Research Topics
Species | G BarrionuevoSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
NMDA receptor hypofunction, parvalbumin-positive neurons, and cortical gamma oscillations in schizophreniaGuillermo Gonzalez-Burgos
Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Schizophr Bull 38:950-7. 2012....
Dopamine modulation of neuronal function in the monkey prefrontal cortexG Gonzalez-Burgos
Department of Neuroscience, University of Pittsburgh, 15260, Pittsburgh, PA, USA
Physiol Behav 77:537-43. 2002....- Functional properties of fast spiking interneurons and their synaptic connections with pyramidal cells in primate dorsolateral prefrontal cortexGuillermo Gonzalez-Burgos
Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2593, USA
J Neurophysiol 93:942-53. 2005.... - Dopaminergic modulation of short-term synaptic plasticity in fast-spiking interneurons of primate dorsolateral prefrontal cortexG Gonzalez-Burgos
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
J Neurophysiol 94:4168-77. 2005..EPSP bursts displaying short-term depression may transmit spike-timing-dependent temporal codes contained in presynaptic spike trains. Thus DA neuromodulation may increase the signal-to-noise ratio at fast-spiking cell inputs... - Functional maturation of excitatory synapses in layer 3 pyramidal neurons during postnatal development of the primate prefrontal cortexGuillermo Gonzalez-Burgos
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA15261, USA
Cereb Cortex 18:626-37. 2008..Thus, remodeling of excitatory connectivity in the DLPFC during adolescence may occur in the absence of widespread maturational changes in synaptic strength... - GABA neurons and the mechanisms of network oscillations: implications for understanding cortical dysfunction in schizophreniaGuillermo Gonzalez-Burgos
Translational Neuroscience Program, Department of Psychiatry, Pittsburgh, PA 15213, USA
Schizophr Bull 34:944-61. 2008.... - GABA transporter GAT1 prevents spillover at proximal and distal GABA synapses onto primate prefrontal cortex neuronsGuillermo Gonzalez-Burgos
Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, W1651 Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15261, USA
J Neurophysiol 101:533-47. 2009.... - Alterations of cortical GABA neurons and network oscillations in schizophreniaGuillermo Gonzalez-Burgos
Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh School of Medicine, Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
Curr Psychiatry Rep 12:335-44. 2010.... - GABA neuron alterations, cortical circuit dysfunction and cognitive deficits in schizophreniaGuillermo Gonzalez-Burgos
Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Neural Plast 2011:723184. 2011..Alterations of GABA signaling that impair gamma oscillations and, as a result, cognitive function suggest paths for novel therapeutic interventions... - Synaptic efficacy during repetitive activation of excitatory inputs in primate dorsolateral prefrontal cortexGuillermo Gonzalez-Burgos
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213 2593, USA
Cereb Cortex 14:530-42. 2004.... - Properties of excitatory synaptic responses in fast-spiking interneurons and pyramidal cells from monkey and rat prefrontal cortexN V Povysheva
Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213 2593, USA
Cereb Cortex 16:541-52. 2006..Similar results were obtained in monkey and rat PFC, suggesting a stable role of FS interneurons in this circuitry across species... - Protein phosphatase-mediated regulation of protein kinase C during long-term depression in the adult hippocampus in vivoE Thiels
Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurosci 20:7199-207. 2000..Our findings are consistent with the idea that protein dephosphorylation contributes to the expression of LTD... - Synaptic targets of the intrinsic axon collaterals of supragranular pyramidal neurons in monkey prefrontal cortexD S Melchitzky
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Comp Neurol 430:209-21. 2001.... - Voltage-gated sodium channels shape subthreshold EPSPs in layer 5 pyramidal neurons from rat prefrontal cortexG Gonzalez-Burgos
Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurophysiol 86:1671-84. 2001..Our results indicate that in layer 5 pyramidal neurons from PFC, Na(+), and K(+) voltage-gated channels shape EPSPs within the voltage range that is subthreshold for somatic action potentials... - Revisiting the role of the hippocampal mossy fiber synapseN N Urban
Department of Neuroscience and Center for Neural Basis of Cognition, University of Pittsburgh, Pennsylvania, USA
Hippocampus 11:408-17. 2001.... - Selective reduction by dopamine of excitatory synaptic inputs to pyramidal neurons in primate prefrontal cortexNathaniel N Urban
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Physiol 539:707-12. 2002..This input specificity may be a critical aspect of the dopaminergic regulation of recurrent excitatory circuits in the PFC... - Release of D,L-threo-beta-hydroxyaspartate as a false transmitter from excitatory amino acid-releasing nerve terminalsM W Fleck
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neurochem Int 39:75-81. 2001..These data suggest that tHA selectively accumulates in a vesicular aspartate pool and is released upon depolarization as a false transmitter from EAA nerve terminals... - Impairment of long-term potentiation and associative memory in mice that overexpress extracellular superoxide dismutaseE Thiels
Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurosci 20:7631-9. 2000..These findings strongly suggest that superoxide, rather than being considered exclusively a neurotoxic molecule, should also be considered a signaling molecule necessary for normal neuronal function... - Dopamine increases inhibition in the monkey dorsolateral prefrontal cortex through cell type-specific modulation of interneuronsSven Kroner
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
Cereb Cortex 17:1020-32. 2007..Thus, DA and D1 receptor activation affect local recurrent circuits by selectively modulating FS interneurons that control the firing of PCs through perisomatic innervation... - Cluster analysis-based physiological classification and morphological properties of inhibitory neurons in layers 2-3 of monkey dorsolateral prefrontal cortexLeonid S Krimer
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Neurophysiol 94:3009-22. 2005..Thus a quantitative approach enabled us to demonstrate that intrinsic electrophysiological properties of neurons in the monkey prefrontal cortex define distinct cell types, which also display distinct morphologies... - Bidirectional Hebbian plasticity at hippocampal mossy fiber synapses on CA3 interneuronsEmilio J Galvan
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurosci 28:14042-55. 2008..We conclude that L-M interneurons are endowed with Ca(2+) signaling cascades suitable for controlling the polarity of MF long-term plasticity induced by joint presynaptic and postsynaptic activities... - Short- and long-term plasticity of the perforant path synapse in hippocampal area CA3David B T McMahon
Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurophysiol 88:528-33. 2002..Our results support the conceptual framework that regards CA3 as an autoassociative memory network in which efficient retrieval of previously stored activity patterns is mediated by associative plasticity of the PP synapse... - Mediodorsal thalamic afferents to layer III of the rat prefrontal cortex: synaptic relationships to subclasses of interneuronsDiana C Rotaru
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Comp Neurol 490:220-38. 2005..The apparent preferential input to ParV cells endows MD afferents with a strong indirect inhibitory influence on pyramidal neuron activity by virtue of ParV cell synapses onto soma, proximal dendrites, and axon initial segments... - Giant miniature EPSCs at the hippocampal mossy fiber to CA3 pyramidal cell synapse are monoquantalDarrell A Henze
Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurophysiol 87:15-29. 2002..It is concluded that release of the contents of a single large clear vesicle generates giant mEPSCs at the MF to CA3 pyramidal cell synapse... - Dopamine modulates excitability of basolateral amygdala neurons in vitroSven Kroner
Center for Neural Basics Cognition, Deptartment of Neuroscience, University of Pittsburgh, Pittsburgh, Penssylvania
J Neurophysiol 93:1598-610. 2005.... - Synaptosomal and vesicular accumulation of L-glutamate, L-aspartate and D-aspartateM W Fleck
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neurochem Int 39:217-25. 2001..Maximal accumulation of [3H]-L-glutamate was non-competitively inhibited by both 100 microM unlabeled L-aspartate and 100 microM D-aspartate, suggesting that all are accumulated into a common vesicular pool by different transporters... - Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneuronsEmilio J Galvan
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurosci 30:2844-55. 2010..Together, our data indicate that MF LTP in L-M interneurons at synapses containing primarily CI-AMPARs requires some of the same signaling cascades as does LTP of glutamatergic input to CA3 or CA1 pyramidal cells...