Boris Bastian

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma
    B C Bastian
    Cancer Genetics Program, Cancer Center, University of California San Francisco, 94143 0808, USA
    J Invest Dermatol 113:1065-9. 1999
  2. ncbi request reprint Molecular genetics of melanocytic neoplasia: practical applications for diagnosis
    Boris C Bastian
    Department of Dermatology, University of California, San Francisco, CA 94143, USA
    Pathology 36:458-61. 2004
  3. pmc Classifying melanocytic tumors based on DNA copy number changes
    Boris C Bastian
    Departments of Pathology and Dermatology, Dermatopathology Section, University of California San Francisco, San Francisco, CA 94143 0808, USA
    Am J Pathol 163:1765-70. 2003
  4. ncbi request reprint Understanding the progression of melanocytic neoplasia using genomic analysis: from fields to cancer
    Boris C Bastian
    Departments of Dermatology and Pathology, UCSF Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94115, USA
    Oncogene 22:3081-6. 2003
  5. ncbi request reprint The longer your telomeres, the larger your nevus?
    Boris C Bastian
    Department of Dermatology, University of California, San Francisco, 94115, USA
    Am J Dermatopathol 25:83-4. 2003
  6. pmc Genetic changes in neoplasms arising in congenital melanocytic nevi: differences between nodular proliferations and melanomas
    Boris C Bastian
    Department of Dermatology and Pathology, University of California at San Francisco Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143 0808, USA
    Am J Pathol 161:1163-9. 2002
  7. ncbi request reprint Gene amplifications characterize acral melanoma and permit the detection of occult tumor cells in the surrounding skin
    B C Bastian
    Cancer Center, Department of Pathology, University of California San Francisco, 94143 0808, USA
    Cancer Res 60:1968-73. 2000
  8. pmc Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features
    B C Bastian
    Departments of Dermatology and Pathology and UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143 0808, USA
    Am J Pathol 157:967-72. 2000
  9. ncbi request reprint Genomic analysis of melanocytic neoplasia
    Jurgen Bauer
    University of California at San Francisco Comprehensive Cancer Center, San Francisco, California, USA
    Adv Dermatol 21:81-99. 2005
  10. ncbi request reprint Distinguishing melanocytic nevi from melanoma by DNA copy number changes: comparative genomic hybridization as a research and diagnostic tool
    Jurgen Bauer
    Departments of Dermatology and Pathology, UCSF Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94143 0808, USA
    Dermatol Ther 19:40-9. 2006

Research Grants

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma
    B C Bastian
    Cancer Genetics Program, Cancer Center, University of California San Francisco, 94143 0808, USA
    J Invest Dermatol 113:1065-9. 1999
    ....
  2. ncbi request reprint Molecular genetics of melanocytic neoplasia: practical applications for diagnosis
    Boris C Bastian
    Department of Dermatology, University of California, San Francisco, CA 94143, USA
    Pathology 36:458-61. 2004
    ..This article reviews recent molecular studies that have revealed differences in the pattern of chromosomal aberrations between naevi and melanoma that could become relevant as adjunctive diagnostic methods in the future...
  3. pmc Classifying melanocytic tumors based on DNA copy number changes
    Boris C Bastian
    Departments of Pathology and Dermatology, Dermatopathology Section, University of California San Francisco, San Francisco, CA 94143 0808, USA
    Am J Pathol 163:1765-70. 2003
    ..In addition, we show marked differences in the genetic make-up of melanomas that depend on anatomical location and sun-exposure pattern indicating that potential therapeutic targets might vary among melanoma types...
  4. ncbi request reprint Understanding the progression of melanocytic neoplasia using genomic analysis: from fields to cancer
    Boris C Bastian
    Departments of Dermatology and Pathology, UCSF Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94115, USA
    Oncogene 22:3081-6. 2003
    ..Genomic analysis is a powerful tool to obtain insight in the progression of melanocytic neoplasms with potential clinical applications for classification and detection of minimal residual melanoma...
  5. ncbi request reprint The longer your telomeres, the larger your nevus?
    Boris C Bastian
    Department of Dermatology, University of California, San Francisco, 94115, USA
    Am J Dermatopathol 25:83-4. 2003
  6. pmc Genetic changes in neoplasms arising in congenital melanocytic nevi: differences between nodular proliferations and melanomas
    Boris C Bastian
    Department of Dermatology and Pathology, University of California at San Francisco Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143 0808, USA
    Am J Pathol 161:1163-9. 2002
    ..This difference compared to the aberration pattern found in melanoma might explain their more benign clinical behavior and may be of diagnostic value in ambiguous cases...
  7. ncbi request reprint Gene amplifications characterize acral melanoma and permit the detection of occult tumor cells in the surrounding skin
    B C Bastian
    Cancer Center, Department of Pathology, University of California San Francisco, 94143 0808, USA
    Cancer Res 60:1968-73. 2000
    ....
  8. pmc Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features
    B C Bastian
    Departments of Dermatology and Pathology and UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143 0808, USA
    Am J Pathol 157:967-72. 2000
    ..Although there is no data suggesting that Spitz nevi with HRAS activation are at risk for progression to melanoma, future studies are warranted to assess their biological behavior more accurately...
  9. ncbi request reprint Genomic analysis of melanocytic neoplasia
    Jurgen Bauer
    University of California at San Francisco Comprehensive Cancer Center, San Francisco, California, USA
    Adv Dermatol 21:81-99. 2005
  10. ncbi request reprint Distinguishing melanocytic nevi from melanoma by DNA copy number changes: comparative genomic hybridization as a research and diagnostic tool
    Jurgen Bauer
    Departments of Dermatology and Pathology, UCSF Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94143 0808, USA
    Dermatol Ther 19:40-9. 2006
    ..In addition to potential diagnostic applications, detailed analyses of recurrent aberrations can lead to the identification of genes relevant in melanocytic neoplasia...
  11. pmc Use of fluorescence in situ hybridization (FISH) to distinguish intranodal nevus from metastatic melanoma
    Scott R Dalton
    Department of Pathology, Wilford Hall Medical Center, Lackland AFB, TX, USA
    Am J Surg Pathol 34:231-7. 2010
    ..Our data indicate that FISH is a useful adjunct tool to traditional methods in the diagnostic workup of deposits of melanocytes in lymph nodes that are histopathologically ambiguous...
  12. pmc Improving melanoma classification by integrating genetic and morphologic features
    Amaya Viros
    Department of Dermatology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Med 5:e120. 2008
    ....
  13. ncbi request reprint Persistent (recurrent) Spitz nevi: a histopathologic, immunohistochemical, and molecular pathologic study of 22 cases
    Jeff D Harvell
    Department of Pathology, Stanford University Medical Center, Stanford, California, USA
    Am J Surg Pathol 26:654-61. 2002
    ..Although ancillary molecular techniques such as CGH are of great help in distinguishing these from melanoma, until such techniques become widely available we advocate complete but conservative excision of any recurrent Spitz nevus...
  14. pmc Mechanisms of cell-cycle arrest in Spitz nevi with constitutive activation of the MAP-kinase pathway
    Janet L Maldonado
    Department of Dermatology, University of California, San Francisco, California 94143, USA
    Am J Pathol 164:1783-7. 2004
    ..We propose that in benign nevi with constitutive activation of the MAP-kinase pathway, p16 functions as an essential mediator of oncogene-induced senescence preventing progression to melanoma...
  15. ncbi request reprint Distinct sets of genetic alterations in melanoma
    John A Curtin
    Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143 0808, USA
    N Engl J Med 353:2135-47. 2005
    ..We hypothesized that the clinical heterogeneity is explained by genetically distinct types of melanoma with different susceptibility to ultraviolet light...
  16. ncbi request reprint Fluorescence in situ hybridization (FISH) as an ancillary diagnostic tool in the diagnosis of melanoma
    Pedram Gerami
    Department of Dermatology and the Lurie Cancer Center, Northwestern University, The Feinberg School of Medicine University of California, San Francisco, CA, USA
    Am J Surg Pathol 33:1146-56. 2009
    ..As a diagnostic aid to traditional histologic evaluation, this assay can have significant clinical impact and improve classification of melanocytic neoplasms with conflicting morphologic criteria...
  17. ncbi request reprint Cyclin D1 is a candidate oncogene in cutaneous melanoma
    Edward R Sauter
    Department of Dermatology, University of California San Francisco, San Francisco, CA 94143, USA
    Cancer Res 62:3200-6. 2002
    ..However, it did not alter the growth of normal melanocytes. Together, these results suggest that CD1 may be an oncogene in melanoma and that targeting its expression may be therapeutically beneficial...
  18. ncbi request reprint Somatic activation of KIT in distinct subtypes of melanoma
    John A Curtin
    Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143 0808, USA
    J Clin Oncol 24:4340-6. 2006
    ..This raises the question of whether other aberrations are occurring in the MAP kinase cascade in the melanoma types with infrequent mutations of BRAF and NRAS...
  19. ncbi request reprint Genomic analysis of blue nevi and related dermal melanocytic proliferations
    John C Maize
    Department of Dermatology, Medical University of South Carolina, Charleston, SC, USA
    Am J Surg Pathol 29:1214-20. 2005
    ..Ambiguous lesions can be separated into lesions with and without chromosomal aberrations. Future studies with clinical follow-up are necessary to determine which aberrations are most informative for classification of these lesions...
  20. ncbi request reprint Molecular cytogenetics as a diagnostic tool for typing melanocytic tumors
    Boris C Bastian
    Comprehensive Cancer Center and Department of Dermatology and Pathology, University of California, San Francisco 94115, USA
    Recent Results Cancer Res 160:92-9. 2002
    ..As this aberration has not been observed in melanomas, the measurement of chromosomal aberrations should be further evaluated as a diagnostic tool for ambiguous melanocytic tumors...
  21. ncbi request reprint Atypical junctional melanocytic proliferations in benign lichenoid keratosis
    Scott R Dalton
    Department of Pathology, Brooke Army Medical Center, Fort Sam Houston, Texas, USA
    Hum Pathol 34:706-9. 2003
    ..Pathologists should approach a diagnosis of BLK cautiously in the setting of severely sun-damaged skin...
  22. pmc The prevalence and prognostic value of BRAF mutation in thyroid cancer
    Electron Kebebew
    Department of Surgery, University of California, San Francisco, San Francisco, California 94143 1674, USA
    Ann Surg 246:466-70; discussion 470-1. 2007
    ..To examine the prevalence of BRAF mutation among thyroid cancer histologic subtypes and determine the association of BRAF mutation with indicators of poor prognosis for papillary thyroid cancer and patient outcome...
  23. ncbi request reprint Determinants of BRAF mutations in primary melanomas
    Janet L Maldonado
    Department of Dermatology, University of California, San Francisco, San Francisco, CA 94115, USA
    J Natl Cancer Inst 95:1878-90. 2003
    ..The high mutation frequency in melanomas arising on intermittently sun-exposed skin suggests a complex causative role of such exposure that mandates further evaluation...
  24. pmc Distribution and significance of occult intraepidermal tumor cells surrounding primary melanoma
    Jeffrey P North
    UCSF School of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 128:2024-30. 2008
    ..These field cells provide a plausible explanation for the tendency of certain melanoma types to recur locally despite apparently having undergone complete excision...
  25. pmc KIT as a therapeutic target in melanoma
    Maria C Garrido
    Department of Dermatology and UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
    J Invest Dermatol 130:20-7. 2010
    ....
  26. pmc Lack of somatic alterations of MC1R in primary melanoma
    R D Kim
    Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA, USA
    Pigment Cell Melanoma Res 21:579-82. 2008
    ..In conclusion, our findings indicate that MC1R is not a frequent target of somatic alterations in melanoma...
  27. doi request reprint Frequent p16-independent inactivation of p14ARF in human melanoma
    Daniel E Freedberg
    Department of Dermatology, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    J Natl Cancer Inst 100:784-95. 2008
    ....
  28. pmc Elevated cutaneous Smad activation associates with enhanced skin tumor susceptibility in organ transplant recipients
    Kelly A Harradine
    UCSF Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA
    Clin Cancer Res 15:5101-7. 2009
    ..This study investigates whether TGF-beta signaling is elevated in transplant patients...
  29. ncbi request reprint Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations
    Jurgen Bauer
    Department of Dermatology, University of California at San Francisco, San Francisco, California, USA
    J Invest Dermatol 127:179-82. 2007
    ..The results are consistent with the finding in melanoma that BRAF mutations are uncommon in neoplasms that develop in the absence of sun-exposure...
  30. ncbi request reprint Hypothesis: a role for telomere crisis in spontaneous regression of melanoma
    Boris C Bastian
    Arch Dermatol 139:667-8. 2003
  31. ncbi request reprint PI3-kinase subunits are infrequent somatic targets in melanoma
    John A Curtin
    J Invest Dermatol 126:1660-3. 2006
  32. pmc MC1R variants increase risk of melanomas harboring BRAF mutations
    Maria Concetta Fargnoli
    Department of Dermatology, University of L Aquila, L Aquila, Italy
    J Invest Dermatol 128:2485-90. 2008
    ..This study confirms that the known MC1R-melanoma risk association is confined to subjects whose melanomas harbor BRAF mutations...
  33. ncbi request reprint Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway
    Christophe Denoyelle
    Department of Dermatology and Comprehensive Cancer Center, University of Michigan, 1500E Medical Center Drive, 4217 CCGC, Ann Arbor, MI 48109, USA
    Nat Cell Biol 8:1053-63. 2006
    ..These results argue against premature senescence as a converging mechanism of response to activating oncogenes and support a direct role of the ER as a gatekeeper of tumour control...
  34. pmc Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development
    Veronique Delmas
    Developmental Genetics of Melanocytes, UMR 146, Centre National de Recherche Scientifique Institut Curie, 91405 Orsay Cedex, France
    Genes Dev 21:2923-35. 2007
    ..The results reveal that synergy between the Wnt and mitogen-activated protein (MAP) kinase pathways may represent an important mechanism underpinning the genesis of melanoma, a highly aggressive and increasingly common disease...
  35. pmc Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice
    Mingjian James You
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:1455-60. 2002
    ..This study provides genetic evidence of collaboration between Pten and Ink4a/Arf in constraining the growth and oncogenic transformation of cultured cells and in suppressing a wide spectrum of tumors in vivo...
  36. ncbi request reprint Two cases of unusual acral melanocytic tumors: illustration of molecular cytogenetics as a diagnostic tool
    Minoru Takata
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Takara machi, Kanazawa, Japan
    Hum Pathol 34:89-92. 2003
    ..5 years of follow-up, whereas case 2 developed lymph node metastasis. We conclude that molecular techniques such as CGH can be of diagnostic help in the classification of histologically ambiguous lesions...
  37. ncbi request reprint Establishment of a novel melanoma cell line SMYM-PRGP showing cytogenetic and biological characteristics of the radial growth phase of acral melanomas
    Hiroshi Murata
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Cancer Sci 98:958-63. 2007
    ..SMYM-PRGP is an excellent tool for investigating the development and progression of acral melanoma...
  38. ncbi request reprint Consumption of the epidermis: a diagnostic criterion for the differential diagnosis of melanoma and Spitz nevus
    Markus Hantschke
    Dermatopathologische Gemeinschaftspraxis, Friedrichshafen, Germany
    Am J Surg Pathol 28:1621-5. 2004
    ..Future studies are required to analyze the prognostic value of COE itself...
  39. doi request reprint Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation
    Jose Lutzky
    Pigment Cell Melanoma Res 21:492-3. 2008
  40. ncbi request reprint A full-coverage, high-resolution human chromosome 22 genomic microarray for clinical and research applications
    Patrick G Buckley
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden
    Hum Mol Genet 11:3221-9. 2002
    ..Furthermore, comprehensive epigenetic profiling of 22q-located genes and high-resolution analysis of replication timing across the entire chromosome can be studied using our array...
  41. ncbi request reprint Absence of PDGFRA mutations in primary melanoma
    John A Curtin
    J Invest Dermatol 128:488-9. 2008
  42. ncbi request reprint In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling
    Nicolas Dumaz
    Signal Transduction Team, The Institute for Cancer Research, Cancer Research UK Centre of Cell and Molecular Biology, London, United Kingdom
    Cancer Res 66:9483-91. 2006
    ..These data have important implications for the development of therapeutic strategies to treat this life-threatening disease...
  43. ncbi request reprint MC1R germline variants confer risk for BRAF-mutant melanoma
    Maria Teresa Landi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Science 313:521-2. 2006
    ..In this tumor subtype, the risk for melanoma associated with MC1R is due to an increase in risk of developing melanomas with BRAF mutations...
  44. doi request reprint Expanding the genetic spectrum of pigmentation
    Boris C Bastian
    Pigment Cell Melanoma Res 21:507-8. 2008

Research Grants5

  1. Classification of ambiguous melanocytic tumors
    Boris Bastian; Fiscal Year: 2005
    ..In addition, this project will provide a detailed view of the aberrations found in melanocytic tumors, their prevalence and prognostic relevance. ..
  2. Biomarker Discovery for the Classification of Melanoma
    Boris Bastian; Fiscal Year: 2009
    ..The goal of this project is the discovery of markers that improve classification, diagnosis, and stratification for therapy. ..
  3. The GNAQ pathway as a therapeutic target in uveal melanoma
    Boris C Bastian; Fiscal Year: 2010
    ..The goal of this project is to study its function and develop rationally-based treatment strategies and to discover the equivalent genetic alterations in the remaining 50% of uveal melanomas. ..
  4. Biomarker Discovery for the Classification of Melanoma
    Boris C Bastian; Fiscal Year: 2010
    ..The goal of this project is the discovery of markers that improve classification, diagnosis, and stratification for therapy. ..