Ruth M Barrientos

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. ncbi Peripheral infection and aging interact to impair hippocampal memory consolidation
    Ruth M Barrientos
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309 0345, USA
    Neurobiol Aging 27:723-32. 2006
  2. ncbi Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus
    Ruth M Barrientos
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, CB345, Boulder, CO 80309, USA
    Behav Brain Res 134:291-8. 2002
  3. ncbi Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration
    Ruth M Barrientos
    Department of Psychology and the Center for Neuroscience, University of Colorado, CB345, Boulder, CO 80309, USA
    Behav Brain Res 134:299-306. 2002
  4. ncbi Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist
    R M Barrientos
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309, USA
    Neuroscience 121:847-53. 2003
  5. ncbi BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration
    Ruth M Barrientos
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309, USA
    J Neuroimmunol 155:119-26. 2004
  6. ncbi IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344xBN F1 rats
    Matthew G Frank
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 24:254-62. 2010
  7. ncbi Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection
    Ruth M Barrientos
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 23:46-54. 2009
  8. ncbi Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus
    Timothy R Chapman
    Department of Psychology and Neuroscience and The Center for Neuroscience, University of Colorado, Boulder, CO 80309, USA
    Neurobiol Aging 33:832.e1-14. 2012
  9. ncbi Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes
    Ruth M Barrientos
    Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309, USA
    J Neurosci 31:11578-86. 2011
  10. ncbi Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats
    Ruth M Barrientos
    Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309, USA
    J Neurosci 32:14641-8. 2012

Research Grants

  1. Cytokines and Memory Consolidation
    RUTH BARRIENTOS; Fiscal Year: 2004

Collaborators

Detail Information

Publications23

  1. ncbi Peripheral infection and aging interact to impair hippocampal memory consolidation
    Ruth M Barrientos
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309 0345, USA
    Neurobiol Aging 27:723-32. 2006
    ..It is possible that this cognitive vulnerability is mediated by age-related changes in the glial environment that results in an exaggerated brain pro-inflammatory response to infection...
  2. ncbi Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus
    Ruth M Barrientos
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, CB345, Boulder, CO 80309, USA
    Behav Brain Res 134:291-8. 2002
    ..At this time the mechanisms responsible for this impairment are not understood, but may involve late-phase protein synthesis processes associated with LTP, because later consolidation processes are being disrupted...
  3. ncbi Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration
    Ruth M Barrientos
    Department of Psychology and the Center for Neuroscience, University of Colorado, CB345, Boulder, CO 80309, USA
    Behav Brain Res 134:299-306. 2002
    ....
  4. ncbi Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist
    R M Barrientos
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309, USA
    Neuroscience 121:847-53. 2003
    ..These data suggest that hippocampal-dependent memory impairments induced by elevated levels of brain IL-1beta may occur via an IL-1beta-induced downregulation in hippocampal BDNF...
  5. ncbi BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration
    Ruth M Barrientos
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309, USA
    J Neuroimmunol 155:119-26. 2004
    ..These data support the idea that IL-1beta-produced memory deficits may be mediated via BDNF mRNA reductions in hippocampus...
  6. ncbi IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344xBN F1 rats
    Matthew G Frank
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 24:254-62. 2010
    ..The present results suggest that central pro-inflammatory cytokines play a salient role in the suppression of Arc and impairments of LTM by a peripheral immune challenge in older animals...
  7. ncbi Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection
    Ruth M Barrientos
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 23:46-54. 2009
    ..These data suggest that the exaggerated and prolonged elevation of IL-1 beta, specifically in the hippocampus, may be responsible for hippocampal-dependent memory impairments observed in aging rats following a bacterial infection...
  8. ncbi Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus
    Timothy R Chapman
    Department of Psychology and Neuroscience and The Center for Neuroscience, University of Colorado, Boulder, CO 80309, USA
    Neurobiol Aging 33:832.e1-14. 2012
    ..Effects in dentate were minimal. Northern blot analysis confirmed an aging-associated loss of total BDNF mRNA in areas CA1 and CA3, and revealed a parallel, preferential loss of BDNF mRNA transcripts with long 3' UTRs...
  9. ncbi Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes
    Ruth M Barrientos
    Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309, USA
    J Neurosci 31:11578-86. 2011
    ..Moreover, voluntary exercise abrogated age-related microglial sensitization, suggesting a possible mechanism for exercise-induced neuroprotection in aging...
  10. ncbi Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats
    Ruth M Barrientos
    Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309, USA
    J Neurosci 32:14641-8. 2012
    ..Furthermore, the long-lasting presence of IL-1RA in the brain (4 d) compared with in the blood (<24 h) underscores the value of intracisternal administration of IL-1RA for therapeutic purposes...
  11. ncbi Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst late-phase long-term potentiation in hippocampal area CA1
    Timothy R Chapman
    Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 30:7598-603. 2010
    ....
  12. ncbi The role of the dorsal hippocampus in the acquisition and retrieval of context memory representations
    Patricia Matus-Amat
    Department of Psychology, Center for Neuroscience, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 24:2431-9. 2004
    ....
  13. ncbi IL-1RA injected intra-cisterna magna confers extended prophylaxis against lipopolysaccharide-induced neuroinflammatory and sickness responses
    Matthew G Frank
    Department of Psychology and Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    J Neuroimmunol 252:33-9. 2012
    ..IL-1RA might be administered prophylactically to prevent the neuroinflammatory effects of trauma...
  14. ncbi Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo
    Matthew G Frank
    Department of Psychology and Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    J Neuroimmunol 226:181-4. 2010
    ..The present results demonstrate that aging sensitizes hippocampal microglia to pro-inflammatory challenges...
  15. ncbi Aging and a peripheral immune challenge interact to reduce mature brain-derived neurotrophic factor and activation of TrkB, PLCgamma1, and ERK in hippocampal synaptoneurosomes
    Giuseppe P Cortese
    Department of Psychology and Neuroscience, and the Center for Neuroscience, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 31:4274-9. 2011
    ..These data suggest that inflammation-evoked reductions in BDNF at synapses might contribute to inflammation-evoked disruptions in long-term memory and synaptic plasticity in aging...
  16. ncbi Hippocampal formation supports conditioning to memory of a context
    Jerry W Rudy
    Department of Psychology, University of Colorado, Boulder 80309, USA
    Behav Neurosci 116:530-8. 2002
    ..These results support the hypothesis that the hippocampal formation supports contextual fear conditioning by storing a conjunctive representation of context...
  17. ncbi Characterization of the sickness response in young and aging rats following E. coli infection
    Ruth M Barrientos
    Department of Psychology and Center for Neuroscience, University of Colorado, Campus Box 345, Boulder, CO 80309, USA
    Brain Behav Immun 23:450-4. 2009
    ....
  18. ncbi mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging
    Matthew G Frank
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309 0345, USA
    Neurobiol Aging 27:717-22. 2006
    ..The present results indicate that normal brain aging is characterized by a shift towards a pro-inflammatory microenvironment in the CNS...
  19. ncbi Aging-related changes in neuroimmune-endocrine function: implications for hippocampal-dependent cognition
    Ruth M Barrientos
    Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA
    Horm Behav 62:219-27. 2012
    ..We will show that each of these mechanisms is important for long-term memory formation, and is compromised by elevated pro-inflammatory cytokines...
  20. ncbi Spinal gap junctions: potential involvement in pain facilitation
    Leah E Spataro
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 90309-0345, USA
    J Pain 5:392-405. 2004
    ..In addition, it decreased gp120-induced proinflammatory cytokines. This suggests gap junction activation might lead to proinflammatory cytokine release by distantly activated glia...
  21. ncbi Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood
    Staci D Bilbo
    Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA
    Brain Behav Immun 22:451-5. 2008
    ..Taken together, these data indicate that early infection strongly influences the induction of IL-1beta and BDNF within distinct regions of the hippocampus, which likely contribute to observed memory impairments in adulthood...
  22. ncbi Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide
    Marucia Chacur
    Instituto Butantan, Sao Paolo, Brazil
    Pain 108:180-91. 2004
    ..As a variety of immune cells also produce and release sPLA2s during inflammatory states, the data may have general implications for the understanding of inflammatory pain...
  23. ncbi Corticotropin releasing hormone (CRH) antagonist attenuates adjuvant induced arthritis: role of CRH in peripheral inflammation
    Elizabeth L Webster
    Integrative Neural-Immune Program, Section on Neuroendocrine Immunology and Behavior, National Institute of Mental Health, National Institutes of Health, Bethesda 20892, USA
    J Rheumatol 29:1252-61. 2002
    ....

Research Grants1

  1. Cytokines and Memory Consolidation
    RUTH BARRIENTOS; Fiscal Year: 2004
    ..These studies will answer some important questions about where and how pro-inflammatory cytokines may act to impair hippocampal-dependent memory processes. ..