Research Topics
Genomes and Genes
| B L BassSummaryAffiliation: University of Utah Country: USA Publications
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Detail Information
Publications
RNA editing by adenosine deaminases that act on RNABrenda L Bass
Department of Biochemistry and Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
Annu Rev Biochem 71:817-46. 2002..This review summarizes ongoing investigations of the enzyme family and their substrates, focusing on biological function as well as biochemical mechanism...
Double-stranded RNA as a template for gene silencingB L Bass
Department of Biochemistry and Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City 84132, USA
Cell 101:235-8. 2000- How does RNA editing affect dsRNA-mediated gene silencing?B L Bass
Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA
Cold Spring Harb Symp Quant Biol 71:285-92. 2006..Examples of how ADARs alter gene silencing pathways such as RNA interference, as well as mechanisms that allow the pathways to coexist and maintain their unique functions, are discussed... - A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegansS W Knight
Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, 50 North Medical Drive, Room 211, Salt Lake City, UT 84132, USA
Science 293:2269-71. 2001..Mutant animals have germ line defects that lead to sterility, suggesting that cleavage of dsRNA to short pieces is a requisite event in normal development... - A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editingP J Aruscavage
Department of Biochemistry Howard Hughes Medical Institute, University of Utah, Salt Lake City 84132, USA
RNA 6:257-69. 2000..The approximately 600-nt intron 13 of gluR-C was particularly remarkable, showing >94% nucleotide identity between human and chicken, organisms estimated to have diverged 310 million years ago... - A Xenopus zinc finger protein that specifically binds dsRNA and RNA-DNA hybridsP J Finerty
Department of Biochemistry and Howard Hughes Medical Institute, 6110a EIHG, Salt Lake City, UT, 84112, USA
J Mol Biol 271:195-208. 1997..In addition, dsRBP-ZFa does not contain the previously described dsRNA binding motif, suggesting certain zinc fingers may provide an alternative way to recognize the A-form helix... - RNA editing and hypermutation by adenosine deaminationB L Bass
Department of Biochemistry, University of Utah, Salt Lake City 84112, USA
Trends Biochem Sci 22:157-62. 1997.... - A link between RNA interference and nonsense-mediated decay in Caenorhabditis elegansM E Domeier
Huntsman Cancer Institute Center for Children and Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA
Science 289:1928-31. 2000..The levels of target messenger RNAs were restored during recovery, and RNA editing and degradation of the dsRNA were identical to those of the wild type. We suggest that persistence of RNA interference relies on a subset of smg genes... - Evidence for auto-inhibition by the N terminus of hADAR2 and activation by dsRNA bindingMark R Macbeth
Howard Hughes Medical Institute and Department of Biochemistry, University of Utah, Salt Lake City, UT 84132, USA
RNA 10:1563-71. 2004..We propose that the N-terminal domain of hADAR2 contains sequences that cause auto-inhibition of the enzyme. Our results suggest activation requires binding to an RNA substrate long enough to accommodate interactions with both dsRBMs... - RNA hairpins in noncoding regions of human brain and Caenorhabditis elegans mRNA are edited by adenosine deaminases that act on RNADaniel P Morse
Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, 20 North 1900 East, Salt Lake City, UT 84132-3201, USA
Proc Natl Acad Sci U S A 99:7906-11. 2002.... - C. elegans and H. sapiens mRNAs with edited 3' UTRs are present on polysomesHeather A Hundley
Department of Biochemistry, University of Utah, Salt Lake City, Utah 84112, USA
RNA 14:2050-60. 2008..Importantly, whereas previous studies indicate that inosine-containing RNAs are retained in the nucleus, we show that both C. elegans and Homo sapiens mRNAs with edited, structured 3' UTRs are present on translating ribosomes... - Analysis of Xenopus dsRNA adenosine deaminase cDNAs reveals similarities to DNA methyltransferasesR F Hough
Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112, USA
RNA 3:356-70. 1997.... - Large-scale overexpression and purification of ADARs from Saccharomyces cerevisiae for biophysical and biochemical studiesMark R Macbeth
Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah, USA
Methods Enzymol 424:319-31. 2007.... - Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editingMark R Macbeth
Department of Biochemistry, University of Utah, Salt Lake City, UT 84132, USA
Science 309:1534-9. 2005..Indeed, IP6 is also essential for in vivo and in vitro deamination of adenosine 37 of tRNAala by ADAT1... - A transition state analogue for an RNA-editing reactionBrittany L Haudenschild
Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USA
J Am Chem Soc 126:11213-9. 2004..These results advance our understanding of substrate recognition during ADAR-catalyzed RNA editing and are important for structural studies of ADAR.RNA complexes... - Mutations in RNAi rescue aberrant chemotaxis of ADAR mutantsLeath A Tonkin
Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, 20 North 1900 East, Salt Lake City, UT 84132-3201, USA
Science 302:1725. 2003 - RNA editing by ADARs is important for normal behavior in Caenorhabditis elegansLeath A Tonkin
Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, 20 North 1900 East, Salt Lake City, UT 84132, USA
EMBO J 21:6025-35. 2002..Using chemotaxis assays, we show that both ADARs are important for normal behavior. Biochemical, molecular and phenotypic analyses indicate that ADR-1 and ADR-2 have distinct roles in C.elegans, but sometimes act together... - The role of RNA editing by ADARs in RNAiScott W Knight
Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, 20 North 1900 East, Salt Lake City, UT 84132, USA
Mol Cell 10:809-17. 2002..In wild-type animals we detect edited dsRNA corresponding to transgenes, and we propose that editing of this dsRNA prevents somatic transgenes from initiating RNAi in wild-type animals... - ADAR editing in double-stranded UTRs and other noncoding RNA sequencesHeather A Hundley
Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA
Trends Biochem Sci 35:377-83. 2010..Although the role of editing in noncoding sequences remains unclear, ongoing research suggests functions in the regulation of a variety of post-transcriptional processes... - miRNA editing--we should have inosine this comingJeffrey W Habig
Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112, USA
Mol Cell 25:792-3. 2007..In a recent issue of Science, Nishikura and colleagues provide the first evidence that editing of a microRNA (miRNA) precursor by ADARs can modulate the target specificity of the mature miRNA (Kawahara et al., 2007)... - RDE-4 preferentially binds long dsRNA and its dimerization is necessary for cleavage of dsRNA to siRNAGreg S Parker
Department of Biochemistry HHMI, University of Utah, Salt Lake City 84112 5650, USA
RNA 12:807-18. 2006..Using extracts from wild-type and rde-4 mutant C. elegans, we show that the C-terminal dimerization domain is required for the production of siRNA. Our findings suggest a model for RDE-4 function during the initiation of RNAi... - Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genesNoah C Welker
Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT, 84112, USA
RNA 13:1090-102. 2007..However, all three data sets are enriched in genes important for innate immunity and, specifically, show increased expression of innate immunity genes... - A starvation-induced noncoding RNA modulates expression of Dicer-regulated genesSabine Hellwig
Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112, USA
Proc Natl Acad Sci U S A 105:12897-902. 2008..Certain viruses express dsRNA to compete with cellular dsRNA-mediated pathways, and our data suggest that rncs-1 provides a cellular correlate of this phenomenon...