghomi
    University of Wisconsin Carbone Cancer Center and Departments of Oncology and Medicine, University of Wisconsin Madison, Madison, WI 53705, USA
    Cancer Res 70:4560-8. 2010
  6. ncbi request reprint Long-chain polyamines (oligoamines) exhibit strong cytotoxicities against human prostate cancer cells
    Aldonia Valasinas
    SLIL Biomedical Corp, 535 Science Drive, Suite C, Madison, WI 53711, USA
    Bioorg Med Chem 11:4121-31. 2003
  7. ncbi request reprint Macrocyclic polyamines deplete cellular ATP levels and inhibit cell growth in human prostate cancer cells
    Benjamin Frydman
    SLIL Biomedical Corp, 535 Science Dr, Suite C, Madison, Wisconsin 53711 1066, USA
    J Med Chem 47:1051-9. 2004
  8. ncbi request reprint Induction of AP-1 activity by androgen activation of the androgen receptor in LNCaP human prostate carcinoma cells
    Dawn R Church
    University of Wisconsin Comprehensive Cancer Center, University of Wisconsin, Madison, USA
    Prostate 63:155-68. 2005
  9. ncbi request reprint A novel polyamine analog (SL-11093) inhibits growth of human prostate tumor xenografts in nude mice
    Benjamin Frydman
    SLIL Biomedical Corporation, Suite C, 535 Science Dr, Madison, WI 53711 1066, USA
    Cancer Chemother Pharmacol 51:488-92. 2003

Research Grants

Collaborators

  • GEORGE A WILDING
  • Benjamin J Frydman
  • Farideh Mehraein-Ghomi
  • Dawn R Church
  • Elyse Lee
  • Todd A Thompson
  • Aldonia Valasinas
  • F Michael Hoffmann
  • Eric A Ariazi
  • Maureen O Ripple
  • Venodhar K Reddy
  • Subhra Bhattacharya
  • Andrei V Blokhin
  • Laurence J Marton
  • Aparajita Sarkar

Detail Information

Publications9

  1. pmc A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model
    Hirak S Basu
    University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, WI 53792 5669, USA
    Cancer Res 69:7689-95. 2009
    ..These data show that polyamine oxidation is not only a major pathway for ROS production in prostate, but inhibiting this pathway also successfully delays CaP progression...
  2. doi request reprint Pretreatment with anti-oxidants sensitizes oxidatively stressed human cancer cells to growth inhibitory effect of suberoylanilide hydroxamic acid (SAHA)
    Hirak S Basu
    Wisconsin Institutes for Medical Research, University of Wisconsin Carbone Comprehensive Cancer Center, Madison, WI 53705, USA
    Cancer Chemother Pharmacol 67:705-15. 2011
    ..We have examined whether the high oxidative stress in these cells causes a loss of SAHA activity and if so, whether pretreatment with an anti-oxidant can sensitize these cells to SAHA...
  3. ncbi request reprint Cyclopropane-containing polyamine analogues are efficient growth inhibitors of a human prostate tumor xenograft in nude mice
    Benjamin Frydman
    SLIL Biomedical Corporation, 535 Science Drive, Suite C, Madison, WI 53711 1066, USA
    J Med Chem 46:4586-600. 2003
    ..In liver and kidney, the deethyl metabolites of 10 accumulated over a 96 h period after cessation of dosing...
  4. doi request reprint JunD mediates androgen-induced oxidative stress in androgen dependent LNCaP human prostate cancer cells
    Farideh Mehraein-Ghomi
    University of Wisconsin Paul P Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, USA
    Prostate 68:924-34. 2008
    ..We previously reported that androgen-androgen receptor induced ROS production in androgen-dependent LNCaP human prostate cancer cells is associated with increased JunD level/AP-1 transcriptional activity...
  5. pmc Androgen receptor requires JunD as a coactivator to switch on an oxidative stress generation pathway in prostate cancer cells
    Farideh Mehraein-Ghomi
    University of Wisconsin Carbone Cancer Center and Departments of Oncology and Medicine, University of Wisconsin Madison, Madison, WI 53705, USA
    Cancer Res 70:4560-8. 2010
    ....
  6. ncbi request reprint Long-chain polyamines (oligoamines) exhibit strong cytotoxicities against human prostate cancer cells
    Aldonia Valasinas
    SLIL Biomedical Corp, 535 Science Drive, Suite C, Madison, WI 53711, USA
    Bioorg Med Chem 11:4121-31. 2003
    ..Interestingly, all 10 oligoamines were efficient DNA aggregators in a cell-free system and their cytotoxicities generally parallel their capacities to aggregate DNA...
  7. ncbi request reprint Macrocyclic polyamines deplete cellular ATP levels and inhibit cell growth in human prostate cancer cells
    Benjamin Frydman
    SLIL Biomedical Corp, 535 Science Dr, Suite C, Madison, Wisconsin 53711 1066, USA
    J Med Chem 47:1051-9. 2004
    ..As ATP is a scarce metabolite in cancer cells, where it can only be replenished through the very ATP-inefficient glycolytic pathway; macrocyclic polyamines appear to be promising new anticancer agents...
  8. ncbi request reprint Induction of AP-1 activity by androgen activation of the androgen receptor in LNCaP human prostate carcinoma cells
    Dawn R Church
    University of Wisconsin Comprehensive Cancer Center, University of Wisconsin, Madison, USA
    Prostate 63:155-68. 2005
    ..Effects of androgen-activated androgen receptor on AP-1 activity were determined in the LNCaP human prostate carcinoma cell model...
  9. ncbi request reprint A novel polyamine analog (SL-11093) inhibits growth of human prostate tumor xenografts in nude mice
    Benjamin Frydman
    SLIL Biomedical Corporation, Suite C, 535 Science Dr, Madison, WI 53711 1066, USA
    Cancer Chemother Pharmacol 51:488-92. 2003
    ..We tested the polyamine analog SL-11093 (3,8,13,18-tetraaza-10,11-[(E)-1,2-cyclopropyl]eicosane tetrahydrochloride) as an effective chemotherapeutic agent against human prostate cancer grown in nude mice...

Research Grants2