S W Barthold

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Influence of arthritis-related protein (BBF01) on infectivity of Borrelia burgdorferi B31
    Denise Imai
    Center for Comparative Medicine, Schools of Veterinary Medicine and Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
    BMC Microbiol 13:100. 2013
  2. pmc Ineffectiveness of tigecycline against persistent Borrelia burgdorferi
    Stephen W Barthold
    Center for Comparative Medicine, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Antimicrob Agents Chemother 54:643-51. 2010
  3. pmc Antibody-mediated disease remission in the mouse model of lyme borreliosis
    Stephen W Barthold
    Center for Comparative Medicine, School of Medicine, University of California at Davis, One Shields Avenue, Davis, California 95616, USA
    Infect Immun 74:4817-25. 2006
  4. ncbi request reprint Genetically altered mice: phenotypes, no phenotypes, and Faux phenotypes
    Stephen W Barthold
    Center for Comparative Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Genetica 122:75-88. 2004
  5. ncbi request reprint Musings of a Connecticut Yankee in King Arthur's court: antemortem analysis of the veterinary profession
    Stephen W Barthold
    Center for Comparative Medicine, Director of the Mouse Biology Program, and Professor of Pathology at the University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    J Vet Med Educ 32:306-13. 2005
  6. pmc Specificity of infection-induced immunity among Borrelia burgdorferi sensu lato species
    S W Barthold
    Center for Comparative Medicine, School of Medicine, University of California, Davis 95616, USA
    Infect Immun 67:36-42. 1999
  7. ncbi request reprint Infection of mice with the agent of human granulocytic ehrlichiosis after different routes of inoculation
    E Hodzic
    Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California, Davis 95616, USA
    J Infect Dis 183:1781-6. 2001
  8. pmc Lyme arthritis resolution with antiserum to a 37-kilodalton Borrelia burgdorferi protein
    S Feng
    Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California, Davis, California 95616, USA
    Infect Immun 68:4169-73. 2000
  9. ncbi request reprint Cutting edge: T cell-mediated pathology in murine Lyme borreliosis
    M D McKisic
    Center for Comparative Medicine, University of California, Davis 95616, USA
    J Immunol 164:6096-9. 2000
  10. ncbi request reprint Acquisition dynamics of Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis at the host-vector interface
    E Hodzic
    Center for Comparative Medicine, School of Medicine, University of California Davis, 95616, USA
    Vector Borne Zoonotic Dis 1:149-58. 2001

Research Grants

  1. MOUSE MODEL OF LYME BORRELIOSIS
    Stephen Barthold; Fiscal Year: 2006
  2. VETERINARY STUDENT RESEARCH TRAINING PROGRAM
    Stephen Barthold; Fiscal Year: 2007
  3. COMPARATIVE MEDICAL SCIENCE TRAINING PROGRAM
    Stephen Barthold; Fiscal Year: 2007
  4. 5th Comparative Medicine Resource Center Director Mtg.
    Stephen Barthold; Fiscal Year: 2007
  5. MOUSE MODEL OF LYME BORRELIOSIS
    STEPHEN WILLIAM BARTHOLD; Fiscal Year: 2010
  6. Humoral responses to Lyme Borreliosis: A mouse model
    Nicole Baumgarth; Fiscal Year: 2010
  7. HELICOBACTER DIAGNOSTIC ASSAYS FOR LABORATORY MICE
    Stephen Barthold; Fiscal Year: 2004
  8. MOUSE MODEL OF LYME BORRELIOSIS
    Stephen Barthold; Fiscal Year: 2001
  9. 3RD ANNUAL MUTANT MOUSE REGIONAL RESOURCE CENTER MEETING
    Stephen Barthold; Fiscal Year: 2003
  10. UCD MUTANT MOUSE REGIONAL RESOUCE CENTER
    Stephen Barthold; Fiscal Year: 2003

Collaborators

Detail Information

Publications57

  1. pmc Influence of arthritis-related protein (BBF01) on infectivity of Borrelia burgdorferi B31
    Denise Imai
    Center for Comparative Medicine, Schools of Veterinary Medicine and Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
    BMC Microbiol 13:100. 2013
    ..burgdorferi s.s. isolates, has been shown to be antigenic in humans with Lyme borreliosis, and a target for antibody-mediated disease resolution in the mouse model...
  2. pmc Ineffectiveness of tigecycline against persistent Borrelia burgdorferi
    Stephen W Barthold
    Center for Comparative Medicine, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Antimicrob Agents Chemother 54:643-51. 2010
    ..burgdorferi genes. These results extended previous studies with ceftriaxone, indicating that antibiotic treatment is unable to clear persisting spirochetes, which remain viable and infectious, but are nondividing or slowly dividing...
  3. pmc Antibody-mediated disease remission in the mouse model of lyme borreliosis
    Stephen W Barthold
    Center for Comparative Medicine, School of Medicine, University of California at Davis, One Shields Avenue, Davis, California 95616, USA
    Infect Immun 74:4817-25. 2006
    ..These results suggest that Arp and DbpA antibodies may be active as disease-resolving components in immune serum but antibody against other antigens may be involved in reductions of spirochetes in tissues...
  4. ncbi request reprint Genetically altered mice: phenotypes, no phenotypes, and Faux phenotypes
    Stephen W Barthold
    Center for Comparative Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Genetica 122:75-88. 2004
    ..Infectious disease, including clinically silent infections, can and do influence phenotype, and can jeopardize research considerably through lost time, wasted effort, cost, and even loss of valuable strains...
  5. ncbi request reprint Musings of a Connecticut Yankee in King Arthur's court: antemortem analysis of the veterinary profession
    Stephen W Barthold
    Center for Comparative Medicine, Director of the Mouse Biology Program, and Professor of Pathology at the University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    J Vet Med Educ 32:306-13. 2005
  6. pmc Specificity of infection-induced immunity among Borrelia burgdorferi sensu lato species
    S W Barthold
    Center for Comparative Medicine, School of Medicine, University of California, Davis 95616, USA
    Infect Immun 67:36-42. 1999
    ..These results indicate that protective immunity and disease-modulating immunity that develop during active infection are universal among species related to B. burgdorferi sensu lato but are species specific...
  7. ncbi request reprint Infection of mice with the agent of human granulocytic ehrlichiosis after different routes of inoculation
    E Hodzic
    Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California, Davis 95616, USA
    J Infect Dis 183:1781-6. 2001
    ....
  8. pmc Lyme arthritis resolution with antiserum to a 37-kilodalton Borrelia burgdorferi protein
    S Feng
    Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California, Davis, California 95616, USA
    Infect Immun 68:4169-73. 2000
    ..burgdorferi isolates but hybridized with those isolates only under very-low-stringency conditions. Arp antiserum reacted against proteins of similar size in a wide range of B. burgdorferi isolates...
  9. ncbi request reprint Cutting edge: T cell-mediated pathology in murine Lyme borreliosis
    M D McKisic
    Center for Comparative Medicine, University of California, Davis 95616, USA
    J Immunol 164:6096-9. 2000
    ..These data demonstrate directly the deleterious effect of T cells in Lyme disease...
  10. ncbi request reprint Acquisition dynamics of Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis at the host-vector interface
    E Hodzic
    Center for Comparative Medicine, School of Medicine, University of California Davis, 95616, USA
    Vector Borne Zoonotic Dis 1:149-58. 2001
    ..In contrast, results indicate that the aoHGE relies upon hematogenous acquisition. Thus, these two cotransmitted tick-borne pathogens utilize distinctly different means of vector acquisition...
  11. ncbi request reprint Evaluation of diagnostic methods for Helicobacter bilis infection in laboratory mice
    E Hodzic
    Center for Comparative Medicine, School of Medicine, University of California, Davis 95616, USA
    Comp Med 51:406-12. 2001
    ..Results underscore the need for improved seroassays for this important group of murine pathogens...
  12. pmc T-cell-independent responses to Borrelia burgdorferi are critical for protective immunity and resolution of lyme disease
    M D McKisic
    Center for Comparative Medicine, University of California, Davis, California 95616, USA
    Infect Immun 68:5190-7. 2000
    ..These data demonstrate that B-cell activation during a T-cell-independent response may be critical for resolution of arthritis and carditis and that protective antibodies are generated during this response...
  13. ncbi request reprint Thrombocytopenia in a mouse model of human granulocytic ehrlichiosis
    D L Borjesson
    Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Infect Dis 184:1475-9. 2001
    ..This study validates the appropriateness of the mouse as a model of HGE, including its usefulness for the investigation of thrombocytopenia...
  14. pmc Humoral immunity to Borrelia burgdorferi N40 decorin binding proteins during infection of laboratory mice
    S Feng
    Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California, Davis, California 95616, USA
    Infect Immun 66:2827-35. 1998
    ..DNA amplification and serology suggest that DbpB and DbpA are likely to have homologs throughout the B. burgdorferi sensu lato family, but they are likely to be heterogeneous...
  15. pmc Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality
    W L William Chang
    Center for Comparative Medicine, University of California, Davis, County Road 98 and Hutchison Drive, Davis, CA 95616, USA
    J Virol 78:8720-31. 2004
    ..Collectively, we show that cmvIL-10 causes long-term functional alterations at all stages of DC activation...
  16. pmc Rigid interferon-alpha subtype responses of human plasmacytoid dendritic cells
    Richard Szubin
    Center for Comparative Medicine, University of California, Davis, California 95616, USA
    J Interferon Cytokine Res 28:749-63. 2008
    ..These data are most consistent with the induction of optimized ratios of IFN-alpha subtypes, each of which may have differing signaling properties or alternatively, a great degree of redundancy in the IFN-alpha response...
  17. pmc Human cytomegalovirus suppresses type I interferon secretion by plasmacytoid dendritic cells through its interleukin 10 homolog
    W L William Chang
    Center for Comparative Medicine, University of California, Davis, CA 95616, USA
    Virology 390:330-7. 2009
    ..These results suggest that HCMV subverts innate immunity by suppressing type I IFN production of PDCs during primary viral infection via its IL-10 homolog...
  18. ncbi request reprint Exposure of myeloid dendritic cells to exogenous or endogenous IL-10 during maturation determines their longevity
    W L William Chang
    Center for Comparative Medicine, University of California Davis, County Road 98 and Hutchison Drive, Davis, CA 95616, USA
    J Immunol 178:7794-804. 2007
    ..This regulatory mechanism of IL-10 is associated with the dynamic control of antiapoptotic Bcl-2 proteins...
  19. doi request reprint The double life of a B-1 cell: self-reactivity selects for protective effector functions
    Nicole Baumgarth
    Center for Comparative Medicine, University of California, Davis, California 95616, USA
    Nat Rev Immunol 11:34-46. 2011
    ....
  20. pmc Highly tissue substructure-specific effects of human papilloma virus in mucosa of HIV-infected patients revealed by laser-dissection microscopy-assisted gene expression profiling
    Nicole Baumgarth
    Center for Comparative Medicine, University of California, Davis, CA, USA
    Am J Pathol 165:707-18. 2004
    ..Because of its large dynamic measurement range it could also become a method of choice to confirm and better quantify results obtained by microarray analysis...
  21. doi request reprint Lyme neuroborreliosis in 2 horses
    D M Imai
    Center of Comparative Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    Vet Pathol 48:1151-7. 2011
    ..In both horses, spirochetes were visualized in affected tissues with Steiner silver impregnation and by immunohistochemistry, predominantly within the dense collagenous tissue of the dura mater and leptomeninges...
  22. ncbi request reprint Type I IFN receptor signals directly stimulate local B cells early following influenza virus infection
    Elizabeth S Coro
    Center for Comparative Medicine, University of California, Davis, 95616, USA
    J Immunol 176:4343-51. 2006
    ..Thus, ligand(s) of the type I IFNR are direct nonredundant early innate signals that regulate local antiviral B cell responses...
  23. ncbi request reprint B-cell immunophenotyping
    Nicole Baumgarth
    Center for Comparative Medicine, University of California, Davis, Davis, California 95616, USA
    Methods Cell Biol 75:643-62. 2004
  24. pmc Dual role for B-1a cells in immunity to influenza virus infection
    Youn Soo Choi
    Graduate Group in Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    J Exp Med 205:3053-64. 2008
    ..With that, our data reveal fundamental differences in the response regulation of B-1 and B-2 cells during an infection...
  25. ncbi request reprint Coinfection with Borrelia burgdorferi sensu stricto and Borrelia garinii alters the course of murine Lyme borreliosis
    Joppe W R Hovius
    Section of Rheumatology, Department of Internal Medicine, Yale University, School of Medicine, New Haven, Connecticut, USA
    FEMS Immunol Med Microbiol 49:224-34. 2007
    ..Moreover, we suggest that competition of the two Borrelia species within the reservoir host could have led to preferential maintenance, and a rising prevalence, of B. burgdorferi sensu stricto in European I. ricinus populations...
  26. ncbi request reprint 'One medicine---one pathology': are veterinary and human pathology prepared?
    Robert D Cardiff
    Center for Comparative Medicine, University of California, Davis, CA 95616, USA
    Lab Invest 88:18-26. 2008
    ..The impending glut of new genetically engineered mice creates an urgent need for prepared investigators and pathologists...
  27. pmc Persistence of Borrelia burgdorferi following antibiotic treatment in mice
    Emir Hodzic
    Center for Comparative Medicine, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Antimicrob Agents Chemother 52:1728-36. 2008
    ..Results indicated that following antibiotic treatment, mice remained infected with nondividing but infectious spirochetes, particularly when antibiotic treatment was commenced during the chronic stage of infection...
  28. pmc Coinfection with Anaplasma phagocytophilum alters Borrelia burgdorferi population distribution in C3H/HeN mice
    Kevin Holden
    Center for Comparative Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Infect Immun 73:3440-4. 2005
    ..burgdorferi modulates pathogen burden and host antibody responses. This may be explained by the ability of A. phagocytophilum to functionally impair neutrophils, important cells in the early defense against B. burgdorferi infection...
  29. pmc Simultaneous serodetection of 10 highly prevalent mouse infectious pathogens in a single reaction by multiplex analysis
    Imran H Khan
    Center for Comparative Medicine, and Department of Pathology and Laboratory Medicine, University of California at Davis, Davis, California 95616, USA
    Clin Diagn Lab Immunol 12:513-9. 2005
    ..Thus, this multiplex microbead assay is a reliable, efficient, and cost-effective diagnostic modality that will impact serosurveillance of mice used in research...
  30. pmc Infection of mice with lyme disease spirochetes constitutively producing outer surface proteins a and B
    Keith O Strother
    Department of Microbiology and Immunology, University of Chapel Hill, Chapel Hill, NC 27599, USA
    Infect Immun 75:2786-94. 2007
    ..We conclude that spirochetes producing OspA and B from the flaB promoter in immunocompetent mice stimulate an immune response that clear the bacteria without any signs of disease development in the mice...
  31. pmc P26-based serodiagnosis for Bartonella spp. infection in cats
    Jonathan A Werner
    Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California, Davis, CA, USA
    Comp Med 58:375-80. 2008
    ..were seropositive. We propose that rP26-based serology can serve as a useful adjunct tool for the diagnosis of feline infection with B. henselae and B. clarridgeiae, but it may not be useful for feline infection with B. koehlerae...
  32. pmc Recombinant Helicobacter bilis protein P167 for mouse serodiagnosis in a multiplex microbead assay
    Sunlian Feng
    Center for Comparative Medicine, University of California at Davis, One Shields Ave, Davis, CA 95616, USA
    Clin Diagn Lab Immunol 11:1094-9. 2004
    ..Thus, recombinant antigens are highly suitable in the multiplex microbead assay format for serodetection of H. bilis infection...
  33. ncbi request reprint Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity
    Juan Anguita
    Department of Biology, University of North Carolina, Charlotte, NC 28223, USA
    J Immunol 168:6352-7. 2002
    ..Overall, these data indicated that the p38 MAP kinase pathway plays an important role in B. burgdorferi-elicited inflammation and point to potential new therapeutic approaches to the treatment of inflammation induced by the spirochete...
  34. pmc Borrelia burgdorferi population kinetics and selected gene expression at the host-vector interface
    Emir Hodzic
    Center for Comparative Medicine, School of Medicine, University of California at Davis, Davis, California 95616, USA
    Infect Immun 70:3382-8. 2002
    ..Evidence of ospA transcription in skin could be found 1 day after tick attachment but not thereafter...
  35. ncbi request reprint Detection of attenuated, noninfectious spirochetes in Borrelia burgdorferi-infected mice after antibiotic treatment
    Linda K Bockenstedt
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8031, USA
    J Infect Dis 186:1430-7. 2002
    ..These results provide evidence that noninfectious spirochetes can persist for a limited duration after antibiotics but are not associated with disease in mice...
  36. ncbi request reprint Cyclooxygenase 2 activity modulates the severity of murine Lyme arthritis
    Juan Anguita
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    FEMS Immunol Med Microbiol 34:187-91. 2002
    ..burgdorferi-specific antibody or cytokine responses. Cox-2 activity is therefore associated with the genesis of infectious arthritis caused by B. burgdorferi...
  37. ncbi request reprint Kinetics of CD11b/CD18 up-regulation during infection with the agent of human granulocytic ehrlichiosis in mice
    Dori L Borjesson
    Center for Comparative Medicine, School of Medicine, University of California, Davis, California 95616, USA
    Lab Invest 82:303-11. 2002
    ..The data support crucial roles of CD11b/CD18 and IFN-gamma-mediated cell activation as mechanisms that limit bacterial replication...
  38. ncbi request reprint Roles of neutrophil beta 2 integrins in kinetics of bacteremia, extravasation, and tick acquisition of Anaplasma phagocytophila in mice
    Dori L Borjesson
    Center for Comparative Medicine, Schools of Medicine Veterinary Medicine, University of California, Davis 95616, USA
    Blood 101:3257-64. 2003
    ..Establishment of feeding pools that rely less on leukocyte trafficking and more on small hemorrhages may explain the ready amplification of A phagocytophila DNA from ticks infested on CD11/CD18-deficient mouse strains...
  39. pmc Humoral immunity reflects altered T helper cell bias in Borrelia burgdorferi-infected gamma delta T-cell-deficient mice
    Linda K Bockenstedt
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Infect Immun 71:2938-40. 2003
    ..Arthropod transmission of Borrelia burgdorferi spirochetes results in similar antibody isotypes when gamma delta T cells are present, suggesting that vector effects can negate gamma delta T-cell functions in vivo...
  40. pmc Infection and inflammation in skeletal muscle from nonhuman primates infected with different genospecies of the Lyme disease spirochete Borrelia burgdorferi
    Diego Cadavid
    Department of Neuroscience, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Infect Immun 71:7087-98. 2003
    ..We conclude that myositis can be a prominent feature of Lyme borreliosis depending on the infecting organism and host immune status...
  41. pmc Borrelia burgdorferi population dynamics and prototype gene expression during infection of immunocompetent and immunodeficient mice
    Emir Hodzic
    Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California at Davis, Davis, California 95616, USA
    Infect Immun 71:5042-55. 2003
    ..Gene transcription showed variation among tissues, with the highest levels of transcription in heart and joint tissue, which are sites of inflammation...
  42. pmc Immunogenicity of Borrelia burgdorferi arthritis-related protein
    Sunlian Feng
    Center for Comparative Medicine, School of Medicine, University of California at Davis, 95616, USA
    Infect Immun 71:7211-4. 2003
    ..Results suggest that the arthritis-resolving immunogenicity is specific to Arp, but the relevant epitopes may be conformational...
  43. ncbi request reprint Spinal cord involvement in the nonhuman primate model of Lyme disease
    Yunhong Bai
    Department of Neurology and Neuroscience, and Center for the Study of Emerging Pathogens, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Lab Invest 84:160-72. 2004
    ..C1q mRNA expression was significantly increased in inflamed spinal cord. This is the first comprehensive study of spinal cord involvement in Lyme borreliosis...
  44. ncbi request reprint Use of the P167 recombinant antigen for serodiagnosis of Helicobacter bilis
    Lon V Kendall
    Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California, Davis, Davis, California 95616, USA
    Comp Med 54:44-8. 2004
    ..These findings suggest that the recombinant P167C and D fragments of the p167 gene product from H. bilis can be used as specific reagents in the serodiagnosis of H. bilis infection in mice...
  45. pmc Myeloid differentiation antigen 88 deficiency impairs pathogen clearance but does not alter inflammation in Borrelia burgdorferi-infected mice
    Nengyin Liu
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Infect Immun 72:3195-203. 2004
    ..Our results show that MyD88-dependent signaling pathways are not required for B. burgdorferi-induced inflammation but are necessary for the efficient control of the pathogen burden by phagocytes...
  46. ncbi request reprint Experimental infection of domestic cats with passaged genotype I Bartonella henselae
    Jonathan A Werner
    Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Microbiol 122:290-7. 2007
    ..Furthermore, in vitro passage results in phenotypic and antigenic changes in the bacterial membrane protein profile, which warrants caution in the interpretation of studies involving passaged B. henselae strains...
  47. ncbi request reprint Hidden costs of biodefense research
    Stephen W Barthold
    Department of Comparative Medicine, University of California, Davis, USA
    ILAR J 46:1-3. 2005
  48. ncbi request reprint Biomedical research and veterinarians: where's Waldo?
    Stephen W Barthold
    Center for Comparative Medicine, University of California, Davis 95616, USA
    Comp Med 52:95-6. 2002
  49. pmc Cloning and expression of a Helicobacter bilis immunoreactive protein
    Sunlian Feng
    Center for Comparative Medicine, School of Medicine, University of California at Davis, Davis, California 95616, USA
    Clin Diagn Lab Immunol 9:627-32. 2002
    ..hepaticus, and all five primer sets amplified DNA from H. muridarum. These results suggest that P167 is an immunodominant, H. bilis-specific antigen that may have potential for use in serodiagnosis...
  50. ncbi request reprint "Muromics": genomics from the perspective of the laboratory mouse
    Stephen W Barthold
    Center for Comparative Medicine, University of California at Davis, 95616, USA
    Comp Med 52:206-23. 2002
  51. ncbi request reprint "Outbreak of hind limb paralysis in young CFW Swiss Webster mice"
    Stephen W Barthold
    Comp Med 52:303; author reply 303-4. 2002
  52. pmc Immunoglobulin-regulated expression of Borrelia burgdorferi outer surface protein A in vivo
    Emir Hodzic
    Center for Comparative Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Infect Immun 73:3313-21. 2005
    ..Collectively, our results indicate that ospA mRNA transcription in the host is regulated by nonspecific immunoglobulin, which may be a natural antibody...
  53. ncbi request reprint The mouse as a model for investigation of human granulocytic ehrlichiosis: current knowledge and future directions
    Dori L Borjesson
    Department of Diagnostic Medicine, Veterinary Diagnostic Laboratory, University of Minnesota, St Paul, Minnesota 55108, USA
    Comp Med 52:403-13. 2002
    ..Included is a discussion of current changes in ehrlichial classification and nomenclature, a review of ehrlichial biology and ecology, and highlights of clinical disease in animals and people...
  54. doi request reprint Anti-tumor necrosis factor-alpha activation of Borrelia burgdorferi spirochetes in antibiotic-treated murine Lyme borreliosis: an unproven conclusion
    Gary P Wormser
    J Infect Dis 196:1865-6; author reply 1866-7. 2007
  55. ncbi request reprint Over 60% of NIH extramural funding involves animal-related research
    Ted Valli
    Vet Pathol 44:962-3, author reply 963-4. 2007
  56. pmc Cloning, characterization, and expression of Bartonella henselae p26
    Jonathan A Werner
    Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California at Davis, California 95616, USA
    Clin Vaccine Immunol 13:830-6. 2006
    ..The p26 protein product is an immunodominant antigen that is expressed during infection in cats as a preprotein and is subsequently cleaved to form mature P26...
  57. ncbi request reprint From whence will they come? - A perspective on the acute shortage of pathologists in biomedical research
    Stephen W Barthold
    J Vet Diagn Invest 19:455-6. 2007

Research Grants36

  1. MOUSE MODEL OF LYME BORRELIOSIS
    Stephen Barthold; Fiscal Year: 2006
    ....
  2. VETERINARY STUDENT RESEARCH TRAINING PROGRAM
    Stephen Barthold; Fiscal Year: 2007
    ..abstract_text> ..
  3. COMPARATIVE MEDICAL SCIENCE TRAINING PROGRAM
    Stephen Barthold; Fiscal Year: 2007
    ..Faculty within the Center for Comparative Medicine as well as faculty in other linked programs will provide the mentoring for students, thereby providing maximal opportunity to match students with their areas of interest. ..
  4. 5th Comparative Medicine Resource Center Director Mtg.
    Stephen Barthold; Fiscal Year: 2007
    ....
  5. MOUSE MODEL OF LYME BORRELIOSIS
    STEPHEN WILLIAM BARTHOLD; Fiscal Year: 2010
    ..The proposed studies will incisively investigate the mechanisms of Borrelia burgdorferi persistence, which will help lead to more effective treatment. ..
  6. Humoral responses to Lyme Borreliosis: A mouse model
    Nicole Baumgarth; Fiscal Year: 2010
    ..Such information is necessary to develop vaccines and treatments for this increasingly prevalent disease. ..
  7. HELICOBACTER DIAGNOSTIC ASSAYS FOR LABORATORY MICE
    Stephen Barthold; Fiscal Year: 2004
    ..abstract_text> ..
  8. MOUSE MODEL OF LYME BORRELIOSIS
    Stephen Barthold; Fiscal Year: 2001
    ..They offer the potential for development of a therapeutic vaccine for Lyme disease and development of a model for chronic arthritis. ..
  9. 3RD ANNUAL MUTANT MOUSE REGIONAL RESOURCE CENTER MEETING
    Stephen Barthold; Fiscal Year: 2003
    ....
  10. UCD MUTANT MOUSE REGIONAL RESOUCE CENTER
    Stephen Barthold; Fiscal Year: 2003
    ..abstract_text> ..
  11. MOUSE MODEL OF LYME BORRELIOSIS
    STEPHEN WILLIAM BARTHOLD; Fiscal Year: 2011
    ..The proposed studies will incisively investigate the mechanisms of Borrelia burgdorferi persistence, which will help lead to more effective treatment. ..