Research Topics
Genomes and Genes | Sanford H BarskySummaryAffiliation: University of California Country: USA Publications
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Publications
Histopathologic and molecular alterations in bronchial epithelium in habitual smokers of marijuana, cocaine, and/or tobaccoS H Barsky
Department of Pathology, University of California, Los Angeles, USA
J Natl Cancer Inst 90:1198-205. 1998....
Myoepithelial mRNA expression profiling reveals a common tumor-suppressor phenotypeSanford H Barsky
Department of Pathology and Revlon UCLA Breast Center, UCLA School of Medicine, Los Angeles, CA 90024, USA
Exp Mol Pathol 74:113-22. 2003..Developmental genes were also differentially expressed (either over or underexpressed). These studies confirm our previous impression that human myoepithelial cells express a distinct tumor-suppressor phenotype...
Breast carcinomatous tumoral emboli can result from encircling lymphovasculogenesis rather than lymphovascular invasionSepi Mahooti
Department of Pathology, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
Oncotarget 1:131-47. 2010..Collectively both experimental as well as observational studies suggested the possibility that these breast cancer emboli resulted from encircling lymphovasculogenesis rather than conventional lymphovascular invasion...
Establishment of an immortalized cell line and transplantable xenograft from a bronchioloalveolar lung carcinoma of a catDeborah A Grossman
Department of Pathology, UCLA School of Medicine, Los Angeles, CA 90024, USA
Am J Vet Res 63:1745-53. 2002..CONCLUSIONS: Both the cell line and xenograft retained their autochthonous BAC phenotype, making them useful for the subsequent dissection of molecular abnormalities in feline BAC and in vitro screening of chemotherapeutic agents...
Singular v dual inhibition of SNF2L and its isoform, SNF2LT, have similar effects on DNA damage but opposite effects on the DNA damage response, cancer cell growth arrest and apoptosisYin Ye
Department of Pathology, University of Nevada School of Medicine, Reno, NV, USA
Oncotarget 3:475-89. 2012..Cancer cell lines which endogenously express low levels of both SNF2L and its isoform mimic the situation of dual knockdown and permit DNA damage which is allowed to propagate unchecked...
Inhibition of expression of the chromatin remodeling gene, SNF2L, selectively leads to DNA damage, growth inhibition, and cancer cell deathYin Ye
Department of Pathology, University of Nevada School of Medicine, Reno, NV 89557 0350, USA
Mol Cancer Res 7:1984-99. 2009..This raised the hypothesis that cancers are sensitive to SNF2L knockdown because, unlike their normal counterparts, they lack sufficient compensation from other family members...
Early to intermediate steps of tumor embolic formation involve specific proteolytic processing of E-cadherin regulated by Rab7Yin Ye
Department of Pathology, University of Nevada School of Medicine, Reno, NV 89557, USA
Mol Cancer Res 10:713-26. 2012....
Myoepithelial cells: autocrine and paracrine suppressors of breast cancer progressionSanford H Barsky
Department of Pathology, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
J Mammary Gland Biol Neoplasia 10:249-60. 2005....
Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancerZahida Qamri
Department of Pathology, Ohio State University Medical Center, Columbus, OH 43210, USA
Mol Cancer Ther 8:3117-29. 2009..These results indicate that CB1 and CB2 receptors could be used to develop novel therapeutic strategies against breast cancer growth and metastasis...
ERalpha suppresses slug expression directly by transcriptional repressionYin Ye
Department of Pathology, The Ohio State University College of Medicine, 129 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, USA
Biochem J 416:179-87. 2008..The efficacy of the effect of ERalpha on slug repression was dependent on the overall level of ERalpha. These observations confirmed that slug was an E2-responsive gene...
Piwil2 is expressed in various stages of breast cancers and has the potential to be used as a novel biomarkerJames J Liu
Department of Pathology, Ohio State University Medical Center, Columbus, OH 43210, USA
Int J Clin Exp Pathol 3:328-37. 2010..In conclusion, piwil2 is expressed in various stages of breast cancers and has the potential to be used a novel biomarker...
The lymphovascular embolus of inflammatory breast cancer expresses a stem cell-like phenotypeYi Xiao
Department of Pathology, The Ohio State University College of Medicine, 129 Hamilton Hall, 1645 Neil Ave, Columbus, OH 43210 1218, USA
Am J Pathol 173:561-74. 2008..This stem cell-like phenotype may contribute to the aggressive nature of IBC but also may lend itself to selective targeting...
E-cadherin accumulation within the lymphovascular embolus of inflammatory breast cancer is due to altered traffickingYin Ye
Department of Pathology, University of Nevada School of Medicine, Reno, NV 89557, USA
Anticancer Res 30:3903-10. 2010..These findings suggest that it is the altered E-cadherin trafficking that contributes to its oncogenic rather than suppressive role in IBC...
Relationship of sialyl-Lewis(x/a) underexpression and E-cadherin overexpression in the lymphovascular embolus of inflammatory breast carcinomaMary L Alpaugh
Department of Pathology, University of California at Los Angeles School of Medicine, Los Angeles, California 90024, USA
Am J Pathol 161:619-28. 2002..Our findings support the cooperative relationship of sLe(x/a) underexpression and E-cadherin overexpression in the genesis of the lymphovascular embolus of IBC...
Mechanisms of disease: breast tumor pathogenesis and the role of the myoepithelial cellSanford H Barsky
Department of Pathology, The Ohio State University College of Medicine, Columbus, OH 43210, USA
Nat Clin Pract Oncol 3:138-51. 2006..Studies of primary and immortalized myoepithelial cell lines indicate that these cells exhibit a natural tumor suppressor function. Functional studies show that these cells have anti-invasive and antiangiogenic phenotypes...
Angiosarcoma developing in a breast after conservation treatment for breast cancerRobert G Parker
Department of Radiation Oncology, UCLA Medical Center, Los Angeles, California, USA
Am J Clin Oncol 26:486-8. 2003
Reversible model of spheroid formation allows for high efficiency of gene delivery ex vivo and accurate gene assessment in vivoMary L Alpaugh
Department of Pathology, UCLA School of Medicine, Los Angeles, CA 90024, USA
Hum Gene Ther 13:1245-58. 2002..If more broadly applied, this model could be used to examine the effects of any gene, using any gene delivery system in the three-dimensional context of native tumoral architecture...
Images in clinical medicine. Pseudomyxoma peritoneiSanford H Barsky
UCLA School of Medicine, Los Angeles, CA 90024, USA
N Engl J Med 350:e13. 2004
Atypical ductal hyperplasia presenting as pseudomicrocalcificationsHenry C H Tsai
Department of Pathology, UCLA School of Medicine, Los Angeles, California 90024, USA
Breast J 9:39-40. 2003..Upon excision, these turned out to be pseudomicrocalcifications created by the intraductal cellular proliferations of atypical ductal hyperplasia so dense as to create radiodensities...
Comparative oncological studies of feline bronchioloalveolar lung carcinoma, its derived cell line and xenograftDeborah A Grossman
Department of Pathology, University of California-Los Angeles School of Medicine, Los Angeles, California 90024, USA
Cancer Res 62:3826-33. 2002..These studies of feline BAC may allow insights into the human disease that are not possible by studying human BAC directly...
Clinicopathologic analysis of sentinel lymph node mapping in early breast cancerSeung-Hye Choi
Department of Surgery, Revlon/UCLA Breast Center, UCLA Medical Center, Los Angeles, California 90095, USA
Breast J 9:153-62. 2003....
Anatomy of the nipple and breast ducts revisitedSusan M Love
Department of General Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
Cancer 101:1947-57. 2004..Increasing interest in the intraductal approach to the breast has necessitated revisiting the anatomy of the breast...
MUC2 is a molecular marker for pseudomyxoma peritoneiJerome T O'Connell
Department of Pathology, UCLA School of Medicine, Los Angeles, California 90024, USA
Mod Pathol 15:958-72. 2002..In all cases studied, the fidelity of MUC2 and MUC5AC expression held irrespective of the degree of malignant transformation which was present. MUC2 is therefore a reliable molecular marker for pseudomyxoma peritonei...
Cooperative role of E-cadherin and sialyl-Lewis X/A-deficient MUC1 in the passive dissemination of tumor emboli in inflammatory breast carcinomaMary L Alpaugh
Department of Pathology, UCLA School of Medicine, Los Angeles, California, CA 90024, USA
Oncogene 21:3631-43. 2002..1). Our findings support the cooperative role of E-cadherin and sialyl-Lewis X/A-deficient MUC1 in the passive dissemination of tumor emboli in IBC...
Identification of a novel endothelial-derived gene EG-1Canhui Liu
Division of Surgical Oncology, UCLA School of Medicine, Los Angeles, CA 90095, USA
Biochem Biophys Res Commun 290:602-12. 2002..4-kb RNA form. Our data suggest that EG-1 is associated with a stimulated state in endothelial and epithelial cells, and may have a role in tumor angiogenesis...
Precancerous stem cells can serve as tumor vasculogenic progenitorsRulong Shen
Department of Pathology and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA
PLoS ONE 3:e1652. 2008..Our studies indicate that pCSCs can serve as tumor vasculogenic stem/progenitor cells (TVPCs), and may explain why anti-angiogenic cancer therapy trials are facing challenge...
Semi-automated imaging system to quantitate Her-2/neu membrane receptor immunoreactivity in human breast cancerAparna S Joshi
BioImagene Inc, Suite 212, Cupertino, California 95014, USA
Cytometry A 71:273-85. 2007..Immunocytochemical methods for quantitating Her-2/neu immunoreactivity rest on subjective semi-quantitative interpretations with resulting interobserver, intraobserver, and fatigue variability...
Novel interactions of vitamin E and estrogen in breast cancerHilda Chamras
Division of Hematology Oncology, Department of Medicine, University of California at Los Angeles, School of Medicine 90095 1678, USA
Nutr Cancer 52:43-8. 2005..This provides evidence that vitamin E may inhibit ER-positive cell growth by altering the cellular response to estrogen...
