Allan Basbaum

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The modality-specific contribution of peptidergic and non-peptidergic nociceptors is manifest at the level of dorsal horn nociresponsive neurons
    Jie Zhang
    Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA
    J Physiol 591:1097-110. 2013
  2. pmc Cellular and molecular mechanisms of pain
    Allan I Basbaum
    Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 139:267-84. 2009
  3. pmc TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms
    Noritaka Imamachi
    Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:11330-5. 2009
  4. pmc Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences
    Igor Mitrovic
    Department of Physiology, University of California, San Francisco, 94143, USA
    Proc Natl Acad Sci U S A 100:271-6. 2003
  5. pmc Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan
    Tetsuro Nikai
    Department of Anatomy, University of California San Francisco, USA
    Pain 139:533-40. 2008
  6. ncbi request reprint Peptidergic nociceptors of both trigeminal and dorsal root ganglia express serotonin 1D receptors: implications for the selective antimigraine action of triptans
    Sonja Potrebic
    Department of Neurology, University of California, San Francisco, San Francisco, California 94143 0452, USA
    J Neurosci 23:10988-97. 2003
  7. ncbi request reprint Characterization of wide dynamic range neurons in the deep dorsal horn of the spinal cord in preprotachykinin-a null mice in vivo
    William J Martin
    Department of Anatomy and the W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
    J Neurophysiol 91:1945-54. 2004
  8. ncbi request reprint Co-localization of endomorphin-2 and substance P in primary afferent nociceptors and effects of injury: a light and electron microscopic study in the rat
    Katarina Sanderson Nydahl
    Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA
    Eur J Neurosci 19:1789-99. 2004
  9. pmc Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers
    Simona Neumann
    Department of Anatomy and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 28:7936-44. 2008
  10. doi request reprint Genetically expressed transneuronal tracer reveals direct and indirect serotonergic descending control circuits
    João Manuel Braz
    Department of Anatomy, University of California San Francisco, San Francisco, California 94158, USA
    J Comp Neurol 507:1990-2003. 2008

Research Grants

  1. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 2000
  2. SPINAL MECHANISMS OF OPIOID ANALGESIA AND TOLERANCE
    Allan Basbaum; Fiscal Year: 2000
  3. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 1999
  4. SPINAL MECHANISMS OF OPIOID ANALGESIA AND TOLERANCE
    Allan Basbaum; Fiscal Year: 2001
  5. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 2001
  6. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 2007
  7. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 2007
  8. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 2005
  9. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 2006
  10. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 2005

Collaborators

Detail Information

Publications44

  1. pmc The modality-specific contribution of peptidergic and non-peptidergic nociceptors is manifest at the level of dorsal horn nociresponsive neurons
    Jie Zhang
    Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA
    J Physiol 591:1097-110. 2013
    ....
  2. pmc Cellular and molecular mechanisms of pain
    Allan I Basbaum
    Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 139:267-84. 2009
    ..Genetic, electrophysiological, and pharmacological studies are elucidating the molecular mechanisms that underlie detection, coding, and modulation of noxious stimuli that generate pain...
  3. pmc TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms
    Noritaka Imamachi
    Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:11330-5. 2009
    ..Thus, TRPV1 neurons are equipped with multiple signaling mechanisms that respond to different pruritogens. Some of these require TRPV1 function; others use alternate signal transduction pathways...
  4. pmc Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences
    Igor Mitrovic
    Department of Physiology, University of California, San Francisco, 94143, USA
    Proc Natl Acad Sci U S A 100:271-6. 2003
    ..Finally, our results suggest that the reduced pain responsiveness of male compared with female mice results in part from GIRK2-coupled postsynaptic receptors that are activated by endogenous antinociceptive systems...
  5. pmc Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan
    Tetsuro Nikai
    Department of Anatomy, University of California San Francisco, USA
    Pain 139:533-40. 2008
    ..The pronounced activity of intrathecal sumatriptan against inflammatory pain in mice raises the possibility that there is a wider spectrum of therapeutic indications for triptans beyond headache...
  6. ncbi request reprint Peptidergic nociceptors of both trigeminal and dorsal root ganglia express serotonin 1D receptors: implications for the selective antimigraine action of triptans
    Sonja Potrebic
    Department of Neurology, University of California, San Francisco, San Francisco, California 94143 0452, USA
    J Neurosci 23:10988-97. 2003
    ..Our finding, that 5-HT1D receptors are distributed in nociceptors throughout the body, raises the possibility that triptans can regulate not only headache-associated pain but also nociceptive responses in extracranial tissues...
  7. ncbi request reprint Characterization of wide dynamic range neurons in the deep dorsal horn of the spinal cord in preprotachykinin-a null mice in vivo
    William J Martin
    Department of Anatomy and the W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
    J Neurophysiol 91:1945-54. 2004
    ..Thus whereas behavioral hypersensitivity after injury is preserved in ppt-A -/- mice, our results suggest that the magnitude and duration of these behavioral responses would be reduced in the absence of SP and/or NKA...
  8. ncbi request reprint Co-localization of endomorphin-2 and substance P in primary afferent nociceptors and effects of injury: a light and electron microscopic study in the rat
    Katarina Sanderson Nydahl
    Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA
    Eur J Neurosci 19:1789-99. 2004
    ..We suggest that the very strong anatomical relationship between primary afferent nociceptors that express SP and EM2 underlies an EM2 regulation of SP release via mu-opioid autoreceptors...
  9. pmc Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers
    Simona Neumann
    Department of Anatomy and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 28:7936-44. 2008
    ....
  10. doi request reprint Genetically expressed transneuronal tracer reveals direct and indirect serotonergic descending control circuits
    João Manuel Braz
    Department of Anatomy, University of California San Francisco, San Francisco, California 94158, USA
    J Comp Neurol 507:1990-2003. 2008
    ..Our results indicate that 5HT neurons influence "pain" processing at the spinal cord level both directly and indirectly via feedforward connections with multiple non-5HT descending control pathways...
  11. pmc Inputs to serotonergic neurons revealed by conditional viral transneuronal tracing
    Joao M Braz
    Department of Anatomy and W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, California 94158, USA
    J Comp Neurol 514:145-60. 2009
    ..This spinoreticular pathway constitutes an anatomical substrate through which a noxious stimulus can activate 5HT neurons of the NRM and in turn could trigger descending serotonergic antinociceptive controls...
  12. pmc Tissue injury regulates serotonin 1D receptor expression: implications for the control of migraine and inflammatory pain
    Andrew H Ahn
    Department of Neurology, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 26:8332-8. 2006
    ..Moreover, the widespread expression of 5-HT1D receptor in somatic nociceptive afferents suggests that triptans could, in certain circumstances, treat pain in nontrigeminal regions of the body...
  13. pmc Sustaining intrinsic growth capacity of adult neurons promotes spinal cord regeneration
    Simona Neumann
    Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:16848-52. 2005
    ..The first lesion, we hypothesize, enhances intrinsic growth capacity, and the second one sustains it, providing a paradigm for promoting CNS regeneration after injury...
  14. ncbi request reprint Parallel "pain" pathways arise from subpopulations of primary afferent nociceptor
    Joao M Braz
    Department of Anatomy and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 47:787-93. 2005
    ..Our results indicate that parallel, perhaps independent pain pathways arise from different nociceptor classes and that motor as well as limbic targets predominate in the circuits that originate from the nonpeptide population...
  15. ncbi request reprint Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons
    Shannon D Shields
    Departments of Anatomy and Physiology and W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, CA 94158, USA
    Pain 131:8-20. 2007
    ..To date we have not detected a differential phenotype suggestive of a functional contribution of AQP1 to nociceptive processing...
  16. pmc Where do triptans act in the treatment of migraine?
    Andrew H Ahn
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
    Pain 115:1-4. 2005
  17. ncbi request reprint A new way to lose your nerve
    Allan I Basbaum
    Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA
    Sci Aging Knowledge Environ 2004:pe15. 2004
    ..Thus, the possibility that comparable bilateral changes occur in patients and that such changes contribute to neuropathic pain conditions must be considered...
  18. pmc Differential ATF3 expression in dorsal root ganglion neurons reveals the profile of primary afferents engaged by diverse noxious chemical stimuli
    Joao M Braz
    Department of Anatomy, WM Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, CA 94158, USA
    Pain 150:290-301. 2010
    ..We conclude that purportedly selective agonists can activate a heterogeneous population of sensory neurons, which ultimately could contribute to the behavioral responses evoked...
  19. ncbi request reprint The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors
    Karla P Zeitz
    Department of Anatomy, W M Keck Foundation Center for Integrative Neuroscience, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 22:1010-9. 2002
    ..We conclude that activation of both peripheral and central 5-HT(3) receptors is pronociceptive and that the contribution of peripheral 5-HT(3) receptors involves a novel complement of primary afferent nociceptors...
  20. pmc TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain
    Xidao Wang
    Department of Anatomy and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 29:5508-15. 2009
    ..We conclude that TrkB signaling is not only an important contributor to the induction of heat and mechanical hypersensitivity produced by tissue or nerve injury but also to the persistence of the pain...
  21. ncbi request reprint Spared nerve injury model of neuropathic pain in the mouse: a behavioral and anatomic analysis
    Shannon D Shields
    Department of Anatomy, University of California San Francisco, San Francisco, California, USA
    J Pain 4:465-70. 2003
    ....
  22. pmc Transneuronal tracing of diverse CNS circuits by Cre-mediated induction of wheat germ agglutinin in transgenic mice
    Joao M Braz
    Department of Anatomy and Physiology and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco 94143, USA
    Proc Natl Acad Sci U S A 99:15148-53. 2002
    ..Because the lectin can be induced in developing and adult animals, and in all regions of the brain and spinal cord, these ZW may prove extremely valuable for numerous studies of CNS circuit analysis...
  23. ncbi request reprint Toward better pain control
    Allan I Basbaum
    Department of Anatomy, University of California, San Francisco, USA
    Sci Am 294:60-7. 2006
  24. ncbi request reprint TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents
    Diana M Bautista
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 124:1269-82. 2006
    ..Thus, TRPA1 is an important component of the transduction machinery through which environmental irritants and endogenous proalgesic agents depolarize nociceptors to elicit inflammatory pain...
  25. ncbi request reprint Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T
    Annika B Malmberg
    Department of Anatomy 0452, University of California, San Francisco, San Francisco, CA 94143 0452, USA
    Pain 101:109-16. 2003
    ..The study supports the notion that drugs directed against subtypes of the NMDA receptor, by virtue of their reduced side-effect profile, hold promise as novel therapeutic agents for the control of pain...
  26. pmc Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors
    Rebecca P Seal
    Department of Physiology, University of California, San Francisco School of Medicine, California 94143, USA
    Nature 462:651-5. 2009
    ..The analysis of Vglut3(-/-) mice now indicates a critical role for C-LTMRs in the mechanical hypersensitivity caused by injury...
  27. doi request reprint Loss of function genetic screens reveal MTGR1 as an intracellular repressor of beta1 integrin-dependent neurite outgrowth
    Valeria S Ossovskaya
    Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA
    J Neurosci Methods 177:322-33. 2009
    ..These results reveal novel contributions of MTGR1 and GFI1 to the regulation of neurite outgrowth and identify novel repressors of integrin-dependent neurite outgrowth...
  28. ncbi request reprint Mu and delta opioid receptor-like immunoreactivity in the cervical spinal cord of the rat after dorsal rhizotomy or neonatal capsaicin: an analysis of pre- and postsynaptic receptor distributions
    Catherine Abbadie
    Department of Anatomy, W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, CA 94143, USA
    Brain Res 930:150-62. 2002
    ..Our results suggest that presynaptic delta opioid actions predominate, but that there are mixed pre- and postsynaptic inhibitory effects exerted by opioid analgesics that act at the spinal cord mu opioid receptor...
  29. pmc Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli
    Daniel J Cavanaugh
    Department of Anatomy, University of California, San Francisco CA 94158, USA
    Proc Natl Acad Sci U S A 106:9075-80. 2009
    ..This double-dissociation suggests that the brain can distinguish different noxious stimulus modalities from the earliest stages of sensory processing...
  30. ncbi request reprint A neuropeptide courier for delta-opioid receptors?
    David Julius
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143, USA
    Cell 122:496-8. 2005
    ..Moreover, in mice lacking this precursor, the contribution of the delta-opioid receptor to pain processing is dramatically altered. These observations suggest a new role for peptide precursors as sorting signals in vesicular transport...
  31. ncbi request reprint Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation
    Simona Neumann
    Department of Anatomy and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, CA 94143, USA
    Neuron 34:885-93. 2002
    ..Thus, stimulating cAMP signaling increases the intrinsic growth capacity of injured sensory axons. This approach may be useful in promoting regeneration after spinal cord injury...
  32. pmc Dissociation of the opioid receptor mechanisms that control mechanical and heat pain
    Gregory Scherrer
    Department of Anatomy and Physiology and WM Keck Center for Integrative Neuroscience, University of California, San Francisco, CA 94158, USA
    Cell 137:1148-59. 2009
    ..These results demonstrate that behaviorally relevant pain modalities can be selectively regulated through the targeting of distinct subsets of primary afferent pain fibers...
  33. ncbi request reprint Spider toxins activate the capsaicin receptor to produce inflammatory pain
    Jan Siemens
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, 600 16th Street, San Francisco, California 94143 2140, USA
    Nature 444:208-12. 2006
    ..TRP channels can now be included among the targets of peptide toxins, showing that animals, like plants (for example, chilli peppers), avert predators by activating TRP channels on sensory nerve fibres to elicit pain and inflammation...
  34. ncbi request reprint Immunoreactive TRPV-2 (VRL-1), a capsaicin receptor homolog, in the spinal cord of the rat
    Robin D Lewinter
    Department of Anatomy, University of California, San Francisco, San Francisco, California 94143, USA
    J Comp Neurol 470:400-8. 2004
    ..These results emphasize that VRL-1, in contrast to VR1, is present in a diverse population of neurons and undoubtedly contributes to numerous functions in addition to nociceptive processing...
  35. ncbi request reprint The menthol receptor TRPM8 is the principal detector of environmental cold
    Diana M Bautista
    Department of Physiology, University of California, San Francisco, California 94143, USA
    Nature 448:204-8. 2007
    ....
  36. ncbi request reprint Systemic morphine-induced release of serotonin in the rostroventral medulla is not mimicked by morphine microinjection into the periaqueductal gray
    Bradley K Taylor
    Department of Pharmacology SL83, Health Sciences Center, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70118, USA
    J Neurochem 86:1129-41. 2003
    ..Further studies will be required to elucidate the contribution of 5-HT and DA release in the RVM to opioid analgesia and opioid withdrawal...
  37. doi request reprint Contribution of the Reelin signaling pathways to nociceptive processing
    Alin L Akopians
    Department of Physiological Science, UCLA, Box 951606, Los Angeles, CA 90095 1606, USA
    Eur J Neurosci 27:523-37. 2008
    ....
  38. ncbi request reprint Contribution of substance P and neurokinin A to the differential injury-induced thermal and mechanical responsiveness of lamina I and V neurons
    Javier Mazario
    Laboratorio de Función Sensitivomotora, Hospital Nacional de Paraplejicos, 45071 Toledo, Spain
    J Neurosci 27:762-70. 2007
    ..Finally, we conclude that lamina I sensitization to mechanical stimulation is not required for this form of injury-increased responsiveness of lamina V neurons...
  39. pmc Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo
    Gregory Scherrer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM, Universite Louis Pasteur, 1 rue Laurent Fries, 67404 Illkirch, France
    Proc Natl Acad Sci U S A 103:9691-6. 2006
    ..Direct receptor visualization in mice is a unique approach to receptor biology and drug design...
  40. ncbi request reprint Reviews: topical, systematic and once again, comprehensive
    Allan I Basbaum
    Pain 124:237. 2006
  41. ncbi request reprint Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system
    Edward D Hogestatt
    Division of Clinical Chemistry and Pharmacology, Department of Laboratory Medicine, Lund University, SE 221 85 Lund, Sweden
    J Biol Chem 280:31405-12. 2005
    ....
  42. pmc 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
    Marcello Trevisani
    Department of Critical Care Medicine and Surgery, Florence University, 4 50121 Florence, Italy
    Proc Natl Acad Sci U S A 104:13519-24. 2007
    ..Our results also provide a mechanism-based rationale for developing novel analgesic or anti-inflammatory agents that target HNE production or TRPA1 activation...
  43. ncbi request reprint Long-term deprivation of substance P in PPT-A mutant mice alters the anoxic response of the isolated respiratory network
    Petra Telgkamp
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Neurophysiol 88:206-13. 2002
    ..Long-term deficiency in substance P leads to compensatory mechanisms that result in an apparently normal respiratory activity under normoxic conditions but a significantly altered response of the respiratory network during anoxia...
  44. ncbi request reprint Preprotachykinin-A gene deletion protects mice against acute pancreatitis and associated lung injury
    Madhav Bhatia
    Department of Pharmacology, National University of Singapore, Singapore 117597
    Am J Physiol Gastrointest Liver Physiol 284:G830-6. 2003
    ..These results show that PPT-A gene products are critical proinflammatory mediators in acute pancreatitis and the associated lung injury...

Research Grants44

  1. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 2000
    ..This multidisciplinary approach is directed at providing a comprehensive analysis of the neural substrate of pain and its control. ..
  2. SPINAL MECHANISMS OF OPIOID ANALGESIA AND TOLERANCE
    Allan Basbaum; Fiscal Year: 2000
    ..Taken together these studies will provide important information on the spinal cord mechanisms through which injury and opioid tolerance-associated changes in nociceptive processing are produced. ..
  3. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 1999
    ..This multidisciplinary approach is directed at providing a comprehensive analysis of the neural substrate of pain and its control. ..
  4. SPINAL MECHANISMS OF OPIOID ANALGESIA AND TOLERANCE
    Allan Basbaum; Fiscal Year: 2001
    ..Taken together these studies will provide important information on the spinal cord mechanisms through which injury and opioid tolerance-associated changes in nociceptive processing are produced. ..
  5. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 2001
    ..This multidisciplinary approach is directed at providing a comprehensive analysis of the neural substrate of pain and its control. ..
  6. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 2007
    ..Taken together, these studies will provide an entirely new anatomical perspective on the circuits that process the nociceptive messages resulting in acute and persistent pain. ..
  7. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 2007
    ..Taken together, these studies will provide an entirely new anatomical perspective on the circuits that process the nociceptive messages resulting in acute and persistent pain. ..
  8. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 2005
    ..Taken together, these studies will provide an entirely new anatomical perspective on the circuits that process the nociceptive messages resulting in acute and persistent pain. ..
  9. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 2006
    ..Taken together, these studies will provide an entirely new anatomical perspective on the circuits that process the nociceptive messages resulting in acute and persistent pain. ..
  10. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 2005
    ..Taken together, these studies will provide an entirely new anatomical perspective on the circuits that process the nociceptive messages resulting in acute and persistent pain. ..
  11. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 2004
    ..Taken together, these studies will provide an entirely new anatomical perspective on the circuits that process the nociceptive messages resulting in acute and persistent pain. ..
  12. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 2003
    ..This multidisciplinary approach is directed at providing a comprehensive analysis of the neural substrate of pain and its control. ..
  13. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 2002
    ..This multidisciplinary approach is directed at providing a comprehensive analysis of the neural substrate of pain and its control. ..
  14. SPINAL MECHANISMS OF OPIOID ANALGESIA AND TOLERANCE
    Allan Basbaum; Fiscal Year: 2002
    ..Taken together these studies will provide important information on the spinal cord mechanisms through which injury and opioid tolerance-associated changes in nociceptive processing are produced. ..
  15. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 1980
    ..Taken together, these studies will advance our understanding of the anatomical substrates and physiological mechanism of action of endogenous pain control systems. ..
  16. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 1993
    ..This multidisciplinary approach is directed at providing a comprehensive analysis of the neural substrate of pain and its control...
  17. SPINAL MECHANISMS OF OPIOID ANALGESIA AND TOLERANCE
    Allan Basbaum; Fiscal Year: 1999
    ..Taken together these studies will provide important information on the spinal cord mechanisms through which injury and opioid tolerance-associated changes in nociceptive processing are produced. ..
  18. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 1999
    ..Taken together, these studies will provide important new information that can be used to develop new therapeutic approaches to treat persistent pain conditions. ..
  19. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 1991
    ..This will provide important information as the mechanisms through which opiates generate analgesia by interactions in the PAG and will provide information about the relevant endogenous opioid peptides which contribute to that control...
  20. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 1990
    ..This will provide important information as the mechanisms through which opiates generate analgesia by interactions in the PAG and will provide information about the relevant endogenous opioid peptides which contribute to that control...
  21. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan Basbaum; Fiscal Year: 1992
    ..This multidisciplinary approach is directed at providing a comprehensive analysis of the neural substrate of pain and its control...
  22. SPINAL MECHANISMS OF OPIOID ANALGESIA AND TOLERANCE
    Allan Basbaum; Fiscal Year: 1993
    ....