G Barrionuevo

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc NMDA receptor hypofunction, parvalbumin-positive neurons, and cortical gamma oscillations in schizophrenia
    Guillermo Gonzalez-Burgos
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Schizophr Bull 38:950-7. 2012
  2. ncbi request reprint Dopamine modulation of neuronal function in the monkey prefrontal cortex
    G Gonzalez-Burgos
    Department of Neuroscience, University of Pittsburgh, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:537-43. 2002
  3. ncbi request reprint Functional properties of fast spiking interneurons and their synaptic connections with pyramidal cells in primate dorsolateral prefrontal cortex
    Guillermo Gonzalez-Burgos
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2593, USA
    J Neurophysiol 93:942-53. 2005
  4. ncbi request reprint Dopaminergic modulation of short-term synaptic plasticity in fast-spiking interneurons of primate dorsolateral prefrontal cortex
    G Gonzalez-Burgos
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    J Neurophysiol 94:4168-77. 2005
  5. ncbi request reprint Functional maturation of excitatory synapses in layer 3 pyramidal neurons during postnatal development of the primate prefrontal cortex
    Guillermo Gonzalez-Burgos
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA15261, USA
    Cereb Cortex 18:626-37. 2008
  6. pmc GABA neurons and the mechanisms of network oscillations: implications for understanding cortical dysfunction in schizophrenia
    Guillermo Gonzalez-Burgos
    Translational Neuroscience Program, Department of Psychiatry, Pittsburgh, PA 15213, USA
    Schizophr Bull 34:944-61. 2008
  7. pmc GABA transporter GAT1 prevents spillover at proximal and distal GABA synapses onto primate prefrontal cortex neurons
    Guillermo Gonzalez-Burgos
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, W1651 Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15261, USA
    J Neurophysiol 101:533-47. 2009
  8. pmc Alterations of cortical GABA neurons and network oscillations in schizophrenia
    Guillermo Gonzalez-Burgos
    Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh School of Medicine, Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Curr Psychiatry Rep 12:335-44. 2010
  9. pmc GABA neuron alterations, cortical circuit dysfunction and cognitive deficits in schizophrenia
    Guillermo Gonzalez-Burgos
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Neural Plast 2011:723184. 2011
  10. ncbi request reprint Synaptic efficacy during repetitive activation of excitatory inputs in primate dorsolateral prefrontal cortex
    Guillermo Gonzalez-Burgos
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213 2593, USA
    Cereb Cortex 14:530-42. 2004

Collaborators

Detail Information

Publications27

  1. pmc NMDA receptor hypofunction, parvalbumin-positive neurons, and cortical gamma oscillations in schizophrenia
    Guillermo Gonzalez-Burgos
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Schizophr Bull 38:950-7. 2012
    ....
  2. ncbi request reprint Dopamine modulation of neuronal function in the monkey prefrontal cortex
    G Gonzalez-Burgos
    Department of Neuroscience, University of Pittsburgh, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:537-43. 2002
    ....
  3. ncbi request reprint Functional properties of fast spiking interneurons and their synaptic connections with pyramidal cells in primate dorsolateral prefrontal cortex
    Guillermo Gonzalez-Burgos
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2593, USA
    J Neurophysiol 93:942-53. 2005
    ....
  4. ncbi request reprint Dopaminergic modulation of short-term synaptic plasticity in fast-spiking interneurons of primate dorsolateral prefrontal cortex
    G Gonzalez-Burgos
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    J Neurophysiol 94:4168-77. 2005
    ..EPSP bursts displaying short-term depression may transmit spike-timing-dependent temporal codes contained in presynaptic spike trains. Thus DA neuromodulation may increase the signal-to-noise ratio at fast-spiking cell inputs...
  5. ncbi request reprint Functional maturation of excitatory synapses in layer 3 pyramidal neurons during postnatal development of the primate prefrontal cortex
    Guillermo Gonzalez-Burgos
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA15261, USA
    Cereb Cortex 18:626-37. 2008
    ..Thus, remodeling of excitatory connectivity in the DLPFC during adolescence may occur in the absence of widespread maturational changes in synaptic strength...
  6. pmc GABA neurons and the mechanisms of network oscillations: implications for understanding cortical dysfunction in schizophrenia
    Guillermo Gonzalez-Burgos
    Translational Neuroscience Program, Department of Psychiatry, Pittsburgh, PA 15213, USA
    Schizophr Bull 34:944-61. 2008
    ....
  7. pmc GABA transporter GAT1 prevents spillover at proximal and distal GABA synapses onto primate prefrontal cortex neurons
    Guillermo Gonzalez-Burgos
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, W1651 Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15261, USA
    J Neurophysiol 101:533-47. 2009
    ....
  8. pmc Alterations of cortical GABA neurons and network oscillations in schizophrenia
    Guillermo Gonzalez-Burgos
    Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh School of Medicine, Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Curr Psychiatry Rep 12:335-44. 2010
    ....
  9. pmc GABA neuron alterations, cortical circuit dysfunction and cognitive deficits in schizophrenia
    Guillermo Gonzalez-Burgos
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Neural Plast 2011:723184. 2011
    ..Alterations of GABA signaling that impair gamma oscillations and, as a result, cognitive function suggest paths for novel therapeutic interventions...
  10. ncbi request reprint Synaptic efficacy during repetitive activation of excitatory inputs in primate dorsolateral prefrontal cortex
    Guillermo Gonzalez-Burgos
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213 2593, USA
    Cereb Cortex 14:530-42. 2004
    ....
  11. ncbi request reprint Properties of excitatory synaptic responses in fast-spiking interneurons and pyramidal cells from monkey and rat prefrontal cortex
    N V Povysheva
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213 2593, USA
    Cereb Cortex 16:541-52. 2006
    ..Similar results were obtained in monkey and rat PFC, suggesting a stable role of FS interneurons in this circuitry across species...
  12. ncbi request reprint Protein phosphatase-mediated regulation of protein kinase C during long-term depression in the adult hippocampus in vivo
    E Thiels
    Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 20:7199-207. 2000
    ..Our findings are consistent with the idea that protein dephosphorylation contributes to the expression of LTD...
  13. ncbi request reprint Voltage-gated sodium channels shape subthreshold EPSPs in layer 5 pyramidal neurons from rat prefrontal cortex
    G Gonzalez-Burgos
    Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurophysiol 86:1671-84. 2001
    ..Our results indicate that in layer 5 pyramidal neurons from PFC, Na(+), and K(+) voltage-gated channels shape EPSPs within the voltage range that is subthreshold for somatic action potentials...
  14. ncbi request reprint Synaptic targets of the intrinsic axon collaterals of supragranular pyramidal neurons in monkey prefrontal cortex
    D S Melchitzky
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Comp Neurol 430:209-21. 2001
    ....
  15. ncbi request reprint Revisiting the role of the hippocampal mossy fiber synapse
    N N Urban
    Department of Neuroscience and Center for Neural Basis of Cognition, University of Pittsburgh, Pennsylvania, USA
    Hippocampus 11:408-17. 2001
    ....
  16. pmc Selective reduction by dopamine of excitatory synaptic inputs to pyramidal neurons in primate prefrontal cortex
    Nathaniel N Urban
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Physiol 539:707-12. 2002
    ..This input specificity may be a critical aspect of the dopaminergic regulation of recurrent excitatory circuits in the PFC...
  17. ncbi request reprint Release of D,L-threo-beta-hydroxyaspartate as a false transmitter from excitatory amino acid-releasing nerve terminals
    M W Fleck
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neurochem Int 39:75-81. 2001
    ..These data suggest that tHA selectively accumulates in a vesicular aspartate pool and is released upon depolarization as a false transmitter from EAA nerve terminals...
  18. ncbi request reprint Impairment of long-term potentiation and associative memory in mice that overexpress extracellular superoxide dismutase
    E Thiels
    Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 20:7631-9. 2000
    ..These findings strongly suggest that superoxide, rather than being considered exclusively a neurotoxic molecule, should also be considered a signaling molecule necessary for normal neuronal function...
  19. ncbi request reprint Dopamine increases inhibition in the monkey dorsolateral prefrontal cortex through cell type-specific modulation of interneurons
    Sven Kroner
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Cereb Cortex 17:1020-32. 2007
    ..Thus, DA and D1 receptor activation affect local recurrent circuits by selectively modulating FS interneurons that control the firing of PCs through perisomatic innervation...
  20. ncbi request reprint Cluster analysis-based physiological classification and morphological properties of inhibitory neurons in layers 2-3 of monkey dorsolateral prefrontal cortex
    Leonid S Krimer
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Neurophysiol 94:3009-22. 2005
    ..Thus a quantitative approach enabled us to demonstrate that intrinsic electrophysiological properties of neurons in the monkey prefrontal cortex define distinct cell types, which also display distinct morphologies...
  21. pmc Bidirectional Hebbian plasticity at hippocampal mossy fiber synapses on CA3 interneurons
    Emilio J Galvan
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 28:14042-55. 2008
    ..We conclude that L-M interneurons are endowed with Ca(2+) signaling cascades suitable for controlling the polarity of MF long-term plasticity induced by joint presynaptic and postsynaptic activities...
  22. ncbi request reprint Short- and long-term plasticity of the perforant path synapse in hippocampal area CA3
    David B T McMahon
    Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurophysiol 88:528-33. 2002
    ..Our results support the conceptual framework that regards CA3 as an autoassociative memory network in which efficient retrieval of previously stored activity patterns is mediated by associative plasticity of the PP synapse...
  23. ncbi request reprint Mediodorsal thalamic afferents to layer III of the rat prefrontal cortex: synaptic relationships to subclasses of interneurons
    Diana C Rotaru
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Comp Neurol 490:220-38. 2005
    ..The apparent preferential input to ParV cells endows MD afferents with a strong indirect inhibitory influence on pyramidal neuron activity by virtue of ParV cell synapses onto soma, proximal dendrites, and axon initial segments...
  24. ncbi request reprint Giant miniature EPSCs at the hippocampal mossy fiber to CA3 pyramidal cell synapse are monoquantal
    Darrell A Henze
    Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurophysiol 87:15-29. 2002
    ..It is concluded that release of the contents of a single large clear vesicle generates giant mEPSCs at the MF to CA3 pyramidal cell synapse...
  25. ncbi request reprint Dopamine modulates excitability of basolateral amygdala neurons in vitro
    Sven Kroner
    Center for Neural Basics Cognition, Deptartment of Neuroscience, University of Pittsburgh, Pittsburgh, Penssylvania
    J Neurophysiol 93:1598-610. 2005
    ....
  26. ncbi request reprint Synaptosomal and vesicular accumulation of L-glutamate, L-aspartate and D-aspartate
    M W Fleck
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neurochem Int 39:217-25. 2001
    ..Maximal accumulation of [3H]-L-glutamate was non-competitively inhibited by both 100 microM unlabeled L-aspartate and 100 microM D-aspartate, suggesting that all are accumulated into a common vesicular pool by different transporters...
  27. pmc Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons
    Emilio J Galvan
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 30:2844-55. 2010
    ..Together, our data indicate that MF LTP in L-M interneurons at synapses containing primarily CI-AMPARs requires some of the same signaling cascades as does LTP of glutamatergic input to CA3 or CA1 pyramidal cells...