K T Barnhart

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi The optimal analysis of MRI data to quantify the distribution of a microbicide
    Kurt T Barnhart
    Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, 19104, USA
    Contraception 73:82-7. 2006
  2. ncbi Assisted reproductive technologies and perinatal morbidity: interrogating the association
    Kurt T Barnhart
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania Electronic address
    Fertil Steril 99:299-302. 2013
  3. ncbi Validation of a clinical risk scoring system, based solely on clinical presentation, for the management of pregnancy of unknown location
    Kurt T Barnhart
    Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 99:193-8. 2013
  4. ncbi Early pregnancy failure: beware of the pitfalls of modern management
    Kurt T Barnhart
    Departments of Obstetrics and Gynecology and Epidemiology, Perelman School of Medicine at the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Electronic address
    Fertil Steril 98:1061-5. 2012
  5. ncbi Clinical factors affecting the accuracy of ultrasonography in symptomatic first-trimester pregnancy
    Kurt T Barnhart
    Department of Obstetrics and Gynecology, Center for Clinical Epidemiology and Biostatistics, Philadelphia, PA 19104, USA
    Obstet Gynecol 117:299-306. 2011
  6. ncbi Pregnancy of unknown location: a consensus statement of nomenclature, definitions, and outcome
    Kurt Barnhart
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 95:857-66. 2011
  7. ncbi Does a prediction model for pregnancy of unknown location developed in the UK validate on a US population?
    K T Barnhart
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania, 3701 Market Street, Suite 800, Philadelphia, PA 19104, USA
    Hum Reprod 25:2434-40. 2010
  8. ncbi A randomized trial to determine the distribution of four topical gel formulations in the human vagina
    Kurt Barnhart
    Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Contraception 79:297-303. 2009
  9. ncbi Use of "2-dose" regimen of methotrexate to treat ectopic pregnancy
    Kurt Barnhart
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 87:250-6. 2007
  10. ncbi Prediction of location of a symptomatic early gestation based solely on clinical presentation
    Kurt T Barnhart
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Obstet Gynecol 112:1319-26. 2008

Research Grants

  1. RISK FACTORS AS PREDICTORS OF ECTOPIC PREGNANCY
    Kurt Barnhart; Fiscal Year: 2003
  2. RISK FACTORS AS PREDICTORS OF ECTOPIC PREGNANCY
    Kurt Barnhart; Fiscal Year: 2007
  3. RISK FACTORS AS PREDICTORS OF ECTOPIC PREGNANCY
    Kurt T Barnhart; Fiscal Year: 2010

Detail Information

Publications89

  1. ncbi The optimal analysis of MRI data to quantify the distribution of a microbicide
    Kurt T Barnhart
    Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, 19104, USA
    Contraception 73:82-7. 2006
    ..The objective of this study was to systematically review the use of MRI for the evaluation of deployment characteristics of vaginal microbicides and to understand the relationship of gel spread with potential influencing factors...
  2. ncbi Assisted reproductive technologies and perinatal morbidity: interrogating the association
    Kurt T Barnhart
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania Electronic address
    Fertil Steril 99:299-302. 2013
    ..Optimizing the environment at the time a woman conceives will likely have an effect on gestation as well as the health of children. Reproduction effects health and health effects reproduction...
  3. ncbi Validation of a clinical risk scoring system, based solely on clinical presentation, for the management of pregnancy of unknown location
    Kurt T Barnhart
    Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 99:193-8. 2013
    ..To assess a scoring system to triage women with a pregnancy of unknown location...
  4. ncbi Early pregnancy failure: beware of the pitfalls of modern management
    Kurt T Barnhart
    Departments of Obstetrics and Gynecology and Epidemiology, Perelman School of Medicine at the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Electronic address
    Fertil Steril 98:1061-5. 2012
    ..This article reviews some of the pitfalls of the modern management of early pregnancy failure and introduces a series of articles on the subject...
  5. ncbi Clinical factors affecting the accuracy of ultrasonography in symptomatic first-trimester pregnancy
    Kurt T Barnhart
    Department of Obstetrics and Gynecology, Center for Clinical Epidemiology and Biostatistics, Philadelphia, PA 19104, USA
    Obstet Gynecol 117:299-306. 2011
    ..To evaluate factors associated with accuracy of initial ultrasonography in patients with symptomatic first-trimester pregnancy...
  6. ncbi Pregnancy of unknown location: a consensus statement of nomenclature, definitions, and outcome
    Kurt Barnhart
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 95:857-66. 2011
    ..To improve the interpretation of future studies in women who are initially diagnosed with a pregnancy of unknown location (PUL), we propose a consensus statement with definitions of population, target disease, and final outcome...
  7. ncbi Does a prediction model for pregnancy of unknown location developed in the UK validate on a US population?
    K T Barnhart
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania, 3701 Market Street, Suite 800, Philadelphia, PA 19104, USA
    Hum Reprod 25:2434-40. 2010
    ..The purpose of this paper was to assess the utility of this model to predict the outcome for a woman (PUL) in a US population...
  8. ncbi A randomized trial to determine the distribution of four topical gel formulations in the human vagina
    Kurt Barnhart
    Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Contraception 79:297-303. 2009
    ..We compared distribution and acceptability of four different gel formulations to be used as a vehicle for a microbicide...
  9. ncbi Use of "2-dose" regimen of methotrexate to treat ectopic pregnancy
    Kurt Barnhart
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 87:250-6. 2007
    ..To evaluate the safety and acceptability of a novel dosing regimen of methotrexate to treat ectopic pregnancy...
  10. ncbi Prediction of location of a symptomatic early gestation based solely on clinical presentation
    Kurt T Barnhart
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Obstet Gynecol 112:1319-26. 2008
    ..To evaluate three strategies for diagnosis of women at risk for ectopic pregnancy based on information collected at initial presentation...
  11. ncbi Return to fertility after cessation of a continuous oral contraceptive
    Kurt Barnhart
    Department of Obstetrics and Gynecology, Penn Fertility Care, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Fertil Steril 91:1654-6. 2009
    ..To evaluate the return to fertility among women planning to become pregnant after the use of a continuous regimen of levonorgestrel 90 microg and ethinyl E(2) 20 microg...
  12. ncbi Return to fertility following discontinuation of oral contraceptives
    Kurt T Barnhart
    Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Fertil Steril 91:659-63. 2009
    ..To provide an overview of the studies that have evaluated the return to fertility following cessation of oral contraceptives (OCs), including recent evidence in women discontinuing extended-cycle and continuous-use regimens...
  13. ncbi Contraceptive efficacy of a novel spermicidal microbicide used with a diaphragm: a randomized controlled trial
    Kurt T Barnhart
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Obstet Gynecol 110:577-86. 2007
    ..The objective of this study was to assess the gel's contraceptive effects, safety, and acceptability...
  14. ncbi The challenge and enjoyment of the interpretation of epidemiologic data
    Kurt T Barnhart
    Penn Fertility Care, Department of Obstetrics and Gynecology, and Center for Clinical Epidemiology and Biostatics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 86:527-8; discussion 534. 2006
    ..While the factors associated with this trend are likely many, complex, and interrelated, we cannot overlook the positive impact of those individuals who practice in the field of reproductive medicine...
  15. ncbi Safety and efficacy of bedtime versus daytime administration of the miconazole nitrate 1200 mg vaginal ovule insert to treat vulvovaginal candidiasis
    Kurt Barnhart
    Reproductive Research Unit, Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Curr Med Res Opin 21:127-34. 2005
    ..Safety, efficacy, and ' therapeutic cure with bedtime versus daytime treatment of vulvovaginal candidiasis (VVC) were assessed to potentially improve compliance and convenience with vaginal antifungal treatment...
  16. ncbi Epidemiology of male and female reproductive disorders and impact on fertility regulation and population growth
    Kurt T Barnhart
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology and the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 95:2200-3. 2011
    ..Our future research agenda should investigate how reproduction affects health and how health affects reproduction...
  17. ncbi Role of periovulatory luteinizing hormone concentrations during assisted reproductive technology cycles stimulated exclusively with recombinant follicle-stimulating hormone
    M A Esposito
    Center for Reproductive Medicine and Surgery, Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, USA
    Fertil Steril 75:519-24. 2001
    ..It may be of clinical benefit, when exclusively using r-hFSH in ART cycles, to add LH in the late follicular phase or to further reduce the dose of GnRH agonist...
  18. ncbi Diagnosing ectopic pregnancy: decision analysis comparing six strategies
    C R Gracia
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 10104, USA
    Obstet Gynecol 97:464-70. 2001
    ..Ultrasound as the first step was the most efficient and accurate method of diagnosing ectopic pregnancies...
  19. ncbi Hormone therapy and coronary heart disease in young women
    Mark G Weiner
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Menopause 15:86-93. 2008
    ..Given the similarity between our UK General Practice Research Database (GPRD) study of older women and the WHI RCT, the GPRD methodology was used to study a cohort of younger women...
  20. ncbi The effect of ambulation on vaginal distribution of miconazole nitrate (1200 mg)
    Seema Menon
    Reproductive Research Unit, Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Womens Health (Larchmt) 16:703-6. 2007
    ..To evaluate the effect activity has on the vaginal distribution of a 1200 mg miconazole nitrate gelatin encapsulated insert, an antifungal agent commonly used to treat vaginal vulvocandidiasis...
  21. ncbi Distribution of a spermicide containing Nonoxynol-9 in the vaginal canal and the upper female reproductive tract
    K T Barnhart
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Hum Reprod 16:1151-4. 2001
    ..This finding suggests that topical microbicides/spermicides may act both in the vaginal canal and in the upper female genital tract...
  22. ncbi Decline of serum human chorionic gonadotropin and spontaneous complete abortion: defining the normal curve
    Kurt Barnhart
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Obstet Gynecol 104:975-81. 2004
    ..We sought to estimate a standard curve of serum human chorionic gonadotropin (hCG) decline that characterizes spontaneous abortion...
  23. ncbi A simulation using data from a primary care practice database closely replicated the women's health initiative trial
    Richard L Tannen
    Department of Medicine, University of Pennsylvania School of Medicine, 295 John Morgan Building, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
    J Clin Epidemiol 60:686-95. 2007
    ..To assess the validity of a novel observational study design, we compared the WHI RCT with a simulation using data from the United Kingdom General Practice Research Database (GPRD)...
  24. ncbi Estrogen affects post-menopausal women differently than estrogen plus progestin replacement therapy
    Richard L Tannen
    Department of Medicine, University of Pennsylvaniua School of Medicine, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
    Hum Reprod 22:1769-77. 2007
    ..Since we previously reasonably replicated the combined estrogen-progestin WHI RCT using the UK General Practice Research Database (GPRD), estrogen-only treatment was investigated using a similar methodology...
  25. ncbi The clinical rationale for menses-free contraception
    Kat Lin
    Reproductive Research Unit, Center for Reproductive Medicine and Surgery, University of Pennsylvania, Philadelphia, PA 19107, USA
    J Womens Health (Larchmt) 16:1171-80. 2007
    ....
  26. ncbi The truth is out there: a guide to the pitfalls of interpreting evidence-based medicine in studies of human reproduction
    Kurt Barnhart
    Center for Reproductive Medicine and Surgery, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Fertil Steril 77:223-8. 2002
  27. ncbi Effect of endometriosis on in vitro fertilization
    Kurt Barnhart
    Center for Reproductive Medicine and Surgery, University of Pennsylvania Medical Center and Health System, Philadelphia, Pennsylvania, USA
    Fertil Steril 77:1148-55. 2002
    ..To investigate the IVF outcome for patients with endometriosis...
  28. ncbi Use of MRI to determine the in vivo position of a silicone vaginal barrier contraceptive device
    E Scott Pretorius
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Contraception 65:343-6. 2002
    ..After insertion, the Lea's Shield occupies the upper vagina and completely covers the cervix...
  29. ncbi Magnetic resonance imaging to determine the distribution of a vaginal gel: before, during, and after both simulated and real intercourse
    E Scott Pretorius
    Departments of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Contraception 66:443-51. 2002
    ..simulated intercourse, or on post-intercourse scans of 3 mL versus 5 mL. MRI is a sensitive, reproducible means of tracking the spread of intravaginal medications...
  30. ncbi Race, socioeconomic status, and response to methotrexate treatment of ectopic pregnancy in an urban population
    Samantha F Butts
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 94:2789-92. 2010
    ..In this retrospective cohort study, a racial disparity in methotrexate effectiveness was not found, but a significant relationship between low socioeconomic status and methotrexate failure was demonstrated...
  31. ncbi Correlation of telomere length and telomerase activity with occult ovarian insufficiency
    Samantha Butts
    Division of Infertility and Reproductive Endocrinology, University of Pennsylvania Medical School, 3701 Market Street, Suite 800, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 94:4835-43. 2009
    ..Abnormalities in telomere length and telomerase activity in human granulosa cells may serve as molecular markers for this condition...
  32. ncbi Patient acceptability of manual versus electric vacuum aspiration for early pregnancy loss
    Scott Edwards
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Womens Health (Larchmt) 16:1429-36. 2007
    ....
  33. ncbi Vaginal distribution of miconazole nitrate suspension from administration of a single vaginal insert
    Kurt Barnhart
    Reproductive Research Unit, Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Reprod Med 49:83-8. 2004
    ....
  34. ncbi Prophylactic methotrexate after linear salpingostomy: a decision analysis
    C R Gracia
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Fertil Steril 76:1191-5. 2001
    ..3%. CONCLUSION(S): Prophylactic methotrexate at the time of linear salpingostomy for the treatment of ectopic pregnancy is preferable to observation as long as certain conditions exist...
  35. ncbi Diagnostic accuracy of ultrasound above and below the beta-hCG discriminatory zone
    K T Barnhart
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 10104, USA
    Obstet Gynecol 94:583-7. 1999
    ....
  36. ncbi Is factor V Leiden mutation a cause of in vitro fertilization failure?
    Briana Rudick
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, California, USA
    Fertil Steril 92:1256-9. 2009
    ..6%) and had a preliminarily positive association with pregnancy, suggesting that routine testing in a general IVF population for FVL mutation as a cause of IVF failure and infertility is not indicated...
  37. ncbi Defining the curve when initial levels of human chorionic gonadotropin in patients with spontaneous abortions are low
    Karine Chung
    Penn Fertility Care, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Fertil Steril 85:508-10. 2006
    ..When initial levels lie between 50 and 500 mIU/mL, the slowest expected percentage decline ranges from 12% to 24% in 2 days and from 34% to 68% in 7 days...
  38. ncbi Exposure to soy-based formula in infancy and endocrinological and reproductive outcomes in young adulthood
    B L Strom
    University of Pennsylvania, Center for Clinical Epidemiology and Biostatistics, 824 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
    JAMA 286:807-14. 2001
    ..However, a paucity of data exists on the long-term effects of infant soy formulas...
  39. ncbi Noncontraceptive benefits and therapeutic uses of the oral contraceptive pill
    M Dayal
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Semin Reprod Med 19:295-303. 2001
    ..Counseling and education are necessary to help women make well-informed health-care decisions and improve compliance...
  40. ncbi A moderately elevated day 3 FSH concentration has limited predictive value, especially in younger women
    M A Esposito
    Division of Human Reproduction, Center for Reproductive Medicine and Surgery, Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA
    Hum Reprod 17:118-23. 2002
    ..CONCLUSIONS: Much of the predictive value of an elevated FSH is confounded by poor response to gonadotrophin stimulation, which may be overcome in younger women...
  41. ncbi Human chorionic gonadotropin profile for women with ectopic pregnancy
    Celso Silva
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Obstet Gynecol 107:605-10. 2006
    ..The hCG profile in women with ectopic pregnancy can mimic that of an intrauterine pregnancy or a completed spontaneous abortion in approximately 29% of cases. LEVEL OF EVIDENCE: II-2...
  42. ncbi Safety analysis of the diaphragm in combination with lubricant or acidifying microbicide gels: effects on markers of inflammation and innate immunity in cervicovaginal fluid
    Deborah J Anderson
    Department of Obstetrics and Gynecology, Boston University School of Medicine, 670 Albany St, Suite 516, Boston, MA 02118, USA
    Am J Reprod Immunol 61:121-9. 2009
    ..The purpose of this study was to determine whether use of a diaphragm with microbicide or placebo gel causes cervicovaginal inflammation or perturbations in cervicovaginal immune defense...
  43. ncbi Interobserver and intraobserver variability in the histological dating of the endometrium in fertile and infertile women
    Evan R Myers
    Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Fertil Steril 82:1278-82. 2004
    ..To assess effects of biopsy timing and fertility status on inter- and intraobserver variability in dating of the endometrium...
  44. ncbi Reliability of clinicians versus radiologists for detecting abnormalities on hysterosalpingogram films
    Linda Renbaum
    Department of Obstetrics and Gynecology, Pennsylvania Hospital, Philadelphia 19104, USA
    Fertil Steril 78:614-8. 2002
    ..Clinicians more reliably diagnose hydrosalpinx and tubal obstruction, while radiologists more reliably detect the more subtle findings of salpingitis isthmica nodosa or uterine adhesions...
  45. ncbi Risk factors and clinical features of recurrent ectopic pregnancy: a case control study
    Samantha Butts
    Center for Reproductive Medicine and Surgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 80:1340-4. 2003
    ..Clinicians' ability to both diagnose and counsel patients at risk for recurrent ectopic pregnancy can be optimized by awareness of the clinical features of this condition...
  46. ncbi Bleeding patterns after misoprostol vs surgical treatment of early pregnancy failure: results from a randomized trial
    Anne R Davis
    Columbia University, Department of Obstetrics and Gynecology, 622 West 168th St, PH 16 Room 80, New York, NY 10032, USA
    Am J Obstet Gynecol 196:31.e1-7. 2007
    ..The purpose of this study was to describe bleeding patterns after misoprostol or curettage for early pregnancy failure (EPF)...
  47. ncbi Cost-effectiveness of inhaled nitric oxide for the management of persistent pulmonary hypertension of the newborn
    Scott A Lorch
    Department of Pediatrics, Center for Outcomes Research, Children s Hospital of Philadelphia, 3535 Market St, Ste 1029, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 114:417-26. 2004
    ..The objective of this study was to evaluate the economic impact of adding iNO to the treatment protocol of PPHN for term infants from birth to the time of discharge from their initial hospitalization...
  48. ncbi Comparative crossover study of the PATH Woman's Condom and the FC Female Condom
    Jill L Schwartz
    Department of Obstetrics and Gynecology, CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
    Contraception 78:465-73. 2008
    ..The Program for Appropriate Technology in Health (PATH) Woman's Condom (WC) was developed in an effort to overcome these obstacles...
  49. ncbi Hormone pattern after misoprostol administration for a nonviable first-trimester gestation
    Kurt T Barnhart
    University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 5509, USA
    Fertil Steril 81:1099-105. 2004
    ..To evaluate serial hormone concentrations in subjects treated with vaginally administered misoprostol for early pregnancy failure...
  50. ncbi Lesson learned and dispelled myths: three-dimensional imaging of the human vagina
    Kurt T Barnhart
    Department of Obstetrics and Gynecology, and Senior Scholar, Center Clinical Epidemiology and Biostatistics, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Fertil Steril 81:1383-4. 2004
    ..Three-dimensional imaging of the human vagina demonstrates that the cross section can be a "W," rather than an "H," and that intravaginal gel can ascend into the endocervix and presumably into the endometrium...
  51. ncbi Endometrial stripe thickness and pregnancy outcome in first-trimester pregnancies with bleeding, pain or both
    Beata Seeber
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Reprod Med 52:757-61. 2007
    ....
  52. ncbi Symptomatic patients with an early viable intrauterine pregnancy: HCG curves redefined
    Kurt T Barnhart
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Obstet Gynecol 104:50-5. 2004
    ..To analyze the change in serial human chorionic gonadotropin (hCG) levels in women symptomatic with pain or bleeding who presented with nondiagnostic ultrasonography but were ultimately confirmed to have a viable intrauterine pregnancy...
  53. ncbi Acute and chronic presentation of ectopic pregnancy may be two clinical entities
    Kurt T Barnhart
    Center for Reproductive Medicine and Surgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 80:1345-51. 2003
    ..The purpose of this study is to analyze whether these clinical presentations represent a spectrum of disease...
  54. ncbi Symptomatic fibroids in two patients on hormone replacement therapy with primary ovarian failure secondary to prepubertal gonadotoxic cancer treatment
    Suleena Kansal Kalra
    Division of Reproductive Endocrinology and Infertility, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Womens Health (Larchmt) 17:1035-7. 2008
    ..We report two childhood cancer patients with primary ovarian failure who underwent exogenous hormone-induced puberty and had symptomatic fibroids while on hormone replacement therapy (HRT)...
  55. ncbi Do sperm DNA integrity tests predict pregnancy with in vitro fertilization?
    John A Collins
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Fertil Steril 89:823-31. 2008
    ..To evaluate the predictive value of sperm DNA integrity tests for pregnancy from in vitro fertilization treatment...
  56. ncbi Disruption of the upper female reproductive tract epithelium by nonoxynol-9
    Molina B Dayal
    Center for Research on Reproduction and Women's Health, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Contraception 68:273-9. 2003
    ..Although these results were observed in a mouse model, similar disruption of the upper reproductive tract epithelium in women by N-9 may facilitate HIV infection and serve as an unrecognized portal of human HIV transmission...
  57. ncbi Usefulness of pipelle endometrial biopsy in the diagnosis of women at risk for ectopic pregnancy
    Kurt T Barnhart
    Center for Reproductive Medicine and Surgery, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Am J Obstet Gynecol 188:906-9. 2003
    ..3% (95% CI, 76.1-99.8). CONCLUSION: In patients with suspected ectopic pregnancy, Pipelle sampling is not a substitute for curettage because the sensitivity and predictive values are unacceptable...
  58. ncbi Role of previous ectopic pregnancy in altering the presentation of suspected ectopic pregnancy
    Steven D Spandorfer
    Center for Reproductive Medicine and Infertility, Department of Obstetrics and Gynecology, Weill Medical College, Cornell University, New York, New York, USA
    J Reprod Med 48:133-6. 2003
    ..To evaluate the differences in the presentations of women with and without a prior history of an ectopic pregnancy and a suspicion of a current ectopic...
  59. ncbi The medical management of ectopic pregnancy: a meta-analysis comparing "single dose" and "multidose" regimens
    Kurt T Barnhart
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Obstet Gynecol 101:778-84. 2003
    ..This analysis systematically compares the success and prevalence of side effects of these two regimens...
  60. ncbi Is Rh immune globulin needed in early first-trimester abortion? A review
    Sami Jabara
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia 19104, USA
    Am J Obstet Gynecol 188:623-7. 2003
    ..The evidence to support the use of Rh immune globulin in the first trimester is sparse, but there is theoretic evidence of its necessity. Despite weak evidence to support its use, there is little risk...
  61. ncbi Presumed diagnosis of ectopic pregnancy
    Kurt T Barnhart
    Center for Reproductive Medicine and Surgery, University of Pennsylvania Medical Center, Philadelphia 10104, USA
    Obstet Gynecol 100:505-10. 2002
    ..The presumed diagnosis of ectopic pregnancy is inaccurate in almost 40% of cases. A D&C is necessary to differentiate an ectopic pregnancy from a miscarriage before a woman is presumptively treated with methotrexate...
  62. ncbi A phase I comparative postcoital testing study of three concentrations of C31G
    Christine K Mauck
    CONRAD, Eastern Virginia Medical School, 1611 North Kent Street, Suite 806, Arlington, VA 22209, USA
    Contraception 70:227-31. 2004
    ..5%, 1.0% and 1.7%, administered as a 3.5-mL dose of a vaginal gel to prevent sperm from entering mid-cycle cervical mucus. Irritation of the genitalia and acceptability were also assessed...
  63. ncbi Cost-effectiveness of presumptively medically treating women at risk for ectopic pregnancy compared with first performing a dilatation and curettage
    Monica Ailawadi
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Fertil Steril 83:376-82. 2005
    ....
  64. ncbi Suspected ectopic pregnancy
    Beata E Seeber
    Department of Obstetrics and Gynecology, Penn Fertility Care, Philadelphia, PA 19003, USA
    Obstet Gynecol 107:399-413. 2006
    ..Surgical treatment may be conservative or definitive and should be attempted in most cases via laparoscopy...
  65. ncbi Effects of long-term use of nonoxynol-9 on vaginal flora
    Courtney A Schreiber
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine and Magee Womens Research Institute, Pittsburgh, Pennsylvania, USA
    Obstet Gynecol 107:136-43. 2006
    ..This longitudinal study was conducted to examine the effects of nonoxynol-9 on the vaginal ecology...
  66. ncbi Participant characteristics associated with withdrawal from a large randomized trial of spermicide effectiveness
    Elizabeth G Raymond
    Family Health International, Research Triangle Park, NC, USA
    BMC Med Res Methodol 4:23. 2004
    ..The objective of this analysis was to explore characteristics of participants who failed to complete seven months of planned participation in a trial of spermicide efficacy...
  67. ncbi Defining the rise of serum HCG in viable pregnancies achieved through use of IVF
    Karine Chung
    University of Pennsylvania, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, 3701 Market Street, Suite 800, Philadelphia, PA 19104, USA
    Hum Reprod 21:823-8. 2006
    ..We aimed to characterize the rate of HCG rise associated with viable IVF pregnancies, and to evaluate the association between HCG rise and potentially influential factors...
  68. ncbi Risk factors for spontaneous abortion in early symptomatic first-trimester pregnancies
    Clarisa R Gracia
    Department of Obstetrics and Gynecology, Penn Fertility Care, University of Pennsylvania Medical Center, 3701 Market Street, Philadelphia, PA 19104, USA
    Obstet Gynecol 106:993-9. 2005
    ..Heavy bleeding was most strongly associated with miscarriage. Concurrent cervical infections should not be overlooked as a cause of bleeding in early pregnancy and were not associated with miscarriage. LEVEL OF EVIDENCE: II-2...
  69. ncbi Occupational exposures and male infertility
    Clarisa R Gracia
    Division of Reproductive Endocrinology and Infertility, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Epidemiol 162:729-33. 2005
    ..Overall, no clear, clinically important associations between occupational exposures and male infertility could be identified in this study...
  70. ncbi In vivo assessment of NuvaRing placement
    Kurt T Barnhart
    Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Contraception 72:196-9. 2005
    ..In vivo, NuvaRing is compressed laterally forming a gentle oval in the anterior-posterior direction (5-7 mm longer than wide), an effect that is seen more in nulliparous women...
  71. ncbi Vaginal distribution of two volumes of the novel microbicide gel cellulose sulfate (2.5 and 3.5 mL)
    Kurt T Barnhart
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Contraception 72:65-70. 2005
    ..Most linear spreading took place in the first 5 min after insertion, although lateral spreading continued to increase with time especially when ambulation took place. Leakage and gel was not a significant problem at either volume...
  72. ncbi Acceptability of five nonoxynol-9 spermicides
    Elizabeth G Raymond
    Family Health International, PO Box 13950, Research Triangle Park, NC 27709, USA
    Contraception 71:438-42. 2005
    ..To examine the acceptability of five nonoxynol-9 (N-9) spermicides...
  73. ncbi Microbiology of the endometrium and in vitro fertilization: do we yet understand the implications?
    Kurt T Barnhart
    Penn Fertility Care and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Fertil Steril 82:797-8. 2004
    ..The hypothesis that bacteria in the uterus may be detrimental to an embryo is very thought provoking. The data, however, do not yet support that this is a clinically relevant issue...
  74. ncbi Distribution of a 3.5-mL (1.0%) C31G vaginal gel using magnetic resonance imaging
    Kurt T Barnhart
    Center for Reproductive Medicine and Surgery, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Contraception 71:357-61. 2005
    ..Repeat application of the gel may be necessary if intercourse has not occurred within the first few hours after initial insertion...
  75. ncbi Baseline dimensions of the human vagina
    Kurt T Barnhart
    Penn Fertility Care, Department of Obstetrics and Gynecology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hum Reprod 21:1618-22. 2006
    ..Vaginal anatomy has been poorly studied. This study aimed to measure baseline dimensions of the undistended vagina of women of reproductive age...
  76. ncbi Risk factors for ectopic pregnancy in women with symptomatic first-trimester pregnancies
    Kurt T Barnhart
    Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, USA
    Fertil Steril 86:36-43. 2006
    ..To evaluate the association between ectopic pregnancy (EP) and clinical and historical factors among women presenting with pain and/or bleeding in early pregnancy...
  77. ncbi Application of redefined human chorionic gonadotropin curves for the diagnosis of women at risk for ectopic pregnancy
    Beata E Seeber
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 86:454-9. 2006
    ..Use of a more conservative cutoff for minimal rise in hCG, one as slow as 35% over 2 days, to characterize a potentially viable gestation would minimize potential interruption of a desired pregnancy...
  78. ncbi A randomized Phase I vaginal safety study of three concentrations of C31G vs. Extra Strength Gynol II
    Christine K Mauck
    CONRAD, Eastern Virginia Medical School, 1611 North Kent Street, Arlington, VA 22209, USA
    Contraception 70:233-40. 2004
    ..C31G is an antimicrobial and spermicidal agent that contains two surface-active compounds, cetyl betaine and myristamine oxide. It is being developed as a vaginal microbicide and contraceptive...
  79. ncbi Establishing a human chorionic gonadotropin cutoff to guide methotrexate treatment of ectopic pregnancy: a systematic review
    Seema Menon
    Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 87:481-4. 2007
    ..Successful medical management of an ectopic pregnancy is inversely associated with initial hCG level. The purpose of this publication is to assess whether there is a level of hCG above which failure rate substantially increases...
  80. ncbi Factors influencing adverse perinatal outcomes in pregnancies achieved through use of in vitro fertilization
    Karine Chung
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Fertil Steril 86:1634-41. 2006
    ..To determine the associations of specific components of IVF treatment with abnormal perinatal outcomes...
  81. ncbi Pitfalls of partial meta-analysis: single- versus multidose for the treatment of ectopic pregnancy
    Kurt T Barnhart
    Am J Obstet Gynecol 196:e22; author reply e22-3. 2007
  82. ncbi Is there an optimal algorithm treatment of infertility?
    Clarisa R Gracia
    Fertil Steril 82:764-5; author reply 765. 2004
  83. ncbi Panel of markers can accurately predict endometriosis in a subset of patients
    Beata Seeber
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Fertil Steril 89:1073-81. 2008
    ..To evaluate whether a combination of putative markers of inflammation and CA-125 could serve as a multiple-marker screening test for endometriosis in a heterogeneous population of patients...
  84. ncbi Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss: a meta-analysis
    George Kovalevsky
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Medical Center, Philadelphia, USA
    Arch Intern Med 164:558-63. 2004
    ..Hereditary thrombophilias may be an unrecognized cause of RPL. We recommend testing for these mutations in women with RPL...
  85. ncbi Supplementation with DHEA: effect on muscle size, strength, quality of life, and lipids
    Molina Dayal
    Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Womens Health (Larchmt) 14:391-400. 2005
    ....
  86. ncbi Ultrasound diagnosis of ectopic pregnancy
    Kurt T Barnhart
    Hum Reprod 22:1493; author reply 1494. 2007
  87. ncbi Risk factors for ectopic pregnancy: a comparison between adults and adolescent women
    Seema Menon
    Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Pediatr Adolesc Gynecol 20:181-5. 2007
    ..To compare the prevalence of classical risk factors and presenting signs and symptoms between adolescents and adults with ectopic pregnancy (EP)...
  88. ncbi Statistical power to detect differences
    Kurt T Barnhart
    Fertil Steril 87:1499; author reply 1499-500. 2007
  89. ncbi Ectopic pregnancies in unusual locations
    Thomas A Molinaro
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Semin Reprod Med 25:123-30. 2007
    ..In this article, we attempt to summarize the current data regarding diagnosis and optimal treatment of these unusual ectopic pregnancies...

Research Grants9

  1. RISK FACTORS AS PREDICTORS OF ECTOPIC PREGNANCY
    Kurt Barnhart; Fiscal Year: 2003
    ..abstract_text> ..
  2. RISK FACTORS AS PREDICTORS OF ECTOPIC PREGNANCY
    Kurt Barnhart; Fiscal Year: 2007
    ....
  3. RISK FACTORS AS PREDICTORS OF ECTOPIC PREGNANCY
    Kurt T Barnhart; Fiscal Year: 2010
    ....