Research Topics
Species | Peter BarnesSummaryAffiliation: University of Texas Health Center Country: USA Publications
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Publications
Enzyme-linked immunospot and tuberculin skin testing to detect latent tuberculosis infectionHomayoun Shams
CPIDC, University of Texas Health Center, 11937 U S Highway 271, Tyler, TX 75708 3154
Am J Respir Crit Care Med 172:1161-8. 2005..Diagnosis of latent tuberculosis infection (LTBI) is currently based on the tuberculin skin test. The enzyme-linked immunospot assay (ELISPOT) is a new blood test to diagnose LTBI...
Progress in understanding the human immune responses to Mycobacterium tuberculosisPeter F Barnes
Department of Medicine, The University of Texas Health Science Center at Tyler, Tyler, TX, USA
Tuberculosis (Edinb) 89:S5-9. 2009....
Tuberculosis in patients with HIV infectionPeter F Barnes
Center for Pulmonary and Infectious Disease Control, Departments of Medicine, Microbiology and Immunology, University of Texas Health Center, Tyler, Texas, USA
Infect Dis Clin North Am 16:107-26. 2002..New guidelines are available for the treatment of active and latent TB infection in patients with HIV...- Molecular epidemiology of tuberculosisPeter F Barnes
Center for Pulmonary and Infectious Disease Control, Department of Medicine, University of Texas Health Center, Tyler, TX 75708-3154, USA
N Engl J Med 349:1149-56. 2003 - The NKp46 receptor contributes to NK cell lysis of mononuclear phagocytes infected with an intracellular bacteriumRamakrishna Vankayalapati
Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708, USA
J Immunol 168:3451-7. 2002.... - Cyclic AMP response element-binding protein positively regulates production of IFN-gamma by T cells in response to a microbial pathogenBuka Samten
Center for Pulmonary and Infectious Disease Control, Department of Microbiology and Immunology, University of Texas Health Center, Tyler, TX 75708, USA
J Immunol 174:6357-63. 2005..These findings demonstrate that CREB positively regulates IFN-gamma production by human T cells that respond to M. tuberculosis... - NK cells regulate CD8+ T cell effector function in response to an intracellular pathogenRamakrishna Vankayalapati
Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 US Highway 271, Tyler, TX 75708, USA
J Immunol 172:130-7. 2004..tuberculosis and other intracellular pathogens... - NK cells lyse T regulatory cells that expand in response to an intracellular pathogenSugata Roy
Center for Pulmonary and Infectious Disease Control, Department of Microbiology and Immunology, University of Texas Health Center, 11937 U S Highway 271, Tyler, TX 75708, USA
J Immunol 180:1729-36. 2008..Our study identifies a potential new role for NK cells in maintaining the delicate balance between the regulatory and effector arms of the immune response... - NKG2D-dependent IL-17 production by human T cells in response to an intracellular pathogenPadmaja Paidipally
Departments of Microbiology, University of Texas Health Center, Center for Pulmonary and Infectious Disease Control, Tyler, TX 75708, USA
J Immunol 183:1940-5. 2009..We conclude that binding of NKG2D to UL-16 binding protein (ULB)1 contributes to IL-23-dependent IL-17 production by CD4(+) cells in human M. tuberculosis infection... - Vaccination strategies to enhance local immunity and protection against Mycobacteriun tuberculosisPeter Klucar
Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center at Tyler, Tyler, TX 75708, United States
Vaccine 27:1816-24. 2009..We conclude that CFP10 is a potential vaccine candidate and that coating vaccines with PEI enhances local protective immunity to tuberculosis.. - Vimentin expressed on Mycobacterium tuberculosis-infected human monocytes is involved in binding to the NKp46 receptorAnkita Garg
Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 U S Highway 271, Tyler, TX 75708, USA
J Immunol 177:6192-8. 2006..ELISA and Far Western blotting showed that recombinant vimentin bound to a NKp46 fusion protein. These results indicate that vimentin is involved in binding of NKp46 to M. tuberculosis H37Ra-infected mononuclear phagocytes... - Reduced expression of nuclear cyclic adenosine 5'-monophosphate response element-binding proteins and IFN-gamma promoter function in disease due to an intracellular pathogenBuka Samten
Department of Microbiology and Immunology, and Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708, USA
J Immunol 168:3520-6. 2002..These data suggest that reduced expression of CREB nuclear proteins in tuberculosis patients results in decreased IFN-gamma promoter activity and reduced IFN-gamma production... - Characterization of effector functions of human peptide-specific CD4+ T-cell clones for an intracellular pathogenPeter Klucar
Department of Microbiology and Immunology, University of Texas Health Center at Tyler, Tyler, TX, USA
Hum Immunol 69:475-83. 2008.... - The principal sigma factor sigA mediates enhanced growth of Mycobacterium tuberculosis in vivoShiping Wu
Department of Microbiology and Immunology, Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 US Highway 271, Tyler, TX, USA
Mol Microbiol 51:1551-62. 2004..This effect may be mediated in part by increased resistance to reactive oxygen intermediates... - IL-22 produced by human NK cells inhibits growth of Mycobacterium tuberculosis by enhancing phagolysosomal fusionRohan Dhiman
Center for Pulmonary and Infectious Disease Control, Department of Microbiology and Immunology, University of Texas Health Center, Tyler, TX 75708 3154, USA
J Immunol 183:6639-45. 2009..tuberculosis through production of IL-22, which inhibits intracellular mycobacterial growth by enhancing phagolysosomal fusion. IL-15 and DAP-10 elicit IL-22 production by NK cells in response to M. tuberculosis... - Serum cytokine concentrations do not parallel Mycobacterium tuberculosis-induced cytokine production in patients with tuberculosisRamakrishna Vankayalapati
Center for Pulmonary and Infectious Disease Control, and Department of Microbiology and Immunology, University of Texas Health Center, Tyler, TX 75708-3154, USA
Clin Infect Dis 36:24-8. 2003..tuberculosis-induced cytokine levels, and increased IL-10 serum levels in patients with tuberculosis inhibit IFN-gamma production in response to mycobacterial antigens... - CD40 ligand trimer enhances the response of CD8+ T cells to Mycobacterium tuberculosisBuka Samten
Department of Microbiology and Immunology and Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708, USA
J Immunol 170:3180-6. 2003..We conclude that CD40LT can enhance CD8(+) T cell effector function in response to M. tuberculosis... - CREB, ATF, and AP-1 transcription factors regulate IFN-gamma secretion by human T cells in response to mycobacterial antigenBuka Samten
Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708, USA
J Immunol 181:2056-64. 2008..Additionally, ATF-2 controls expression of CREB and c-Jun during T cell activation... - Mycobacterium tuberculosis ESX-1 system-secreted protein ESAT-6 but not CFP10 inhibits human T-cell immune responsesBuka Samten
Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center, Tyler, TX 75708 3154, USA
Tuberculosis (Edinb) 89:S74-6. 2009..We conclude that ESAT-6 directly inhibits human T-cell responses by affecting TCR signaling pathways downstream of ZAP70... - ESAT-6 inhibits production of IFN-gamma by Mycobacterium tuberculosis-responsive human T cellsXisheng Wang
Department of Microbiologyand Immunology, Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center, Tyler, TX 75708, USA
J Immunol 182:3668-77. 2009..We conclude that ESAT-6 directly inhibits human T cell responses to mycobacterial Ags by affecting TCR signaling pathways downstream of ZAP70... - An antibody against the surfactant protein A (SP-A)-binding domain of the SP-A receptor inhibits T cell-mediated immune responses to Mycobacterium tuberculosisBuka Samten
Department of Microbiology and Immunology, the Center for Pulmonary and Infectious Disease Control, The University of Texas Health Center, 11937 U S Hwy 271, Tyler, TX 75708, USA
J Leukoc Biol 84:115-23. 2008..Together, these findings support the hypothesis that SP-A, via SP-R210, suppresses cell-mediated immunity against M. tuberculosis via a mechanism that up-regulates secretion of IL-10 and TGF-beta1... - Activation of the eis gene in a W-Beijing strain of Mycobacterium tuberculosis correlates with increased SigA levels and enhanced intracellular growthShiping Wu
Department of Microbiology and Immunology, University of Texas Health Science Center at Tyler, Tyler, TX 75708 3154, USA
Microbiology 155:1272-81. 2009..tuberculosis strain 210 to grow in monocytes... - Mannose-capped lipoarabinomannan- and prostaglandin E2-dependent expansion of regulatory T cells in human Mycobacterium tuberculosis infectionAnkita Garg
Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708 3154, USA
Eur J Immunol 38:459-69. 2008..These findings demonstrate that Tregs expand in response to M. tuberculosis through mechanisms that depend on ManLAM and PGE2... - Multiple Chlamydia pneumoniae antigens prime CD8+ Tc1 responses that inhibit intracellular growth of this vacuolar pathogenBenjamin Wizel
Center for Pulmonary and Infectious Disease Control, Department of Microbiology and Immunology, University of Texas Health Center, Tyler 75708, USA
J Immunol 169:2524-35. 2002.... - Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA allelesHomayoun Shams
Center for Pulmonary and Infectious Disease Control, and Department of Microbiology, University of Texas Health Center, Tyler, TX 75708, USA
J Immunol 173:1966-77. 2004.... - Human CD8+ T cells recognize epitopes of the 28-kDa hemolysin and the 38-kDa antigen of Mycobacterium tuberculosisHomayoun Shams
Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 U S Hwy 271, Tyler, TX 75708 3154, USA
J Leukoc Biol 74:1008-14. 2003..We speculate that hemolysins may alter the phagosomal membrane surrounding intracellular M. tuberculosis, allowing themselves and other antigens to gain access to the major histocompatibility complex class I processing pathway... - Innate and adaptive immune responses to human Mycobacterium tuberculosis infectionRamakrishna Vankayalapati
Department of Microbiology and Immunology, The University of Texas Health Science Center at Tyler, Tyler, TX, USA
Tuberculosis (Edinb) 89:S77-80. 2009.... - A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosisPedro O Flores-Villanueva
Center for Biomedical Research, University of Texas Health Center at Tyler, Tyler, TX 75708, USA
J Exp Med 202:1649-58. 2005..tuberculosis and increases the likelihood that M. tuberculosis infection will progress to active pulmonary tuberculosis... - Role of NK cell-activating receptors and their ligands in the lysis of mononuclear phagocytes infected with an intracellular bacteriumRamakrishna Vankayalapati
Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler 75708, USA
J Immunol 175:4611-7. 2005..tuberculosis-infected mononuclear phagocytes, and that ULBP1 on infected cells is the major ligand for NKG2D. Furthermore, TLR2 contributes to up-regulation of ULBP1 expression... - The CD14 receptor does not mediate entry of Mycobacterium tuberculosis into human mononuclear phagocytesHomayoun Shams
Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 U.S. Highway 271, Tyler, TX 75708-3154, USA
FEMS Immunol Med Microbiol 36:63-9. 2003..tuberculosis; (2) M. tuberculosis infection upregulates CD14 expression on mononuclear phagocytes, and this may facilitate the pathogen's capacity to modulate the immune response... - Spectrum of manifestations of Mycobacterium tuberculosis infection in primates infected with SIVHassan Safi
Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, Texas 75708, USA
AIDS Res Hum Retroviruses 19:585-95. 2003..Such a model will permit delineation of the immunologic and microbial factors that characterize LTBI in HIV-infected persons... - Transmission dynamics of tuberculosis in Tarrant county, TexasStephen E Weis
Division of Public Health, Department of Medicine, University of North Texas Health Science Center at Fort Worth, 76107, USA
Am J Respir Crit Care Med 166:36-42. 2002.... - IS6110 functions as a mobile, monocyte-activated promoter in Mycobacterium tuberculosisHassan Safi
Department of Microbiology, Center for Pulmonary and Infectious Disease Control, University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708-3154, USA
Mol Microbiol 52:999-1012. 2004..The ability to activate genes during infection suggests that IS6110 has the potential to influence growth characteristics of different strains, and indicates another mechanism by which IS6110 can impact M. tuberculosis evolution... - Priming reverse transcription with oligo(dT) does not yield representative samples of Mycobacterium tuberculosis cDNADavid L Lakey
Center for Pulmonary and Infectious Disease Control, and Department of Microbiology, University of Texas Health Center, Tyler, TX 75708, USA
Microbiology 148:2567-72. 2002..tuberculosis microarray. These data demonstrate that priming of reverse transcription of mycobacterial mRNA with oligo(dT) does not yield representative samples of cDNA... - The aged thymus shows normal recruitment of lymphohematopoietic progenitors but has defects in thymic epithelial cellsJingang Gui
Department of Biomedical Research, University of Texas Health Center at Tyler, Tyler, TX 75708, USA
Int Immunol 19:1201-11. 2007.... - Lymphohematopoietic progenitors do not have a synchronized defect with age-related thymic involutionXike Zhu
Department of Biomedical Research, University of Texas Health Center at Tyler, Tyler, TX 75708, USA
Aging Cell 6:663-72. 2007..Together, our findings suggest that the underlying cause of age-related thymic involution results primarily from changes in the thymic microenvironment, causing extrinsic, rather than intrinsic, defects in T-lymphocyte progenitors... - Diagnosing latent tuberculosis infection: turning glitter to goldPeter F Barnes
Am J Respir Crit Care Med 170:5-6. 2004 - Weighing gold or counting spots: which is more sensitive to diagnose latent tuberculosis infection?Peter F Barnes
Am J Respir Crit Care Med 174:731-2. 2006 - Immunotherapy for tuberculosis: wave of the future or tilting at windmills?Peter F Barnes
Am J Respir Crit Care Med 168:142-3. 2003
Research Grants
- NK cells and IL-15 in the human innate immune response to tuberculosisPeter Barnes; Fiscal Year: 2007..This proposal will provide new insight into the immunologic mechanisms for this increased resistance, and harnessing of these mechanisms will be critical to develop a vaccine that maximizes innate resistance to tuberculosis. ..
- Regulation of IFN-gamma production in human tuberculosisPeter Barnes; Fiscal Year: 2007..CREB/ATF/AP-1 levels in T-cells of tuberculosis patients will be enhanced by viral expression vectors and nucleofection, and the effects on IFN-gamma production will be determined. ..
- TRANSMISSION DYNAMICS OF TB ALONG THE U.S.-MEXICO BORDERPeter Barnes; Fiscal Year: 2004..Finally, it will determine if rapid RFLP methods can contribute to TB control efforts. The knowledge gained will permit refinement of TB control strategies along the U.S.-Mexico border and in Latin America. ..
- Regulation of IFN-gamma production in human tuberculosisPeter Barnes; Fiscal Year: 2009..CREB/ATF/AP-1 levels in T-cells of tuberculosis patients will be enhanced by viral expression vectors and nucleofection, and the effects on IFN-gamma production will be determined. ..