Research Topics
Species | G BartzokisSummaryAffiliation: University of California Country: USA Publications
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Publications
Acetylcholinesterase inhibitors may improve myelin integrityGeorge Bartzokis
Department of Neurology, The Laboratory of Neuroimaging in the Division of Brain Mapping, The David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1769, USA
Biol Psychiatry 62:294-301. 2007....
Multimodal magnetic resonance imaging assessment of white matter aging trajectories over the lifespan of healthy individualsGeorge Bartzokis
Department of Psychiatry, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Biol Psychiatry 72:1026-34. 2012..We examined whether known regional differences in axon size and age at myelination influence the timing and rates of development and degeneration/repair trajectories of white matter (WM) microstructure biomarkers...
Impact on intracortical myelination trajectory of long acting injection versus oral risperidone in first-episode schizophreniaGeorge Bartzokis
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Schizophr Res 140:122-8. 2012..Insofar as the trajectory of ICM decline in chronic SZ is due to medication non-adherence or pharmacokinetics, it may be modifiable by long acting injection (LAI) formulations...- Neuroglialpharmacology: myelination as a shared mechanism of action of psychotropic treatmentsGeorge Bartzokis
Department of Psychiatry, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Neuropharmacology 62:2137-53. 2012..Such efforts may provide insights into novel avenues for treatment and prevention of some of the most prevalent and devastating human diseases... - Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseasesGeorge Bartzokis
Department of Neurology, UCLA, Los Angeles, California, USA
Ann N Y Acad Sci 1012:224-36. 2004..In vivo MRI can measure and track brain ferritin iron levels and provides an opportunity to design therapeutic interventions that target high-risk populations early in the course of illness, possibly even before symptoms appear... - Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical "disconnection" in aging and Alzheimer's diseaseGeorge Bartzokis
Department of Neurology, Univeristy of California School of Medicine, Los Angeles, CA 90095, USA
Neurobiol Aging 25:843-51. 2004..In AD this process is globally exacerbated, consistent with an extracellular deleterious process such as amyloid beta-peptide toxicity. Non-invasive measures such as R2 may be useful in primary prevention studies of AD... - Quantifying age-related myelin breakdown with MRI: novel therapeutic targets for preventing cognitive decline and Alzheimer's diseaseGeorge Bartzokis
Department of Neurology, The David Gheffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Alzheimers Dis 6:S53-9. 2004.... - Adjunctive risperidone in the treatment of chronic combat-related posttraumatic stress disorderGeorge Bartzokis
Department of Neurology, University of California School of Medicine, Los Angeles, California, USA
Biol Psychiatry 57:474-9. 2005..The efficacy and safety of risperidone was evaluated in veteran patients with chronic combat-related posttraumatic stress disorder (PTSD) who were referred to a residential treatment program... - Prevalent iron metabolism gene variants associated with increased brain ferritin iron in healthy older menGeorge Bartzokis
Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
J Alzheimers Dis 20:333-41. 2010..Clarifying mechanisms of brain iron accumulation may help identify novel interventions for age-related neurodegenerative diseases... - White matter structural integrity in healthy aging adults and patients with Alzheimer disease: a magnetic resonance imaging studyGeorge Bartzokis
Department of Neurology, Alzheimer s Disease Center, University of California, Los Angeles, 710 Westwood Plaza, Room 2 238, Los Angeles, CA 90095 1769, USA
Arch Neurol 60:393-8. 2003..6 years and then declines. Postmortem evidence indicates that the structural integrity of myelin sheaths deteriorates during normal aging, especially in late myelinating regions such as the frontal lobes... - In vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophreniaGeorge Bartzokis
Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
Schizophr Res 113:322-31. 2009..Increased white matter (WM) volume suggestive of increased myelination was detected in the patient group treated with an atypical antipsychotic compared to a typical one... - Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementiaGeorge Bartzokis
Department of Neurology, The David Geffen School of Medicine at UCLA, USA
Arch Gen Psychiatry 63:63-72. 2006..This may result in a progressive "disconnection" of widely distributed neural networks that may underlie the age risk factor for AD... - Brain ferritin iron may influence age- and gender-related risks of neurodegenerationGeorge Bartzokis
Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Neurobiol Aging 28:414-23. 2007..We hypothesized that brain iron may influence both the age- and gender-related risks of developing these diseases... - Lifespan trajectory of myelin integrity and maximum motor speedGeorge Bartzokis
Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA
Neurobiol Aging 31:1554-62. 2010..We tested the hypothesis that the age-related trajectory of FTS is related to brain myelin integrity... - Differential effects of typical and atypical antipsychotics on brain myelination in schizophreniaGeorge Bartzokis
Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, United States
Schizophr Res 93:13-22. 2007..Atypical antipsychotics have been shown to have a wide spectrum of efficacy across multiple psychiatric diseases and to be particularly efficacious in treatment resistant cases of disorders such as schizophrenia... - Myelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implicationsGeorge Bartzokis
Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Neurochem Res 32:1655-64. 2007..A unique combination of in vivo tissue integrity and iron level assessments was used to examine the hypothesis... - Cortical gray matter volumes are associated with subjective responses to cocaine infusionGeorge Bartzokis
Department of Neurology, University of California Los Angeles School of Medicine, UCLA Alzheimer s Disease Center, 710 Westwood Plaza, Room 2 238, Los Angeles, CA 90095 1769, USA
Am J Addict 13:64-73. 2004..Given the well-established negative linear relationship between cortical gray matter volume and age, cortical gray matter volume may be a marker for the neurobiological substrate of the age-related reduction in addiction rates... - Gender and iron genes may modify associations between brain iron and memory in healthy agingGeorge Bartzokis
Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
Neuropsychopharmacology 36:1375-84. 2011..Combining genetic and MRI biomarkers may provide opportunities to design primary prevention clinical trials that target high-risk groups... - Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's diseaseGeorge Bartzokis
Department of Neurology, UCLA Alzheimer s Disease Center, Los Angeles, CA 90095, USA
Neurobiol Aging 25:5-18; author reply 49-62. 2004.... - Reliability of medial temporal lobe volume measurements using reformatted 3D imagesG Bartzokis
West Los Angeles VA Medical Center, Research Service, CA 90073, USA
Psychiatry Res 82:11-24. 1998..Image contrast is an additional important factor since the reformatted T1 weighted images used in this study, which have suboptimal CSF/brain contrast, worsened measurement accuracy in the temporal horn... - MRI evaluation of brain iron in earlier- and later-onset Parkinson's disease and normal subjectsG Bartzokis
North Little Rock VA Medical Center, Department of Psychiatry, University of Arkansas for Medical Sciences, 72114, USA
Magn Reson Imaging 17:213-22. 1999..The FDRI results suggest that disregulation of iron metabolism occurs in PD and that this disregulation may differ in earlier- versus later-onset PD... - Increased basal ganglia iron levels in Huntington diseaseG Bartzokis
Department of Psychiatry, University of Arkansas for Medical Sciences, Central Arkansas Veterans Healthcare System, Little Rock 72114, USA
Arch Neurol 56:569-74. 1999..To quantify in vivo brain ferritin iron levels in patients with Huntington disease (HD) and normal control subjects... - In vivo evaluation of brain iron in Alzheimer disease using magnetic resonance imagingG Bartzokis
Department of Psychiatry, University of Arkansas for Medical Sciences and the Mental Health Service, Central Arkansas Veterans Healthcare System, Little Rock, USA
Arch Gen Psychiatry 57:47-53. 2000..Treatments aimed at reducing oxidative damage have offered novel ways to delay the rate of progression and could possibly defer the onset of AD. Brain iron levels were quantified in vivo using a new magnetic resonance imaging method... - Age-related brain volume reductions in amphetamine and cocaine addicts and normal controls: implications for addiction researchG Bartzokis
Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Psychiatry Res 98:93-102. 2000..These age-related cortical gray matter volume reductions may be a biological marker for the risk of addictive behavior, which also decreases with age... - MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimer's and Huntingon's diseaseG Bartzokis
University of Arkansas Medical Sciences Department of Psychiatry, Little Rock 72205, USA
Cell Mol Biol (Noisy-le-grand) 46:821-33. 2000..Magnetic resonance imaging (MRI) can quantify transverse relaxation rates, which can be used to quantify tissue iron stores as well as evaluate increases in MR-visible water (an indicator of tissue damage)... - Alzheimer's disease as homeostatic responses to age-related myelin breakdownGeorge Bartzokis
Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Neurobiol Aging 32:1341-71. 2011..Such interventions could potentially treat multiple degenerative brain disorders by mitigating the effects of aging and associated changes in iron, cholesterol, and free radicals on oligodendrocytes and their myelin... - Increased CSF volumes are associated with diminished subjective responses to cocaine infusionG Bartzokis
Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Neuropsychopharmacology 23:468-73. 2000..The age-related brain volume reductions underlying the volume increase in these two CSF spaces may be the neurobiological basis of the age-related reduction in the rates of addiction... - Age-related changes in frontal and temporal lobe volumes in men: a magnetic resonance imaging studyG Bartzokis
Central Arkansas Veterans Healthcare System, 2200 Fort Roots Dr, Bldg 170, 116A NLR, North Little Rock, AR 72114, USA
Arch Gen Psychiatry 58:461-5. 2001..We examined the effects of the aging process on the frontal and temporal lobes... - Schizophrenia: breakdown in the well-regulated lifelong process of brain development and maturationGeorge Bartzokis
Department of Neurology, University of California, Los Angeles, CA, USA
Neuropsychopharmacology 27:672-83. 2002.... - Long acting injection versus oral risperidone in first-episode schizophrenia: differential impact on white matter myelination trajectoryGeorge Bartzokis
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States
Schizophr Res 132:35-41. 2011..Insofar as the trajectory of WM decline associated with chronic disease may be due to medication non-adherence, it may be modifiable by long acting injection (LAI) formulations... - Neuroglialpharmacology: white matter pathophysiologies and psychiatric treatmentsGeorge Bartzokis
Department of Psychiatry, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Front Biosci 16:2695-733. 2011.... - Apolipoprotein E affects both myelin breakdown and cognition: implications for age-related trajectories of decline into dementiaGeorge Bartzokis
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Biol Psychiatry 62:1380-7. 2007..Apolipoprotein E (ApoE) 4 allele is the second most important AD risk factor. We tested the hypothesis that ApoE4 accelerates age-related slowing in CPS through the process of myelin breakdown... - Dysregulated brain development in adult men with schizophrenia: a magnetic resonance imaging studyGeorge Bartzokis
Department of Neurology, University of California School of Medicine, Los Angeles 90095-1769, USA
Biol Psychiatry 53:412-21. 2003..The importance of myelination to the continued maturation and normal functioning of the brain has implications for the diagnosis, treatment, and prognosis of schizophrenia... - Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjectsE C Mormino
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
Brain 132:1310-23. 2009..This pattern suggests that declining EM in older individuals may be caused by Abeta-induced hippocampus atrophy... - Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's diseaseDavid A Wolk
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 107:10256-61. 2010.... - Fluphenazine levels during maintenance treatment of recent-onset schizophrenia: relation to side effects, psychosocial function and depressionM J Gitlin
Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, 90095 6968, USA
Psychopharmacology (Berl) 148:350-4. 2000..The utility of fluphenazine levels during maintenance treatment of schizophrenia is still unclear... - Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiativeOwen Carmichael
Department of Neurology, School of Medicine, University of California, Davis, CA, USA
Arch Neurol 67:1370-8. 2010.... - Amygdala astrocyte reduction in subjects with major depressive disorder but not bipolar disorderLori L Altshuler
VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
Bipolar Disord 12:541-9. 2010..Specifically, it is not known whether differences in the density and/or volume of neurons or glial cells contribute to tissue volume changes seen on magnetic resonance images... - Increased amygdala activation during mania: a functional magnetic resonance imaging studyLori Altshuler
UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095 7057, USA
Am J Psychiatry 162:1211-3. 2005..This study sought to investigate neural activity in the amygdala during episodes of mania... - Ambulatory blood pressure and the brain: a 5-year follow-upIris B Goldstein
Department of Psychiatry, University of California, 760 Westwood Plaza, Los Angeles, CA 90095 1759, USA
Neurology 64:1846-52. 2005..To determine if initial values of casual and ambulatory systolic blood pressure (SBP) predict white matter hyperintensities, insular subcortex hyperintensities, and brain atrophy 5 years later in a group of healthy elderly individuals... - Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutationsJohn M Ringman
UCLA Department of Neurology, Alzheimer s Disease Research Center, 10911 Weyburn Ave, Suite 200, Los Angeles, CA 90095 7226, USA
Brain 130:1767-76. 2007..Decreased FA in of the columns of the fornix is particularly robust in early FAD and may provide a biomarker for early disease in sporadic Alzheimer's disease... - Diagnosing depression in Alzheimer disease with the national institute of mental health provisional criteriaEdmond Teng
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
Am J Geriatr Psychiatry 16:469-77. 2008.... - Time-lapse mapping of cortical changes in schizophrenia with different treatmentsPaul M Thompson
Laboratory of Neuro Imaging, Department of Neurology, University of California Los Anges, School of Medicine, Los Angeles, CA 90095 7332, USA
Cereb Cortex 19:1107-23. 2009..These maps revise current models of schizophrenia progression; due to power limitations, the findings require confirmation in a sample large enough to model group x time interactions... - Apolipoprotein E genotype is associated with temporal and hippocampal atrophy rates in healthy elderly adults: a tensor-based morphometry studyPo H Lu
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7226, USA
J Alzheimers Dis 23:433-42. 2011..Possession of the ε4 allele is associated with greater temporal and hippocampal volume reduction well before the onset of cognitive deficits... - Relationship between blood pressure and subcortical lesions in healthy elderly peopleI B Goldstein
Department of Psychiatry, University of California, Los Angeles 90024 1759, USA
Stroke 29:765-72. 1998..The relationship between blood pressure (BP) and heart rate (HR) and MRI assessments of subcortical T2 hyperintensities was evaluated in healthy elderly men and women... - Brain maturation may be arrested in chronic cocaine addictsGeorge Bartzokis
Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA
Biol Psychiatry 51:605-11. 2002..The findings suggest that in adults, cocaine dependence may arrest normal white matter maturation in the frontal and temporal lobes of addicts who continue using cocaine... - Exploratory voxel-based analysis of diffusion indices and hemispheric asymmetry in normal agingSiamak Ardekani
Biomedical Engineering IDP, University of California Los Angeles, Los Angeles, CA 90095, USA
Magn Reson Imaging 25:154-67. 2007..The study shows the feasibility of the VBA of DTI indices for exploratory investigations of subtle differences in population cohorts, especially when findings are not localized and/or known a priori... - Variation in neurophysiological function and evidence of quantitative electroencephalogram discordance: predicting cocaine-dependent treatment attritionSandy Venneman
Medication Development Unit, Research Service, and Psychiatry Service, West Los Angeles VA Medical Center, California, USA
J Neuropsychiatry Clin Neurosci 18:208-16. 2006..Failure to complete the trial was not explained by depression, craving, benzoylecgonine levels or quantitative electroencephalogram (QEEG) power; thus cordance may help identify attrition risk... - White-matter abnormalities in brain during early abstinence from methamphetamine abuseMarc C Tobias
Semel Institute for Neuroscience and Biobehavioral Studies, University of California Los Angeles, Los Angeles, CA, USA
Psychopharmacology (Berl) 209:13-24. 2010..As certain metabolic changes in the brain first manifest after early abstinence from methamphetamine, it is also possible that microstructural white-matter abnormalities are not yet present during early abstinence... - Assessment and familial aggregation of psychosis in Alzheimer's disease from the National Institute on Aging Late Onset Alzheimer's Disease Family StudyRobert A Sweet
Department of Psychiatry, University of Pittsburgh, Biomedical Science Tower, Rm W 1645, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
Brain 133:1155-62. 2010..Future studies should examine the linkage and association of psychosis with genetic variation within these families... - Ambulatory blood pressure and brain atrophy in the healthy elderlyIris B Goldstein
Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, CA 90095, USA
Neurology 59:713-9. 2002..Moreover, not only do BP level and variability relate to brain atrophy, but the combination of high level and greater variability shows an even stronger relationship to brain atrophy than either one of these variables alone... - Differences between smokers and nonsmokers in regional gray matter volumes and densitiesArthur L Brody
Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90095, USA
Biol Psychiatry 55:77-84. 2004..These findings might reflect effects of chronic smoking, predisposing traits that lead to smoking, or some combination of these factors... - Abuse of amphetamines and structural abnormalities in the brainSteven Berman
Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024 1759, USA
Ann N Y Acad Sci 1141:195-220. 2008..Longitudinal designs in which multimodal datasets are acquired and are subjected to multivariate analyses would enhance our ability to provide general conclusions regarding the associations between amphetamine abuse and brain structure... - A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderlyApril J Ho
Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 107:8404-9. 2010..These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly... - Biological underpinnings of treatment resistance in schizophrenia: an hypothesisGeorge Bartzokis
Psychopharmacol Bull 37:5-7. 2003 - Reduced intracortical myelination in schizophreniaGeorge Bartzokis
Am J Psychiatry 162:1229-30. 2005 - Myelination and brain electrophysiology in healthy and schizophrenic individualsGeorge Bartzokis
Neuropsychopharmacology 28:1217-8. 2003 - The Alzheimer's Disease Neuroimaging Initiative (ADNI): MRI methodsClifford R Jack
Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
J Magn Reson Imaging 27:685-91. 2008..The approach taken in ADNI to standardization across sites and platforms of the MRI protocol, postacquisition corrections, and phantom-based monitoring of all scanners could be used as a model for other multisite trials...
Research Grants
- Brain Development on Adults with SchizophreniaGeorge Bartzokis; Fiscal Year: 2007..This will change our concept of how we could treat this illness, the feasibility of changing its lifelong course, and would encourage the development of novel pharmacologic interventions to improve myelination. ..
- Brain Iron in Aging AdultsGeorge Bartzokis; Fiscal Year: 2007....
- Brain Iron in Aging AdultsGeorge Bartzokis; Fiscal Year: 2010....