G Bartzokis

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Acetylcholinesterase inhibitors may improve myelin integrity
    George Bartzokis
    Department of Neurology, The Laboratory of Neuroimaging in the Division of Brain Mapping, The David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1769, USA
    Biol Psychiatry 62:294-301. 2007
  2. doi request reprint Multimodal magnetic resonance imaging assessment of white matter aging trajectories over the lifespan of healthy individuals
    George Bartzokis
    Department of Psychiatry, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Biol Psychiatry 72:1026-34. 2012
  3. pmc Impact on intracortical myelination trajectory of long acting injection versus oral risperidone in first-episode schizophrenia
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Schizophr Res 140:122-8. 2012
  4. pmc Neuroglialpharmacology: myelination as a shared mechanism of action of psychotropic treatments
    George Bartzokis
    Department of Psychiatry, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuropharmacology 62:2137-53. 2012
  5. ncbi request reprint Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseases
    George Bartzokis
    Department of Neurology, UCLA, Los Angeles, California, USA
    Ann N Y Acad Sci 1012:224-36. 2004
  6. ncbi request reprint Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical "disconnection" in aging and Alzheimer's disease
    George Bartzokis
    Department of Neurology, Univeristy of California School of Medicine, Los Angeles, CA 90095, USA
    Neurobiol Aging 25:843-51. 2004
  7. ncbi request reprint Quantifying age-related myelin breakdown with MRI: novel therapeutic targets for preventing cognitive decline and Alzheimer's disease
    George Bartzokis
    Department of Neurology, The David Gheffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Alzheimers Dis 6:S53-9. 2004
  8. ncbi request reprint Adjunctive risperidone in the treatment of chronic combat-related posttraumatic stress disorder
    George Bartzokis
    Department of Neurology, University of California School of Medicine, Los Angeles, California, USA
    Biol Psychiatry 57:474-9. 2005
  9. pmc Prevalent iron metabolism gene variants associated with increased brain ferritin iron in healthy older men
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
    J Alzheimers Dis 20:333-41. 2010
  10. ncbi request reprint White matter structural integrity in healthy aging adults and patients with Alzheimer disease: a magnetic resonance imaging study
    George Bartzokis
    Department of Neurology, Alzheimer s Disease Center, University of California, Los Angeles, 710 Westwood Plaza, Room 2 238, Los Angeles, CA 90095 1769, USA
    Arch Neurol 60:393-8. 2003

Research Grants

  1. Brain Development on Adults with Schizophrenia
    George Bartzokis; Fiscal Year: 2007
  2. Brain Iron in Aging Adults
    George Bartzokis; Fiscal Year: 2007
  3. Brain Iron in Aging Adults
    George Bartzokis; Fiscal Year: 2010

Detail Information

Publications58

  1. ncbi request reprint Acetylcholinesterase inhibitors may improve myelin integrity
    George Bartzokis
    Department of Neurology, The Laboratory of Neuroimaging in the Division of Brain Mapping, The David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1769, USA
    Biol Psychiatry 62:294-301. 2007
    ....
  2. doi request reprint Multimodal magnetic resonance imaging assessment of white matter aging trajectories over the lifespan of healthy individuals
    George Bartzokis
    Department of Psychiatry, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Biol Psychiatry 72:1026-34. 2012
    ..We examined whether known regional differences in axon size and age at myelination influence the timing and rates of development and degeneration/repair trajectories of white matter (WM) microstructure biomarkers...
  3. pmc Impact on intracortical myelination trajectory of long acting injection versus oral risperidone in first-episode schizophrenia
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Schizophr Res 140:122-8. 2012
    ..Insofar as the trajectory of ICM decline in chronic SZ is due to medication non-adherence or pharmacokinetics, it may be modifiable by long acting injection (LAI) formulations...
  4. pmc Neuroglialpharmacology: myelination as a shared mechanism of action of psychotropic treatments
    George Bartzokis
    Department of Psychiatry, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuropharmacology 62:2137-53. 2012
    ..Such efforts may provide insights into novel avenues for treatment and prevention of some of the most prevalent and devastating human diseases...
  5. ncbi request reprint Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseases
    George Bartzokis
    Department of Neurology, UCLA, Los Angeles, California, USA
    Ann N Y Acad Sci 1012:224-36. 2004
    ..In vivo MRI can measure and track brain ferritin iron levels and provides an opportunity to design therapeutic interventions that target high-risk populations early in the course of illness, possibly even before symptoms appear...
  6. ncbi request reprint Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical "disconnection" in aging and Alzheimer's disease
    George Bartzokis
    Department of Neurology, Univeristy of California School of Medicine, Los Angeles, CA 90095, USA
    Neurobiol Aging 25:843-51. 2004
    ..In AD this process is globally exacerbated, consistent with an extracellular deleterious process such as amyloid beta-peptide toxicity. Non-invasive measures such as R2 may be useful in primary prevention studies of AD...
  7. ncbi request reprint Quantifying age-related myelin breakdown with MRI: novel therapeutic targets for preventing cognitive decline and Alzheimer's disease
    George Bartzokis
    Department of Neurology, The David Gheffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Alzheimers Dis 6:S53-9. 2004
    ....
  8. ncbi request reprint Adjunctive risperidone in the treatment of chronic combat-related posttraumatic stress disorder
    George Bartzokis
    Department of Neurology, University of California School of Medicine, Los Angeles, California, USA
    Biol Psychiatry 57:474-9. 2005
    ..The efficacy and safety of risperidone was evaluated in veteran patients with chronic combat-related posttraumatic stress disorder (PTSD) who were referred to a residential treatment program...
  9. pmc Prevalent iron metabolism gene variants associated with increased brain ferritin iron in healthy older men
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
    J Alzheimers Dis 20:333-41. 2010
    ..Clarifying mechanisms of brain iron accumulation may help identify novel interventions for age-related neurodegenerative diseases...
  10. ncbi request reprint White matter structural integrity in healthy aging adults and patients with Alzheimer disease: a magnetic resonance imaging study
    George Bartzokis
    Department of Neurology, Alzheimer s Disease Center, University of California, Los Angeles, 710 Westwood Plaza, Room 2 238, Los Angeles, CA 90095 1769, USA
    Arch Neurol 60:393-8. 2003
    ..6 years and then declines. Postmortem evidence indicates that the structural integrity of myelin sheaths deteriorates during normal aging, especially in late myelinating regions such as the frontal lobes...
  11. pmc In vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophrenia
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
    Schizophr Res 113:322-31. 2009
    ..Increased white matter (WM) volume suggestive of increased myelination was detected in the patient group treated with an atypical antipsychotic compared to a typical one...
  12. ncbi request reprint Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementia
    George Bartzokis
    Department of Neurology, The David Geffen School of Medicine at UCLA, USA
    Arch Gen Psychiatry 63:63-72. 2006
    ..This may result in a progressive "disconnection" of widely distributed neural networks that may underlie the age risk factor for AD...
  13. ncbi request reprint Brain ferritin iron may influence age- and gender-related risks of neurodegeneration
    George Bartzokis
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neurobiol Aging 28:414-23. 2007
    ..We hypothesized that brain iron may influence both the age- and gender-related risks of developing these diseases...
  14. pmc Lifespan trajectory of myelin integrity and maximum motor speed
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA
    Neurobiol Aging 31:1554-62. 2010
    ..We tested the hypothesis that the age-related trajectory of FTS is related to brain myelin integrity...
  15. pmc Differential effects of typical and atypical antipsychotics on brain myelination in schizophrenia
    George Bartzokis
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, United States
    Schizophr Res 93:13-22. 2007
    ..Atypical antipsychotics have been shown to have a wide spectrum of efficacy across multiple psychiatric diseases and to be particularly efficacious in treatment resistant cases of disorders such as schizophrenia...
  16. ncbi request reprint Myelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implications
    George Bartzokis
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neurochem Res 32:1655-64. 2007
    ..A unique combination of in vivo tissue integrity and iron level assessments was used to examine the hypothesis...
  17. ncbi request reprint Cortical gray matter volumes are associated with subjective responses to cocaine infusion
    George Bartzokis
    Department of Neurology, University of California Los Angeles School of Medicine, UCLA Alzheimer s Disease Center, 710 Westwood Plaza, Room 2 238, Los Angeles, CA 90095 1769, USA
    Am J Addict 13:64-73. 2004
    ..Given the well-established negative linear relationship between cortical gray matter volume and age, cortical gray matter volume may be a marker for the neurobiological substrate of the age-related reduction in addiction rates...
  18. pmc Gender and iron genes may modify associations between brain iron and memory in healthy aging
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
    Neuropsychopharmacology 36:1375-84. 2011
    ..Combining genetic and MRI biomarkers may provide opportunities to design primary prevention clinical trials that target high-risk groups...
  19. ncbi request reprint Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's disease
    George Bartzokis
    Department of Neurology, UCLA Alzheimer s Disease Center, Los Angeles, CA 90095, USA
    Neurobiol Aging 25:5-18; author reply 49-62. 2004
    ....
  20. ncbi request reprint Reliability of medial temporal lobe volume measurements using reformatted 3D images
    G Bartzokis
    West Los Angeles VA Medical Center, Research Service, CA 90073, USA
    Psychiatry Res 82:11-24. 1998
    ..Image contrast is an additional important factor since the reformatted T1 weighted images used in this study, which have suboptimal CSF/brain contrast, worsened measurement accuracy in the temporal horn...
  21. ncbi request reprint MRI evaluation of brain iron in earlier- and later-onset Parkinson's disease and normal subjects
    G Bartzokis
    North Little Rock VA Medical Center, Department of Psychiatry, University of Arkansas for Medical Sciences, 72114, USA
    Magn Reson Imaging 17:213-22. 1999
    ..The FDRI results suggest that disregulation of iron metabolism occurs in PD and that this disregulation may differ in earlier- versus later-onset PD...
  22. ncbi request reprint Increased basal ganglia iron levels in Huntington disease
    G Bartzokis
    Department of Psychiatry, University of Arkansas for Medical Sciences, Central Arkansas Veterans Healthcare System, Little Rock 72114, USA
    Arch Neurol 56:569-74. 1999
    ..To quantify in vivo brain ferritin iron levels in patients with Huntington disease (HD) and normal control subjects...
  23. ncbi request reprint In vivo evaluation of brain iron in Alzheimer disease using magnetic resonance imaging
    G Bartzokis
    Department of Psychiatry, University of Arkansas for Medical Sciences and the Mental Health Service, Central Arkansas Veterans Healthcare System, Little Rock, USA
    Arch Gen Psychiatry 57:47-53. 2000
    ..Treatments aimed at reducing oxidative damage have offered novel ways to delay the rate of progression and could possibly defer the onset of AD. Brain iron levels were quantified in vivo using a new magnetic resonance imaging method...
  24. ncbi request reprint Age-related brain volume reductions in amphetamine and cocaine addicts and normal controls: implications for addiction research
    G Bartzokis
    Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Psychiatry Res 98:93-102. 2000
    ..These age-related cortical gray matter volume reductions may be a biological marker for the risk of addictive behavior, which also decreases with age...
  25. ncbi request reprint MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimer's and Huntingon's disease
    G Bartzokis
    University of Arkansas Medical Sciences Department of Psychiatry, Little Rock 72205, USA
    Cell Mol Biol (Noisy-le-grand) 46:821-33. 2000
    ..Magnetic resonance imaging (MRI) can quantify transverse relaxation rates, which can be used to quantify tissue iron stores as well as evaluate increases in MR-visible water (an indicator of tissue damage)...
  26. pmc Alzheimer's disease as homeostatic responses to age-related myelin breakdown
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neurobiol Aging 32:1341-71. 2011
    ..Such interventions could potentially treat multiple degenerative brain disorders by mitigating the effects of aging and associated changes in iron, cholesterol, and free radicals on oligodendrocytes and their myelin...
  27. ncbi request reprint Increased CSF volumes are associated with diminished subjective responses to cocaine infusion
    G Bartzokis
    Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Neuropsychopharmacology 23:468-73. 2000
    ..The age-related brain volume reductions underlying the volume increase in these two CSF spaces may be the neurobiological basis of the age-related reduction in the rates of addiction...
  28. ncbi request reprint Age-related changes in frontal and temporal lobe volumes in men: a magnetic resonance imaging study
    G Bartzokis
    Central Arkansas Veterans Healthcare System, 2200 Fort Roots Dr, Bldg 170, 116A NLR, North Little Rock, AR 72114, USA
    Arch Gen Psychiatry 58:461-5. 2001
    ..We examined the effects of the aging process on the frontal and temporal lobes...
  29. ncbi request reprint Schizophrenia: breakdown in the well-regulated lifelong process of brain development and maturation
    George Bartzokis
    Department of Neurology, University of California, Los Angeles, CA, USA
    Neuropsychopharmacology 27:672-83. 2002
    ....
  30. pmc Long acting injection versus oral risperidone in first-episode schizophrenia: differential impact on white matter myelination trajectory
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States
    Schizophr Res 132:35-41. 2011
    ..Insofar as the trajectory of WM decline associated with chronic disease may be due to medication non-adherence, it may be modifiable by long acting injection (LAI) formulations...
  31. ncbi request reprint Neuroglialpharmacology: white matter pathophysiologies and psychiatric treatments
    George Bartzokis
    Department of Psychiatry, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Front Biosci (Landmark Ed) 16:2695-733. 2011
    ....
  32. ncbi request reprint Apolipoprotein E affects both myelin breakdown and cognition: implications for age-related trajectories of decline into dementia
    George Bartzokis
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Biol Psychiatry 62:1380-7. 2007
    ..Apolipoprotein E (ApoE) 4 allele is the second most important AD risk factor. We tested the hypothesis that ApoE4 accelerates age-related slowing in CPS through the process of myelin breakdown...
  33. ncbi request reprint Dysregulated brain development in adult men with schizophrenia: a magnetic resonance imaging study
    George Bartzokis
    Department of Neurology, University of California School of Medicine, Los Angeles 90095 1769, USA
    Biol Psychiatry 53:412-21. 2003
    ..The possibility that a dysregulation of this process may contribute to the syndrome of schizophrenia was investigated using magnetic resonance imaging...
  34. pmc Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects
    E C Mormino
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Brain 132:1310-23. 2009
    ..This pattern suggests that declining EM in older individuals may be caused by Abeta-induced hippocampus atrophy...
  35. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  36. ncbi request reprint Fluphenazine levels during maintenance treatment of recent-onset schizophrenia: relation to side effects, psychosocial function and depression
    M J Gitlin
    Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, 90095 6968, USA
    Psychopharmacology (Berl) 148:350-4. 2000
    ..The utility of fluphenazine levels during maintenance treatment of schizophrenia is still unclear...
  37. pmc Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative
    Owen Carmichael
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Arch Neurol 67:1370-8. 2010
    ....
  38. doi request reprint Amygdala astrocyte reduction in subjects with major depressive disorder but not bipolar disorder
    Lori L Altshuler
    VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
    Bipolar Disord 12:541-9. 2010
    ..Specifically, it is not known whether differences in the density and/or volume of neurons or glial cells contribute to tissue volume changes seen on magnetic resonance images...
  39. ncbi request reprint Increased amygdala activation during mania: a functional magnetic resonance imaging study
    Lori Altshuler
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095 7057, USA
    Am J Psychiatry 162:1211-3. 2005
    ..This study sought to investigate neural activity in the amygdala during episodes of mania...
  40. ncbi request reprint Ambulatory blood pressure and the brain: a 5-year follow-up
    Iris B Goldstein
    Department of Psychiatry, University of California, 760 Westwood Plaza, Los Angeles, CA 90095 1759, USA
    Neurology 64:1846-52. 2005
    ..To determine if initial values of casual and ambulatory systolic blood pressure (SBP) predict white matter hyperintensities, insular subcortex hyperintensities, and brain atrophy 5 years later in a group of healthy elderly individuals...
  41. ncbi request reprint Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations
    John M Ringman
    UCLA Department of Neurology, Alzheimer s Disease Research Center, 10911 Weyburn Ave, Suite 200, Los Angeles, CA 90095 7226, USA
    Brain 130:1767-76. 2007
    ..Decreased FA in of the columns of the fornix is particularly robust in early FAD and may provide a biomarker for early disease in sporadic Alzheimer's disease...
  42. pmc Diagnosing depression in Alzheimer disease with the national institute of mental health provisional criteria
    Edmond Teng
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Am J Geriatr Psychiatry 16:469-77. 2008
    ....
  43. pmc Time-lapse mapping of cortical changes in schizophrenia with different treatments
    Paul M Thompson
    Laboratory of Neuro Imaging, Department of Neurology, University of California Los Anges, School of Medicine, Los Angeles, CA 90095 7332, USA
    Cereb Cortex 19:1107-23. 2009
    ..These maps revise current models of schizophrenia progression; due to power limitations, the findings require confirmation in a sample large enough to model group x time interactions...
  44. pmc Apolipoprotein E genotype is associated with temporal and hippocampal atrophy rates in healthy elderly adults: a tensor-based morphometry study
    Po H Lu
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7226, USA
    J Alzheimers Dis 23:433-42. 2011
    ..Possession of the ε4 allele is associated with greater temporal and hippocampal volume reduction well before the onset of cognitive deficits...
  45. ncbi request reprint Relationship between blood pressure and subcortical lesions in healthy elderly people
    I B Goldstein
    Department of Psychiatry, University of California, Los Angeles 90024 1759, USA
    Stroke 29:765-72. 1998
    ..The relationship between blood pressure (BP) and heart rate (HR) and MRI assessments of subcortical T2 hyperintensities was evaluated in healthy elderly men and women...
  46. ncbi request reprint Brain maturation may be arrested in chronic cocaine addicts
    George Bartzokis
    Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA
    Biol Psychiatry 51:605-11. 2002
    ..Recent magnetic resonance imaging (MRI) data have confirmed continued white matter volume increase in these regions, reaching a maximum at age 47...
  47. ncbi request reprint Exploratory voxel-based analysis of diffusion indices and hemispheric asymmetry in normal aging
    Siamak Ardekani
    Biomedical Engineering IDP, University of California Los Angeles, Los Angeles, CA 90095, USA
    Magn Reson Imaging 25:154-67. 2007
    ..The study shows the feasibility of the VBA of DTI indices for exploratory investigations of subtle differences in population cohorts, especially when findings are not localized and/or known a priori...
  48. ncbi request reprint Variation in neurophysiological function and evidence of quantitative electroencephalogram discordance: predicting cocaine-dependent treatment attrition
    Sandy Venneman
    Medication Development Unit, Research Service, and Psychiatry Service, West Los Angeles VA Medical Center, California, USA
    J Neuropsychiatry Clin Neurosci 18:208-16. 2006
    ..Failure to complete the trial was not explained by depression, craving, benzoylecgonine levels or quantitative electroencephalogram (QEEG) power; thus cordance may help identify attrition risk...
  49. pmc White-matter abnormalities in brain during early abstinence from methamphetamine abuse
    Marc C Tobias
    Semel Institute for Neuroscience and Biobehavioral Studies, University of California Los Angeles, Los Angeles, CA, USA
    Psychopharmacology (Berl) 209:13-24. 2010
    ..As certain metabolic changes in the brain first manifest after early abstinence from methamphetamine, it is also possible that microstructural white-matter abnormalities are not yet present during early abstinence...
  50. pmc Assessment and familial aggregation of psychosis in Alzheimer's disease from the National Institute on Aging Late Onset Alzheimer's Disease Family Study
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh, Biomedical Science Tower, Rm W 1645, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Brain 133:1155-62. 2010
    ..Future studies should examine the linkage and association of psychosis with genetic variation within these families...
  51. ncbi request reprint Ambulatory blood pressure and brain atrophy in the healthy elderly
    Iris B Goldstein
    Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, CA 90095, USA
    Neurology 59:713-9. 2002
    ..Brain lesions and atrophy increase with age and hypertension...
  52. ncbi request reprint Differences between smokers and nonsmokers in regional gray matter volumes and densities
    Arthur L Brody
    Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90095, USA
    Biol Psychiatry 55:77-84. 2004
    ..Using MRI, we examined these regions for differences in gray matter between smokers and nonsmokers...
  53. pmc Abuse of amphetamines and structural abnormalities in the brain
    Steven Berman
    Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024 1759, USA
    Ann N Y Acad Sci 1141:195-220. 2008
    ..Longitudinal designs in which multimodal datasets are acquired and are subjected to multivariate analyses would enhance our ability to provide general conclusions regarding the associations between amphetamine abuse and brain structure...
  54. pmc A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
    April J Ho
    Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:8404-9. 2010
    ..These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly...
  55. ncbi request reprint Biological underpinnings of treatment resistance in schizophrenia: an hypothesis
    George Bartzokis
    Psychopharmacol Bull 37:5-7. 2003
  56. ncbi request reprint Reduced intracortical myelination in schizophrenia
    George Bartzokis
    Am J Psychiatry 162:1229-30. 2005
  57. ncbi request reprint Myelination and brain electrophysiology in healthy and schizophrenic individuals
    George Bartzokis
    Neuropsychopharmacology 28:1217-8. 2003
  58. pmc The Alzheimer's Disease Neuroimaging Initiative (ADNI): MRI methods
    Clifford R Jack
    Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Magn Reson Imaging 27:685-91. 2008
    ..The approach taken in ADNI to standardization across sites and platforms of the MRI protocol, postacquisition corrections, and phantom-based monitoring of all scanners could be used as a model for other multisite trials...

Research Grants9

  1. Brain Development on Adults with Schizophrenia
    George Bartzokis; Fiscal Year: 2007
    ..This will change our concept of how we could treat this illness, the feasibility of changing its lifelong course, and would encourage the development of novel pharmacologic interventions to improve myelination. ..
  2. Brain Iron in Aging Adults
    George Bartzokis; Fiscal Year: 2007
    ....
  3. Brain Iron in Aging Adults
    George Bartzokis; Fiscal Year: 2010
    ....