GREGORY BARTON

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Viral recognition by Toll-like receptors
    Gregory M Barton
    Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, United States
    Semin Immunol 19:33-40. 2007
  2. pmc The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor
    Sarah E Ewald
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, 405 Life Sciences Addition, Berkeley, California 94720 3200, USA
    Nature 456:658-62. 2008
  3. pmc Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase
    Sarah E Ewald
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    J Exp Med 208:643-51. 2011
  4. pmc Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands
    Roman Barbalat
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, California, USA
    Nat Immunol 10:1200-7. 2009
  5. pmc UNC93B1 mediates differential trafficking of endosomal TLRs
    Bettina L Lee
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States
    elife 2:e00291. 2013
  6. pmc A calculated response: control of inflammation by the innate immune system
    Gregory M Barton
    Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720 3200, USA
    J Clin Invest 118:413-20. 2008
  7. pmc A cell biological view of Toll-like receptor function: regulation through compartmentalization
    Gregory M Barton
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720 3200, USA
    Nat Rev Immunol 9:535-42. 2009
  8. doi request reprint Nucleic acid recognition by the innate immune system
    Roman Barbalat
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, 94720 3200, USA
    Annu Rev Immunol 29:185-214. 2011
  9. ncbi request reprint Toll-like receptor signaling pathways
    Gregory M Barton
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, 300 Cedar Street, CABS660, New Haven, CT 06520, USA
    Science 300:1524-5. 2003
  10. ncbi request reprint Linking Toll-like receptors to IFN-alpha/beta expression
    Gregory M Barton
    Nat Immunol 4:432-3. 2003

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Viral recognition by Toll-like receptors
    Gregory M Barton
    Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, United States
    Semin Immunol 19:33-40. 2007
    ..In this review, I discuss the various strategies used by TLRs to recognize viruses as well as the experimental evidence implicating TLRs in viral immunity...
  2. pmc The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor
    Sarah E Ewald
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, 405 Life Sciences Addition, Berkeley, California 94720 3200, USA
    Nature 456:658-62. 2008
    ..We propose that ectodomain cleavage represents a strategy to restrict receptor activation to endolysosomal compartments and prevent TLRs from responding to self nucleic acids...
  3. pmc Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase
    Sarah E Ewald
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    J Exp Med 208:643-51. 2011
    ..These results define the core proteolytic steps required for TLR9 function and suggest that receptor proteolysis may represent a general regulatory strategy for all TLRs involved in nucleic acid recognition...
  4. pmc Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands
    Roman Barbalat
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, California, USA
    Nat Immunol 10:1200-7. 2009
    ..Thus, the innate immune system can detect certain non-nucleic acid features of viruses and links this recognition to the induction of specific antiviral genes...
  5. pmc UNC93B1 mediates differential trafficking of endosomal TLRs
    Bettina L Lee
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States
    elife 2:e00291. 2013
    ..Thus, our study describes a mechanism for differential sorting of endosomal TLRs by UNC93B1, which may explain the distinct roles played by these receptors in certain autoimmune diseases.DOI:http://dx.doi.org/10.7554/eLife.00291.001...
  6. pmc A calculated response: control of inflammation by the innate immune system
    Gregory M Barton
    Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720 3200, USA
    J Clin Invest 118:413-20. 2008
    ..Here I provide an overview of these innate receptors and suggest that the innate immune system can interpret the context of an inflammatory trigger and direct inflammation accordingly...
  7. pmc A cell biological view of Toll-like receptor function: regulation through compartmentalization
    Gregory M Barton
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720 3200, USA
    Nat Rev Immunol 9:535-42. 2009
    ..This emerging area of research will provide important information on how immune signal transduction networks depend on (and in some cases influence) the generic regulators that organize eukaryotic cells...
  8. doi request reprint Nucleic acid recognition by the innate immune system
    Roman Barbalat
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, 94720 3200, USA
    Annu Rev Immunol 29:185-214. 2011
    ..In this review, we highlight our current understanding of nucleic acid sensing by innate immune receptors and discuss the regulatory mechanisms that normally prevent inappropriate responses to self...
  9. ncbi request reprint Toll-like receptor signaling pathways
    Gregory M Barton
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, 300 Cedar Street, CABS660, New Haven, CT 06520, USA
    Science 300:1524-5. 2003
    ..TLRs and their pathways are numerous; Science's Signal Transduction Knowledge Environment's TLR Connections Map provides an immediate, clear overview of the known components and relations of this complex system...
  10. ncbi request reprint Linking Toll-like receptors to IFN-alpha/beta expression
    Gregory M Barton
    Nat Immunol 4:432-3. 2003
  11. ncbi request reprint The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
    Tiffany Horng
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 420:329-33. 2002
    ..Thus, TIRAP is differentially involved in signalling by members of the TLR family and may account for specificity in the downstream signalling of individual TLRs...
  12. ncbi request reprint Control of adaptive immune responses by Toll-like receptors
    Gregory M Barton
    Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, 310 Cedar Street, BML 458, New Haven, CT 06520, USA
    Curr Opin Immunol 14:380-3. 2002
    ..However, recent studies have suggested that Toll-like receptors may only control the induction of Th1 responses and that a separate system of recognition regulates Th2 responses...

Research Grants4

  1. The cell biology of Toll-like receptor 9: a mechanism to prevent autoimmunity
    GREGORY BARTON; Fiscal Year: 2009
    ..The goal of this research is to understand how TLR9 recognizes viral DNA while avoiding self DNA. ..
  2. The cell biology of Toll-like receptor 9: a mechanism to prevent autoimmunity
    Gregory M Barton; Fiscal Year: 2010
    ..The goal of this research is to understand how TLR9 recognizes viral DNA while avoiding self DNA. ..
  3. The cell biology of Toll-like receptor 9: a mechanism to prevent autoimmunity
    GREGORY BARTON; Fiscal Year: 2009
    ..The goal of this research is to understand how TLR9 recognizes viral DNA while avoiding self DNA. ..