Antoni Barrientos


Affiliation: University of Miami
Country: USA


  1. Lobo Jarne T, Nyvltová E, Pérez Pérez R, Timón Gómez A, Molinié T, Choi A, et al. Human COX7A2L Regulates Complex III Biogenesis and Promotes Supercomplex Organization Remodeling without Affecting Mitochondrial Bioenergetics. Cell Rep. 2018;25:1786-1799.e4 pubmed publisher
  2. Hess K, Liu J, Manfredi G, Muhlschlegel F, Buck J, Levin L, et al. A mitochondrial CO2-adenylyl cyclase-cAMP signalosome controls yeast normoxic cytochrome c oxidase activity. FASEB J. 2014;28:4369-80 pubmed publisher
    ..These residues are not conserved in the Cox5b-containing hypoxic enzyme, which is not regulated by ATP. We conclude that across evolution, a CO2-sAC-cAMP-PKA axis regulates normoxic COX activity. ..
  3. Tu Y, Barrientos A. The Human Mitochondrial DEAD-Box Protein DDX28 Resides in RNA Granules and Functions in Mitoribosome Assembly. Cell Rep. 2015;: pubmed publisher
    ..Our findings identify DDX28 as essential during the early stages of mitoribosome mt-LSU biogenesis, a process that takes place mainly near the mitochondrial nucleoids, in the compartment defined by the RNA granules. ..
  4. Ruetenik A, Barrientos A. Dietary restriction, mitochondrial function and aging: from yeast to humans. Biochim Biophys Acta. 2015;1847:1434-47 pubmed publisher
    ..This article is part of a Special Issue entitled: Mitochondrial Dysfunction in Aging. ..
  5. Zeng R, Smith E, Barrientos A. Yeast Mitoribosome Large Subunit Assembly Proceeds by Hierarchical Incorporation of Protein Clusters and Modules on the Inner Membrane. Cell Metab. 2018;27:645-656.e7 pubmed publisher
    ..Our results define the yeast mtLSU assembly landscape in vivo and provide a foundation for studies of mitoribosome assembly across evolution. ..
  6. Barrientos A, Zambrano A, Tzagoloff A. Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces cerevisiae. EMBO J. 2004;23:3472-82 pubmed
    ..The release of Mss51p from the complex occurs at a downstream step in the assembly pathway, probably catalyzed by Shy1p. ..
  7. Barrientos A. Complementary roles of mitochondrial respiration and ROS signaling on cellular aging and longevity. Aging (Albany NY). 2012;4:578-9 pubmed
  8. Bourens M, Barrientos A. A CMC1-knockout reveals translation-independent control of human mitochondrial complex IV biogenesis. EMBO Rep. 2017;18:477-494 pubmed publisher
  9. Kim H, Maiti P, Barrientos A. Mitochondrial ribosomes in cancer. Semin Cancer Biol. 2017;47:67-81 pubmed publisher
    ..We will also highlight recent developments in targeting mitochondrial ribosomes for the treatment of cancer. ..

More Information


  1. Timón Gómez A, Nyvltová E, Abriata L, Vila A, Hosler J, Barrientos A. Mitochondrial cytochrome c oxidase biogenesis: Recent developments. Semin Cell Dev Biol. 2018;76:163-178 pubmed publisher
  2. Bourens M, Barrientos A. Human mitochondrial cytochrome c oxidase assembly factor COX18 acts transiently as a membrane insertase within the subunit 2 maturation module. J Biol Chem. 2017;292:7774-7783 pubmed publisher
    ..Therefore, COX18 is a new candidate when screening for mitochondrial disorders associated with isolated CIV deficiency. ..