Research Topics
Species | Alon BarsheshetSummaryAffiliation: University of Rochester Country: USA Publications
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Detail Information
Publications
Effect of elapsed time from coronary revascularization to implantation of a cardioverter defibrillator on long-term survival in the MADIT-II trialAlon Barsheshet
Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
J Cardiovasc Electrophysiol 22:1237-42. 2011..This study was designed to evaluate the effect of elapsed time from CR on long-term mortality and arrhythmic risk among patients who receive an implantable cardioverter defibrillator (ICD)...
Applicability of a risk score for prediction of the long-term (8-year) benefit of the implantable cardioverter-defibrillatorAlon Barsheshet
Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
J Am Coll Cardiol 59:2075-9. 2012..The present study was designed to explore the 8-year survival benefit of a nonresynchronization implantable cardioverter-defibrillator (ICD) according to a simple risk stratification score...
Response to preventive cardiac resynchronization therapy in patients with ischaemic and nonischaemic cardiomyopathy in MADIT-CRTAlon Barsheshet
Cardiology Division, Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY, USA
Eur Heart J 32:1622-30. 2011..We evaluated the outcome of patients enrolled in MADIT-CRT by ischaemic and non-ischaemic aetiology of cardiomyopathy (ICM and non-ICM, respectively)...
Relation of bundle branch block to long-term (four-year) mortality in hospitalized patients with systolic heart failureAlon Barsheshet
Cardiology Division, University of Rochester Medical Center, New York, USA
Am J Cardiol 107:540-4. 2011..Deleterious effects of RBBB compared to LBBB appear to be more pronounced in patients with more advanced left ventricular dysfunction...
Genotype-specific QT correction for heart rate and the risk of life-threatening cardiac events in adolescents with congenital long-QT syndromeAlon Barsheshet
Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
Heart Rhythm 8:1207-13. 2011..A prolonged QT interval corrected for heart rate (QTc) is a major risk factor in patients with long QT syndrome (LQTS). However, heart rate-related risk in this genetic disorder differs among genotypes...
Cardiovascular syncope: diagnostic approach and risk assessmentA Barsheshet
University of Rochester Medical Center, Rochester, NY, USA
Minerva Med 102:223-38. 2011....
Risk of syncope in family members who are genotype-negative for a family-associated long-QT syndrome mutationAlon Barsheshet
Cardiology Division, University of Rochester Medical Center, Rochester, NY 14642, USA
Circ Cardiovasc Genet 4:491-9. 2011..The present study was designed to assess the clinical course of individuals who are found negative for the LQTS-causing mutation in their families...
Reverse remodeling and the risk of ventricular tachyarrhythmias in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy)Alon Barsheshet
Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
J Am Coll Cardiol 57:2416-23. 2011..We aimed to evaluate the relationship between echocardiographic response to cardiac resynchronization therapy (CRT) and the risk of subsequent ventricular tachyarrhythmias (VTAs)...
Genetics of sudden cardiac deathAlon Barsheshet
Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY 14642, USA
Curr Cardiol Rep 13:364-76. 2011..This paper reviews the current data regarding genotype-phenotype correlations and the role of clinical genetic testing in diagnosis, prognosis, and management of inheritable disorders leading to sudden cardiac death...
Time-dependent benefit of preventive cardiac resynchronization therapy after myocardial infarctionAlon Barsheshet
Cardiology Division, Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY, USA
Eur Heart J 32:1614-21. 2011..The present study was designed to evaluate the relationship between elapsed time from MI and the benefit of preventive CRT-D therapy in patients with ischaemic cardiomyopathy (ICM)...
Time dependence of life-threatening ventricular tachyarrhythmias after coronary revascularization in MADIT-CRTAlon Barsheshet
Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
Heart Rhythm 7:1421-7. 2010..Coronary revascularization (CR) may confer electrical stability in patients with ischemic cardiomyopathy. However, data regarding the effect of CR on the development of ventricular tachyarrhythmias in this population are limited...
Long-term implications of cumulative right ventricular pacing among patients with an implantable cardioverter-defibrillatorAlon Barsheshet
Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
Heart Rhythm 8:212-8. 2011..Limited data regarding the effect of right ventricular pacing (RVP) on long-term survival following implantable cardioverter-defibrillator (ICD) implantation are available...
Predictors of long-term (4-year) mortality in elderly and young patients with acute heart failureAlon Barsheshet
Heart Institute, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Eur J Heart Fail 12:833-40. 2010..The present study was designed to identify and compare predictors of short- and long-term mortality in elderly and young patients hospitalized with acute heart failure (HF)...
Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndromeJason Costa
Cardiology Division, University of Rochester Medical Center, Rochester, NY 14642, USA
Heart Rhythm 9:892-8. 2012..Men and women with type 1 long QT syndrome (LQT1) exhibit time-dependent differences in the risk for cardiac events...
Effect of cardiac resynchronization therapy on the risk of first and recurrent ventricular tachyarrhythmic events in MADIT-CRTGregory Ouellet
Cardiology Division, Department of Medicine, University of Rochester, Rochester, New York 14642, USA
J Am Coll Cardiol 60:1809-16. 2012..This study aimed to evaluate the effect of cardiac resynchronization therapy with a defibrillator (CRT-D) on the risks of first and recurrent ventricular tachyarrhythmic events (VTEs) in the MADIT-CRT...
Trigger-specific risk factors and response to therapy in long QT syndrome type 2James A Kim
Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
Heart Rhythm 7:1797-805. 2010..Cardiac events in patients with long QT syndrome type 2 (LQT2) are predominately associated with sudden arousal. However, exercise-induced events also occur in this population...
Trigger-specific ion-channel mechanisms, risk factors, and response to therapy in type 1 long QT syndromeIlan Goldenberg
Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
Heart Rhythm 9:49-56. 2012..Arrhythmic events in long-QT syndrome type 1 (LQT1) may be associated with exercise, acute arousal, or rest/sleep...
Mutation and gender-specific risk in type 2 long QT syndrome: implications for risk stratification for life-threatening cardiac events in patients with long QT syndromeDimitry Migdalovich
Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
Heart Rhythm 8:1537-43. 2011..We hypothesized that data regarding the location of the disease-causing mutation in the KCNH2 channel may affect gender-specific risk in LQT2...
Risk of recurrent cardiac events after onset of menopause in women with congenital long-QT syndrome types 1 and 2Jonathan Buber
Leviev Heart Center, Sheba Medical Center, Tel Hashomer, Israel
Circulation 123:2784-91. 2011..We hypothesized that the hormonal changes associated with menopause may affect clinical risk in this population...
Improved outcome with preventive cardiac resynchronization therapy in the elderly: a MADIT-CRT substudyJustin Penn
Department of Internal Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
J Cardiovasc Electrophysiol 22:892-7. 2011..Elderly patients comprise a large portion of patients with heart failure (HF). Limited data exist on the effectiveness of cardiac resynchronization therapy with defibrillator (CRT-D) in patients with mild HF symptoms in this population...
Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndromeAlon Barsheshet
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Circulation 125:1988-96. 2012..We evaluated a possible association between ion channel response to β-adrenergic stimulation and clinical response to β-blocker therapy according to mutation location...
Risk factors for recurrent heart failure events in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II)Edward Sze
Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
J Cardiovasc Electrophysiol 21:1217-23. 2010..Risk Factors for Recurrent Heart Failure...
Effect of bundle branch block patterns on mortality in hospitalized patients with heart failureAlon Barsheshet
Heart Institute, Sheba Medical Center, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Am J Cardiol 101:1303-8. 2008..In conclusion, RBBB rather than LBBB is an independent predictor of mortality in hospitalized patients with systolic HF. This prognostic marker could be used for risk stratification and the selection of treatment...
Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervalsIlan Goldenberg
Cardiology Division of Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
J Am Coll Cardiol 57:51-9. 2011..This study was designed to assess the clinical course and to identify risk factors for life-threatening events in patients with long-QT syndrome (LQTS) with normal corrected QT (QTc) intervals...
Relation between renal function and response to cardiac resynchronization therapy in Multicenter Automatic Defibrillator Implantation Trial--Cardiac Resynchronization Therapy (MADIT-CRT)Ilan Goldenberg
Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
Heart Rhythm 7:1777-82. 2010..Cardiorenal interactions have been shown to affect outcome in heart failure patients but were not related to response to cardiac resynchronization therapy (CRT)...
Clinical course and outcome of patients enrolled in US and non-US centres in MADIT-CRTJonathan Buber
The Leviev Heart Center, Heart Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel
Eur Heart J 32:2697-704. 2011..We aimed to evaluate within the MADIT-CRT database whether different enrollment characteristics between US and non-US centres affected the clinical course of study patients...
Reduction of the risk of recurring heart failure events with cardiac resynchronization therapy: MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy)Ilan Goldenberg
Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
J Am Coll Cardiol 58:729-37. 2011..The evaluation of the risk of recurring heart failure events (HFEs) was a pre-specified substudy of MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy)...
Cardiac resynchronization therapy is more effective in women than in men: the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy) trialAysha Arshad
Cardiology Division, St Luke s and Roosevelt Hospitals and Columbia University, New York, New York, USA
J Am Coll Cardiol 57:813-20. 2011....
Risk of life-threatening cardiac events among patients with long QT syndrome and multiple mutationsJamie Mullally
Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
Heart Rhythm 10:378-82. 2013..Patients with long QT syndrome (LQTS) who harbor multiple mutations (i.e. ≥ 2 mutations in ≥ 1 LQTS-susceptibility gene) may experience increased risk for life-threatening cardiac events...
Baseline functional capacity and the benefit of cardiac resynchronization therapy in patients with mildly symptomatic heart failure enrolled in MADIT-CRTAndrew Brenyo
Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
Heart Rhythm 9:1454-9. 2012..However, the relationship between functional capacity (FC) and CRT-D benefit in the trial was not assessed...
Ion channel mechanisms related to sudden cardiac death in phenotype-negative long-QT syndrome genotype-phenotype correlations of the KCNQ1(S349W) mutationSamuel Horr
Cardiology Division, Department of Medicine, Cardiovascular Research Institute Department of Nephrology, University of Rochester Medical Center, Rochester, New York, USA
J Cardiovasc Electrophysiol 22:193-200. 2011....
Effectiveness of cardiac resynchronization therapy in diabetic patients with ischemic and nonischemic cardiomyopathyJenie George
Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
Ann Noninvasive Electrocardiol 17:14-21. 2012..We aimed to identify differences in response to cardiac resynchronization therapy with a defibrillator (CRT-D) among DM patients with ischemic or nonischemic cardiomyopathy...
Wearable defibrillator in congenital structural heart disease and inherited arrhythmiasMohan Rao
Cardiology Division, University of Rochester Medical Center, New York, USA
Am J Cardiol 108:1632-8. 2011..Patients with IA showed a greater rate of ventricular tachyarrhythmias during therapy but significantly lower long-term mortality rates...
Predictors of response to cardiac resynchronization therapy in the Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT)Ilan Goldenberg
Heart Research Follow Up Program, Box 653, Cardiology Division, University of Rochester Medical Center, Rochester, NY 14642, USA
Circulation 124:1527-36. 2011..We hypothesized that combined assessment of factors that are associated with favorable reverse remodeling after cardiac resynchronization-defibrillator therapy (CRT-D) can be used to predict clinical response to the device...
Reduction in life-threatening ventricular tachyarrhythmias in statin-treated patients with nonischemic cardiomyopathy enrolled in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy)Jonathan Buber
Leviev Heart Center, Chaim Sheba Medical Center, Tel Hashomer, Israel
J Am Coll Cardiol 60:749-55. 2012....
Risk Factors for Recurrent Syncope and Subsequent Fatal or Near-Fatal Events in Children and Adolescents With Long QT SyndromeJudy F Liu
Heart Research Follow Up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York
J Am Coll Cardiol 57:941-50. 2011..We aimed to identify risk factors for recurrent syncope in children and adolescents with congenital long QT syndrome (LQTS)...
The effects of anodal stimulation on electrocardiogram, left ventricular dyssynchrony, and acute haemodynamics in patients with biventricular pacemakersRaed Abu Sham'a
Davidai Arrhythmia Center, Tel Aviv University, Tel Hashomer, Israel
Europace 13:997-1003. 2011..Its incidence varies according to the implanted hardware. We aim at evaluating the incidence of ANS and its acute haemodynamic effects among CRT patients...
QRS Axis and the Benefit of Cardiac Resynchronization Therapy in Patients with Mildly Symptomatic Heart Failure Enrolled in MADIT-CRTAndrew Brenyo
Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA Cardiology Division, Good Samaritan Hospital, Los Angeles, California, USA Cardiology Division, Consorcio Hospital General, Valencia, Spain
J Cardiovasc Electrophysiol 24:442-8. 2013..In LBBB patients, those without LAD seem to benefit more from CRT-D than those with LAD. (J Cardiovasc Electrophysiol, Vol. 24, pp. 442-448, April 2013)...
Sex-related differences in patients' responses to heart failure therapyAlon Barsheshet
Cardiology Division, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Nat Rev Cardiol 9:234-42. 2012..These data suggest that sex-related differences might exist in response to both medical and device therapies for patients with heart failure...
Cardiac resynchronization therapy reduces left atrial volume and the risk of atrial tachyarrhythmias in MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy)Andrew Brenyo
Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
J Am Coll Cardiol 58:1682-9. 2011..We hypothesized that reductions in left atrial volume (LAV) with a cardiac resynchronization therapy-defibrillator (CRT-D) would translate into a subsequent reduction in the risk of atrial tachyarrhythmias (AT)...
Usefulness of mild therapeutic hypothermia for hospitalized comatose patients having out-of-hospital cardiac arrestAvishag Laish-Farkash
ICCU Leviev Heart Center, Sheba Medical Center, Tel Hashomer, Israel
Am J Cardiol 108:173-8. 2011..Good prognostic factors for patients with non-VF could be young age, good left ventricular function, and short anoxic time...
QRS fragmentation and the risk of sudden cardiac death in MADIT IIAndrew Brenyo
Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
J Cardiovasc Electrophysiol 23:1343-8. 2012..Its prognostic value for sudden cardiac death (SCD) and ventricular arrhythmias in ischemic cardiomyopathy (ICM) remains unknown...
Admission blood glucose level and mortality among hospitalized nondiabetic patients with heart failureAlon Barsheshet
Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer 52621, Israel
Arch Intern Med 166:1613-9. 2006..CONCLUSIONS: Elevated admission blood glucose levels are associated with increased in-hospital and 60-day mortality, but not 6-month or 1-year mortality, in nondiabetic patients hospitalized because of HF...
The influence of left ventricular ejection fraction on the effectiveness of cardiac resynchronization therapy: MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy)Valentina Kutyifa
University of Rochester Medical Center, Rochester, New York Semmelweis University, Heart Center, Budapest, Hungary
J Am Coll Cardiol 61:936-44. 2013..The goal of this study was to evaluate the influence of left ventricular (LV) lead position on the risk of ventricular tachyarrhythmia in patients undergoing cardiac resynchronization therapy (CRT)...
Tilt training: does it have a role in preventing vasovagal syncope?Osnat Gurevitz
Heart Institute, Sheba Medical Center, Tei Hashomer, Israel
Pacing Clin Electrophysiol 30:1499-505. 2007..Previous trials have shown effectiveness of tilt training in treating this condition. We conducted a prospective, randomized study in order to evaluate the role of tilt-training in young adults with vasovagal syncope...
Epileptic seizure vs. myocardial infarction: the significance of cardiac troponin levelsGilad Twig
Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel
Isr Med Assoc J 9:889-90. 2007
The downside of right ventricular apical pacingAndrew Brenyo
Division of Cardiology, Department of Medicine, University of Rochester Medical Center, Rochester, NY
Indian Pacing Electrophysiol J 12:102-13. 2012..In particular, the role of RV apical pacing induced ventricular dyssynchrony is highlighted with a specific focus on differential outcome based upon QRS morphology at implant...
Atrial burst pacing with biphasic and monophasic waveforms for atrial fibrillationAlon Barsheshet
Cardiology Division, University of Rochester Medical Center, Rochester, NY, USA
Ann Noninvasive Electrocardiol 17:22-7. 2012..We aimed to evaluate the safety and efficacy of rapid atrial pacing to convert atrial fibrillation (AF) to normal sinus rhythm...
The significance of pulse oximetry in the diagnosis of pacemaker failure to outputAthanasios Michailidis
Heart Institute, Sheba Medical Center, Tel Hashomer, Israel
Ann Noninvasive Electrocardiol 15:293-5. 2010..Pulse oximeter plethysmographic wave signal virtually excluded this suspicion. This case report demonstrates the clinical utility of initial pulse oximeter wave analysis in excluding pacemaker failure to output...
Cardiac resynchronization therapy for prevention of heart failure events in elderly patients with left ventricular dysfunctionOlena Dotsenko
Cardiology Division, University of Rochester Medical Center, Rochester, NY 14642, USA
Expert Rev Cardiovasc Ther 10:1319-27. 2012..As the proportion of elderly patient with LV systolic dysfunction is increasing dramatically, further research is warranted to confirm these possible clinically beneficial effects of CRT in this population...
Acute ST elevation myocardial infarction during intravenous immunoglobulin infusionAlon Barsheshet
Heart Institute, Sheba Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Israel
Ann N Y Acad Sci 1110:315-8. 2007..Evaluation of each patient for cardiovascular risk prior to IVIG treatment is recommended as is the assessment of risk versus benefit. If IVIG is prescribed, we propose close monitoring and slow infusion rate...
