Peter Barnes

Summary

Affiliation: University of Texas Health Center
Country: USA

Publications

  1. pmc Enzyme-linked immunospot and tuberculin skin testing to detect latent tuberculosis infection
    Homayoun Shams
    CPIDC, University of Texas Health Center, 11937 U S Highway 271, Tyler, TX 75708 3154
    Am J Respir Crit Care Med 172:1161-8. 2005
  2. doi request reprint Progress in understanding the human immune responses to Mycobacterium tuberculosis
    Peter F Barnes
    Department of Medicine, The University of Texas Health Science Center at Tyler, Tyler, TX, USA
    Tuberculosis (Edinb) 89:S5-9. 2009
  3. ncbi request reprint Tuberculosis in patients with HIV infection
    Peter F Barnes
    Center for Pulmonary and Infectious Disease Control, Departments of Medicine, Microbiology and Immunology, University of Texas Health Center, Tyler, Texas, USA
    Infect Dis Clin North Am 16:107-26. 2002
  4. ncbi request reprint Molecular epidemiology of tuberculosis
    Peter F Barnes
    Center for Pulmonary and Infectious Disease Control, Department of Medicine, University of Texas Health Center, Tyler, TX 75708 3154, USA
    N Engl J Med 349:1149-56. 2003
  5. ncbi request reprint The NKp46 receptor contributes to NK cell lysis of mononuclear phagocytes infected with an intracellular bacterium
    Ramakrishna Vankayalapati
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 168:3451-7. 2002
  6. ncbi request reprint Cyclic AMP response element-binding protein positively regulates production of IFN-gamma by T cells in response to a microbial pathogen
    Buka Samten
    Center for Pulmonary and Infectious Disease Control, Department of Microbiology and Immunology, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 174:6357-63. 2005
  7. ncbi request reprint NK cells regulate CD8+ T cell effector function in response to an intracellular pathogen
    Ramakrishna Vankayalapati
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 US Highway 271, Tyler, TX 75708, USA
    J Immunol 172:130-7. 2004
  8. ncbi request reprint NK cells lyse T regulatory cells that expand in response to an intracellular pathogen
    Sugata Roy
    Center for Pulmonary and Infectious Disease Control, Department of Microbiology and Immunology, University of Texas Health Center, 11937 U S Highway 271, Tyler, TX 75708, USA
    J Immunol 180:1729-36. 2008
  9. doi request reprint NKG2D-dependent IL-17 production by human T cells in response to an intracellular pathogen
    Padmaja Paidipally
    Departments of Microbiology, University of Texas Health Center, Center for Pulmonary and Infectious Disease Control, Tyler, TX 75708, USA
    J Immunol 183:1940-5. 2009
  10. pmc Vaccination strategies to enhance local immunity and protection against Mycobacteriun tuberculosis
    Peter Klucar
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center at Tyler, Tyler, TX 75708, United States
    Vaccine 27:1816-24. 2009

Collaborators

Detail Information

Publications39

  1. pmc Enzyme-linked immunospot and tuberculin skin testing to detect latent tuberculosis infection
    Homayoun Shams
    CPIDC, University of Texas Health Center, 11937 U S Highway 271, Tyler, TX 75708 3154
    Am J Respir Crit Care Med 172:1161-8. 2005
    ..Diagnosis of latent tuberculosis infection (LTBI) is currently based on the tuberculin skin test. The enzyme-linked immunospot assay (ELISPOT) is a new blood test to diagnose LTBI...
  2. doi request reprint Progress in understanding the human immune responses to Mycobacterium tuberculosis
    Peter F Barnes
    Department of Medicine, The University of Texas Health Science Center at Tyler, Tyler, TX, USA
    Tuberculosis (Edinb) 89:S5-9. 2009
    ....
  3. ncbi request reprint Tuberculosis in patients with HIV infection
    Peter F Barnes
    Center for Pulmonary and Infectious Disease Control, Departments of Medicine, Microbiology and Immunology, University of Texas Health Center, Tyler, Texas, USA
    Infect Dis Clin North Am 16:107-26. 2002
    ..New guidelines are available for the treatment of active and latent TB infection in patients with HIV...
  4. ncbi request reprint Molecular epidemiology of tuberculosis
    Peter F Barnes
    Center for Pulmonary and Infectious Disease Control, Department of Medicine, University of Texas Health Center, Tyler, TX 75708 3154, USA
    N Engl J Med 349:1149-56. 2003
  5. ncbi request reprint The NKp46 receptor contributes to NK cell lysis of mononuclear phagocytes infected with an intracellular bacterium
    Ramakrishna Vankayalapati
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 168:3451-7. 2002
    ....
  6. ncbi request reprint Cyclic AMP response element-binding protein positively regulates production of IFN-gamma by T cells in response to a microbial pathogen
    Buka Samten
    Center for Pulmonary and Infectious Disease Control, Department of Microbiology and Immunology, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 174:6357-63. 2005
    ..These findings demonstrate that CREB positively regulates IFN-gamma production by human T cells that respond to M. tuberculosis...
  7. ncbi request reprint NK cells regulate CD8+ T cell effector function in response to an intracellular pathogen
    Ramakrishna Vankayalapati
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 US Highway 271, Tyler, TX 75708, USA
    J Immunol 172:130-7. 2004
    ..tuberculosis and other intracellular pathogens...
  8. ncbi request reprint NK cells lyse T regulatory cells that expand in response to an intracellular pathogen
    Sugata Roy
    Center for Pulmonary and Infectious Disease Control, Department of Microbiology and Immunology, University of Texas Health Center, 11937 U S Highway 271, Tyler, TX 75708, USA
    J Immunol 180:1729-36. 2008
    ..Our study identifies a potential new role for NK cells in maintaining the delicate balance between the regulatory and effector arms of the immune response...
  9. doi request reprint NKG2D-dependent IL-17 production by human T cells in response to an intracellular pathogen
    Padmaja Paidipally
    Departments of Microbiology, University of Texas Health Center, Center for Pulmonary and Infectious Disease Control, Tyler, TX 75708, USA
    J Immunol 183:1940-5. 2009
    ..We conclude that binding of NKG2D to UL-16 binding protein (ULB)1 contributes to IL-23-dependent IL-17 production by CD4(+) cells in human M. tuberculosis infection...
  10. pmc Vaccination strategies to enhance local immunity and protection against Mycobacteriun tuberculosis
    Peter Klucar
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center at Tyler, Tyler, TX 75708, United States
    Vaccine 27:1816-24. 2009
    ..We conclude that CFP10 is a potential vaccine candidate and that coating vaccines with PEI enhances local protective immunity to tuberculosis..
  11. ncbi request reprint Vimentin expressed on Mycobacterium tuberculosis-infected human monocytes is involved in binding to the NKp46 receptor
    Ankita Garg
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 U S Highway 271, Tyler, TX 75708, USA
    J Immunol 177:6192-8. 2006
    ..ELISA and Far Western blotting showed that recombinant vimentin bound to a NKp46 fusion protein. These results indicate that vimentin is involved in binding of NKp46 to M. tuberculosis H37Ra-infected mononuclear phagocytes...
  12. ncbi request reprint Reduced expression of nuclear cyclic adenosine 5'-monophosphate response element-binding proteins and IFN-gamma promoter function in disease due to an intracellular pathogen
    Buka Samten
    Department of Microbiology and Immunology, and Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 168:3520-6. 2002
    ..These data suggest that reduced expression of CREB nuclear proteins in tuberculosis patients results in decreased IFN-gamma promoter activity and reduced IFN-gamma production...
  13. doi request reprint Characterization of effector functions of human peptide-specific CD4+ T-cell clones for an intracellular pathogen
    Peter Klucar
    Department of Microbiology and Immunology, University of Texas Health Center at Tyler, Tyler, TX, USA
    Hum Immunol 69:475-83. 2008
    ....
  14. ncbi request reprint The principal sigma factor sigA mediates enhanced growth of Mycobacterium tuberculosis in vivo
    Shiping Wu
    Department of Microbiology and Immunology, Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 US Highway 271, Tyler, TX, USA
    Mol Microbiol 51:1551-62. 2004
    ..This effect may be mediated in part by increased resistance to reactive oxygen intermediates...
  15. doi request reprint IL-22 produced by human NK cells inhibits growth of Mycobacterium tuberculosis by enhancing phagolysosomal fusion
    Rohan Dhiman
    Center for Pulmonary and Infectious Disease Control, Department of Microbiology and Immunology, University of Texas Health Center, Tyler, TX 75708 3154, USA
    J Immunol 183:6639-45. 2009
    ..tuberculosis through production of IL-22, which inhibits intracellular mycobacterial growth by enhancing phagolysosomal fusion. IL-15 and DAP-10 elicit IL-22 production by NK cells in response to M. tuberculosis...
  16. ncbi request reprint Serum cytokine concentrations do not parallel Mycobacterium tuberculosis-induced cytokine production in patients with tuberculosis
    Ramakrishna Vankayalapati
    Center for Pulmonary and Infectious Disease Control, and Department of Microbiology and Immunology, University of Texas Health Center, Tyler, TX 75708 3154, USA
    Clin Infect Dis 36:24-8. 2003
    ..tuberculosis-induced cytokine levels, and increased IL-10 serum levels in patients with tuberculosis inhibit IFN-gamma production in response to mycobacterial antigens...
  17. ncbi request reprint CD40 ligand trimer enhances the response of CD8+ T cells to Mycobacterium tuberculosis
    Buka Samten
    Department of Microbiology and Immunology and Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 170:3180-6. 2003
    ..We conclude that CD40LT can enhance CD8(+) T cell effector function in response to M. tuberculosis...
  18. pmc CREB, ATF, and AP-1 transcription factors regulate IFN-gamma secretion by human T cells in response to mycobacterial antigen
    Buka Samten
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 181:2056-64. 2008
    ..Additionally, ATF-2 controls expression of CREB and c-Jun during T cell activation...
  19. doi request reprint Mycobacterium tuberculosis ESX-1 system-secreted protein ESAT-6 but not CFP10 inhibits human T-cell immune responses
    Buka Samten
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center, Tyler, TX 75708 3154, USA
    Tuberculosis (Edinb) 89:S74-6. 2009
    ..We conclude that ESAT-6 directly inhibits human T-cell responses by affecting TCR signaling pathways downstream of ZAP70...
  20. doi request reprint ESAT-6 inhibits production of IFN-gamma by Mycobacterium tuberculosis-responsive human T cells
    Xisheng Wang
    Department of Microbiologyand Immunology, Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center, Tyler, TX 75708, USA
    J Immunol 182:3668-77. 2009
    ..We conclude that ESAT-6 directly inhibits human T cell responses to mycobacterial Ags by affecting TCR signaling pathways downstream of ZAP70...
  21. pmc An antibody against the surfactant protein A (SP-A)-binding domain of the SP-A receptor inhibits T cell-mediated immune responses to Mycobacterium tuberculosis
    Buka Samten
    Department of Microbiology and Immunology, the Center for Pulmonary and Infectious Disease Control, The University of Texas Health Center, 11937 U S Hwy 271, Tyler, TX 75708, USA
    J Leukoc Biol 84:115-23. 2008
    ..Together, these findings support the hypothesis that SP-A, via SP-R210, suppresses cell-mediated immunity against M. tuberculosis via a mechanism that up-regulates secretion of IL-10 and TGF-beta1...
  22. pmc Activation of the eis gene in a W-Beijing strain of Mycobacterium tuberculosis correlates with increased SigA levels and enhanced intracellular growth
    Shiping Wu
    Department of Microbiology and Immunology, University of Texas Health Science Center at Tyler, Tyler, TX 75708 3154, USA
    Microbiology 155:1272-81. 2009
    ..tuberculosis strain 210 to grow in monocytes...
  23. pmc Mannose-capped lipoarabinomannan- and prostaglandin E2-dependent expansion of regulatory T cells in human Mycobacterium tuberculosis infection
    Ankita Garg
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708 3154, USA
    Eur J Immunol 38:459-69. 2008
    ..These findings demonstrate that Tregs expand in response to M. tuberculosis through mechanisms that depend on ManLAM and PGE2...
  24. ncbi request reprint Multiple Chlamydia pneumoniae antigens prime CD8+ Tc1 responses that inhibit intracellular growth of this vacuolar pathogen
    Benjamin Wizel
    Center for Pulmonary and Infectious Disease Control, Department of Microbiology and Immunology, University of Texas Health Center, Tyler 75708, USA
    J Immunol 169:2524-35. 2002
    ....
  25. ncbi request reprint Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles
    Homayoun Shams
    Center for Pulmonary and Infectious Disease Control, and Department of Microbiology, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 173:1966-77. 2004
    ....
  26. ncbi request reprint Human CD8+ T cells recognize epitopes of the 28-kDa hemolysin and the 38-kDa antigen of Mycobacterium tuberculosis
    Homayoun Shams
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 U S Hwy 271, Tyler, TX 75708 3154, USA
    J Leukoc Biol 74:1008-14. 2003
    ..We speculate that hemolysins may alter the phagosomal membrane surrounding intracellular M. tuberculosis, allowing themselves and other antigens to gain access to the major histocompatibility complex class I processing pathway...
  27. doi request reprint Innate and adaptive immune responses to human Mycobacterium tuberculosis infection
    Ramakrishna Vankayalapati
    Department of Microbiology and Immunology, The University of Texas Health Science Center at Tyler, Tyler, TX, USA
    Tuberculosis (Edinb) 89:S77-80. 2009
    ....
  28. pmc A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis
    Pedro O Flores-Villanueva
    Center for Biomedical Research, University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    J Exp Med 202:1649-58. 2005
    ..tuberculosis and increases the likelihood that M. tuberculosis infection will progress to active pulmonary tuberculosis...
  29. ncbi request reprint Role of NK cell-activating receptors and their ligands in the lysis of mononuclear phagocytes infected with an intracellular bacterium
    Ramakrishna Vankayalapati
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler 75708, USA
    J Immunol 175:4611-7. 2005
    ..tuberculosis-infected mononuclear phagocytes, and that ULBP1 on infected cells is the major ligand for NKG2D. Furthermore, TLR2 contributes to up-regulation of ULBP1 expression...
  30. ncbi request reprint The CD14 receptor does not mediate entry of Mycobacterium tuberculosis into human mononuclear phagocytes
    Homayoun Shams
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 U S Highway 271, Tyler, TX 75708 3154, USA
    FEMS Immunol Med Microbiol 36:63-9. 2003
    ..tuberculosis; (2) M. tuberculosis infection upregulates CD14 expression on mononuclear phagocytes, and this may facilitate the pathogen's capacity to modulate the immune response...
  31. ncbi request reprint Spectrum of manifestations of Mycobacterium tuberculosis infection in primates infected with SIV
    Hassan Safi
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, Texas 75708, USA
    AIDS Res Hum Retroviruses 19:585-95. 2003
    ..Such a model will permit delineation of the immunologic and microbial factors that characterize LTBI in HIV-infected persons...
  32. ncbi request reprint Transmission dynamics of tuberculosis in Tarrant county, Texas
    Stephen E Weis
    Division of Public Health, Department of Medicine, University of North Texas Health Science Center at Fort Worth, 76107, USA
    Am J Respir Crit Care Med 166:36-42. 2002
    ....
  33. ncbi request reprint IS6110 functions as a mobile, monocyte-activated promoter in Mycobacterium tuberculosis
    Hassan Safi
    Department of Microbiology, Center for Pulmonary and Infectious Disease Control, University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Mol Microbiol 52:999-1012. 2004
    ..The ability to activate genes during infection suggests that IS6110 has the potential to influence growth characteristics of different strains, and indicates another mechanism by which IS6110 can impact M. tuberculosis evolution...
  34. ncbi request reprint Priming reverse transcription with oligo(dT) does not yield representative samples of Mycobacterium tuberculosis cDNA
    David L Lakey
    Center for Pulmonary and Infectious Disease Control, and Department of Microbiology, University of Texas Health Center, Tyler, TX 75708, USA
    Microbiology 148:2567-72. 2002
    ..tuberculosis microarray. These data demonstrate that priming of reverse transcription of mycobacterial mRNA with oligo(dT) does not yield representative samples of cDNA...
  35. ncbi request reprint The aged thymus shows normal recruitment of lymphohematopoietic progenitors but has defects in thymic epithelial cells
    Jingang Gui
    Department of Biomedical Research, University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Int Immunol 19:1201-11. 2007
    ....
  36. ncbi request reprint Lymphohematopoietic progenitors do not have a synchronized defect with age-related thymic involution
    Xike Zhu
    Department of Biomedical Research, University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Aging Cell 6:663-72. 2007
    ..Together, our findings suggest that the underlying cause of age-related thymic involution results primarily from changes in the thymic microenvironment, causing extrinsic, rather than intrinsic, defects in T-lymphocyte progenitors...
  37. ncbi request reprint Diagnosing latent tuberculosis infection: turning glitter to gold
    Peter F Barnes
    Am J Respir Crit Care Med 170:5-6. 2004
  38. ncbi request reprint Weighing gold or counting spots: which is more sensitive to diagnose latent tuberculosis infection?
    Peter F Barnes
    Am J Respir Crit Care Med 174:731-2. 2006
  39. ncbi request reprint Immunotherapy for tuberculosis: wave of the future or tilting at windmills?
    Peter F Barnes
    Am J Respir Crit Care Med 168:142-3. 2003

Research Grants12

  1. NK cells and IL-15 in the human innate immune response to tuberculosis
    Peter Barnes; Fiscal Year: 2007
    ..This proposal will provide new insight into the immunologic mechanisms for this increased resistance, and harnessing of these mechanisms will be critical to develop a vaccine that maximizes innate resistance to tuberculosis. ..
  2. Regulation of IFN-gamma production in human tuberculosis
    Peter Barnes; Fiscal Year: 2007
    ..CREB/ATF/AP-1 levels in T-cells of tuberculosis patients will be enhanced by viral expression vectors and nucleofection, and the effects on IFN-gamma production will be determined. ..
  3. TRANSMISSION DYNAMICS OF TB ALONG THE U.S.-MEXICO BORDER
    Peter Barnes; Fiscal Year: 2004
    ..Finally, it will determine if rapid RFLP methods can contribute to TB control efforts. The knowledge gained will permit refinement of TB control strategies along the U.S.-Mexico border and in Latin America. ..
  4. Regulation of IFN-gamma production in human tuberculosis
    Peter Barnes; Fiscal Year: 2009
    ..CREB/ATF/AP-1 levels in T-cells of tuberculosis patients will be enhanced by viral expression vectors and nucleofection, and the effects on IFN-gamma production will be determined. ..