Antoni Barrientos

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc HIV-1 infection is blocked at an early stage in cells devoid of mitochondrial DNA
    Gaofei Lu
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 8:e78035. 2013
  2. pmc Complementary roles of mitochondrial respiration and ROS signaling on cellular aging and longevity
    Antoni Barrientos
    Departments of Neurology and of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Aging (Albany NY) 4:578-9. 2012
  3. pmc Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces cerevisiae
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, NY, USA
    EMBO J 23:3472-82. 2004
  4. pmc Suppression mechanisms of COX assembly defects in yeast and human: insights into the COX assembly process
    Antoni Barrientos
    Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Biochim Biophys Acta 1793:97-107. 2009
  5. pmc Mss51 and Ssc1 facilitate translational regulation of cytochrome c oxidase biogenesis
    Flavia Fontanesi
    Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Mol Cell Biol 30:245-59. 2010
  6. pmc Aberrant translation of cytochrome c oxidase subunit 1 mRNA species in the absence of Mss51p in the yeast Saccharomyces cerevisiae
    Andrea Zambrano
    Department of Neurology and Biochemistry and Molecular Biology, The John T Macdonald Foundation Center for Medical Genetics, University of Miami School of Medicine, Miami, FL 33136, USA
    Mol Biol Cell 18:523-35. 2007
  7. pmc A heme-sensing mechanism in the translational regulation of mitochondrial cytochrome c oxidase biogenesis
    ILIANA C SOTO
    Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Cell Metab 16:801-13. 2012
  8. pmc Cox25 teams up with Mss51, Ssc1, and Cox14 to regulate mitochondrial cytochrome c oxidase subunit 1 expression and assembly in Saccharomyces cerevisiae
    Flavia Fontanesi
    Departments of Neurology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 286:555-66. 2011
  9. ncbi request reprint Exploring protein-protein interactions involving newly synthesized mitochondrial DNA-encoded proteins
    Darryl Horn
    Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL, USA
    Methods Mol Biol 457:125-39. 2008
  10. pmc Synthesis of cytochrome c oxidase subunit 1 is translationally downregulated in the absence of functional F1F0-ATP synthase
    Ileana C Soto
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine Miami, FL 33136, USA
    Biochim Biophys Acta 1793:1776-86. 2009

Research Grants

  1. CYTOCHROME C OXIDASE IN HEALTH AND DISEASE
    Antoni Barrientos; Fiscal Year: 2010
  2. CYTOCHROME C OXIDASE IN HEALTH AND DISEASE
    Antoni Barrientos; Fiscal Year: 2006
  3. CYTOCHROME C OXIDASE IN HEALTH AND DISEASE
    Antoni Barrientos; Fiscal Year: 2007
  4. CYTOCHROME C OXIDASE IN HEALTH AND DISEASE
    Antoni Barrientos; Fiscal Year: 2006
  5. CYTOCHROME C OXIDASE IN HEALTH AND DISEASE
    Antoni Barrientos; Fiscal Year: 2009
  6. CYTOCHROME C OXIDASE IN HEALTH AND DISEASE
    Antoni Barrientos; Fiscal Year: 2009

Collaborators

Detail Information

Publications48

  1. pmc HIV-1 infection is blocked at an early stage in cells devoid of mitochondrial DNA
    Gaofei Lu
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 8:e78035. 2013
    ..Collectively, our data strongly indicate that mitochondria play an important role during early stages of HIV-1 infection, probably through direct association with HIV-1 intracellular complexes. ..
  2. pmc Complementary roles of mitochondrial respiration and ROS signaling on cellular aging and longevity
    Antoni Barrientos
    Departments of Neurology and of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Aging (Albany NY) 4:578-9. 2012
    ....
  3. pmc Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces cerevisiae
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, NY, USA
    EMBO J 23:3472-82. 2004
    ..The release of Mss51p from the complex occurs at a downstream step in the assembly pathway, probably catalyzed by Shy1p...
  4. pmc Suppression mechanisms of COX assembly defects in yeast and human: insights into the COX assembly process
    Antoni Barrientos
    Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Biochim Biophys Acta 1793:97-107. 2009
    ..Additionally, they have the potential to provide useful information for devising therapeutic approaches to combat human disorders associated with COX deficiency...
  5. pmc Mss51 and Ssc1 facilitate translational regulation of cytochrome c oxidase biogenesis
    Flavia Fontanesi
    Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Mol Cell Biol 30:245-59. 2010
    ..We conclude that Ssc1, by interacting with Mss51 and Mss51-containing complexes, plays a critical role in Cox1 biogenesis, COX assembly, and the translational regulation of these processes...
  6. pmc Aberrant translation of cytochrome c oxidase subunit 1 mRNA species in the absence of Mss51p in the yeast Saccharomyces cerevisiae
    Andrea Zambrano
    Department of Neurology and Biochemistry and Molecular Biology, The John T Macdonald Foundation Center for Medical Genetics, University of Miami School of Medicine, Miami, FL 33136, USA
    Mol Biol Cell 18:523-35. 2007
    ..These results support a key role for Mss51p in translationally regulating Cox1p synthesis by the status of cytochrome oxidase assembly...
  7. pmc A heme-sensing mechanism in the translational regulation of mitochondrial cytochrome c oxidase biogenesis
    ILIANA C SOTO
    Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Cell Metab 16:801-13. 2012
    ..We conclude that heme sensing by Mss51 regulates COX biogenesis and aerobic energy production...
  8. pmc Cox25 teams up with Mss51, Ssc1, and Cox14 to regulate mitochondrial cytochrome c oxidase subunit 1 expression and assembly in Saccharomyces cerevisiae
    Flavia Fontanesi
    Departments of Neurology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 286:555-66. 2011
    ..These results suggest that once Ssc1-Mss51 are released from the Cox1 stabilization complex, Cox25 continues to interact with Cox14 and Cox1 to facilitate the formation of multisubunit COX assembly intermediates...
  9. ncbi request reprint Exploring protein-protein interactions involving newly synthesized mitochondrial DNA-encoded proteins
    Darryl Horn
    Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL, USA
    Methods Mol Biol 457:125-39. 2008
    ....
  10. pmc Synthesis of cytochrome c oxidase subunit 1 is translationally downregulated in the absence of functional F1F0-ATP synthase
    Ileana C Soto
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine Miami, FL 33136, USA
    Biochim Biophys Acta 1793:1776-86. 2009
    ..Our findings imply that fully assembled ATPase and its proton pumping function are both required for COX biogenesis in yeast and mammalian cells through a mechanism independent of Cox1p synthesis...
  11. pmc The DEAD box protein Mrh4 functions in the assembly of the mitochondrial large ribosomal subunit
    Dasmanthie De Silva
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Cell Metab 18:712-25. 2013
    ..We conclude that Mrh4 plays an essential role during the late stages of mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. ..
  12. pmc Mitochondrial respiratory thresholds regulate yeast chronological life span and its extension by caloric restriction
    Alejandro Ocampo
    Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Cell Metab 16:55-67. 2012
    ....
  13. pmc Biogenesis and assembly of eukaryotic cytochrome c oxidase catalytic core
    Ileana C Soto
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Biochim Biophys Acta 1817:883-97. 2012
    ..This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes...
  14. pmc Cytochrome c oxidase biogenesis: new levels of regulation
    Flavia Fontanesi
    Department of Neurology, The John T Macdonald Foundation Center for Medical Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    IUBMB Life 60:557-68. 2008
    ..The different mechanisms of regulation of COX assembly are reviewed and discussed...
  15. doi request reprint Suppression of polyglutamine-induced cytotoxicity in Saccharomyces cerevisiae by enhancement of mitochondrial biogenesis
    Alejandro Ocampo
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA
    FASEB J 24:1431-41. 2010
    ..Our results suggest that therapeutic approaches enhancing mitochondrial biogenesis could reduce polyQ toxicity and delay the development of clinical symptoms in patients...
  16. pmc Cmc1p is a conserved mitochondrial twin CX9C protein involved in cytochrome c oxidase biogenesis
    Darryl Horn
    Department of Biochemistry and Molecular Biology, The John T Macdonald Foundation Center for Medical Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA
    Mol Cell Biol 28:4354-64. 2008
    ..Our results suggest that Cmc1p could play a direct or indirect role in copper trafficking and distribution to COX and Sod1p...
  17. ncbi request reprint In vivo labeling and analysis of mitochondrial translation products in budding and in fission yeasts
    Karine Gouget
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA
    Methods Mol Biol 457:113-24. 2008
    ..cerevisiae, they have not been optimized yet for studies in S. pombe. In this chapter, we present an easy, fast and reliable method to in vivo radiolabel mitochondrial translation products from this fission yeast...
  18. pmc Shy1p is necessary for full expression of mitochondrial COX1 in the yeast model of Leigh's syndrome
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    EMBO J 21:43-52. 2002
    ..We propose that Shy1p promotes the formation of an assembly intermediate in which Cox1 is one of the partners...
  19. pmc NAD+ salvage pathway proteins suppress proteotoxicity in yeast models of neurodegeneration by promoting the clearance of misfolded/oligomerized proteins
    Alejandro Ocampo
    Department of Biochemistry and Molecular Biology and 2Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Hum Mol Genet 22:1699-708. 2013
    ....
  20. pmc Role of cytochrome C in apoptosis: increased sensitivity to tumor necrosis factor alpha is associated with respiratory defects but not with lack of cytochrome C release
    Uma D Vempati
    University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA
    Mol Cell Biol 27:1771-83. 2007
    ..These studies underscore the importance of oxidative phosphorylation and apoptosome function to both the intrinsic and extrinsic apoptotic pathways...
  21. pmc The conserved mitochondrial twin Cx9C protein Cmc2 Is a Cmc1 homologue essential for cytochrome c oxidase biogenesis
    Darryl Horn
    Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Biol Chem 285:15088-99. 2010
    ..We conclude that Cmc1 and Cmc2 have cooperative but nonoverlapping functions in cytochrome c oxidase biogenesis...
  22. ncbi request reprint Assembly of mitochondrial cytochrome c-oxidase, a complicated and highly regulated cellular process
    Flavia Fontanesi
    Departments of Neurology, The John T Macdonald Foundation Center for Medical Genetics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Am J Physiol Cell Physiol 291:C1129-47. 2006
    ....
  23. ncbi request reprint Defects in the biosynthesis of mitochondrial heme c and heme a in yeast and mammals
    Carlos T Moraes
    Department of Neurology, University of Miami School of Medicine, USA
    Biochim Biophys Acta 1659:153-9. 2004
    ..The production of mouse models recapitulating these diseases is providing novel information on the pathogenesis of clinical syndromes...
  24. pmc Role of twin Cys-Xaa9-Cys motif cysteines in mitochondrial import of the cytochrome C oxidase biogenesis factor Cmc1
    Myriam Bourens
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 287:31258-69. 2012
    ..The three proteins are shown to form a ternary complex in mitochondria. Our results suggest that this mechanism facilitates efficient formation of multiple disulfides and prevents the formation of non-native disulfide bonds...
  25. pmc Evaluation of the mitochondrial respiratory chain and oxidative phosphorylation system using polarography and spectrophotometric enzyme assays
    Antoni Barrientos
    University of Miami Miller School of Medicine, Miami, Florida, USA
    Curr Protoc Hum Genet . 2009
    ..Based on the methods described elsewhere, the assays describe methods that form a biochemical characterization of the OXPHOS system in cells and mitochondria isolated from cultured cells or tissues...
  26. pmc MTG1 codes for a conserved protein required for mitochondrial translation
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Mol Biol Cell 14:2292-302. 2003
    ..This is consistent with the peripheral localization of Mtg1p on the matrix side of the inner membrane and the results of in vivo mitochondrial translation assays in a temperature-sensitive mtg1 mutant...
  27. ncbi request reprint Transcriptional activators HAP/NF-Y rescue a cytochrome c oxidase defect in yeast and human cells
    Flavia Fontanesi
    Department of Neurology, The John T Macdonald Foundation Center for Medical Genetics, University of Miami Miller School of Medicine, Miami, FL, USA
    Hum Mol Genet 17:775-88. 2008
    ..Analogously, overexpression of the Hap complex human homologue NF-YA/B/C transcription complex in SURF1-deficient fibroblasts from an LS patient efficiently rescues their COX deficiency...
  28. pmc Mitochondrial copper metabolism and delivery to cytochrome c oxidase
    Darryl Horn
    Department of Biochemistry and Molecular Biology, The John T Macdonald Foundation Center for Medical Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    IUBMB Life 60:421-9. 2008
    ..The different pathways are reviewed and discussed in the context of both mitochondrial COX assembly and copper homeostasis...
  29. pmc SIT4 regulation of Mig1p-mediated catabolite repression in Saccharomyces cerevisiae
    Can Jin
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    FEBS Lett 581:5658-63. 2007
    ..Our evidence suggests that this pathway involves turnover of Mig1p...
  30. ncbi request reprint Cytotoxicity of a mutant huntingtin fragment in yeast involves early alterations in mitochondrial OXPHOS complexes II and III
    Asun Solans
    Department of Neurology, Dr John T Macdonald Foundation Center for Medical Genetics, University of Miami, Miller School of Medicine, 1600 NW 10th Avenue, Miami, FL 33136, USA
    Hum Mol Genet 15:3063-81. 2006
    ..Our yeast model represents a very useful paradigm to study mitochondrial physiology alterations in the pathogenic mechanism of HD...
  31. pmc Evaluation of the mitochondrial respiratory chain and oxidative phosphorylation system using yeast models of OXPHOS deficiencies
    Flavia Fontanesi
    University of Miami Miller School of Medicine, Miami, Florida, USA
    Curr Protoc Hum Genet . 2009
    ..Several approaches for the assessment of the OXPHOS system enzymes have been developed. Based on the methods described elsewhere, this unit describes the creation and study of yeast models of mitochondrial OXPHOS deficiencies...
  32. ncbi request reprint Yeast dihydroxybutanone phosphate synthase, an enzyme of the riboflavin biosynthetic pathway, has a second unrelated function in expression of mitochondrial respiration
    Can Jin
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 278:14698-703. 2003
    ..Most of the protein was localized in the cytosolic fraction, but a small fraction was detected in the mitochondrial intermembrane space...
  33. ncbi request reprint Cytochrome oxidase assembly does not require catalytically active cytochrome C
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, New York, 10027, USA
    J Biol Chem 278:8881-7. 2003
    ..Mutants containing wild type apocytochrome c in mitochondria lack COX, suggesting that only the folded and mature protein is able to promote COX assembly...
  34. pmc Evaluation of the mitochondrial respiratory chain and oxidative phosphorylation system using blue native gel electrophoresis
    Francisca Diaz
    University of Miami Miller School of Medicine, Miami, Florida, USA
    Curr Protoc Hum Genet . 2009
    ....
  35. doi request reprint From the bakery to the brain business: developing inducible yeast models of human neurodegenerative disorders
    Alejandro Ocampo
    The Department of Biochemistry and Molecular Biology, The John T Macdonald Foundation Center for Medical Genetics, University of Miami, Miller School of Medicine, Miami, FL, USA
    Biotechniques 45:vii-xiv. 2008
    ..The different models are compared and evaluated...
  36. ncbi request reprint Atp10p assists assembly of Atp6p into the F0 unit of the yeast mitochondrial ATPase
    Alexander Tzagoloff
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    J Biol Chem 279:19775-80. 2004
    ..Based on these observations, we propose Atp10p to be an Atp6p-specific chaperone that facilitates the incorporation of Atp6p into an intermediate subcomplex of ATPase subunits...
  37. pmc Redox and reactive oxygen species regulation of mitochondrial cytochrome C oxidase biogenesis
    Myriam Bourens
    1 Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida
    Antioxid Redox Signal 19:1940-52. 2013
    ..Antioxid. Redox Signal. 19, 1940-1952. ..
  38. pmc Bot1p is required for mitochondrial translation, respiratory function, and normal cell morphology in the fission yeast Schizosaccharomyces pombe
    David J Wiley
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, P O Box 016129, Miami, FL 33101 6129, USA
    Eukaryot Cell 7:619-29. 2008
    ..Our observations also indicate that in fission yeast, alterations of mitochondrial function are linked to changes in cell cycle and cell morphology control mechanisms...
  39. doi request reprint Developing yeast models of human neurodegenerative disorders
    Alejandro Ocampo
    Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, Miami, FL, USA
    Methods Mol Biol 793:113-27. 2011
    ..Here, we describe how to create yeast models of neurodegenerative proteinopathies by ectopic expression of human proteins and how to perform a basic characterization of these models by analyzing cellular toxicity and protein aggregation...
  40. pmc I function, therefore I am: overcoming skepticism about mitochondrial supercomplexes
    Antoni Barrientos
    Department of Neurology, University of Miami Miller School of Medicine, FL 33136, USA
    Cell Metab 18:147-9. 2013
    ..A recent study in Science (Lapuente-Brun et al., 2013) now reports that dynamic supercomplex assembly determines electron flux from different substrates through the respiratory chain...
  41. ncbi request reprint Yeast models of human mitochondrial diseases
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    IUBMB Life 55:83-95. 2003
    ..The usefulness of yeast as a model system for human mitochondrial disorders is evaluated...
  42. ncbi request reprint Cytochrome oxidase in health and disease
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Gene 286:53-63. 2002
    ..The latter impinge on all aspects of the biogenesis process. Here we review the current state of information about the functions of the COX-specific gene products and of their relationship to human COX deficiencies...
  43. ncbi request reprint Quick and reliable assessment of chronological life span in yeast cell populations by flow cytometry
    Alejandro Ocampo
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, United States
    Mech Ageing Dev 132:315-23. 2011
    ..The method was validated by determining CLS of several strains used in yeast ageing research and by evaluating the effect of genetic disturbances known to extend or reduce yeast chronological life span...
  44. pmc Ischemic preconditioning targets the respiration of synaptic mitochondria via protein kinase C epsilon
    Kunjan R Dave
    The Cerebral Vascular Disease Research Center, and The John T MacDonald Center for Medical Genetics, Leonard M Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Neurosci 28:4172-82. 2008
    ..We propose that, at 48 h of reperfusion after ischemic preconditioning, epsilonPKC is poised at synaptic mitochondria to respond to ischemia either by direct phosphorylation or activation of the epsilonPKC signaling pathway...
  45. ncbi request reprint In vivo and in organello assessment of OXPHOS activities
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Methods 26:307-16. 2002
    ....
  46. pmc Transcriptional regulation of yeast oxidative phosphorylation hypoxic genes by oxidative stress
    Jingjing Liu
    1 Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, Florida
    Antioxid Redox Signal 19:1916-27. 2013
    ..Antioxid. Redox Signal. 19, 1916-1927. ..
  47. ncbi request reprint COX16 encodes a novel protein required for the assembly of cytochrome oxidase in Saccharomyces cerevisiae
    Christopher G Carlson
    Department of Medical Genetics, University of Alberta, Edmonton, Canada
    J Biol Chem 278:3770-5. 2003
    ..Like other recently described nuclear gene products involved in expression of cytochrome oxidase, COX16 is a candidate for screening in inherited human COX deficiencies...
  48. pmc Cytochrome c release and mitochondria involvement in programmed cell death induced by acetic acid in Saccharomyces cerevisiae
    Paula Ludovico
    Centro de Ciências do Ambiente, Departamento de Biologia, Universidade do Minho, 4710 057 Braga, Portugal
    Mol Biol Cell 13:2598-606. 2002
    ..The understanding of the involvement of a mitochondria-dependent apoptotic pathway in S. cerevisiae PCD process will be most useful in the further elucidation of an ancestral pathway common to PCD in metazoans...

Research Grants7

  1. CYTOCHROME C OXIDASE IN HEALTH AND DISEASE
    Antoni Barrientos; Fiscal Year: 2010
    ..The yeast paradigm will be exploited by biochemical and genetic meansto gain a complete understanding of the function of Shylp and therefore of Surflp as well, and to clarifythe molecular basis of human COX deficiencies. ..
  2. CYTOCHROME C OXIDASE IN HEALTH AND DISEASE
    Antoni Barrientos; Fiscal Year: 2006
    ..The yeast paradigm will be exploited by biochemical and genetic means to gain a complete understanding of the function of Shylp and therefore of Surflp as well, and to clarify the molecular basis of human COX deficiencies. ..
  3. CYTOCHROME C OXIDASE IN HEALTH AND DISEASE
    Antoni Barrientos; Fiscal Year: 2007
    ..The yeast paradigm will be exploited by biochemical and genetic means to gain a complete understanding of the function of Shylp and therefore of Surflp as well, and to clarify the molecular basis of human COX deficiencies. ..
  4. CYTOCHROME C OXIDASE IN HEALTH AND DISEASE
    Antoni Barrientos; Fiscal Year: 2006
    ..abstract_text> ..
  5. CYTOCHROME C OXIDASE IN HEALTH AND DISEASE
    Antoni Barrientos; Fiscal Year: 2009
    ..The yeast paradigm will be exploited by biochemical and genetic meansto gain a complete understanding of the function of Shylp and therefore of Surflp as well, and to clarifythe molecular basis of human COX deficiencies. ..
  6. CYTOCHROME C OXIDASE IN HEALTH AND DISEASE
    Antoni Barrientos; Fiscal Year: 2009
    ..In this application we propose to use human cell cultures to characterize ZMYND17 and its function. ..