R J Barnard

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2
    Naoko Kobayashi
    Department of Urology, Division of Clinical Nutrition and Hematology Oncology, University of California, Los Angeles School of Medicine, 90095 1738, USA
    Clin Cancer Res 12:4662-70. 2006
  2. pmc Analyzing serum-stimulated prostate cancer cell lines after low-fat, high-fiber diet and exercise intervention
    Sherry Soliman
    Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
    Evid Based Complement Alternat Med 2011:529053. 2011
  3. ncbi request reprint A high-fat, refined-carbohydrate diet affects renal NO synthase protein expression and salt sensitivity
    Christian K Roberts
    Department of Physiological Science, University of California, Los Angeles 90095, USA
    J Appl Physiol (1985) 94:941-6. 2003
  4. ncbi request reprint Prostate cancer: another aspect of the insulin-resistance syndrome?
    R J Barnard
    Obes Rev 3:303-8. 2002
  5. ncbi request reprint Preclinical models relevant to diet, exercise, and cancer risk
    R James Barnard
    Departments of Physiological Science and Urology, University of California, Los Angeles, Los Angeles, CA 90095 1606, USA
    Recent Results Cancer Res 166:47-61. 2005
  6. doi request reprint Benign prostatic hyperplasia: does lifestyle play a role?
    R James Barnard
    Department of Physiological Science, University of California, Los Angeles, CA 90095 1606, USA
    Phys Sportsmed 37:141-6. 2009
  7. ncbi request reprint Effects of a low-fat, high-fiber diet and exercise program on breast cancer risk factors in vivo and tumor cell growth and apoptosis in vitro
    R James Barnard
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095 1606, USA
    Nutr Cancer 55:28-34. 2006
  8. ncbi request reprint A mechanism to explain how regular exercise might reduce the risk for clinical prostate cancer
    R James Barnard
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, California 90095 1606, USA
    Eur J Cancer Prev 16:415-21. 2007
  9. ncbi request reprint Prostate cancer prevention by nutritional means to alleviate metabolic syndrome
    R James Barnard
    Department of Physiological Science, University of California, Los Angeles, CA 90096 1606, USA
    Am J Clin Nutr 86:s889-93. 2007
  10. doi request reprint Effect of diet and exercise intervention on the growth of prostate epithelial cells
    R J Barnard
    Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
    Prostate Cancer Prostatic Dis 11:362-6. 2008

Detail Information

Publications44

  1. pmc Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2
    Naoko Kobayashi
    Department of Urology, Division of Clinical Nutrition and Hematology Oncology, University of California, Los Angeles School of Medicine, 90095 1738, USA
    Clin Cancer Res 12:4662-70. 2006
    ....
  2. pmc Analyzing serum-stimulated prostate cancer cell lines after low-fat, high-fiber diet and exercise intervention
    Sherry Soliman
    Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
    Evid Based Complement Alternat Med 2011:529053. 2011
    ..We conclude that diet and exercise intervention might help prevent clinical PCa as well as aid in the treatment of PCa during the early stages of development...
  3. ncbi request reprint A high-fat, refined-carbohydrate diet affects renal NO synthase protein expression and salt sensitivity
    Christian K Roberts
    Department of Physiological Science, University of California, Los Angeles 90095, USA
    J Appl Physiol (1985) 94:941-6. 2003
    ..Thus chronic consumption of an HFS diet results in hypertension and salt sensitivity, which may be in part due to a combination of ROS-mediated NO inactivation and depressed renal nNOS protein expression...
  4. ncbi request reprint Prostate cancer: another aspect of the insulin-resistance syndrome?
    R J Barnard
    Obes Rev 3:303-8. 2002
    ..This needs to be tested with prospective studies...
  5. ncbi request reprint Preclinical models relevant to diet, exercise, and cancer risk
    R James Barnard
    Departments of Physiological Science and Urology, University of California, Los Angeles, Los Angeles, CA 90095 1606, USA
    Recent Results Cancer Res 166:47-61. 2005
    ..Preliminary results from a clinical study with men on "watchful waiting" indicate that the observed in vitro effects of diet and exercise on prostate cancer cell growth also occur in vivo...
  6. doi request reprint Benign prostatic hyperplasia: does lifestyle play a role?
    R James Barnard
    Department of Physiological Science, University of California, Los Angeles, CA 90095 1606, USA
    Phys Sportsmed 37:141-6. 2009
    ..In cell culture studies, this type of lifestyle regimen has recently been shown to reduce the growth of serum-stimulated prostate epithelial cells and the growth of androgen-dependent prostate cancer cell lines...
  7. ncbi request reprint Effects of a low-fat, high-fiber diet and exercise program on breast cancer risk factors in vivo and tumor cell growth and apoptosis in vitro
    R James Barnard
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095 1606, USA
    Nutr Cancer 55:28-34. 2006
    ..These in vivo serum changes slowed the growth and induced apoptosis in serum-stimulated BCa cell lines in vitro...
  8. ncbi request reprint A mechanism to explain how regular exercise might reduce the risk for clinical prostate cancer
    R James Barnard
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, California 90095 1606, USA
    Eur J Cancer Prev 16:415-21. 2007
    ....
  9. ncbi request reprint Prostate cancer prevention by nutritional means to alleviate metabolic syndrome
    R James Barnard
    Department of Physiological Science, University of California, Los Angeles, CA 90096 1606, USA
    Am J Clin Nutr 86:s889-93. 2007
    ..Adopting a low-fat starch diet with daily exercise controls MS and should reduce the risk of prostate cancer...
  10. doi request reprint Effect of diet and exercise intervention on the growth of prostate epithelial cells
    R J Barnard
    Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
    Prostate Cancer Prostatic Dis 11:362-6. 2008
    ..Future prospective trials should address the effects of this lifestyle modification on BPH symptomatology and progression...
  11. ncbi request reprint A low-fat diet and/or strenuous exercise alters the IGF axis in vivo and reduces prostate tumor cell growth in vitro
    R James Barnard
    Department of Physiological Science, University of California Los Angeles, 621 Charles E Young Drive S, Los Angeles, CA 90095 1606, USA
    Prostate 56:201-6. 2003
    ..When Asian men adopt the US lifestyle, clinical prostate cancer increases greatly. Epidemiological data from men in the US indicate that regular activity may reduce the risk for prostate cancer...
  12. ncbi request reprint Exercise reverses the harmful effects of consumption of a high-fat diet on synaptic and behavioral plasticity associated to the action of brain-derived neurotrophic factor
    R Molteni
    Department of Physiological Science, Brain Injury Research Center, University of California at Los Angeles, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 123:429-40. 2004
    ..Results unveil a possible molecular mechanism by which lifestyle factors can interact at a molecular level, and provide information for potential therapeutic applications to decrease the risk imposed by certain lifestyles...
  13. ncbi request reprint Impaired insulin-receptor autophosphorylation is an early defect in fat-fed, insulin-resistant rats
    J F Youngren
    Division of Diabetes and Endocrine Research, Department of Medicine, Mount Zion Medical Center, University of California, San Francisco 94143 1616, USA
    J Appl Physiol (1985) 91:2240-7. 2001
    ..These results demonstrate that high-fat feeding induces insulin resistance in muscle concomitant with a diminished IR signaling capacity, although the mechanism remains unknown...
  14. ncbi request reprint Evidence of an inhibitory effect of diet and exercise on prostate cancer cell growth
    C N Tymchuk
    Department of Physiological Science, University of California-Los Angeles, Los Angeles, CA, USA
    J Urol 166:1185-9. 2001
    ..CONCLUSIONS: A low fat, high fiber diet and exercise intervention resulted in serum changes that significantly reduced the growth of androgen responsive LNCaP prostate cancer cells in vitro...
  15. ncbi request reprint Reversibility of chronic experimental syndrome X by diet modification
    C K Roberts
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095-1527, USA
    Hypertension 37:1323-8. 2001
    ....
  16. ncbi request reprint Effect of diet and exercise intervention on blood pressure, insulin, oxidative stress, and nitric oxide availability
    Christian K Roberts
    Department of Physiological Science, University of California, Los Angeles 90095 1527, USA
    Circulation 106:2530-2. 2002
    ..Diet and exercise can affect blood pressure and atherosclerotic risk...
  17. ncbi request reprint Protective effects of estrogen on gender-specific development of diet-induced hypertension
    C K Roberts
    Department of Physiological Science, University of California, Los Angeles 90095-1606, USA
    J Appl Physiol 91:2005-9. 2001
    ..This protection is lost by OVX and restored by estrogen replacement. Thus hormone status contributes to the delayed onset of diet-induced hypertension in females compared with males...
  18. ncbi request reprint Insulin-like growth factor I (IGF-I) and IGF binding protein-1 modulate prostate cancer cell growth and apoptosis: possible mediators for the effects of diet and exercise on cancer cell survival
    Tung H Ngo
    Department of Physiological Science, University of California, Los Angeles, California 90095, USA
    Endocrinology 144:2319-24. 2003
    ..DE results in a decrease in serum IGF-I with increased IGFBP-1 in vivo that is associated with apoptosis and reduced LNCaP and LAPC-4 prostate cancer cell growth in vitro...
  19. ncbi request reprint Role of testosterone, estradiol, and insulin in diet- and exercise-induced reductions in serum-stimulated prostate cancer cell growth in vitro
    Christopher N Tymchuk
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Nutr Cancer 42:112-6. 2002
    ..Thus other serum changes must also account for the significant reduction in LNCaP cell growth observed using medium with serum from the diet-and-exercise subjects in the cell culture assay...
  20. ncbi request reprint Effect of a short-term diet and exercise intervention on metabolic syndrome in overweight children
    Andrew K Chen
    Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
    Metabolism 55:871-8. 2006
    ..01) and body mass index (33.2 +/- 1.9 vs 31.8 +/- 1.9 kg/m(2), P < .01). These results indicate that a short-term rigorous diet and exercise regimen can reverse metabolic syndrome, even in youth without documented atherosclerosis...
  21. ncbi request reprint Effect of diet and exercise intervention on inflammatory and adhesion molecules in postmenopausal women on hormone replacement therapy and at risk for coronary artery disease
    Julia K Wegge
    Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
    Metabolism 53:377-81. 2004
    ..The rapid improvements may reduce the risk of acute myocardial infarction (MI), and if sustained, these changes may mitigate the risk for atherosclerosis progression and its clinical consequences...
  22. ncbi request reprint Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome
    Christian K Roberts
    Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
    Metabolism 55:928-34. 2006
    ....
  23. ncbi request reprint Correction of long-term diet-induced hypertension and nitrotyrosine accumulation by diet modification
    Christian K Roberts
    Department of Physiological Science, University of California, PO Box 951527, Los Angeles 90095, USA
    Atherosclerosis 163:321-7. 2002
    ..The effects of the HFS diet and subsequent conversion to the LFCC diet on blood pressure appear to be, in part, mediated by changes in NO availability...
  24. ncbi request reprint Effect of diet and exercise on serum insulin, IGF-I, and IGFBP-1 levels and growth of LNCaP cells in vitro (United States)
    Tung H Ngo
    Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
    Cancer Causes Control 13:929-35. 2002
    ..This study was conducted to determine whether a low-fat diet and exercise (DE) intervention may modulate the IGF axis and reduce prostate cancer cell growth in vitro...
  25. ncbi request reprint Long-term effects of diet on leptin, energy intake, and activity in a model of diet-induced obesity
    Christian K Roberts
    Department of Physiological Science, University of California, Los Angeles, California 90095 1527, USA
    J Appl Physiol 93:887-93. 2002
    ....
  26. ncbi request reprint Effect of diet on adipose tissue and skeletal muscle VLDL receptor and LPL: implications for obesity and hyperlipidemia
    Christian K Roberts
    Department of Physiological Science, UCLA, University of California, PO Box 951606, Los Angeles, CA 90095 1606, USA
    Atherosclerosis 161:133-41. 2002
    ..Conversion to a LFCC diet can ameliorate the dyslipidemia and tissue changes induced by long-term HFS diet consumption...
  27. ncbi request reprint Exercise alters the IGF axis in vivo and increases p53 protein in prostate tumor cells in vitro
    Pak Shan Leung
    Department of Physiological Science, University of California, Los Angeles, California 90095, USA
    J Appl Physiol 96:450-4. 2004
    ..These results indicate that exercise training alters serum factors in vivo that increase cellular p53 protein content and is associated with reduced growth and induced apoptosis in LNCaP prostate cancer cells in vitro...
  28. ncbi request reprint Effect of isocaloric low-fat diet on human LAPC-4 prostate cancer xenografts in severe combined immunodeficient mice and the insulin-like growth factor axis
    Tung H Ngo
    Departments of Physiological Science, University of California, Los Angeles, California 90095 1738, USA
    Clin Cancer Res 9:2734-43. 2003
    ....
  29. ncbi request reprint Effect of a diet and exercise intervention on oxidative stress, inflammation and monocyte adhesion in diabetic men
    Christian K Roberts
    Department of Physiological Science, University of California, Los Angeles, CA 90095 1606, USA
    Diabetes Res Clin Pract 73:249-59. 2006
    ..01). A combination of diet and exercise ameliorates oxidative stress, inflammation, and monocyte-endothelial interaction. Intensive lifestyle modification may improve novel CAD risk factors in men with diabetes...
  30. ncbi request reprint Effect of a short-term diet and exercise intervention in youth on atherosclerotic risk factors
    Christian K Roberts
    Department of Physiological Science, University of California, 4101 Life Sciences Bldg, 621 Charles E Young Dr South, Los Angeles, CA 90095 1606, USA
    Atherosclerosis 191:98-106. 2007
    ..01), These results indicate amelioration of several traditional as well as novel factors associated with atherosclerosis after lifestyle modification, even in youth without documented disease...
  31. pmc Growth inhibitory effect of low fat diet on prostate cancer cells: results of a prospective, randomized dietary intervention trial in men with prostate cancer
    William J Aronson
    Urology Section, Department of Surgery, Veterans Administration, Greater Los Angeles Healthcare System, Los Angeles, California 90095 1738, USA
    J Urol 183:345-50. 2010
    ..We evaluated the effect of a low fat diet on serum factors affecting prostate cancer cell growth by performing a prospective, randomized dietary intervention trial in men with prostate cancer...
  32. ncbi request reprint Effect of a short-term diet and exercise intervention on inflammatory/anti-inflammatory properties of HDL in overweight/obese men with cardiovascular risk factors
    Christian K Roberts
    Department of Physiological Science, and 2Atherosclerosis Research Unit, University of California, Los Angeles, California 90095, USA
    J Appl Physiol (1985) 101:1727-32. 2006
    ..These data indicate that intensive lifestyle modification improves the function of HDL even in the face of reduced levels, suggesting increased turnover of proinflammatory HDL...
  33. ncbi request reprint Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer
    Allan J Pantuck
    Department of Urology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1738, USA
    Clin Cancer Res 12:4018-26. 2006
    ..We sought to determine the effects of pomegranate juice (a major source of antioxidants) consumption on prostate-specific antigen (PSA) progression in men with a rising PSA following primary therapy...
  34. ncbi request reprint A high-fat, refined-carbohydrate diet induces endothelial dysfunction and oxidant/antioxidant imbalance and depresses NOS protein expression
    Christian K Roberts
    Dept of Physiological Science, University of California Los Angeles, 4101 Life Sciences Bldg, 621 Charles E Young Drive South, Los Angeles, CA 90095 1606, USA
    J Appl Physiol (1985) 98:203-10. 2005
    ..Thus nitric oxide deficiency combined with antioxidant/oxidant imbalance, appears to be a primary factor in the development of endothelial dysfunction in this model...
  35. ncbi request reprint Effects of exercise and diet on chronic disease
    Christian K Roberts
    Dept of Physiological Science, University of California Los Angeles, 4101 Life Sciences Bldg, 621 Charles E Young Dr South, Los Angeles, CA 90095 1606, USA
    J Appl Physiol (1985) 98:3-30. 2005
    ....
  36. ncbi request reprint Effect of a short-term diet and exercise intervention on oxidative stress, inflammation, MMP-9, and monocyte chemotactic activity in men with metabolic syndrome factors
    Christian K Roberts
    Department of Physiological Science, University of California, Los Angeles, CA 90095 1606, USA
    J Appl Physiol (1985) 100:1657-65. 2006
    ..Nine of 15 were no longer positive for metabolic syndrome postintervention. Intensive lifestyle modification may ameliorate novel coronary artery disease risk factors in men with metabolic syndrome factors before reversal of obesity...
  37. ncbi request reprint Effect of isocaloric low-fat diet on prostate cancer xenograft progression to androgen independence
    Tung H Ngo
    Department of Physiological Science, University of California Los Angeles, Los Angeles, CA 90095, USA
    Cancer Res 64:1252-4. 2004
    ..Reduced dietary fat intake delayed conversion from androgen-sensitive to -insensitive prostate cancer and significantly prolonged survival of severe combined immunodeficient mice bearing LAPC-4 xenografts...
  38. ncbi request reprint HMG-CoA reductase, cholesterol 7alpha-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome X
    Christian K Roberts
    Department of Physiological Science, University of California, Los Angeles, California, USA
    Kidney Int 66:1503-11. 2004
    ..While plasma lipid abnormalities in syndrome X have been well characterized, their molecular basis remains unclear. This study explored potential mechanisms of hypercholesterolemia in diet-induced syndrome X...
  39. ncbi request reprint A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning
    R Molteni
    Department of Physiological Science, University of California at Los Angeles, 621 Charles E Young Drive, 90095, USA
    Neuroscience 112:803-14. 2002
    ..Our results indicate that a popularly consumed diet can influence crucial aspects of neuronal and behavioral plasticity associated with the function of BDNF...
  40. pmc Effect of low-fat diet on development of prostate cancer and Akt phosphorylation in the Hi-Myc transgenic mouse model
    Naoko Kobayashi
    Department of Urology, School of Medicine, University of California, Los Angeles, CA 90095 1738, USA
    Cancer Res 68:3066-73. 2008
    ..We conclude that dietary fat reduction delays transition from mPIN to invasive cancer in this Myc-driven transgenic mouse model, possibly through suppression of the IGF-Akt pathway and decreased proliferation of mPIN epithelial cells...
  41. ncbi request reprint Relationship of dietary protein and soy isoflavones to serum IGF-1 and IGF binding proteins in the Prostate Cancer Lifestyle Trial
    Antonella Dewell
    Preventive Medicine Research Institute, 900 Bridgeway, Sausalito, CA 94965, USA
    Nutr Cancer 58:35-42. 2007
    ....
  42. ncbi request reprint Intensive lifestyle changes may affect the progression of prostate cancer
    Dean Ornish
    Department of Medicine, Preventive Medicine Research Institute, University of California San Francisco, 94965, USA
    J Urol 174:1065-9; discussion 1069-70. 2005
    ..Therefore, we evaluated the effects of comprehensive lifestyle changes on prostate specific antigen (PSA), treatment trends and serum stimulated LNCaP cell growth in men with early, biopsy proven prostate cancer after 1 year...
  43. ncbi request reprint Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumption
    Susanne M Henning
    Department of Pathology, VA West Los Angeles, CA 90073, USA
    J Nutr 136:1839-43. 2006
    ..001) and GT (P = 0.025) consumption relative to baseline serum This is the first human study to show that tea polyphenols and theaflavins are bioavailable in the prostate where they may be active in the prevention of prostate cancer...
  44. ncbi request reprint Low-carbohydrate diets as compared with low-fat diets
    Christian K Roberts
    N Engl J Med 349:1000-2; author reply 1000-2. 2003