Research Topics
Species | R J BarnardSummaryAffiliation: University of California Country: USA Publications
| Collaborators
|
Detail Information
Publications
Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2Naoko Kobayashi
Department of Urology, Division of Clinical Nutrition and Hematology-Oncology, University of California, Los Angeles School of Medicine, 90095-1738, USA
Clin Cancer Res 12:4662-70. 2006....
A high-fat, refined-carbohydrate diet affects renal NO synthase protein expression and salt sensitivityChristian K Roberts
Department of Physiological Science, University of California, Los Angeles 90095, USA
J Appl Physiol 94:941-6. 2003..Thus chronic consumption of an HFS diet results in hypertension and salt sensitivity, which may be in part due to a combination of ROS-mediated NO inactivation and depressed renal nNOS protein expression...- Prostate cancer: another aspect of the insulin-resistance syndrome?R J Barnard
Obes Rev 3:303-8. 2002..This needs to be tested with prospective studies... - Preclinical models relevant to diet, exercise, and cancer riskR James Barnard
Departments of Physiological Science and Urology, University of California, Los Angeles, Los Angeles, CA 90095 1606, USA
Recent Results Cancer Res 166:47-61. 2005..Preliminary results from a clinical study with men on "watchful waiting" indicate that the observed in vitro effects of diet and exercise on prostate cancer cell growth also occur in vivo... 
Benign prostatic hyperplasia: does lifestyle play a role?R James Barnard
Department of Physiological Science, University of California, Los Angeles, CA 90095 1606, USA
Phys Sportsmed 37:141-6. 2009..In cell culture studies, this type of lifestyle regimen has recently been shown to reduce the growth of serum-stimulated prostate epithelial cells and the growth of androgen-dependent prostate cancer cell lines...- Effects of a low-fat, high-fiber diet and exercise program on breast cancer risk factors in vivo and tumor cell growth and apoptosis in vitroR James Barnard
Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095 1606, USA
Nutr Cancer 55:28-34. 2006..These in vivo serum changes slowed the growth and induced apoptosis in serum-stimulated BCa cell lines in vitro... - A mechanism to explain how regular exercise might reduce the risk for clinical prostate cancerR James Barnard
Department of Physiological Science, University of California, Los Angeles, Los Angeles, California 90095 1606, USA
Eur J Cancer Prev 16:415-21. 2007.... - Prostate cancer prevention by nutritional means to alleviate metabolic syndromeR James Barnard
Department of Physiological Science, University of California, Los Angeles, CA 90096 1606, USA
Am J Clin Nutr 86:s889-93. 2007..Adopting a low-fat starch diet with daily exercise controls MS and should reduce the risk of prostate cancer... - Effect of diet and exercise intervention on the growth of prostate epithelial cellsR J Barnard
Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
Prostate Cancer Prostatic Dis 11:362-6. 2008..Future prospective trials should address the effects of this lifestyle modification on BPH symptomatology and progression... - A low-fat diet and/or strenuous exercise alters the IGF axis in vivo and reduces prostate tumor cell growth in vitroR James Barnard
Department of Physiological Science, University of California Los Angeles, 621 Charles E Young Drive S, Los Angeles, CA 90095 1606, USA
Prostate 56:201-6. 2003..When Asian men adopt the US lifestyle, clinical prostate cancer increases greatly. Epidemiological data from men in the US indicate that regular activity may reduce the risk for prostate cancer... - Exercise reverses the harmful effects of consumption of a high-fat diet on synaptic and behavioral plasticity associated to the action of brain-derived neurotrophic factorR Molteni
Department of Physiological Science, Brain Injury Research Center, University of California at Los Angeles, 621 Charles E. Young Drive, Los Angeles, CA 90095, USA
Neuroscience 123:429-40. 2004..Results unveil a possible molecular mechanism by which lifestyle factors can interact at a molecular level, and provide information for potential therapeutic applications to decrease the risk imposed by certain lifestyles... - Impaired insulin-receptor autophosphorylation is an early defect in fat-fed, insulin-resistant ratsJ F Youngren
Division of Diabetes and Endocrine Research, Department of Medicine, Mount Zion Medical Center, University of California, San Francisco 94143 1616, USA
J Appl Physiol 91:2240-7. 2001..These results demonstrate that high-fat feeding induces insulin resistance in muscle concomitant with a diminished IR signaling capacity, although the mechanism remains unknown... - Evidence of an inhibitory effect of diet and exercise on prostate cancer cell growthC N Tymchuk
Department of Physiological Science, University of California-Los Angeles, Los Angeles, CA, USA
J Urol 166:1185-9. 2001..CONCLUSIONS: A low fat, high fiber diet and exercise intervention resulted in serum changes that significantly reduced the growth of androgen responsive LNCaP prostate cancer cells in vitro... - Reversibility of chronic experimental syndrome X by diet modificationC K Roberts
Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095-1527, USA
Hypertension 37:1323-8. 2001.... - Effect of diet and exercise intervention on blood pressure, insulin, oxidative stress, and nitric oxide availabilityChristian K Roberts
Department of Physiological Science, University of California, Los Angeles 90095-1527, USA
Circulation 106:2530-2. 2002..CONCLUSIONS: This intervention resulted in dramatic improvements in BP, oxidative stress, NO availability, and the metabolic profile within 3 weeks, mitigating the risk for atherosclerosis progression and its clinical sequelae... - Protective effects of estrogen on gender-specific development of diet-induced hypertensionC K Roberts
Department of Physiological Science, University of California, Los Angeles 90095-1606, USA
J Appl Physiol 91:2005-9. 2001..This protection is lost by OVX and restored by estrogen replacement. Thus hormone status contributes to the delayed onset of diet-induced hypertension in females compared with males... - Insulin-like growth factor I (IGF-I) and IGF binding protein-1 modulate prostate cancer cell growth and apoptosis: possible mediators for the effects of diet and exercise on cancer cell survivalTung H Ngo
Department of Physiological Science, University of California, Los Angeles, California 90095, USA
Endocrinology 144:2319-24. 2003..DE results in a decrease in serum IGF-I with increased IGFBP-1 in vivo that is associated with apoptosis and reduced LNCaP and LAPC-4 prostate cancer cell growth in vitro... - Effect of a short-term diet and exercise intervention on metabolic syndrome in overweight childrenAndrew K Chen
Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
Metabolism 55:871-8. 2006..01) and body mass index (33.2 +/- 1.9 vs 31.8 +/- 1.9 kg/m(2), P < .01). These results indicate that a short-term rigorous diet and exercise regimen can reverse metabolic syndrome, even in youth without documented atherosclerosis... - Role of testosterone, estradiol, and insulin in diet- and exercise-induced reductions in serum-stimulated prostate cancer cell growth in vitroChristopher N Tymchuk
Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA
Nutr Cancer 42:112-6. 2002..Thus other serum changes must also account for the significant reduction in LNCaP cell growth observed using medium with serum from the diet-and-exercise subjects in the cell culture assay... - Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndromeChristian K Roberts
Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
Metabolism 55:928-34. 2006.... - Effect of diet and exercise intervention on inflammatory and adhesion molecules in postmenopausal women on hormone replacement therapy and at risk for coronary artery diseaseJulia K Wegge
Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
Metabolism 53:377-81. 2004..The rapid improvements may reduce the risk of acute myocardial infarction (MI), and if sustained, these changes may mitigate the risk for atherosclerosis progression and its clinical consequences... - Correction of long-term diet-induced hypertension and nitrotyrosine accumulation by diet modificationChristian K Roberts
Department of Physiological Science, University of California, PO Box 951527, Los Angeles 90095, USA
Atherosclerosis 163:321-7. 2002..The effects of the HFS diet and subsequent conversion to the LFCC diet on blood pressure appear to be, in part, mediated by changes in NO availability... - Effect of diet and exercise on serum insulin, IGF-I, and IGFBP-1 levels and growth of LNCaP cells in vitro (United States)Tung H Ngo
Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
Cancer Causes Control 13:929-35. 2002..CONCLUSIONS: A low-fat diet and exercise intervention induces in-vivo changes in the circulating IGF axis and is associated with reduced growth and enhanced apoptosis/necrosis of LNCaP tumor cells in vitro... - Effect of isocaloric low-fat diet on human LAPC-4 prostate cancer xenografts in severe combined immunodeficient mice and the insulin-like growth factor axisTung H Ngo
Departments of Physiological Science, University of California, Los Angeles, California 90095 1738, USA
Clin Cancer Res 9:2734-43. 2003.... - Long-term effects of diet on leptin, energy intake, and activity in a model of diet-induced obesityChristian K Roberts
Department of Physiological Science, University of California, Los Angeles, California 90095-1527, USA
J Appl Physiol 93:887-93. 2002.... - Effect of diet on adipose tissue and skeletal muscle VLDL receptor and LPL: implications for obesity and hyperlipidemiaChristian K Roberts
Department of Physiological Science, UCLA, University of California, PO Box 951606, Los Angeles, CA 90095 1606, USA
Atherosclerosis 161:133-41. 2002..Conversion to a LFCC diet can ameliorate the dyslipidemia and tissue changes induced by long-term HFS diet consumption... - Exercise alters the IGF axis in vivo and increases p53 protein in prostate tumor cells in vitroPak-Shan Leung
Department of Physiological Science, University of California, Los Angeles, California 90095, USA
J Appl Physiol 96:450-4. 2004..These results indicate that exercise training alters serum factors in vivo that increase cellular p53 protein content and is associated with reduced growth and induced apoptosis in LNCaP prostate cancer cells in vitro... - Effect of a diet and exercise intervention on oxidative stress, inflammation and monocyte adhesion in diabetic menChristian K Roberts
Department of Physiological Science, University of California, Los Angeles, CA 90095 1606, USA
Diabetes Res Clin Pract 73:249-59. 2006..01). A combination of diet and exercise ameliorates oxidative stress, inflammation, and monocyte-endothelial interaction. Intensive lifestyle modification may improve novel CAD risk factors in men with diabetes... - Effects of exercise and diet on chronic diseaseChristian K Roberts
Dept of Physiological Science, University of California Los Angeles, 4101 Life Sciences Bldg, 621 Charles E Young Dr South, Los Angeles, CA 90095 1606, USA
J Appl Physiol 98:3-30. 2005.... - Effect of a short-term diet and exercise intervention on oxidative stress, inflammation, MMP-9, and monocyte chemotactic activity in men with metabolic syndrome factorsChristian K Roberts
Department of Physiological Science, University of California, Los Angeles, CA 90095 1606, USA
J Appl Physiol 100:1657-65. 2006..Nine of 15 were no longer positive for metabolic syndrome postintervention. Intensive lifestyle modification may ameliorate novel coronary artery disease risk factors in men with metabolic syndrome factors before reversal of obesity... - Growth inhibitory effect of low fat diet on prostate cancer cells: results of a prospective, randomized dietary intervention trial in men with prostate cancerWilliam J Aronson
Urology Section, Department of Surgery, Veterans Administration, Greater Los Angeles Healthcare System, Los Angeles, California 90095 1738, USA
J Urol 183:345-50. 2010..We evaluated the effect of a low fat diet on serum factors affecting prostate cancer cell growth by performing a prospective, randomized dietary intervention trial in men with prostate cancer... - Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancerAllan J Pantuck
Department of Urology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1738, USA
Clin Cancer Res 12:4018-26. 2006..We sought to determine the effects of pomegranate juice (a major source of antioxidants) consumption on prostate-specific antigen (PSA) progression in men with a rising PSA following primary therapy... - A high-fat, refined-carbohydrate diet induces endothelial dysfunction and oxidant/antioxidant imbalance and depresses NOS protein expressionChristian K Roberts
Dept of Physiological Science, University of California Los Angeles, 4101 Life Sciences Bldg, 621 Charles E Young Drive South, Los Angeles, CA 90095 1606, USA
J Appl Physiol 98:203-10. 2005..Thus nitric oxide deficiency combined with antioxidant/oxidant imbalance, appears to be a primary factor in the development of endothelial dysfunction in this model... - Effect of a short-term diet and exercise intervention on inflammatory/anti-inflammatory properties of HDL in overweight/obese men with cardiovascular risk factorsChristian K Roberts
Department of Physiological Science, and 2Atherosclerosis Research Unit, University of California, Los Angeles, California 90095, USA
J Appl Physiol 101:1727-32. 2006..These data indicate that intensive lifestyle modification improves the function of HDL even in the face of reduced levels, suggesting increased turnover of proinflammatory HDL... - Effect of a short-term diet and exercise intervention in youth on atherosclerotic risk factorsChristian K Roberts
Department of Physiological Science, University of California, 4101 Life Sciences Bldg, 621 Charles E Young Dr South, Los Angeles, CA 90095 1606, USA
Atherosclerosis 191:98-106. 2007..01), These results indicate amelioration of several traditional as well as novel factors associated with atherosclerosis after lifestyle modification, even in youth without documented disease... - Effect of isocaloric low-fat diet on prostate cancer xenograft progression to androgen independenceTung H Ngo
Department of Physiological Science, University of California-Los Angeles, Los Angeles, CA 90095, USA
Cancer Res 64:1252-4. 2004..Reduced dietary fat intake delayed conversion from androgen-sensitive to -insensitive prostate cancer and significantly prolonged survival of severe combined immunodeficient mice bearing LAPC-4 xenografts... - HMG-CoA reductase, cholesterol 7alpha-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome XChristian K Roberts
Department of Physiological Science, University of California, Los Angeles, California, USA
Kidney Int 66:1503-11. 2004..These findings point to impaired hepatic catabolism and uptake of cholesterol and inappropriate cholesterol production capacity as the underlying causes of hypercholesterolemia in rats with diet-induced syndrome X... - A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learningR Molteni
Department of Physiological Science, University of California at Los Angeles, 621 Charles E. Young Drive, 90095, USA
Neuroscience 112:803-14. 2002..Our results indicate that a popularly consumed diet can influence crucial aspects of neuronal and behavioral plasticity associated with the function of BDNF... - Effect of low-fat diet on development of prostate cancer and Akt phosphorylation in the Hi-Myc transgenic mouse modelNaoko Kobayashi
Department of Urology, School of Medicine, University of California, Los Angeles, CA 90095 1738, USA
Cancer Res 68:3066-73. 2008..We conclude that dietary fat reduction delays transition from mPIN to invasive cancer in this Myc-driven transgenic mouse model, possibly through suppression of the IGF-Akt pathway and decreased proliferation of mPIN epithelial cells... - Relationship of dietary protein and soy isoflavones to serum IGF-1 and IGF binding proteins in the Prostate Cancer Lifestyle TrialAntonella Dewell
Preventive Medicine Research Institute, 900 Bridgeway, Sausalito, CA 94965, USA
Nutr Cancer 58:35-42. 2007.... - Low-carbohydrate diets as compared with low-fat dietsChristian K Roberts
N Engl J Med 349:1000-2; author reply 1000-2. 2003 - Intensive lifestyle changes may affect the progression of prostate cancerDean Ornish
Department of Medicine, Preventive Medicine Research Institute, University of California San Francisco, 94965, USA
J Urol 174:1065-9; discussion 1069-70. 2005..Therefore, we evaluated the effects of comprehensive lifestyle changes on prostate specific antigen (PSA), treatment trends and serum stimulated LNCaP cell growth in men with early, biopsy proven prostate cancer after 1 year... - Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumptionSusanne M Henning
Department of Pathology, VA West Los Angeles, CA 90073, USA
J Nutr 136:1839-43. 2006..001) and GT (P = 0.025) consumption relative to baseline serum This is the first human study to show that tea polyphenols and theaflavins are bioavailable in the prostate where they may be active in the prevention of prostate cancer...