Alakananda Basu

Summary

Affiliation: University of North Texas
Country: USA

Publications

  1. ncbi request reprint Differential sensitivity of breast cancer cells to tumor necrosis factor-alpha: involvement of protein kinase C
    A Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Biochem Biophys Res Commun 280:883-91. 2001
  2. ncbi request reprint Activation of ERK during DNA damage-induced apoptosis involves protein kinase Cdelta
    Alakananda Basu
    Department of Molecular Biology and Immunology, Institute for Cancer Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Biochem Biophys Res Commun 334:1068-73. 2005
  3. doi request reprint Down-regulation of caspase-2 by rottlerin via protein kinase C-delta-independent pathway
    Alakananda Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Cancer Res 68:2795-802. 2008
  4. pmc Protein kinase Cepsilon makes the life and death decision
    Alakananda Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Cell Signal 19:1633-42. 2007
  5. ncbi request reprint Involvement of protein kinase C-delta in DNA damage-induced apoptosis
    Alakananda Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Cell Mol Med 7:341-50. 2003
  6. pmc Regulation of protein kinase C delta downregulation by protein kinase C epsilon and mammalian target of rapamycin complex 2
    Alakananda Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Cell Signal 21:1680-5. 2009
  7. ncbi request reprint Differential regulation of extrinsic and intrinsic cell death pathways by protein kinase C
    Alakananda Basu
    Department of Molecular Biology and Immunology and Institute for Cancer Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Int J Mol Med 10:541-5. 2002
  8. ncbi request reprint Proteolytic activation of protein kinase C-epsilon by caspase-mediated processing and transduction of antiapoptotic signals
    Alakananda Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth 76107, USA
    J Biol Chem 277:41850-6. 2002
  9. ncbi request reprint Potentiation of tumor necrosis factor-alpha-induced cell death by rottlerin through a cytochrome-C-independent pathway
    Alakananda Basu
    Dept of Molecular Biology and Immunology, University of North Texas Health Science Center, 5300 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Exp Cell Res 278:209-14. 2002
  10. ncbi request reprint Involvement of protein kinase C-delta in DNA damage-induced apoptosis
    A Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Cell Death Differ 8:899-908. 2001

Research Grants

  1. Tumor Necrosis Factor-Alpha Signaling in Breast Cancer
    Alakananda Basu; Fiscal Year: 2009
  2. Tumor Necrosis Factor-Alpha Signaling in Breast Cancer
    Alakananda Basu; Fiscal Year: 2007
  3. Tumor Necrosis Factor-Alpha Signaling in Breast Cancer
    Alakananda Basu; Fiscal Year: 2007
  4. Tumor Necrosis Factor-Alpha Signaling in Breast Cancer
    Alakananda Basu; Fiscal Year: 2006
  5. Tumor Necrosis Factor-Alpha Signaling in Breast Cancer
    Alakananda Basu; Fiscal Year: 2005
  6. Tumor Necrosis Factor-Alpha Signaling in Breast Cancer
    Alakananda Basu; Fiscal Year: 2004
  7. SIGNAL TRANSDUCTION AND CELL DEATH REGULATION
    Alakananda Basu; Fiscal Year: 2004
  8. SIGNAL TRANSDUCTION AND CELL DEATH REGULATION
    Alakananda Basu; Fiscal Year: 2003
  9. SIGNAL TRANSDUCTION AND CELL DEATH REGULATION
    Alakananda Basu; Fiscal Year: 2002
  10. SIGNAL TRANSDUCTION AND CELL DEATH REGULATION
    Alakananda Basu; Fiscal Year: 2001

Collaborators

  • Sanjay Awasthi
  • Daniel Johnson
  • Deepanwita Pal
  • Jie Huang
  • Dongmei Lu
  • Eswar Shankar
  • Rohini Dhar
  • U Sivaprasad
  • Soumya Krishnamurthy
  • Shalini D Persaud
  • Archana Sehrawat
  • Shalini Persaud Outram
  • Sanghamitra Mohanty
  • Savitha Sridharan
  • Wolfram Siede
  • Dilip Jain
  • Swarajit Kumar Biswas
  • Cassie L Johnson
  • Yogesh C Awasthi
  • Charles Warden
  • Sushma Yadav
  • Melanie Shelton
  • Rajiv Paranandi
  • Brett Adkins
  • Chandreyi Basu
  • Nila Patel
  • Rouel Roque
  • Joe R Mireles
  • Usha Sivaprasad
  • Shavonda Morrow
  • E Shankar
  • Van Hoang
  • Shalini Persaud

Detail Information

Publications34

  1. ncbi request reprint Differential sensitivity of breast cancer cells to tumor necrosis factor-alpha: involvement of protein kinase C
    A Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Biochem Biophys Res Commun 280:883-91. 2001
    ..These results suggest that proteolytic cleavage of PKC epsilon may be associated with PKC inhibitor mediated sensitization of breast cancer cells to TNF...
  2. ncbi request reprint Activation of ERK during DNA damage-induced apoptosis involves protein kinase Cdelta
    Alakananda Basu
    Department of Molecular Biology and Immunology, Institute for Cancer Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Biochem Biophys Res Commun 334:1068-73. 2005
    ..Inhibition of PKCdelta by rottlerin or depletion of PKCdelta by siRNA inhibited cisplatin-induced ERK activation. These results suggest that cisplatin-induced DNA damage results in activation of ERK1/2 via PKCdelta...
  3. doi request reprint Down-regulation of caspase-2 by rottlerin via protein kinase C-delta-independent pathway
    Alakananda Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Cancer Res 68:2795-802. 2008
    ..Furthermore, down-regulation of caspase-2 by rottlerin can explain its antiapoptotic function during DNA damage-induced apoptosis...
  4. pmc Protein kinase Cepsilon makes the life and death decision
    Alakananda Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Cell Signal 19:1633-42. 2007
    ..We have also discussed how PKCepsilon mediates its antiapoptotic signal by altering the level or function of pro- and antiapoptotic Bcl-2 family members...
  5. ncbi request reprint Involvement of protein kinase C-delta in DNA damage-induced apoptosis
    Alakananda Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Cell Mol Med 7:341-50. 2003
    ..Both activation and intracellular distribution of PKCdelta may have significant impact on apoptosis. This review intends to assimilate recent views regarding the involvement of PKCdelta in DNA damage-induced apoptosis...
  6. pmc Regulation of protein kinase C delta downregulation by protein kinase C epsilon and mammalian target of rapamycin complex 2
    Alakananda Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Cell Signal 21:1680-5. 2009
    ..Depletion of PKC epsilon also enhanced PKC delta downregulation by PDBu. These results suggest that downregulation of PKC delta is regulated by PKC epsilon and mammalian target of rapamycin complex 2 (mTORC2)...
  7. ncbi request reprint Differential regulation of extrinsic and intrinsic cell death pathways by protein kinase C
    Alakananda Basu
    Department of Molecular Biology and Immunology and Institute for Cancer Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Int J Mol Med 10:541-5. 2002
    ..These results suggest that PKC acts at distinct steps to regulate receptor-mediated and DNA damage-induced apoptosis...
  8. ncbi request reprint Proteolytic activation of protein kinase C-epsilon by caspase-mediated processing and transduction of antiapoptotic signals
    Alakananda Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth 76107, USA
    J Biol Chem 277:41850-6. 2002
    ..These results suggest that cleavage of PKCepsilon by caspase-7 at the SSPD downward arrow G site results in the activation of PKCepsilon. Furthermore, activation of PKCepsilon was associated with its antiapoptotic function...
  9. ncbi request reprint Potentiation of tumor necrosis factor-alpha-induced cell death by rottlerin through a cytochrome-C-independent pathway
    Alakananda Basu
    Dept of Molecular Biology and Immunology, University of North Texas Health Science Center, 5300 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Exp Cell Res 278:209-14. 2002
    ..These results suggest that rottlerin activates a cytochrome-c-independent cell death pathway to potentiate cell death by TNF...
  10. ncbi request reprint Involvement of protein kinase C-delta in DNA damage-induced apoptosis
    A Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Cell Death Differ 8:899-908. 2001
    ..Thus, the PKCdelta inhibitor acts at an early stage of the cDDP-induced cell death pathway that precedes caspase activation...
  11. ncbi request reprint Enhancement of cisplatin sensitivity of cisplatin-resistant human cervical carcinoma cells by bryostatin 1
    Sanghamitra Mohanty
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Clin Cancer Res 11:6730-7. 2005
    ..We have investigated how bryostatin 1 influences PKCdelta regulation in cisplatin-resistant HeLa (HeLa/CP) cells, and if bryostatin 1 could be used to reverse cisplatin resistance...
  12. ncbi request reprint Down-regulation of Bcl-2 is associated with cisplatin resistance in human small cell lung cancer H69 cells
    Swarajit Kumar Biswas
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX, USA
    Mol Cancer Ther 3:327-34. 2004
    ..These results suggest that the acquisition of cisplatin resistance by H69 cells was not due to an increase in the level/phosphorylation status of the anti-apoptotic protein Bcl-2...
  13. ncbi request reprint Involvement of proteolytic activation of PKCdelta in cisplatin-induced apoptosis in human small cell lung cancer H69 cells
    Shalini D Persaud
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, 76107, USA
    Int J Oncol 27:149-54. 2005
    ..These results suggest that the proteolytic fragment of PKCdelta does not play a critical role in the induction of apoptosis in H69 cells...
  14. pmc Upregulation of PKCη by PKCε and PDK1 involves two distinct mechanisms and promotes breast cancer cell survival
    Deepanwita Pal
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Biochim Biophys Acta 1830:4040-5. 2013
    ..We recently showed that these activators induced selective upregulation of PKCη in breast cancer cells. The objective of this study is to understand unique regulation of PKCη and its importance in breast cancer...
  15. doi request reprint Enhancement of cisplatin sensitivity by NSC109268 in budding yeast and human cancer cells is associated with inhibition of S-phase progression
    Dilip Jain
    Department of Cell Biology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA
    Cancer Chemother Pharmacol 66:945-52. 2010
    ..We explored if similar effects could be found in human cancer cells and if cell cycle analysis could hint at the underlying molecular mechanism...
  16. ncbi request reprint Constitutive activation of p70 S6 kinase is associated with intrinsic resistance to cisplatin
    Rohini Dhar
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center and Institute for Cancer Research, Fort Worth, TX 76107, USA
    Int J Oncol 32:1133-7. 2008
    ....
  17. ncbi request reprint Cisplatin resistance is associated with deregulation in protein kinase C-delta
    Jie Huang
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Biochem Biophys Res Commun 316:1002-8. 2004
    ..The ability of PDBu to enhance cisplatin-induced cell death was attenuated in cisplatin-resistant HeLa cells. Thus, a deregulation in PKCdelta was associated with reduced cellular sensitivity to cisplatin...
  18. pmc Proteolytic cleavage of p70 ribosomal S6 kinase by caspase-3 during DNA damage-induced apoptosis
    Rohini Dhar
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Biochemistry 48:1474-80. 2009
    ..These results suggest that p70S6K is a novel substrate for caspase-3 and that the proteolytic cleavage of p70S6K is important for cisplatin-induced apoptosis...
  19. ncbi request reprint Protein kinase Cepsilon activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-alpha-induced cell death
    Dongmei Lu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Biol Chem 281:22799-807. 2006
    ..These results suggest that PKCepsilon activates Akt via DNA-PK to mediate its antiapoptotic function. Furthermore, we report for the first time that DNA-PK can regulate receptor-initiated apoptosis via Akt...
  20. ncbi request reprint Protein kinase C-epsilon protects MCF-7 cells from TNF-mediated cell death by inhibiting Bax translocation
    Dongmei Lu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Apoptosis 12:1893-900. 2007
    ..PKCepsilon was coimmunoprecipitated with Bax in MCF-7 cells. These results suggest that PKCepsilon mediates its antiapoptotic effect partly by preventing activation and translocation of Bax to the mitochondria...
  21. ncbi request reprint Deregulation of PKB influences antiapoptotic signaling by PKC in breast cancer cells
    Dongmei Lu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Int J Oncol 25:671-6. 2004
    ..In contrast, Ly294002 either alone or in combination with TNF had little effect on cell death in MDA-MB-231 cells. These results suggest that the status of PKB in breast cancer cells influences antiapoptotic signaling by PKC...
  22. ncbi request reprint Regulation of p53 stabilization by DNA damage and protein kinase C
    Cassie L Johnson
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Institute for Cancer Research, Fort Worth, Texas 76107, USA
    Mol Cancer Ther 1:861-7. 2002
    ..Furthermore, an increase in p53 was not associated with enhanced sensitivity of HeLa cells to CP...
  23. ncbi request reprint PKCepsilon induces Bcl-2 by activating CREB
    Eswar Shankar
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center and Institute for Cancer Research, Fort Worth, TX 76107, USA
    Int J Oncol 36:883-8. 2010
    ..In addition, knockdown of CREB sensitized MDA-MB-231 cells to TRAIL-mediated cell death. These results suggest that PKCepsilon regulates Bcl-2 induction through activation of the transcription factor CREB...
  24. pmc Novel regulation of protein kinase C-η
    Deepanwita Pal
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Biochem Biophys Res Commun 425:836-41. 2012
    ..Knockdown of PKCε but not PKCα inhibited PKC activator-induced upregulation of PKCη. Thus, our results suggest that the regulation of PKCη is unique and PKCε is required for the PKC activator-induced upregulation of PKCη...
  25. doi request reprint Manipulation of PKC isozymes by RNA interference and inducible expression of PKC constructs
    Alakananda Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, USA
    Methods Enzymol 446:141-57. 2008
    ..In this chapter, we describe the use of RNA interference (siRNA) technology and tetracycline-inducible expression of PKC isozymes to study their function in apoptosis...
  26. pmc S6 kinase 2 promotes breast cancer cell survival via Akt
    Savitha Sridharan
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, USA
    Cancer Res 71:2590-9. 2011
    ..Taken together, our study shows that the two homologues of S6K have distinct effects on Akt activation and cell survival. Thus, targeting S6K2 may be an effective therapeutic strategy to treat cancers...
  27. pmc NSC109268 potentiates cisplatin-induced cell death in a p53-independent manner
    Eswar Shankar
    Department of Molecular Biology and Immunology, University of North Texas, Health Science Center, Fort Worth, Texas, USA
    J Mol Signal 5:4. 2010
    ..During a yeast-based drug screening, NSC109268 was identified to enhance cellular sensitivity to cisplatin. The objective of the present study is to determine if p53 is responsible for cisplatin sensitization by NSC109268...
  28. doi request reprint Two faces of protein kinase Cδ: the contrasting roles of PKCδ in cell survival and cell death
    Alakananda Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center and Institute for Cancer Research, Fort Worth, TX, USA
    ScientificWorldJournal 10:2272-84. 2010
    ..This review discusses the current literature on the contrasting roles of PKCδ in cell survival and cell death...
  29. doi request reprint Inhibition of ERK attenuates autophagy and potentiates tumour necrosis factor-alpha-induced cell death in MCF-7 cells
    U Sivaprasad
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    J Cell Mol Med 12:1265-71. 2008
    ..These data suggest that TNF-induces autophagy through ERK1/2 and that inhibition of autophagy increases cellular sensitivity to TNF...
  30. ncbi request reprint Downregulation of Bid is associated with PKCepsilon-mediated TRAIL resistance
    U Sivaprasad
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Cell Death Differ 14:851-60. 2007
    ..Thus, our results suggest that PKCepsilon acts upstream of mitochondria and mediates TRAIL resistance via both Bcl-2 and Bid in MCF-7 cells...
  31. ncbi request reprint The unique protein kinase Cη: Implications for breast cancer (Review)
    Deepanwita Pal
    Department of Molecular and Medical Genetics, University of North Texas Health Science Center and Institute for Cancer Research, Fort Worth, TX 76107, USA
    Int J Oncol 45:493-8. 2014
    ..We have also discussed the functional implications of PKCη in cancer with particular emphasis on breast cancer. ..
  32. pmc P300 regulates the human RLIP76 promoter activity and gene expression
    Archana Sehrawat
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Biochem Pharmacol 85:1203-11. 2013
    ..Thus, we report for the first time that p300 associates with the RLIP76 promoter via an overlapping cMYB and cETS binding site and regulates RLIP76 promoter activity and its expression...
  33. pmc Regulation of IKKε Expression by Akt2 Isoform
    Soumya Krishnamurthy
    University of North Texas Health Science Center, Fort Worth, TX, USA
    Genes Cancer 2:1044-50. 2011
    ..Taken together, these results demonstrate for the first time that IKKε functions downstream of Akt2 to promote breast cancer cell survival...

Research Grants14

  1. Tumor Necrosis Factor-Alpha Signaling in Breast Cancer
    Alakananda Basu; Fiscal Year: 2009
    ..The long-term objective is to develop strategies to intervene with these pathways to inhibit progression of breast cancer. ..
  2. Tumor Necrosis Factor-Alpha Signaling in Breast Cancer
    Alakananda Basu; Fiscal Year: 2007
    ..abstract_text> ..
  3. Tumor Necrosis Factor-Alpha Signaling in Breast Cancer
    Alakananda Basu; Fiscal Year: 2007
    ..The long-term objective is to develop strategies to intervene with these pathways to inhibit progression of breast cancer. ..
  4. Tumor Necrosis Factor-Alpha Signaling in Breast Cancer
    Alakananda Basu; Fiscal Year: 2006
    ..The long-term objective is to develop strategies to intervene with these pathways to inhibit progression of breast cancer. ..
  5. Tumor Necrosis Factor-Alpha Signaling in Breast Cancer
    Alakananda Basu; Fiscal Year: 2005
    ..The long-term objective is to develop strategies to intervene with these pathways to inhibit progression of breast cancer. ..
  6. Tumor Necrosis Factor-Alpha Signaling in Breast Cancer
    Alakananda Basu; Fiscal Year: 2004
    ..The long-term objective is to develop strategies to intervene with these pathways to inhibit progression of breast cancer. ..
  7. SIGNAL TRANSDUCTION AND CELL DEATH REGULATION
    Alakananda Basu; Fiscal Year: 2004
    ....
  8. SIGNAL TRANSDUCTION AND CELL DEATH REGULATION
    Alakananda Basu; Fiscal Year: 2003
    ....
  9. SIGNAL TRANSDUCTION AND CELL DEATH REGULATION
    Alakananda Basu; Fiscal Year: 2002
    ....
  10. SIGNAL TRANSDUCTION AND CELL DEATH REGULATION
    Alakananda Basu; Fiscal Year: 2001
    ....
  11. TUMOR NECROSIS FACTOR ALPHA SIGNALING IN BREAST CANCER
    Alakananda Basu; Fiscal Year: 1999
    ....