EUGENE JOSEPH BARRETT

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. doi request reprint Severe hypernatremia from a urea-induced diuresis due to body protein wasting in an insulin-resistant type 2 diabetic patient
    Amy Anderson
    Division of Endocrinology, Department of Medicine, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 98:1800-2. 2013
  2. pmc The endothelial cell: an "early responder" in the development of insulin resistance
    Eugene J Barrett
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA
    Rev Endocr Metab Disord 14:21-7. 2013
  3. pmc Early microvascular recruitment modulates subsequent insulin-mediated skeletal muscle glucose metabolism during lipid infusion
    Emma M Eggleston
    Division of Endocrinology, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
    Diabetes Care 36:104-10. 2013
  4. ncbi request reprint 2004 presidential address: the sheep, the ostrich, the ant, diabetes, and the tragedy of the common
    Eugene J Barrett
    University of Virginia, P O Box 801410, Charlottesville, VA 22908, USA
    Diabetes Care 27:3005-8. 2004
  5. pmc Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature
    Eugene J Barrett
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Am J Physiol Endocrinol Metab 301:E252-63. 2011
  6. pmc Insulin's effect on glucose production: direct or indirect?
    Eugene J Barrett
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Clin Invest 111:434-5. 2003
  7. ncbi request reprint The American Diabetes Association, the American Cancer Society, and the American Heart Association: a triumvirate of hope for the nation's health
    Eugene J Barrett
    Department of Diabetes Endocrinology, University of Virginia, Charlottesville, VA 22903, USA
    Diabetes Care 27:1789-90. 2004
  8. pmc The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action
    E J Barrett
    University of Virginia Health System, Charlottesville, VA 22908, USA
    Diabetologia 52:752-64. 2009
  9. ncbi request reprint Glucocorticoids differentially modulate insulin-mediated protein and glycogen synthetic signaling downstream of protein kinase B in rat myocardium
    Yangsong Wu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Endocrinology 145:1161-6. 2004
  10. ncbi request reprint Adrenalectomy enhances the insulin sensitivity of muscle protein synthesis
    Wen Long
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Am J Physiol Endocrinol Metab 284:E102-9. 2003

Research Grants

  1. THE EFFECTS OF INSULIN ON THE MICROVASCULATURE
    Eugene Barrett; Fiscal Year: 2005
  2. University of Virginia CTSA Planning Grant
    Eugene Barrett; Fiscal Year: 2006
  3. Effects of insulin on the microvasculature
    Eugene Barrett; Fiscal Year: 2007
  4. RESEARCH TRAINING IN DIABETES AND HORMONE ACTION
    Eugene Barrett; Fiscal Year: 2007
  5. Microvascular regulation of insulin delivery to human muscle
    Eugene Barrett; Fiscal Year: 2007
  6. DIABETES ENDOCRINOLOGY RESEARCH CENTER
    Eugene Barrett; Fiscal Year: 2007
  7. Effects of insulin on the microvasculature
    Eugene Barrett; Fiscal Year: 2009
  8. Microvascular regulation of insulin delivery to human muscle
    Eugene Barrett; Fiscal Year: 2009
  9. Microvascular regulation of insulin delivery to human muscle
    EUGENE JOSEPH BARRETT; Fiscal Year: 2010
  10. Effects of insulin on the microvasculature
    EUGENE JOSEPH BARRETT; Fiscal Year: 2010

Collaborators

Detail Information

Publications54

  1. doi request reprint Severe hypernatremia from a urea-induced diuresis due to body protein wasting in an insulin-resistant type 2 diabetic patient
    Amy Anderson
    Division of Endocrinology, Department of Medicine, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 98:1800-2. 2013
    ..Hypernatremia is encountered after pituitary or hypothalamic surgery and typically is secondary to vasopressin deficiency resulting in increased free water clearance with inadequate water replacement...
  2. pmc The endothelial cell: an "early responder" in the development of insulin resistance
    Eugene J Barrett
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA
    Rev Endocr Metab Disord 14:21-7. 2013
    ..In the current review, we examined the evidence that supports the general concept of vascular endothelium as a target of insulin action and discussed the biochemical and physiological consequences of vascular insulin resistance...
  3. pmc Early microvascular recruitment modulates subsequent insulin-mediated skeletal muscle glucose metabolism during lipid infusion
    Emma M Eggleston
    Division of Endocrinology, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
    Diabetes Care 36:104-10. 2013
    ..To test whether early, insulin-mediated microvascular recruitment in skeletal muscle predicts steady-state glucose metabolism in the setting of physiological elevation of free fatty acid concentrations...
  4. ncbi request reprint 2004 presidential address: the sheep, the ostrich, the ant, diabetes, and the tragedy of the common
    Eugene J Barrett
    University of Virginia, P O Box 801410, Charlottesville, VA 22908, USA
    Diabetes Care 27:3005-8. 2004
  5. pmc Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature
    Eugene J Barrett
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Am J Physiol Endocrinol Metab 301:E252-63. 2011
    ....
  6. pmc Insulin's effect on glucose production: direct or indirect?
    Eugene J Barrett
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Clin Invest 111:434-5. 2003
  7. ncbi request reprint The American Diabetes Association, the American Cancer Society, and the American Heart Association: a triumvirate of hope for the nation's health
    Eugene J Barrett
    Department of Diabetes Endocrinology, University of Virginia, Charlottesville, VA 22903, USA
    Diabetes Care 27:1789-90. 2004
  8. pmc The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action
    E J Barrett
    University of Virginia Health System, Charlottesville, VA 22908, USA
    Diabetologia 52:752-64. 2009
    ..These findings highlight the need to further understand the role of the vascular actions of insulin in metabolic regulation...
  9. ncbi request reprint Glucocorticoids differentially modulate insulin-mediated protein and glycogen synthetic signaling downstream of protein kinase B in rat myocardium
    Yangsong Wu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Endocrinology 145:1161-6. 2004
    ....
  10. ncbi request reprint Adrenalectomy enhances the insulin sensitivity of muscle protein synthesis
    Wen Long
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Am J Physiol Endocrinol Metab 284:E102-9. 2003
    ..In conclusion, glucocorticoid deficiency enhances the insulin sensitivity of muscle protein synthesis, which is mediated by increased phosphorylation of translation initiation-regulatory proteins...
  11. pmc Muscle contraction, but not insulin, increases microvascular blood volume in the presence of free fatty acid-induced insulin resistance
    April C Inyard
    University of Virginia, Charlottesville, Virginia, USA
    Diabetes 58:2457-63. 2009
    ....
  12. ncbi request reprint Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle
    Lucy H Clerk
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, P O Box 801410, 450 Ray C Hunt Drive, Charlottesville, VA 22908, USA
    Diabetes 55:1436-42. 2006
    ..482, P = 0.027) in response to insulin. In conclusion, obesity eliminated the insulin-stimulated muscle microvascular recruitment and increased brachial artery blood flow seen in lean individuals...
  13. ncbi request reprint Mixed meal and light exercise each recruit muscle capillaries in healthy humans
    Michelle A Vincent
    Division of Cardiovascular Medicine, Dept of Internal Medicine, Box 801410, Univ of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Am J Physiol Endocrinol Metab 290:E1191-7. 2006
    ....
  14. pmc Insulin and insulin-like growth factor-I receptors differentially mediate insulin-stimulated adhesion molecule production by endothelial cells
    Guolian Li
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 1410, USA
    Endocrinology 150:3475-82. 2009
    ..Dual-receptor activation may most effectively contribute to the pathogenesis of atherosclerotic disease in diabetes...
  15. ncbi request reprint Tumor necrosis factor-alpha induces insulin resistance in endothelial cells via a p38 mitogen-activated protein kinase-dependent pathway
    Guolian Li
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, P O Box 801410, Charlottesville, Virginia 22908 1410, USA
    Endocrinology 148:3356-63. 2007
    ....
  16. ncbi request reprint Insulin signaling stimulates insulin transport by bovine aortic endothelial cells
    Hong Wang
    Department of Medicine, University of Virginia, Box 801410, Charlottesville, VA 22908, USA
    Diabetes 57:540-7. 2008
    ..Here, we addressed whether insulin signaling within the endothelial cell is required for the first step of transendothelial insulin transport: its uptake by the endothelial cell...
  17. ncbi request reprint Skeletal muscle capillary responses to insulin are abnormal in late-stage diabetes and are restored by angiotensin-converting enzyme inhibition
    Lucy H Clerk
    Division of Endocrinology, University of Virginia Health System, Charlottesville, Virginia
    Am J Physiol Endocrinol Metab 293:E1804-9. 2007
    ..We conclude that insulin-mediated capillary recruitment in skeletal muscle, which participates in glucose utilization, is impaired in animals with DM and can be partially reversed by chronic ACE-I therapy...
  18. pmc Angiotensin II type 1 and type 2 receptors regulate basal skeletal muscle microvascular volume and glucose use
    Weidong Chai
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Hypertension 55:523-30. 2010
    ..Pharmacological manipulation of the balance of AT(1)R and AT(2)R activity affords the potential to improve glucose metabolism...
  19. pmc Infusing lipid raises plasma free fatty acids and induces insulin resistance in muscle microvasculature
    Zhenqi Liu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, P O Box 801410, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 94:3543-9. 2009
    ..Insulin recruits muscle microvasculature, which increases the endothelial exchange surface area to facilitate substrate delivery. Elevated plasma concentrations of free fatty acids (FFAs) cause insulin resistance...
  20. ncbi request reprint Amino acids stimulate translation initiation and protein synthesis through an Akt-independent pathway in human skeletal muscle
    Zhenqi Liu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 87:5553-8. 2002
    ..04) and p70(S6K) (P < 0.001). We conclude that AA act directly as nutrient signals to stimulate protein synthesis through Akt-independent activation of the protein synthetic apparatus in human skeletal muscle...
  21. ncbi request reprint The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake
    Lucy H Clerk
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Diabetes Metab Res Rev 20:3-12. 2004
    ..We also advance the hypothesis that an action on the precapillary arteriole may play the dominant role in mediating perfusion-dependent effects of insulin on glucose metabolism in muscle...
  22. ncbi request reprint The regulation of body and skeletal muscle protein metabolism by hormones and amino acids
    Zhenqi Liu
    Department of Internal Medicine and General Clinical Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Nutr 136:212S-7S. 2006
    ..We will review some of these data, particularly focusing on amino acids, insulin, and the growth hormone axis and their actions in muscle and how these relate to whole-body protein metabolism...
  23. ncbi request reprint Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake
    Emma M Eggleston
    University of Virginia Health System, P O Box 801410, 450 Ray C Hunt Dr, Charlottesville, VA 22908, USA
    Diabetes 56:2958-63. 2007
    ..We further hypothesized that expansion of the microvascular volume of muscle would enhance muscle insulin clearance...
  24. ncbi request reprint The vascular endothelial cell mediates insulin transport into skeletal muscle
    Hong Wang
    Division of Endocrinology and Metabolism, Departmetn of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Physiol Endocrinol Metab 291:E323-32. 2006
    ....
  25. pmc The trafficking/interaction of eNOS and caveolin-1 induced by insulin modulates endothelial nitric oxide production
    Hong Wang
    Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Endocrinol 23:1613-23. 2009
    ..These data show that insulin acutely regulates eNOS and CAV-1 trafficking to PM of vascular endothelial cells where their interaction can regulate eNOS activity...
  26. ncbi request reprint Contraction stimulates nitric oxide independent microvascular recruitment and increases muscle insulin uptake
    April C Inyard
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Diabetes 56:2194-200. 2007
    ..This microvascular response may, in part, explain enhanced insulin action in exercising skeletal muscle...
  27. ncbi request reprint Glucocorticoids modulate amino acid-induced translation initiation in human skeletal muscle
    Zhenqi Liu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908 1410, USA
    Am J Physiol Endocrinol Metab 287:E275-81. 2004
    ....
  28. ncbi request reprint Unlike insulin, amino acids stimulate p70S6K but not GSK-3 or glycogen synthase in human skeletal muscle
    Zhenqi Liu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, PO Box 801410, Charlottesville, VA 22908 1410, USA
    Am J Physiol Endocrinol Metab 286:E523-8. 2004
    ..We conclude that amino acids at physiological concentrations mediate p70(S6K) but, unlike insulin, do not regulate GSK-3 and GS phosphorylation/activity in human skeletal muscle...
  29. pmc Caveolin-1 is required for vascular endothelial insulin uptake
    Hong Wang
    Division of Endocrinology and Metablism, Department of Internal Medicine, University of Virginia Health System, P O Box 801410, 450 Ray C Hunt Dr, Charlottesville, VA 22908, USA
    Am J Physiol Endocrinol Metab 300:E134-44. 2011
    ..Proinflammatory cytokines may inhibit insulin uptake, at least in part, by inhibiting caveolin-1 expression...
  30. ncbi request reprint Vascular recruitment in skeletal muscle during exercise and hyperinsulinemia assessed by contrast ultrasound
    Dana Dawson
    Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Am J Physiol Endocrinol Metab 282:E714-20. 2002
    ..Exercise increases both V(RBC) and capBV, whereas hyperinsulinemia selectively increases only capBV, which may enhance skeletal muscle glucose uptake...
  31. ncbi request reprint Active role for the vasculature in the delivery of insulin to skeletal muscle
    Michelle A Vincent
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Clin Exp Pharmacol Physiol 32:302-7. 2005
    ..Even so, there is now sufficient evidence to indicate that insulin's vascular action within skeletal muscle is a major regulatory locus for its insulin mediated glucose disposal...
  32. ncbi request reprint Insulin at physiological concentrations selectively activates insulin but not insulin-like growth factor I (IGF-I) or insulin/IGF-I hybrid receptors in endothelial cells
    Guolian Li
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, P O Box 801410, Charlottesville, Virginia 22908 1410, USA
    Endocrinology 146:4690-6. 2005
    ....
  33. pmc Resveratrol recruits rat muscle microvasculature via a nitric oxide-dependent mechanism that is blocked by TNF╬▒
    Nasui Wang
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Physiol Endocrinol Metab 300:E195-201. 2011
    ..Thus, chronic inflammation, as seen in type 2 diabetes, may limit resveratrol's vasodilatory actions on muscle microvasculature...
  34. ncbi request reprint Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo
    Michelle A Vincent
    Department of Internal Medicine, Box 801410, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Diabetes 53:1418-23. 2004
    ..05). We conclude that insulin rapidly recruits skeletal muscle capillaries in vivo by a nitric oxide-dependent action, and the increase in capillary recruitment may contribute to the subsequent glucose uptake...
  35. ncbi request reprint Human protein metabolism: its measurement and regulation
    Zhenqi Liu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, and the General Clinical Research Center, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Am J Physiol Endocrinol Metab 283:E1105-12. 2002
    ....
  36. pmc Obesity blunts microvascular recruitment in human forearm muscle after a mixed meal
    Michelle A Keske
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    Diabetes Care 32:1672-7. 2009
    ..Ingestion of a mixed meal recruits flow to muscle capillaries and increases total forearm blood flow in healthy young lean people. We examined whether these vascular responses are blunted by obesity...
  37. pmc Abnormal skeletal muscle capillary recruitment during exercise in patients with type 2 diabetes mellitus and microvascular complications
    Lisa Womack
    General Clinical Research Center, University of Virginia, Charlottesville, USA
    J Am Coll Cardiol 53:2175-83. 2009
    ..We sought to determine whether skeletal muscle capillary recruitment is impaired in type 2 diabetes mellitus (DM) with and without microvascular complications (MC)...
  38. pmc Effects of insulin and transgenic overexpression of UDP-glucose pyrophosphorylase on UDP-glucose and glycogen accumulation in skeletal muscle fibers
    Thomas H Reynolds
    Department of Pharmacology, University of Virginia School of Medicine, 1300 Jefferson Park Ave, Charlottesville, VA 22908, USA
    J Biol Chem 280:5510-5. 2005
    ..The results indicate that UDP-Glc PPL activity is not limiting for glycogen synthesis...
  39. ncbi request reprint A high-carbohydrate, high-fiber meal improves endothelial function in adults with the metabolic syndrome
    David W Brock
    Department of Human Services, University of Virginia, Charlottesville, Virginia, USA
    Diabetes Care 29:2313-5. 2006
  40. ncbi request reprint Comparison of Borg- and OMNI-RPE as markers of the blood lactate response to exercise
    Brian A Irving
    Department of Human Services, Division of Endocrinology and Metabolism, University of Virginia, Charlottesville, VA 22904, USA
    Med Sci Sports Exerc 38:1348-52. 2006
    ..To examine the utility of the Borg (6-20) and adult OMNI walk/run (0-10) ratings of perceived exertion (RPE) scales as markers of the blood lactate response to exercise...
  41. ncbi request reprint Blood flow and muscle metabolism: a focus on insulin action
    Michael G Clark
    Department of Biochemistry, Medical School, University of Tasmania, Hobart 7001, Australia
    Am J Physiol Endocrinol Metab 284:E241-58. 2003
    ..Exercise training improves insulin-mediated capillary recruitment and glucose uptake by muscle...
  42. ncbi request reprint Point: There is capillary recruitment in active skeletal muscle during exercise
    Michael G Clark
    Department of Biochemistry, University of Tasmania, Hobart, Tasmania
    J Appl Physiol 104:889-91. 2008
  43. ncbi request reprint TNF-alpha acutely inhibits vascular effects of physiological but not high insulin or contraction
    Lei Zhang
    Department of Biochemistry, University of Tasmania, Hobart 7001, Australia
    Am J Physiol Endocrinol Metab 285:E654-60. 2003
    ..These findings may have implications for ameliorating muscle insulin resistance resulting from increased plasma TNF-alpha and for the differing mechanisms by which contraction and insulin recruit capillary flow in muscle...
  44. ncbi request reprint Insulin-mediated capillary recruitment in skeletal muscle: is this a mediator of insulin action on glucose metabolism?
    Stephen Rattigan
    Biochemistry, Medical School, University of Tasmania, Private Bag 58, Hobart 7001, Australia
    Curr Diab Rep 3:195-200. 2003
    ..Exercise, which also leads to capillary recruitment, may involve a different mechanism than that used by insulin...
  45. ncbi request reprint Insulin sensitivity of muscle capillary recruitment in vivo
    Lei Zhang
    Department of Biochemistry, University of Tasmania, Hobart, Tasmania, Australia
    Diabetes 53:447-53. 2004
    ..We conclude that the precapillary arterioles that regulate microvascular recruitment are more insulin sensitive than resistance arterioles that regulate total flow...
  46. ncbi request reprint Skeletal muscle contraction stimulates capillary recruitment and glucose uptake in insulin-resistant obese Zucker rats
    Catherine M Wheatley
    Department of Biochemistry, Medical School, University of Tasmania, Hobart, Australia, 7001
    Am J Physiol Endocrinol Metab 287:E804-9. 2004
    ..001). It is concluded that contraction-mediated muscle capillary recruitment and glucose uptake are essentially normal in the obese Zucker rat and that control of FBF and capillary recruitment in exercise is closely linked...
  47. ncbi request reprint Exercise and insulin-mediated capillary recruitment in muscle
    Stephen Rattigan
    Department of Biochemistry, Medical School, University of Tasmania, Private Bag 58, Hobart, Tasmania, 7001, Australia
    Exerc Sport Sci Rev 33:43-8. 2005
    ..Understanding the mechanisms and interactions between contraction- and insulin-mediated alterations in blood flow within muscle may reveal new approaches to overcome insulin resistance...
  48. ncbi request reprint The microvasculature in insulin resistance and type 2 diabetes
    Michael G Clark
    Department of Biochemistry, Medical School, University of Tasmania, Hobart, Australia
    Semin Vasc Med 2:21-31. 2002
    ..Similarly, there are impaired vasodilatory responses in the skin of diabetic subjects...
  49. ncbi request reprint Nutritive blood flow as an essential element supporting muscle anabolism
    Michael G Clark
    University of Tasmania, Hobart, Australia
    Curr Opin Clin Nutr Metab Care 9:185-9. 2006
    ..This review examines the latest developments concerning insulin action to increase nutritive perfusion of muscle and agents that interact with this effect and which could potentially modulate anabolism...
  50. pmc Inhaled insulin
    EMMA MORTON-EGGLESTON
    BMJ 332:1043-4. 2006
  51. ncbi request reprint Graded occlusion of perfused rat muscle vasculature decreases insulin action
    Georgie C Vollus
    Department of Biochemistry, University of Tasmania Medical School, Private Bag 58, 7001, Hobart, Tasmania, Australia
    Clin Sci (Lond) 112:457-66. 2007
    ....
  52. ncbi request reprint Insulin-mediated hemodynamic changes are impaired in muscle of Zucker obese rats
    Michelle G Wallis
    Department of Biochemistry, Medical School, University of Tasmania, Hobart, 7001 Tasmania, Australia
    Diabetes 51:3492-8. 2002
    ..6-fold that of the postinsulin obese. We conclude that muscle insulin resistance of obese Zucker rats is accompanied by impaired hemodynamic responses to insulin, including capillary recruitment and FBF...
  53. ncbi request reprint Hyperglycemic crises in diabetes
    Abbas E Kitabchi
    Diabetes Care 27:S94-102. 2004
  54. ncbi request reprint Hyperglycemic crises in patients with diabetes mellitus
    Abbas E Kitabchi
    Diabetes Care 26:S109-17. 2003

Research Grants34

  1. THE EFFECTS OF INSULIN ON THE MICROVASCULATURE
    Eugene Barrett; Fiscal Year: 2005
    ..In the latter studies we will test directly whether augmenting or diminishing muscle capillary recruitment affects the simultaneously measured action of insulin to promote glucose uptake by skeletal muscle. ..
  2. University of Virginia CTSA Planning Grant
    Eugene Barrett; Fiscal Year: 2006
    ....
  3. Effects of insulin on the microvasculature
    Eugene Barrett; Fiscal Year: 2007
    ..These studies, when successfully completed, should provide a more comprehensive understanding of the role of the microvasculature as a site of regulation of insulin action in health and insulin resistant states. ..
  4. RESEARCH TRAINING IN DIABETES AND HORMONE ACTION
    Eugene Barrett; Fiscal Year: 2007
    ..abstract_text> ..
  5. Microvascular regulation of insulin delivery to human muscle
    Eugene Barrett; Fiscal Year: 2007
    ....
  6. DIABETES ENDOCRINOLOGY RESEARCH CENTER
    Eugene Barrett; Fiscal Year: 2007
    ..Pilot and Feasibility and Enrichment Programs will introduce new investigators to diabetes research in an environment of research excellence. ..
  7. Effects of insulin on the microvasculature
    Eugene Barrett; Fiscal Year: 2009
    ..These studies, when successfully completed, should provide a more comprehensive understanding of the role of the microvasculature as a site of regulation of insulin action in health and insulin resistant states. ..
  8. Microvascular regulation of insulin delivery to human muscle
    Eugene Barrett; Fiscal Year: 2009
    ....
  9. Microvascular regulation of insulin delivery to human muscle
    EUGENE JOSEPH BARRETT; Fiscal Year: 2010
    ....
  10. Effects of insulin on the microvasculature
    EUGENE JOSEPH BARRETT; Fiscal Year: 2010
    ..These studies, when successfully completed, should provide a more comprehensive understanding of the role of the microvasculature as a site of regulation of insulin action in health and insulin resistant states. ..
  11. Ultrasound for clinical microvascular imaging
    Eugene Barrett; Fiscal Year: 2004
    ..It will provide important support for a total of 5 individual NIH RO-1, 2 K08, 1 K23 and 1 T32 supported research programs and to the overall mission of the GCRC which has been supported by a M01 grant for 30 years. ..
  12. REGULATION OF SKELETAL MUSCLE PROTEIN METABOLISM
    Eugene Barrett; Fiscal Year: 1999
    ..Information gained from these mechanistic studies of human muscle protein metabolism should be directly relevant to the rational use of anabolic agents in the treatment or prevention of muscle wasting. ..
  13. REGULATION OF SKELETAL MUSCLE PROTEIN METABOLISM IN MAN
    Eugene Barrett; Fiscal Year: 1993
    ..Likewise, this model will allow isolation of the effect of exercise per se on muscle protein dynamics in man...
  14. Molecular Dynamics Typhoon
    Eugene Barrett; Fiscal Year: 2002
    ..It will provide important support for a total of 18 NIH RO1 supported research programs. ..
  15. Effects of insulin on the microvasculature
    EUGENE JOSEPH BARRETT; Fiscal Year: 2010
    ....