Julio C Barredo

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy
    Tapas K Sengupta
    School of Life Sciences, Indian Institute of Science Education and Research, Kolkata, India
    Mol Cancer 6:46. 2007
  2. pmc AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia
    Gilles M Leclerc
    Department of Pediatric Hematology Oncology, University of Miami Miller School of Medicine, 1601 N, W, 12th Avenue, Miami, FL 33136 USA
    J Mol Signal 5:15. 2010
  3. pmc Metformin induces apoptosis through AMPK-dependent inhibition of UPR signaling in ALL lymphoblasts
    Gilles M Leclerc
    Department of Pediatrics Hematology and Oncology, University of Miami Miller School of Medicine, Miami, Florida, USA
    PLoS ONE 8:e74420. 2013
  4. pmc Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress
    Guy J Leclerc
    Department of Pediatrics, Division of Hematology and Oncology, University of Miami Miller School of Medicine, Miami, FL 33101, USA Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Leuk Res . 2015
  5. doi request reprint Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia
    Joanna DeSalvo
    Department of Pediatric Hematology Oncology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Mol Cancer Res 10:969-78. 2012
  6. doi request reprint Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy
    Haibin Xi
    Sheila and David Fuente Graduate Program in Cancer Biology, University of Miami Miller School of Medicine, 1550 NW 10th Avenue, Fox Building 406, Miami, FL 33136, USA
    Biochem Pharmacol 85:1463-77. 2013
  7. pmc AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia
    Jeffim N Kuznetsov
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1580 NW 10 Ave, Miami, FL 33136, USA
    Mol Cancer Ther 10:437-47. 2011

Collaborators

  • Jaime R Merchan
  • Gilles M Leclerc
  • Guy J Leclerc
  • Joanna DeSalvo
  • Jeffim N Kuznetsov
  • Theodore J Lampidis
  • Jianfeng Du
  • Haibin Xi
  • Tapas K Sengupta
  • Ningguo Gao
  • Mark A Lehrman
  • Guilian Fu
  • Inderjit Singh
  • Ting Ting Hsieh-Kinser

Detail Information

Publications7

  1. pmc Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy
    Tapas K Sengupta
    School of Life Sciences, Indian Institute of Science Education and Research, Kolkata, India
    Mol Cancer 6:46. 2007
    ..We evaluated the effects of the AMPK activator AICAR on cell growth, cell cycle regulators and apoptosis of various childhood ALL cells...
  2. pmc AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia
    Gilles M Leclerc
    Department of Pediatric Hematology Oncology, University of Miami Miller School of Medicine, 1601 N, W, 12th Avenue, Miami, FL 33136 USA
    J Mol Signal 5:15. 2010
    ..We have shown previously that AICAR-induced AMPK activation also induced a compensatory survival mechanism via PI3K/Akt signaling...
  3. pmc Metformin induces apoptosis through AMPK-dependent inhibition of UPR signaling in ALL lymphoblasts
    Gilles M Leclerc
    Department of Pediatrics Hematology and Oncology, University of Miami Miller School of Medicine, Miami, Florida, USA
    PLoS ONE 8:e74420. 2013
    ..Our findings provide evidence for a role of metformin in ALL therapy and support strategies targeting synthetic lethal interactions with Akt and PIM kinases as suitable for future consideration for clinical translation in ALL. ..
  4. pmc Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress
    Guy J Leclerc
    Department of Pediatrics, Division of Hematology and Oncology, University of Miami Miller School of Medicine, Miami, FL 33101, USA Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Leuk Res . 2015
    ..This study supports further consideration of strategies combining energy/ER-stress inducers with BCR-ABL TKIs for future clinical translation in BCR-ABL+ ALL patients...
  5. doi request reprint Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia
    Joanna DeSalvo
    Department of Pediatric Hematology Oncology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Mol Cancer Res 10:969-78. 2012
    ....
  6. doi request reprint Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy
    Haibin Xi
    Sheila and David Fuente Graduate Program in Cancer Biology, University of Miami Miller School of Medicine, 1550 NW 10th Avenue, Fox Building 406, Miami, FL 33136, USA
    Biochem Pharmacol 85:1463-77. 2013
    ..Taken together, our data support a model where under normoxia therapeutic (2-DG) and physiologic (GS) glucose restriction differentially activate autophagy, while under hypoxia they similarly inhibit it...
  7. pmc AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia
    Jeffim N Kuznetsov
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1580 NW 10 Ave, Miami, FL 33136, USA
    Mol Cancer Ther 10:437-47. 2011
    ....

Research Grants2

  1. PEDIATRIC ONCOLOGY GROUP--THE CAROLINAS CONSORTIUM
    Julio Barredo; Fiscal Year: 2002
    ....
  2. Molecular Determinants of Methotrexate in Acute Lymphoblastic Leukemia
    Julio Barredo; Fiscal Year: 2008
    ..More important, because these genetic abnormalities are not present in normal hematopoietic cells, they offer selective targets for gene therapy or other molecular approaches in ALL. ..