Research Topics
Genomes and GenesSpecies | Elizabeth Barrett-ConnorSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
The association of concurrent vitamin D and sex hormone deficiency with bone loss and fracture risk in older men: the osteoporotic fractures in men (MrOS) studyElizabeth Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, USA
J Bone Miner Res 27:2306-13. 2012..In summary, adverse skeletal effects of low sex steroid levels were more pronounced in older men with low VitD levels. The presence of low VitD in the presence of low BioE/high SHBG may contribute substantially to poor skeletal health...- Five-year stability in associations of health-related quality of life measures in community-dwelling older adults: the Rancho Bernardo StudyClaudia Der-Martirosian
Department of Family and Preventive Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0607, La Jolla, CA 92093 0631, USA
Qual Life Res 19:1333-41. 2010..This study examines the five-year stability of the association of SF-12 and SF-6D scores with scores on the longer SF-36 and its domains in community-dwelling older men and women... - Peripheral arterial disease and osteoporosis in older adults: the Rancho Bernardo StudyD Von Muhlen
Division of Epidemiology, Department of Family and Preventive Medicine, University of California, La Jolla, San Diego, CA, USA
Osteoporos Int 20:2071-8. 2009..We found a weak association between PAD and osteoporosis and bone loss only in women, but the association was not independent of age. PAD was not associated with fractures in this community-based population... - Heart disease risk factors in midlife predict subclinical coronary atherosclerosis more than 25 years later in survivors without clinical heart disease: the Rancho Bernardo StudyElizabeth Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0607, La Jolla, CA 92093, USA
J Am Geriatr Soc 57:1041-4. 2009..To determine which of the classic modifiable coronary heart disease (CHD) risk factors, measured in midlife, are associated with subclinical coronary atherosclerosis in older age... 
Risk-benefit profile for raloxifene: 4-year data From the Multiple Outcomes of Raloxifene Evaluation (MORE) randomized trialElizabeth Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, University of California at San Diego, La Jolla, California 92093 0607, USA
J Bone Miner Res 19:1270-5. 2004..39% and 1.83% in the raloxifene and placebo groups, respectively (HR, 0.75; 95% CI, 0.62-0.92), compatible with a favorable risk-benefit profile for raloxifene for treating postmenopausal osteoporosis...- The association of testosterone levels with overall sleep quality, sleep architecture, and sleep-disordered breathingElizabeth Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA 92093 0607, USA
J Clin Endocrinol Metab 93:2602-9. 2008.... - Commentary: observation versus intervention--what's different?Elizabeth Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093 0607, USA
Int J Epidemiol 33:457-9. 2004 - Cardiovascular risk stratification and cardiovascular risk factors associated with erectile dysfunction: assessing cardiovascular risk in men with erectile dysfunctionElizabeth Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California 92093 0607, USA
Clin Cardiol 27:I8-13. 2004..Early detection of ED may allow for early diagnosis and management of CVD and diabetes... 
Design of the POSSIBLE UStrade mark Study: postmenopausal women's compliance and persistence with osteoporosis medicationsE Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0607, USA
Osteoporos Int 20:463-72. 2009..We report our study design and the baseline characteristics of 4,994 postmenopausal women recruited from primary care physician offices in 33 states...- Clinical review 162: cardiovascular endocrinology 3: an epidemiologist looks at hormones and heart disease in womenElizabeth Barrett-Connor
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92093-0607, USA
J Clin Endocrinol Metab 88:4031-42. 2003 - Recency and duration of postmenopausal hormone therapy: effects on bone mineral density and fracture risk in the National Osteoporosis Risk Assessment (NORA) studyElizabeth Barrett-Connor
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093 0607, USA
Menopause 10:412-9. 2003.... - Raloxifene and risk for stroke based on the framingham stroke risk scoreElizabeth Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, Calif 92093 0607, USA
Am J Med 122:754-61. 2009..We assessed whether this risk is concentrated in postmenopausal women already at high stroke risk... - Endogenous and exogenous estrogen, cognitive function, and dementia in postmenopausal women: evidence from epidemiologic studies and clinical trialsElizabeth Barrett-Connor
Departments of Family and Preventive Medicine and Medicine, University of California, San Diego School of Medicine, La Jolla, California 92093 0607, USA
Semin Reprod Med 27:275-82. 2009..Overall, the evidence does not convincingly support the prescription of early or late postmenopausal estrogen therapy to preserve cognitive function or prevent dementia... - Osteoporosis and fracture risk in women of different ethnic groupsElizabeth Barrett-Connor
Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA 92093 0607, USA
J Bone Miner Res 20:185-94. 2005..Weight explained differences in BMD, except among blacks, who had the highest BMD. One SD decrease in BMD predicted a 50% increased fracture risk in each group. Despite similar relative risks, absolute fracture rates differed... - Hormone therapy and coronary artery calcification in asymptomatic postmenopausal women: the Rancho Bernardo StudyElizabeth Barrett-Connor
Department of Family and Preventive Medicine, School of Medicine, Mail Code 0607, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Menopause 12:40-8. 2005.... - Hormones and heart disease in women: where are we in 2005?Elizabeth Barrett-Connor
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093 0607, USA
Curr Atheroscler Rep 8:85-7. 2006 - Association of serum proinsulin with hormone replacement therapy in nondiabetic older women: the Rancho Bernardo StudyDong Jun Kim
Department of FamilyPreventive Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0607, USA
Diabetes Care 29:618-24. 2006..We report here the association of HRT with proinsulin, insulin, and fasting and postchallenge glucose levels in older adults... - Heart disease risk factors predict erectile dysfunction 25 years later (the Rancho Bernardo Study)Elizabeth Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093 0607, USA
Am J Cardiol 96:3M-7M. 2005..In all, 1 in 5 men had > or =3 risk factors and were at a 2.2-fold increased risk of ED. Improving CAD risk factors in midlife may decrease ED risk as well as CAD risk... - Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal womenElizabeth Barrett-Connor
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla 92093 0607, USA
N Engl J Med 355:125-37. 2006..The effect of raloxifene, a selective estrogen-receptor modulator, on coronary heart disease (CHD) and breast cancer is not established... - Women and cardiovascular diseaseElizabeth Barrett-Connor
Department of Family and Preventive Medicine, University of California, La Jolla, Calif 92093-0607, USA
CMAJ 176:791-3. 2007 - An introduction to obesity and dementiaElizabeth Barrett-Connor
Department of Family and Preventive Medicine, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0607, USA
Curr Alzheimer Res 4:97-101. 2007..If any of these factors are in the causal pathway to dementia, their reversal or prevention by weight control would have huge public health importance... - Commentary: Masculinity, femininity and heart diseaseElizabeth Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Int J Epidemiol 36:621-2. 2007 - Hormones and heart disease in women: the timing hypothesisElizabeth Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, CA, USA
Am J Epidemiol 166:506-10. 2007..In the meantime, publicized statements in multiple venues have promoted the timing hypothesis as fact, confusing patients and physicians who do not realize that the hypothesis is stronger than the evidence... - The rise and fall of menopausal hormone therapyElizabeth Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, 92093 0607, USA
Annu Rev Public Health 26:115-40. 2005..Differences between EPT and ET may reflect chance, baseline differences between the EPT and ET cohorts, or a progestin effect. Studies of younger women and lower HT doses with intermediate endpoints are beginning... - Male testosterone: what is normal?Elizabeth Barrett-Connor
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California 92093 0607, USA
Clin Endocrinol (Oxf) 62:263-4. 2005 - Wrist fracture as a predictor of future fractures in younger versus older postmenopausal women: results from the National Osteoporosis Risk Assessment (NORA)E Barrett-Connor
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093 0607, USA
Osteoporos Int 19:607-13. 2008..This 3-year follow-up study of 158,940 women showed a similar future fracture risk in younger and older women with wrist-fracture history... - Coronary artery calcium versus intima-media thickness as a measure of cardiovascular disease among asymptomatic adults (from the Rancho Bernardo Study)Elizabeth Barrett-Connor
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA
Am J Cardiol 99:227-31. 2007..In conclusion, IMT of the carotid arteries predicted the severity of CAC burden an average of 3 years later in community-dwelling asymptomatic older adults... - Post hoc analysis of data from the Multiple Outcomes of Raloxifene Evaluation (MORE) trial on the effects of three years of raloxifene treatment on glycemic control and cardiovascular disease risk factors in women with and without type 2 diabetesElizabeth Barrett-Connor
Department of Family and Preventive Medicine, School of Medicine, University of California at San Diego, La Jolla, California 92093 0607, USA
Clin Ther 25:919-30. 2003..The long-term effects of the selective estrogen-receptor modulator raloxifene hydrochloride on glycemic control and markers of cardiovascular disease risk in postmenopausal women with type 2 diabetes mellitus are unknown... - Raloxifene and cardiovascular events in osteoporotic postmenopausal women: four-year results from the MORE (Multiple Outcomes of Raloxifene Evaluation) randomized trialElizabeth Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego School of Medicine, 9500 Gilman Dr, No 0607, La Jolla, CA 92093 0607, USA
JAMA 287:847-57. 2002..Raloxifene, a selective estrogen receptor modulator, improves cardiovascular risk factors, but its effect on cardiovascular events is unknown... - Raloxifene: risks and benefitsE Barrett-Connor
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla 92093, USA
Ann N Y Acad Sci 949:295-303. 2001..This paper reviews the clinical trial evidence for raloxifene benefits and risks, and how they compare with those of hormone replacement therapy (HRT) and relate to the choices of postmenopausal women... - Treatment satisfaction and persistence among postmenopausal women on osteoporosis medications: 12-month results from POSSIBLE US™E Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0607, USA
Osteoporos Int 23:733-41. 2012..Lower satisfaction among women with moderate/severe side effects increased the risk of discontinuation/switching by 67%. Treatment satisfaction and side effect experience influence osteoporosis medication adherence... - Hormones and the health of women: past, present, and future. Keynote addressElizabeth Barrett-Connor
Department of Family and Preventive Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0607, USA
Menopause 9:23-31. 2002..Future uses of sex hormones are likely to be viewed as overmedicalization initially, and time will tell whether these uses are healthy or merely controversial... - Endogenous sex hormones and cognitive function in older menE Barrett-Connor
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla 92093 0607, USA
J Clin Endocrinol Metab 84:3681-5. 1999..Linear and nonlinear associations were also found, suggesting that an optimal level of sex hormones may exist for some cognitive functions... - Hormones and heart disease in women: Heart and Estrogen/Progestin Replacement Study in perspectiveE Barrett-Connor
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla 92093 0607, USA
J Clin Endocrinol Metab 84:1848-53. 1999..Women who are undecided should be asked to consider participation in clinical trials. The HERS has dramatically illustrated the need for them... - Alendronate and atrial fibrillation: a meta-analysis of randomized placebo-controlled clinical trialsE Barrett-Connor
University of California, San Diego, La Jolla, CA, USA
Osteoporos Int 23:233-45. 2012..Across all studies, no clear association between overall bisphosphonate exposure and the rate of serious or non-serious AF was observed... - Isolated postchallenge hyperglycemia and the risk of fatal cardiovascular disease in older women and men. The Rancho Bernardo StudyE Barrett-Connor
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla 92093 0607, USA
Diabetes Care 21:1236-9. 1998..1 mmol/l with fasting plasma glucose [FPG] < 7.0 mmol/l) increases the risk of fatal cardiovascular disease (CVD) in older women and men... - Hormone replacement therapy, heart disease, and other considerationsE Barrett-Connor
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla 92093 0607, USA
Annu Rev Public Health 19:55-72. 1998..Therefore, until findings from randomized trials confirm and quantitate the benefit of estrogen therapy for prevention of CHD, we believe it should not be recommended to all postmenopausal women... - Epidemiology of rib fractures in older men: Osteoporotic Fractures in Men (MrOS) prospective cohort studyElizabeth Barrett-Connor
Department of Family and Preventive Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0607, USA
BMJ 340:c1069. 2010..To study the causes and consequences of radiologically confirmed rib fractures (seldom considered in the context of osteoporosis) in community dwelling older men... - NIDDM, impaired glucose tolerance, and pulmonary function in older adults. The Rancho Bernardo StudyE Barrett-Connor
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla 92093 0607, USA
Diabetes Care 19:1441-4. 1996..To determine whether NIDDM or plasma glucose level in subjects without diabetes is associated with reduced pulmonary function in 525 men and 714 women, 51-95 years of age... - Does hyperinsulinemia preserve bone?E Barrett-Connor
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla 92093 0607, USA
Diabetes Care 19:1388-92. 1996..Obesity and NIDDM are each associated with increased bone mineral density (BMD). We therefore hypothesize that hyperinsulinemia is an osteogenic factor... - Women and heart disease: neglected directions for future researchElizabeth Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, Mail Code 0607, 9500 Gilman Drive, La Jolla, CA 92093 0607, USA
J Cardiovasc Transl Res 2:256-7. 2009..Where, beyond estrogen therapy, should we go from here to explain the striking sex differences in heart disease rates? A broader spectrum of research about the female cardiovascular advantage and its translation is needed... - A1C and diabetes diagnosis: The Rancho Bernardo StudyCaroline K Kramer
Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California, USA
Diabetes Care 33:101-3. 2010..To examine the sensitivity and specificity of A1C as a diagnostic test for type 2 diabetes in older adults... - Reduced incidence of invasive breast cancer with raloxifene among women at increased coronary riskDeborah Grady
University of California, San Francisco, and San Francisco VA Medical Center, San Francisco, CA 94115, USA
J Natl Cancer Inst 100:854-61. 2008..Here, we provide further details about breast cancer incidence by tumor characteristics, duration of treatment, and subgroup... - Individual and neighborhood socioeconomic status and inflammation in Mexican American women: what is the role of obesity?Linda C Gallo
Department of Psychology, San Diego StateUniversity, San Diego, CA, USA
Psychosom Med 74:535-42. 2012..We examined relationships of individual and neighborhood SES with inflammatory markers in Mexican American women and evaluated contributions of obesity and related heath behaviors to these associations... - Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trialAlka M Kanaya
Division of General Internal Medicine, University of California, San Francisco, 1701 Divisadero Street, Suite 536, San Francisco, CA 94143 1732, USA
Ann Intern Med 138:1-9. 2003..Randomized trials of postmenopausal hormone therapy have found differing effects on fasting glucose levels. No trial has evaluated the effect of hormone therapy on diabetes incidence... - Subclinical coronary atherosclerosis in asymptomatic Filipino and white womenMaria Rosario G Araneta
Department of Family and Preventive Medicine, University of California San Diego, 9500 Gilman Dr, 0607, La Jolla, CA 92093, USA
Circulation 110:2817-23. 2004..Few studies have described EBCT-defined CHD among ethnic minorities with elevated T2DM prevalence. The objective of this study was to compare EBCT-defined CAC in Filipino and white women without known cardiovascular disease... - Predictors of heart failure among women with coronary diseaseKirsten Bibbins-Domingo
Division of General Internal Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA 94143 1364, USA
Circulation 110:1424-30. 2004..We determined the risk factors for developing heart failure among postmenopausal women with established coronary disease... - Serum insulin-like growth factor binding protein-1 levels and bone mineral density in older adults: the Rancho Bernardo StudySimerjot K Jassal
Department of Medicine, University of California San Diego and VA San Diego Healthcare System, La Jolla, CA, USA
Osteoporos Int 16:1948-54. 2005..Studies are needed to further investigate the relationship between inhibitory components of IGF-1 and bone loss... - Elevated natriuretic peptide levels and cognitive function in community-dwelling older adultsLori B Daniels
Division of Cardiology, Department of Medicine, University of California at San Diego, USA
Am J Med 124:670.e1-8. 2011..We assessed the association between N-terminal pro B-type natriuretic peptide (NT-proBNP) levels and cognitive function in community-dwelling ambulatory older adults in the Rancho Bernardo Study... - Walking decreased risk of cardiovascular disease mortality in older adults with diabetesTyler C Smith
Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, 9500 Gilman Drive 0607, La Jolla, CA 92093 0607, USA
J Clin Epidemiol 60:309-17. 2007..This study examines the association of walking with mortality in persons with type 2 diabetes compared to those with normal glucose tolerance... - Sex and time differences in the associations of non-high-density lipoprotein cholesterol versus other lipid and lipoprotein factors in the prediction of cardiovascular death (The Rancho Bernardo Study)Denise von Muhlen
Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA 93093 0607, USA
Am J Cardiol 91:1311-5. 2003..Thus, non-HDL cholesterol is not superior to individual lipids, lipoproteins, or their ratios in the prediction of cardiovascular death in older adults... - Obesity increases and physical activity decreases lower urinary tract symptom risk in older men: the Osteoporotic Fractures in Men studyJ Kellogg Parsons
Division of Urology, University of California San Diego, San Diego, CA, USA
Eur Urol 60:1173-80. 2011..Two potential targets for preventing chronic lower urinary tract symptoms (LUTS) in older men are obesity and physical activity... - Sex differences in the association between proinsulin and intact insulin with coronary heart disease in nondiabetic older adults: the Rancho Bernardo StudyJee-Young Oh
Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla 92093-0607, USA
Circulation 105:1311-6. 2002..CONCLUSIONS: In older nondiabetic men and women, proinsulin was more strongly and consistently associated with CHD than was intact insulin... - Sex differences in the association of Framingham Cardiac Risk Score with cognitive decline in community-dwelling elders without clinical heart diseaseGail A Laughlin
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Psychosom Med 73:683-9. 2011.... - Hyperkyphotic posture and poor physical functional ability in older community-dwelling men and women: the Rancho Bernardo studyDeborah M Kado
Division of Geriatrics, Department of Medicine, David Geffen School of Medicine at UCLA, 10945 Le Conte Ave, Suite 2339, Los Angeles, CA, USA
J Gerontol A Biol Sci Med Sci 60:633-7. 2005..Our study objective was to determine the association between hyperkyphotic posture and physical functional limitations... - The sex-specific association of serum osteoprotegerin and receptor activator of nuclear factor kappaB legend with bone mineral density in older adults: the Rancho Bernardo studyAnna Stern
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0607, USA
Eur J Endocrinol 156:555-62. 2007..We examined the sex-specific associations of serum OPG, RANKL, and their ratio with bone mineral density (BMD) in older adults... - The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo StudyGail A Laughlin
Department of Family and Preventive Medicine, University of California San Diego School of Medicine, La Jolla, California 92093 0607
J Clin Endocrinol Metab 89:114-20. 2004..We conclude that low baseline levels of IGF-I and IGFBP-1 increase the risk of fatal IHD among elderly men and women independent of prevalent IHD and CVD risk factors... - Blood pressure and fasting plasma glucose rather than metabolic syndrome predict coronary artery calcium progression: the Rancho Bernardo StudyCaroline K Kramer
Division of Epidemiology, Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA
Diabetes Care 32:141-6. 2009..To examine the association of the metabolic syndrome, defined by World Health Organization (WHO) and Adult Treatment Panel III (ATP-III) criteria, and its components with coronary artery calcium (CAC) progression... - Kidney Function and Progression of Coronary Artery Calcium in Community-Dwelling Older Adults (from the Rancho Bernardo Study)Simerjot Kaur Jassal
Division of General Internal Medicine, Department of Medicine, University of California, San Diego, La Jolla, California Section of General Internal Medicine and Geriatrics, Veterans Administration San Diego Healthcare System, San Diego, California Electronic address
Am J Cardiol 110:1425-33. 2012..In the elderly, kidney function and CAC may not progress together... - Modifiable predictors of bone loss in older men: a prospective studyLudmila N Bakhireva
University of California, San Diego, Department of Family and Preventive Medicine, Division of Epidemiology, La Jolla, California 92093-0607, USA
Am J Prev Med 26:436-42. 2004..Potentially modifiable characteristics such as low body mass, weight loss, smoking, and physical inactivity were important predictors of bone loss and should be considered for the prevention of osteoporosis in men... - Change in cognitive function by glucose tolerance status in older adults: a 4-year prospective study of the Rancho Bernardo study cohortAlka M Kanaya
Division of General Internal Medicine, University of California, San Francisco, USA
Arch Intern Med 164:1327-33. 2004..A few studies have examined change in cognitive performance by diabetes status with disparate results. We examined the 4-year change in cognitive performance among older adults according to glucose tolerance status... - Plasma neutrophil gelatinase-associated lipocalin is independently associated with cardiovascular disease and mortality in community-dwelling older adults: The Rancho Bernardo StudyLori B Daniels
Division of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, California 92037 7411, USA
J Am Coll Cardiol 59:1101-9. 2012..The purpose of this study was to determine the association between neutrophil gelatinase-associated lipocalin (NGAL) levels and cardiovascular and all-cause mortality in community-dwelling older adults... - Vitamin d, parathyroid hormone, and cardiovascular mortality in older adults: the Rancho Bernardo studySimerjot K Jassal
Division of General Internal Medicine and Geriatrics, Department of Medicine, University of California, San Diego, CA 92161, USA
Am J Med 123:1114-20. 2010..No prior studies have investigated the association between 25-hydroxyvitamin D (25[OH]D), 1,25-dihydroxyvitamin D (1,25[OH](2)D), or intact parathyroid hormone and cardiovascular mortality in a temperate climate... - Searching for polycystic ovary syndrome in postmenopausal women: evidence of a dose-effect association with prevalent cardiovascular diseaseAndrew J Krentz
Department of Family and Preventive Medicine, University of California San Diego, La Jolla 92093 0607, USA
Menopause 14:284-92. 2007..To test the hypothesis that polycystic ovary syndrome (PCOS) is associated with an increased risk of atherosclerotic cardiovascular disease (CVD) in older postmenopausal women... - Visceral adiposity and subclinical coronary artery disease in elderly adults: Rancho Bernardo StudyDong Jun Kim
Department of Family and Preventive Medicine, School of Medicine, University of California San Diego, La Jolla, California, USA
Obesity (Silver Spring) 16:853-8. 2008..We examined this association in elderly, community-dwelling adults without clinically recognized CHD... - Hormone use and lung cancer incidence: the Rancho Bernardo cohort studyJoshua R Smith
Department of Family and Preventive Medicine, School of Medicine, University of California San Diego, La Jolla, CA, USA
Menopause 16:1044-8. 2009..This study examines the association of hormone use and lung cancer among women... - Association of adiponectin with coronary heart disease and mortality: the Rancho Bernardo studyGail A Laughlin
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Am J Epidemiol 165:164-74. 2007..001). These results suggest that use of adiponectin for cardiovascular disease risk stratification is premature... - Noncardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II)Stephen Hulley
Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, San Francisco, CA 94143 0560, USA
JAMA 288:58-66. 2002..The Heart and Estrogen/progestin Replacement Study (HERS) was a randomized trial of estrogen plus progestin therapy after menopause... - The Dehydroepiandrosterone And WellNess (DAWN) study: research design and methodsDenise von Muhlen
University of California, San Diego, United States
Contemp Clin Trials 28:153-68. 2007..Potential mechanisms of DHEA action, including the biotransformation of DHEA to active steroids and steroid metabolites, enhancement of IGF-I bioavailability, and inhibition of IL-6 production can also be evaluated... - Zinc intakes and plasma concentrations in men with osteoporosis: the Rancho Bernardo StudyTaisun H Hyun
Department of Family and Preventive Medicine, School of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0607, USA
Am J Clin Nutr 80:715-21. 2004..However, plasma zinc did not predict bone loss during the 4-y interval. CONCLUSION: Dietary zinc intake and plasma zinc each have a positive association with BMD in men... - Body mass index and quality of well-being in a community of older adultsErik J Groessl
Department of Family and Preventive Medicine, University of California at San Diego, San Diego, California 92093 0994, USA
Am J Prev Med 26:126-9. 2004..This study evaluates the relationship between body mass index (BMI) and HRQOL scores and gives estimates of quality-adjusted life years (QALYs) lost to overweight, obesity, and associated conditions... - Grand multiparity is associated with type 2 diabetes in Filipino American women, independent of visceral fat and adiponectinMaria Rosario G Araneta
Department of Family and Preventive Medicine, University of California San Diego, San Diego, California, USA
Diabetes Care 33:385-9. 2010..To determine whether multiparity is associated with type 2 diabetes, independent of visceral adipose tissue (VAT) and adipokines... - Bone mineral density in postmenopausal Caucasian, Filipina, and Hispanic womenDeborah J Morton
University of California, San Diego, La Jolla, CA 92093, USA
Int J Epidemiol 32:150-6. 2003.... - Low serum testosterone and mortality in older menGail A Laughlin
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0631C, La Jolla, California 92093, USA
J Clin Endocrinol Metab 93:68-75. 2008..Declining testosterone levels in elderly men are thought to underlie many of the symptoms and diseases of aging; however, studies demonstrating associations of low testosterone with clinical outcomes are few... - Type 2 diabetes and metabolic syndrome in Filipina-American women : a high-risk nonobese populationMaria Rosario G Araneta
Department of Family and Preventive Medicine, School of Medicine, University of California San Diego, La Jolla, California 92093-0607, USA
Diabetes Care 25:494-9. 2002..The high prevalence of diabetes in populations who are not of Northern European ancestry may be missed when they are not obese by Western standards... - Endogenous sex hormones and the development of type 2 diabetes in older men and women: the Rancho Bernardo studyJee-Young Oh
Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, California 92093-0607, USA
Diabetes Care 25:55-60. 2002..9 (1.1-8.4) for women in the highest quartile of bioavailable testosterone. CONCLUSIONS: Low testosterone levels in men and high testosterone levels in women predict insulin resistance and incident type 2 diabetes in older adults... - Ghrelin, adiponectin, and leptin do not predict long-term changes in weight and body mass index in older adults: longitudinal analysis of the Rancho Bernardo cohortClaudia Langenberg
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0607, USA
Am J Epidemiol 162:1189-97. 2005..From this analysis of Rancho Bernardo Study data, the authors conclude that ghrelin, adiponectin, and leptin do not predict weight gain beyond reflecting the influence of attained body size on future changes in weight or body mass index... - Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adultsJared P Reis
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California 92093 0607, USA
Diabetes Care 30:1549-55. 2007..We examined the association of 25(OH)D and PTH with the prevalence of metabolic syndrome in a community-based cohort of older adults... - Measures of renal function, BMD, bone loss, and osteoporotic fracture in older adults: the Rancho Bernardo studySimerjot K Jassal
Department of Medicine, University of California, San Diego, CA 92093 0607, USA
J Bone Miner Res 22:203-10. 2007..If confirmed, this may warrant adding mild to moderate renal dysfunction as an indication for osteoporosis screening... - Hysterectomy status and life satisfaction in older womenDonna Kritz-Silverstein
Department of Family and Preventive Medicine, Division of Epidemiology, University of California, San Diego, La Jolla, USA
J Womens Health Gend Based Med 11:181-90. 2002..Relief from symptoms necessitating hysterectomy may be responsible for this increase. This difference may be specific to hysterectomy because there were no differences in general life satisfaction as assessed with standardized measures... - Weight loss: a determinant of hip bone loss in older men and women. The Rancho Bernardo StudyJames D Knoke
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, San Diego, CA 92093-0607, USA
Am J Epidemiol 158:1132-8. 2003.... - Probable NAFLD, by ALT levels, and diabetes among Filipino-American womenCharlene A Wong
Division of Epidemiology and Biostatistics, Graduate School of Public Health, San Diego State University, CA, USA
Diabetes Res Clin Pract 79:133-40. 2008..Studies have shown alanine aminotransferase (ALT), a marker for non-alcoholic fatty liver disease (NAFLD), predicts type 2 diabetes (T2DM)... - Insulin-like growth factor-I and cancer mortality in older menJacqueline M Major
Department of Family and Preventive Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0631C, USA
J Clin Endocrinol Metab 95:1054-9. 2010..These results suggest caution in the use of IGF-I-enhancing therapies to slow the adverse effects of aging... - Predicting the development of diabetes in older adults: the derivation and validation of a prediction ruleAlka M Kanaya
Department of Medicine and Epidemiology and Biostatics, University of California, San Francisco, California 94115, USA
Diabetes Care 28:404-8. 2005..We created a prediction rule in one sample and prospectively validated it for incident diabetes in a separate cohort... - Endothelin-1 and prevalent coronary heart disease in older men and women (the Rancho Bernardo Study)Alka M Kanaya
Division of General Internal Medicine, University of California San Francisco, San Francisco, California, USA
Am J Cardiol 99:486-90. 2007..Further adjustment for ankle-brachial index and carotid intima media thickness did not alter these results. In conclusion, higher endothelin-1 levels are independently associated with CHD in women of all ages and among older men only... - Estrogen therapy and bone mineral density in African-American and Caucasian womenSusan L Eskridge
San Diego Joint Doctoral Program in Public Health Epidemiology, San Diego State University University of California, San Diego, California, USA
Am J Epidemiol 171:808-16. 2010..13-0.37). Results suggest that higher levels of bone mineral density in African-American women were not due to estrogen use... - Sex-specific association of the androgen to oestrogen ratio with adipocytokine levels in older adults: the Rancho Bernardo StudyGail A Laughlin
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0607, USA
Clin Endocrinol (Oxf) 65:506-13. 2006.... - Association of interleukin-6 and C-reactive protein with subclinical carotid atherosclerosis (the Rancho Bernardo Study)Won Young Lee
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA
Am J Cardiol 99:99-102. 2007..The association of IL-6 was independent of CRP, but not vice versa, suggesting an effect of IL-6 on an earlier state of atherosclerosis... - Explaining the sex difference in coronary heart disease mortality among patients with type 2 diabetes mellitus: a meta-analysisAlka M Kanaya
Department of Medicine, Division of General Internal Medicine, University of California, San Diego, USA
Arch Intern Med 162:1737-45. 2002..Most studies suggest that diabetes is a stronger coronary heart disease (CHD) risk factor for women than men, but few have adjusted their results for classic CHD risk factors: age, hypertension, total cholesterol level, and smoking... - The relationship between weight loss and all-cause mortality in older men and women with and without diabetes mellitus: the Rancho Bernardo studyNicole M Wedick
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California 92093, USA
J Am Geriatr Soc 50:1810-5. 2002..CONCLUSION: In this population of older individuals, weight loss predicted increased all-cause mortality risk not explained by covariates... - Cardiovascular death and the metabolic syndrome: role of adiposity-signaling hormones and inflammatory markersClaudia Langenberg
Department of Family and Preventive Medicine, School of Medicine, University of California-San Diego, 9500 Gilman Dr, La Jolla, CA 92093-0607, USA
Diabetes Care 29:1363-9. 2006..CONCLUSIONS: Adiposity-signaling hormones and inflammatory markers explain little to some of the association between the metabolic syndrome and CHD mortality. IL-6 levels predict CHD mortality independently of CRP... - Clinical utility of spine bone density in elderly womenDiane L Schneider
Department of Medicine, University of California, San Diego, La Jolla, CA, USA
J Clin Densitom 9:255-60. 2006..In elderly women 65 yr and older who are likely to have spine OA, the DXA measurement of the spine may not be useful in assessing fracture risk, and DXA of the hip is recommended for identification of osteoporosis... - Bone mineral density and clinical hand osteoarthritis in elderly men and women: the Rancho Bernardo studyDiane L Schneider
Department of Medicine, University of California, San Diego, La Jolla 92093-0607, USA
J Rheumatol 29:1467-72. 2002..Contrary to expectations the only significant difference was that women with hand OA had lower hip BMD. Thus evaluation for osteoporosis should not be overlooked in women with hand OA... - Diabetes and coronary heart disease in Filipino-American women: role of growth and life-course socioeconomic factorsClaudia Langenberg
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0607, USA
Diabetes Care 30:535-41. 2007.... - Pet ownership and blood pressure in old ageJoel David Wright
University of California, San Diego, CA 92093 0631, USA
Epidemiology 18:613-8. 2007..This study examines the relation of pet ownership with systolic and diastolic blood pressure, pulse pressure, mean arterial pressure, and hypertension in a large sample of older men and women... - Hysterectomy, oophorectomy, and cognitive function in older womenDonna Kritz-Silverstein
Department of Family and Preventive Medicine, University of California, San Diego, California 92093, USA
J Am Geriatr Soc 50:55-61. 2002.... - A prospective study of abdominal obesity and coronary artery calcium progression in older adultsCaroline K Kramer
Department of Family and Preventive Medicine, University of California, La Jolla, California 92093 0631, USA
J Clin Endocrinol Metab 94:5039-44. 2009..Little is known about obesity measurements and coronary artery calcium (CAC) progression in older adults. We examined the sex-specific association between measures of body size and fat distribution with CAC progression... - Minimally elevated cardiac troponin T and elevated N-terminal pro-B-type natriuretic peptide predict mortality in older adults: results from the Rancho Bernardo StudyLori B Daniels
Division of Cardiology, Department of Medicine, University of California at San Diego, San Diego, California, USA
J Am Coll Cardiol 52:450-9. 2008..This study investigated the prognostic value of detectable cardiac troponin T (TnT) and elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in a population of community-dwelling older adults... - Sex differences in the association between adiponectin and BMD, bone loss, and fractures: the Rancho Bernardo studyMaria Rosario G Araneta
Department of Family and Preventive Medicine, University of California San Diego, La Jolla, California 92093 0607, USA
J Bone Miner Res 24:2016-22. 2009..13; 95% CI: 1.08-1.23; p = 0.009) among men only. Adiponectin was inversely associated with BMD; however, sex differences were observed by anatomical site and with regards to vertebral fractures... - Lipoprotein-associated phospholipase A2 is an independent predictor of incident coronary heart disease in an apparently healthy older population: the Rancho Bernardo StudyLori B Daniels
Division of Cardiology, Department of Medicine, University of California at San Diego, San Diego, California, USA
J Am Coll Cardiol 51:913-9. 2008..We examined whether the independent association was apparent in older adults... - Prospective study of serum dihydrotestosterone and subsequent risk of benign prostatic hyperplasia in community dwelling men: the Rancho Bernardo StudyJ Kellogg Parsons
Division of Urologic Oncology, Moores University of California San Diego Cancer Center, La Jolla, California, USA
J Urol 184:1040-4. 2010..Little is known about midlife serum levels of dihydrotestosterone and other androgens before the onset of clinical benign prostatic hyperplasia in community dwelling older men...
Research Grants
- CVD Predictors of Cognitive Function Trajectory over 20 YearsElizabeth Barrett Connor; Fiscal Year: 2007..This information is important given the aging of the population, the fact that CVD risk factors are modifiable, and because the maintenance of cognitive function is an essential component of healthy aging. ..
- Osteoporotic Fractures in Men - MrOS RenewalElizabeth Barrett Connor; Fiscal Year: 2007....
- Outcomes of Sleep Disorders in Older MenElizabeth Barrett Connor; Fiscal Year: 2007..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. ..
- Gender differences in Bone Loss and Incident FracturesElizabeth Barrett Connor; Fiscal Year: 2007..abstract_text> ..
- CVD Predictors of Cognitive Function Trajectory over 20 YearsElizabeth Barrett Connor; Fiscal Year: 2009..This information is important given the aging of the population, the fact that CVD risk factors are modifiable, and because the maintenance of cognitive function is an essential component of healthy aging. ..
- Post DPP (Diabetes Prevention Program)Elizabeth Barrett Connor; Fiscal Year: 2007..women, and in older subjects in the DPP. The current application is for 5 years of funding, although the some of the goals of the projects described will require a 10-year study. ..
- Gender differences in Bone Loss and Incident FracturesElizabeth Barrett Connor; Fiscal Year: 2007..Our goal is to develop a coherent picture of the interactive effects of sex hormones and lifestyle, biomarkers, vitamin D, PTH, and genes on each bone outcome. ..
- GENDER DIFFERENCES IN OSTEOPOROSISElizabeth Barrett Connor; Fiscal Year: 2002....
- Endogenous/Exogenous Sex Hormones & CHD Risk FactorsElizabeth Barrett Connor; Fiscal Year: 2003..These observations may aid in deciding whether individual women should use HRT and, if so, which regimen would provide the most benefit with the least risk. ..
- CVD Predictors of Cognitive Function Trajectory over 20 YearsElizabeth L Barrett Connor; Fiscal Year: 2010..This information is important given the aging of the population, the fact that CVD risk factors are modifiable, and because the maintenance of cognitive function is an essential component of healthy aging. ..