Oleg A Barski

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc Dietary carnosine prevents early atherosclerotic lesion formation in apolipoprotein E-null mice
    Oleg A Barski
    Diabetes and Obesity Center, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Arterioscler Thromb Vasc Biol 33:1162-70. 2013
  2. pmc Alternative splicing in the aldo-keto reductase superfamily: implications for protein nomenclature
    Oleg A Barski
    Diabetes and Obesity Center, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Chem Biol Interact 202:153-8. 2013
  3. ncbi Developmental expression and function of aldehyde reductase in proximal tubules of the kidney
    Oleg A Barski
    Harry B and Aileen Gordon Diabetes Research Laboratory, Baylor College of Medicine, Houston, Texas, USA
    Am J Physiol Renal Physiol 289:F200-7. 2005
  4. pmc Kinetics of nucleotide binding to the beta-subunit (AKR6A2) of the voltage-gated potassium (Kv) channel
    Oleg A Barski
    Department of Medicine, Division of Cardiology, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, United States
    Chem Biol Interact 178:165-70. 2009
  5. pmc The aldo-keto reductase superfamily and its role in drug metabolism and detoxification
    Oleg A Barski
    Division of Cardiology, Department of Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, Kentucky 40202, USA
    Drug Metab Rev 40:553-624. 2008
  6. pmc Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice
    Sanjay Srivastava
    Diabetes and Obesity Center, Institute of Molecular Cardiology, Division of Cardiovascular Medicine, Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Circ Res 105:793-802. 2009
  7. pmc Catalytic mechanism and substrate specificity of the beta-subunit of the voltage-gated potassium channel
    Srinivas M Tipparaju
    Division of Cardiology, Department of Medicine, Institute of Molecular Cardiology, University of Louisville, Kentucky 40202, USA
    Biochemistry 47:8840-54. 2008
  8. pmc Reductive metabolism of AGE precursors: a metabolic route for preventing AGE accumulation in cardiovascular tissue
    Shahid P Baba
    Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky, USA
    Diabetes 58:2486-97. 2009
  9. pmc Catalytic reduction of carbonyl groups in oxidized PAPC by Kvβ2 (AKR6)
    Zhengzhi Xie
    Diabetes and Obesity Center, University of Louisville, Louisville, KY 40202, United States
    Chem Biol Interact 191:255-60. 2011
  10. pmc Reductive metabolism increases the proinflammatory activity of aldehyde phospholipids
    Elena Vladykovskaya
    Diabetes and Obesity Center, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    J Lipid Res 52:2209-25. 2011

Collaborators

Detail Information

Publications22

  1. pmc Dietary carnosine prevents early atherosclerotic lesion formation in apolipoprotein E-null mice
    Oleg A Barski
    Diabetes and Obesity Center, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Arterioscler Thromb Vasc Biol 33:1162-70. 2013
    ....
  2. pmc Alternative splicing in the aldo-keto reductase superfamily: implications for protein nomenclature
    Oleg A Barski
    Diabetes and Obesity Center, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Chem Biol Interact 202:153-8. 2013
    ....
  3. ncbi Developmental expression and function of aldehyde reductase in proximal tubules of the kidney
    Oleg A Barski
    Harry B and Aileen Gordon Diabetes Research Laboratory, Baylor College of Medicine, Houston, Texas, USA
    Am J Physiol Renal Physiol 289:F200-7. 2005
    ..Immunoreactive protein is present in the 9-wk-old fetal kidney, indicating that the induction of aldehyde reductase in humans occurs early in development...
  4. pmc Kinetics of nucleotide binding to the beta-subunit (AKR6A2) of the voltage-gated potassium (Kv) channel
    Oleg A Barski
    Department of Medicine, Division of Cardiology, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, United States
    Chem Biol Interact 178:165-70. 2009
    ..Slow cofactor exchange is consistent with the role of the beta-subunit as a metabolic sensor implicated in tonic regulation of potassium currents...
  5. pmc The aldo-keto reductase superfamily and its role in drug metabolism and detoxification
    Oleg A Barski
    Division of Cardiology, Department of Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, Kentucky 40202, USA
    Drug Metab Rev 40:553-624. 2008
    ..The human AKR family differs from the rodent families. Due to their broad substrate specificity, AKRs play an important role in the phase II detoxification of a large number of pharmaceuticals, drugs, and xenobiotics...
  6. pmc Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice
    Sanjay Srivastava
    Diabetes and Obesity Center, Institute of Molecular Cardiology, Division of Cardiovascular Medicine, Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Circ Res 105:793-802. 2009
    ..Products of lipid oxidation, particularly aldehydes, stimulate cytokine production and enhance monocyte adhesion; however, their contribution to atherosclerotic lesion formation remains unclear...
  7. pmc Catalytic mechanism and substrate specificity of the beta-subunit of the voltage-gated potassium channel
    Srinivas M Tipparaju
    Division of Cardiology, Department of Medicine, Institute of Molecular Cardiology, University of Louisville, Kentucky 40202, USA
    Biochemistry 47:8840-54. 2008
    ..These data strengthen the view that Kvbeta proteins are catalytically active AKRs that impart redox sensitivity to Kv channels...
  8. pmc Reductive metabolism of AGE precursors: a metabolic route for preventing AGE accumulation in cardiovascular tissue
    Shahid P Baba
    Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky, USA
    Diabetes 58:2486-97. 2009
    ..To examine the role of aldo-keto reductases (AKRs) in the cardiovascular metabolism of the precursors of advanced glycation end products (AGEs)...
  9. pmc Catalytic reduction of carbonyl groups in oxidized PAPC by Kvβ2 (AKR6)
    Zhengzhi Xie
    Diabetes and Obesity Center, University of Louisville, Louisville, KY 40202, United States
    Chem Biol Interact 191:255-60. 2011
    ..01). These results suggest that Kvβ could serve as a sensor of lipid oxidation via its catalytic activity and thereby alter Kv currents under conditions of oxidative stress...
  10. pmc Reductive metabolism increases the proinflammatory activity of aldehyde phospholipids
    Elena Vladykovskaya
    Diabetes and Obesity Center, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    J Lipid Res 52:2209-25. 2011
    ..Thus, vascular inflammation in atherosclerotic lesions is likely to be regulated by metabolism of phospholipid aldehydes in macrophages...
  11. pmc Postischemic deactivation of cardiac aldose reductase: role of glutathione S-transferase P and glutaredoxin in regeneration of reduced thiols from sulfenic acids
    Karin Wetzelberger
    Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky 40202, USA
    J Biol Chem 285:26135-48. 2010
    ..AR-SSG is then reduced by GRX to AR-SH. Sequential catalysis by GSTP and GRX may be a general redox switching mechanism that regulates the reduction of protein sulfenic acids to cysteines...
  12. pmc Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes
    Matthew Spite
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, USA
    Biochem J 405:95-105. 2007
    ....
  13. doi Detoxification of aldehydes by histidine-containing dipeptides: from chemistry to clinical implications
    Zhengzhi Xie
    Diabetes and Obesity Center, University of Louisville, Louisville, KY 40202, USA
    Chem Biol Interact 202:288-97. 2013
    ..Thus, treatment with carnosine and related histidine dipeptides may be a promising strategy for the prevention and treatment of diseases associated with high carbonyl load...
  14. pmc Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stress
    Elena Vladykovskaya
    Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky 40202, USA
    J Biol Chem 287:11398-409. 2012
    ..The induction of ER stress may be a significant cause of vascular inflammation induced by products of oxidized lipids...
  15. pmc Acrolein consumption induces systemic dyslipidemia and lipoprotein modification
    DANIEL J CONKLIN
    Diabetes and Obesity Center, University of Louisville, Louisville, KY 40202, USA
    Toxicol Appl Pharmacol 243:1-12. 2010
    ..These observations suggest that oral exposure to acrolein could induce or exacerbate systemic dyslipidemia and thereby contribute to cardiovascular disease risk...
  16. pmc NADPH binding to beta-subunit regulates inactivation of voltage-gated K(+) channels
    Srinivas M Tipparaju
    Institute of Molecular Cardiology, Department of Medicine, 421F Delia Baxter Building, University of Louisville, Louisville, KY 40202, USA
    Biochem Biophys Res Commun 359:269-76. 2007
    ..These observations suggest that NADPH binding is essential for optimal interaction between Kvalpha and beta subunits and for Kvbeta-induced inactivation of Kv currents...
  17. pmc Regulation of ion channels by pyridine nucleotides
    Peter J Kilfoil
    Diabetes Obesity Center, University of Louisville, Louisville, KY 40202, USA
    Circ Res 112:721-41. 2013
    ..This mechanism also may be an important component of hypoxic pulmonary vasoconstriction, memory, and circadian rhythms, and disruption of this regulatory axis may be linked to dysregulation of calcium homeostasis and cardiac arrhythmias...
  18. ncbi Human aldehyde reductase promoter allows simultaneous expression of two genes in opposite directions
    Oleg A Barski
    Department of Pediatrics, Baylor College of Medicine, 6621 Fannin, MC3 2353, Houston, TX 77030, USA
    Biotechniques 36:382-4, 386, 388. 2004
  19. pmc Functional expression of novel human and murine AKR1B genes
    Joshua K Salabei
    Diabetes and Obesity Center, School of Medicine, University of Louisville, Louisville, KY 40202, United States
    Chem Biol Interact 191:177-84. 2011
    ..From these observations we conclude that the predicted AKR1B15 and 1b16 genes are expressed in several murine and human tissues. Further studies are required to elucidate their physiological roles...
  20. ncbi Regulation of aldehyde reductase expression by STAF and CHOP
    Oleg A Barski
    Harry B and Aileen Gordon Diabetes Research Laboratory, Molecular Diabetes and Metabolism Section, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Genomics 83:119-29. 2004
    ..This subtle difference in the human promoter suggests a further evolution of the promoter toward responsiveness to exogenous stress and/or toxins...
  21. pmc Scaffold attachment factor B1 functions in development, growth, and reproduction
    Margarita Ivanova
    Department of Medicine, Baylor College of Medicine, Breast Center, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 25:2995-3006. 2005
    ..Together, these in vivo findings establish a critical role for SAFB1 in development, growth regulation, and reproduction...
  22. ncbi Metabolism of trans, trans-muconaldehyde, a cytotoxic metabolite of benzene, in mouse liver by alcohol dehydrogenase Adh1 and aldehyde reductase AKR1A4
    Duncan M Short
    Department of Bioscience, University of Strathclyde, 204 George Street, Glasgow, G1 1XW Scotland, UK
    Toxicol Appl Pharmacol 210:163-70. 2006
    ..This showed a Vmax of 115 nmol/min/mg and a Km of 15+/-2 microM and was not inhibited by pyrazole...