Eileen M Barry

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Immune responses elicited against multiple enterotoxigenic Escherichia coli fimbriae and mutant LT expressed in attenuated Shigella vaccine strains
    Eileen M Barry
    Center for Vaccine Development, University of Maryland, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Vaccine 21:333-40. 2003
  2. ncbi request reprint Immunogenicity of multivalent Shigella-ETEC candidate vaccine strains in a guinea pig model
    Eileen M Barry
    Center for Vaccine Development, University of Maryland, Baltimore, 685 West Baltimore Street, MD 21201, USA
    Vaccine 24:3727-34. 2006
  3. pmc Sindbis virus-based measles DNA vaccines protect cotton rats against respiratory measles: relevance of antibodies, mucosal and systemic antibody-secreting cells, memory B cells, and Th1-type cytokines as correlates of immunity
    Marcela F Pasetti
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore St, Room 480, Baltimore, Maryland 21201, USA
    J Virol 83:2789-94. 2009
  4. pmc Characterization of immune responses induced by intramuscular vaccination with DNA vaccines encoding measles virus hemagglutinin and/or fusion proteins
    Man Ki Song
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, 21201, USA
    J Virol 79:9854-61. 2005
  5. ncbi request reprint Neonatal immunization with a Sindbis virus-DNA measles vaccine induces adult-like neutralizing antibodies and cell-mediated immunity in the presence of maternal antibodies
    Alejandra V E Capozzo
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA
    J Immunol 176:5671-81. 2006
  6. pmc Clinical trials of Shigella vaccines: two steps forward and one step back on a long, hard road
    Myron M Levine
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Nat Rev Microbiol 5:540-53. 2007
  7. ncbi request reprint Safety and immunogenicity of CVD 1208S, a live, oral DeltaguaBA Deltasen Deltaset Shigella flexneri 2a vaccine grown on animal-free media
    Karen L Kotloff
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Hum Vaccin 3:268-75. 2007
  8. ncbi request reprint Deletion in the Shigella enterotoxin genes further attenuates Shigella flexneri 2a bearing guanine auxotrophy in a phase 1 trial of CVD 1204 and CVD 1208
    Karen L Kotloff
    Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Infect Dis 190:1745-54. 2004
  9. doi request reprint Preclinical safety and biodistribution of Sindbis virus measles DNA vaccines administered as a single dose or followed by live attenuated measles vaccine in a heterologous prime-boost regimen
    Karina Ramirez
    Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Hum Gene Ther 19:522-31. 2008
  10. pmc Progress and pitfalls in Shigella vaccine research
    Eileen M Barry
    University of Maryland School of Medicine, Center for Vaccine Development, Baltimore, MD 21201, USA
    Nat Rev Gastroenterol Hepatol 10:245-55. 2013

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Immune responses elicited against multiple enterotoxigenic Escherichia coli fimbriae and mutant LT expressed in attenuated Shigella vaccine strains
    Eileen M Barry
    Center for Vaccine Development, University of Maryland, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Vaccine 21:333-40. 2003
    ..Following mucosal immunization of guinea pigs with a mixed inoculum containing five Shigella strains each expressing a different ETEC antigen, immune responses were observed against each ETEC antigen plus the Shigella vector...
  2. ncbi request reprint Immunogenicity of multivalent Shigella-ETEC candidate vaccine strains in a guinea pig model
    Eileen M Barry
    Center for Vaccine Development, University of Maryland, Baltimore, 685 West Baltimore Street, MD 21201, USA
    Vaccine 24:3727-34. 2006
    ..These studies demonstrate the potential of the use of mixtures of live Shigella derivatives expressing ETEC antigens to serve as an immunogenic multivalent vaccine...
  3. pmc Sindbis virus-based measles DNA vaccines protect cotton rats against respiratory measles: relevance of antibodies, mucosal and systemic antibody-secreting cells, memory B cells, and Th1-type cytokines as correlates of immunity
    Marcela F Pasetti
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore St, Room 480, Baltimore, Maryland 21201, USA
    J Virol 83:2789-94. 2009
    ..pMSIN-H priming conferred 100% protection against pulmonary measles, whereas pMSINH-FdU protected only in conjunction with the live measles virus vaccine boost...
  4. pmc Characterization of immune responses induced by intramuscular vaccination with DNA vaccines encoding measles virus hemagglutinin and/or fusion proteins
    Man Ki Song
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, 21201, USA
    J Virol 79:9854-61. 2005
    ..These data will help guide the design of DNA-based MV vaccines to be used early in life in a heterologous prime-boost strategy...
  5. ncbi request reprint Neonatal immunization with a Sindbis virus-DNA measles vaccine induces adult-like neutralizing antibodies and cell-mediated immunity in the presence of maternal antibodies
    Alejandra V E Capozzo
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA
    J Immunol 176:5671-81. 2006
    ..Such a vaccine could be followed by the current live attenuated MV vaccine in a heterologous prime-boost to protect against measles early in life...
  6. pmc Clinical trials of Shigella vaccines: two steps forward and one step back on a long, hard road
    Myron M Levine
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Nat Rev Microbiol 5:540-53. 2007
    ....
  7. ncbi request reprint Safety and immunogenicity of CVD 1208S, a live, oral DeltaguaBA Deltasen Deltaset Shigella flexneri 2a vaccine grown on animal-free media
    Karen L Kotloff
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Hum Vaccin 3:268-75. 2007
    ....
  8. ncbi request reprint Deletion in the Shigella enterotoxin genes further attenuates Shigella flexneri 2a bearing guanine auxotrophy in a phase 1 trial of CVD 1204 and CVD 1208
    Karen L Kotloff
    Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Infect Dis 190:1745-54. 2004
    ....
  9. doi request reprint Preclinical safety and biodistribution of Sindbis virus measles DNA vaccines administered as a single dose or followed by live attenuated measles vaccine in a heterologous prime-boost regimen
    Karina Ramirez
    Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Hum Gene Ther 19:522-31. 2008
    ..Both vaccines were shown to be well tolerated and suitable for clinical trials and they are currently being tested in phase 1 studies in young adults...
  10. pmc Progress and pitfalls in Shigella vaccine research
    Eileen M Barry
    University of Maryland School of Medicine, Center for Vaccine Development, Baltimore, MD 21201, USA
    Nat Rev Gastroenterol Hepatol 10:245-55. 2013
    ..Herein, we review the latest progress in Shigella vaccine development within the framework of persistent obstacles...
  11. pmc Members of the Francisella tularensis phagosomal transporter subfamily of major facilitator superfamily transporters are critical for pathogenesis
    Mark E Marohn
    University of Maryland School of Medicine, Baltimore, Maryland, USA
    Infect Immun 80:2390-401. 2012
    ..tularensis and suggest that a focus on the development of attenuated Fpt subfamily MFS transporter mutants is a viable strategy toward the development of an efficacious vaccine...
  12. pmc Genetic characterization and immunogenicity of coli surface antigen 4 from enterotoxigenic Escherichia coli when it is expressed in a Shigella live-vector strain
    Zeev Altboum
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 71:1352-60. 2003
    ..These findings pave the way for CS4 to be included in multivalent ETEC vaccines, including an attenuated Shigella live-vector-based ETEC vaccine...
  13. pmc Characterization of rationally attenuated Francisella tularensis vaccine strains that harbor deletions in the guaA and guaB genes
    Araceli E Santiago
    Center for Vaccine Development, University of Maryland, Baltimore, 21201, United States
    Vaccine 27:2426-36. 2009
    ..These findings suggest the specific deletion of these target genes could generate a safe and efficacious live attenuated vaccine...
  14. pmc Live attenuated Shigella dysenteriae type 1 vaccine strains overexpressing shiga toxin B subunit
    Tao Wu
    University of Maryland School of Medicine, Baltimore, MD, USA
    Infect Immun 79:4912-22. 2011
    ..These candidates demonstrate the potential for a live attenuated vaccine to protect against disease caused by S. dysenteriae 1 and potentially to protect against the toxic effects of other Shiga toxin 1-expressing pathogens...
  15. pmc Characterization of intracellular growth regulator icgR by utilizing transcriptomics to identify mediators of pathogenesis in Shigella flexneri
    Carolyn R Morris
    Department of Microbiology and Immunology, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Infect Immun 81:3068-76. 2013
    ....
  16. pmc Chromosomal and plasmid-encoded factors of Shigella flexneri induce secretogenic activity ex vivo
    Christina S Faherty
    Department of Medicine, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e49980. 2012
    ..Moreover, the identification of all Shigella proteins responsible for enterotoxin activity is vital to our understanding of Shigella pathogenicity and to our success in developing safe and effective vaccine candidates...
  17. pmc Vaccines against tularemia
    Eileen M Barry
    University of Maryland School of Medicine, Center for Vaccine Development, Baltimore, MD, USA
    Hum Vaccin 5:832-8. 2009
    ..This information has fostered the development of various vaccine candidates including acellular subunit, killed whole cell and live attenuated. This review summarizes the progress and promise of these various candidates...
  18. pmc Shigella flexneri effectors OspE1 and OspE2 mediate induced adherence to the colonic epithelium following bile salts exposure
    Christina S Faherty
    Department of Medicine, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA
    Mol Microbiol 85:107-21. 2012
    ..The adhesins required for Shigella attachment to the colonic epithelium may serve as ideal targets for vaccine development...
  19. ncbi request reprint Recombinant Salmonella enterica serovar Typhi in a prime-boost strategy
    Christofer J Vindurampulle
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Vaccine 22:3744-50. 2004
    ..An ability to stimulate enhanced, accelerated responses to parenteral vaccination following mucosal priming may be advantageous in the immunoprophylaxis of many infectious diseases, including those of biodefense importance...
  20. pmc Attenuated Salmonella enterica serovar Typhi and Shigella flexneri 2a strains mucosally deliver DNA vaccines encoding measles virus hemagglutinin, inducing specific immune responses and protection in cotton rats
    Marcela F Pasetti
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore 21201, USA
    J Virol 77:5209-17. 2003
    ..flexneri can deliver measles DNA vaccines mucosally in cotton rats, inducing measles immune responses (including neutralizing antibodies) and protection, boosting strategies can now be evaluated in animals primed with MV DNA vaccines...
  21. pmc Novel Catanionic Surfactant Vesicle Vaccines Protect against Francisella tularensis LVS and Confer Significant Partial Protection against F. tularensis Schu S4 Strain
    Katharina Richard
    Department of Microbiology and Immunology, School of Medicine, University of Maryland Baltimore, Baltimore, Maryland, USA
    Clin Vaccine Immunol 21:212-26. 2014
    ..tularensis subunit vaccine and may be applicable for use with other pathogens. ..