Research Topics
| A J BarkovichSummaryAffiliation: University of California Country: USA Publications
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Publications
A developmental and genetic classification for malformations of cortical developmentA J Barkovich
Department of Radiology, University of California, San Francisco, CA, USA
Neurology 65:1873-87. 2005..This classification allows a better conceptual understanding of the disorders, and the use of neuroimaging characteristics allows it to be applied to all patients without necessitating brain biopsy, as in pathology-based classifications...
A familial syndrome of unilateral polymicrogyria affecting the right hemisphereB S Chang
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Neurology 66:133-5. 2006..Core clinical features included contralateral hemiparesis, developmental delay, and focal seizures. The authors' findings suggest that unilateral PMG exists in a familial syndrome of probable germline genetic origin...
MR imaging of the neonatal brainA J Barkovich
Section of Neuroradiology, Department of Radiology, University of California at San Francisco, CA 94143 0628, USA
Neuroimaging Clin N Am 16:117-35, viii-ix. 2006..This article discusses the application of modern MR techniques to some of the causes of encephalopathy in neonates...
Radiologic classification of malformations of cortical developmentA J Barkovich
Section of Neuroradiology, Department of Radiology, L 371, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0628, USA
Curr Opin Neurol 14:145-9. 2001..Characteristics that correlate with and enforce this system of classification can be identified by modern neuroimaging studies...
Magnetic resonance techniques in the assessment of myelin and myelinationA J Barkovich
University of California, San Francisco, California 94143 0628, USA
J Inherit Metab Dis 28:311-43. 2005..The purpose of this review is to provide the reader with the necessary tools for the use of MRI to diagnose and follow patients with leukodystrophies...
An approach to MRI of metabolic disorders in childrenA J Barkovich
Neuroradiology Section, Department of Radiology, University of California at San Francisco, 505 Parnassus Avenue, Room L371, San Francisco, CA 94143 0628, USA
J Neuroradiol 34:75-88. 2007..Proper use of these neuroimaging tools can be very useful for separating these disorders into more manageable groups, and sometimes allows a specific diagnosis to be made...
Neuroimaging in disorders of cortical developmentA James Barkovich
Department of Radiology, University of California at San Francisco, 505 Parnassus Avenue, Box 0628, San Francisco, CA 94143, USA
Neuroimaging Clin N Am 14:231-54, viii. 2004..A better understanding of these disorders helps in genetic counseling of the parents and may help in the treatment of associated epilepsy...
A developmental classification of malformations of the brainstemA James Barkovich
Department of Radiology, Neurology Pediatrics, University of California at San Francisco, San Francisco, CA 94143 0628, USA
Ann Neurol 62:625-39. 2007..With advances in imaging and genetics, malformations of the brainstem are being more commonly identified. We describe and classify brainstem anomalies in 138 patients ascertained over a period of 10 years..
Fetal brain infectionsA James Barkovich
Neuroradiology, Room L371, University of California, 505 Parnassus Avenue, San Francisco, CA 94143 0628, USA
Childs Nerv Syst 19:501-7. 2003..DISCUSSION: This article describes the indications, techniques, and findings that will allow proper use of fetal MRI in the setting of congenital infections...
Diffusion tensor imaging of the pyramidal tracts in infants with motor dysfunctionN A Ludeman
Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
Neurology 71:1676-82. 2008..To determine if diffusion tensor imaging (DTI) metrics of the pyramidal tracts correlate with motor outcome in infants presenting with motor dysfunction...
Three-dimensional proton MR spectroscopic imaging of premature and term neonatesD B Vigneron
Department of Radiology, Magnetic Resonance Science Center, University of California, San Francisco, CA 94143, USA
AJNR Am J Neuroradiol 22:1424-33. 2001..This study also indicates the need for determining topologic and age-matched normative values before metabolic abnormalities in neonates can be accurately assessed by MR spectroscopy...
Variability of homotopic and heterotopic callosal connectivity in partial agenesis of the corpus callosum: a 3T diffusion tensor imaging and Q-ball tractography studyM Wahl
Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94143 0628, USA
AJNR Am J Neuroradiol 30:282-9. 2009..We used tractography based on both diffusion tensor imaging (DTI) and high angular resolution diffusion imaging (HARDI) to investigate interhemispheric white matter connectivity in pAgCC...
Quantitative fiber tracking analysis of the optic radiation correlated with visual performance in premature newbornsJ I Berman
Department of Radiology, University of California San Francisco, San Francisco, California, USA
AJNR Am J Neuroradiol 30:120-4. 2009..Many prematurely born neonates have abnormalities of vision or visual processing. This study tests the hypothesis that a correlation exists between the microstructure of the optic radiation and visual performance in premature neonates...
Brain metabolite levels assessed by lactate-edited MR spectroscopy in premature neonates with and without pentobarbital sedationZ J Wang
Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
AJNR Am J Neuroradiol 29:798-801. 2008..We investigated whether pentobarbital sedation has any effect on the ratios of spectral metabolites lactate, N-acetylaspartate, or choline in a group of premature neonates...
Agenesis of the corpus callosum: an MR imaging analysis of associated abnormalities in the fetusP H Tang
Department of Radiology, University of California, San Francisco, San Francisco, Calif, USA
AJNR Am J Neuroradiol 30:257-63. 2009..This study will assess those anomalies and compare them with postnatal cohorts of ACC, to identify associated fetal brain abnormalities that may give insight into etiology and outcome...
Normative apparent diffusion coefficient values in the developing fetal brainM M Schneider
Departments of Radiology and Biomedical Imaging, Department of Pediatrics, University of California, San Francisco, CA 94143 0628, USA
AJNR Am J Neuroradiol 30:1799-803. 2009....
The normal neonatal brain: MR imaging, diffusion tensor imaging, and 3D MR spectroscopy in healthy term neonatesA I Bartha
Department of Neurology, University of California at San Francisco, CA 94143 0628, USA
AJNR Am J Neuroradiol 28:1015-21. 2007..We report quantitative values from a cohort of healthy term neonates to serve as baseline data for studies assessing brain development and injury...
Diffusion abnormalities and reduced volume of the ventral cingulum bundle in agenesis of the corpus callosum: a 3T imaging studyY Nakata
Department of Radiology, University of California, San Francisco, San Francisco, CA 94143 0628, USA
AJNR Am J Neuroradiol 30:1142-8. 2009..The purpose of this study was to determine whether the ventral cingulum bundle (VCB) is affected in patients with AgCC by using diffusion tensor imaging (DTI) and volumetry...
Diffusion tensor MR imaging tractography of the pyramidal tracts correlates with clinical motor function in children with congenital hemiparesisO A Glenn
Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
AJNR Am J Neuroradiol 28:1796-802. 2007..We hypothesized that the asymmetry correlates with the severity of hemiparesis and that diffusion metrics would be abnormal in the affected tracts and normal in the unaffected tracts...
3D global and regional patterns of human fetal subplate growth determined in uteroJ Corbett-Detig
Biomedical Image Computing Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143 0628, USA
Brain Struct Funct 215:255-63. 2011..During this period, the thickest region was the developing somatosensory/motor cortex. The subplate growth patterns reported here may be used as a baseline for comparison to abnormal fetal brain development...
Classification system for malformations of cortical development: update 2001A J Barkovich
Department of Radiology, University of California, San Francisco, USA
Neurology 57:2168-78. 2001....
Therapeutic hypothermia for neonatal encephalopathy results in improved microstructure and metabolism in the deep gray nucleiS L Bonifacio
Department of Pediatrics, Division of Neonatology, UCSF School of Medicine, 533 Parnassus Ave, Room U 585, Box 0748, San Francisco, CA 94143 0748, USA
AJNR Am J Neuroradiol 33:2050-5. 2012..However, its effects on brain microstructure and metabolism have not been fully characterized. We hypothesized that therapeutic hypothermia improves measures of brain microstructure and metabolism...
Proton spectroscopy and diffusion imaging on the first day of life after perinatal asphyxia: preliminary reportA J Barkovich
Department of Neuroradiology, University of California, San Francisco 94143, USA
AJNR Am J Neuroradiol 22:1786-94. 2001..Further studies are ongoing in an attempt to expand upon this observation...
The role of isotropic diffusion MRI in children under 2 years of ageF M Gelal
Department of Radiology, University of California, 505 Parnassus Avenue L 371, San Francisco, CA 94143 0628, USA
Eur Radiol 11:1006-14. 2001..Diffusion MR is useful in patients with leukodystrophies, metabolic disorders, and patients with acute ischemic lesions...
Quantitative fiber tracking of the optic radiation is correlated with visual-evoked potential amplitude in preterm infantsH C Glass
Department of Pediatrics, University ofCalifornia, San Francisco, San Francisco, CA, USA
AJNR Am J Neuroradiol 31:1424-9. 2010..We examined the relationship between neonatal DTI and sVEP in children born preterm to determine whether visual outcomes are related to early measurements of brain microstructure...
Callosal agenesis with cyst: a better understanding and new classificationA J Barkovich
Neuroradiology Section and Departments of Neurology, Neurological Surgery, and Pediatrics, University of California, San Francisco
Neurology 56:220-7. 2001..To analyze imaging studies of 25 cases of agenesis of the corpus callosum with interhemispheric cyst to assess this malformation itself and associated anomalies...
Magnetic resonance imaging of the fetal brain and spine: an increasingly important tool in prenatal diagnosis, part 1O A Glenn
Department of Radiology, University of California, San Francisco, San Francisco, CA 94143, USA
AJNR Am J Neuroradiol 27:1604-11. 2006..The second part focuses on additional clinical applications of fetal MR imaging, including suspected abnormalities of the corpus callosum, malformations of cortical development, and spine abnormalities...
Multiple risk factors in neonatal sinovenous thrombosisYvonne W Wu
Department of Neurology, University of California San Francisco, 500 Parnassus Avenue, Rm 412, San Francisco, CA 94143 0136, USA
Neurology 59:438-40. 2002..Eighteen neonates had multiple maternal, neonatal, perinatal, or prothrombotic complications. Sinovenous thrombosis was often accompanied by infarction (50%) or intraventricular hemorrhage (33%)...
Sturge-Weber syndrome with no leptomeningeal enhancement on MRIN J Fischbein
Neuroradiology 40:177-80. 1998..We present a case of SWS with no evidence of leptomeningeal enhancement. This case illustrates that leptomeningeal enhancement need not be present in SWS, and the absence of this characteristic finding does not preclude the diagnosis...
Short echo time MR spectroscopic imaging for neonatal pediatric imagingD H Kim
Department of Radiology, University of California at San Francisco, San Francisco, CA 19143, USA
AJNR Am J Neuroradiol 27:1370-2. 2006..Metabolite signal intensity-to-noise ratio < or =40 was acquired in 9 minutes of scan time over an 8 x 8 x 8 spatial matrix with 1 cm(3) isoresolution...
A magnetic resonance approach to metabolic disorders in childhoodA J Barkovich
University of California, San Francisco, USA
Rev Neurol 43:S5-16. 2006..Imaging can aid in diagnosing some disorders, but the imaging findings of many disorders seem to overlap, particularly as more and more disorders are identified and described...
Video-EEG monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermiaK B Nash
Department of Neurology, University of California, San Francisco, USA
Neurology 76:556-62. 2011..Therapeutic hypothermia (TH) is becoming standard of care in newborns with hypoxic-ischemic encephalopathy (HIE). The prognostic value of the EEG and the incidence of seizures during TH are uncertain...
Brain damage from perinatal asphyxia: correlation of MR findings with gestational ageA J Barkovich
Department of Radiology, University of California, San Francisco 94143
AJNR Am J Neuroradiol 11:1087-96. 1990..MR appears to be a powerful tool in the assessment of brain damage resulting from perinatal asphyxia that gives important clues to the time and nature of the asphyxia...
Genomic microarray analysis identifies candidate loci in patients with corpus callosum anomaliesE H Sherr
Department of Neurology, University of California, San Francisco, CA 94143 0748, USA
Neurology 65:1496-8. 2005..Chromosomal deletions and duplications may be a relatively common cause of cerebral malformations...
Endoscopic third ventriculocisternostomy: MR assessment of patency with 2-D cine phase-contrast versus T2-weighted fast spin echo techniqueN J Fischbein
Department of Radiology, University of California at San Francisco, USA
Pediatr Neurosurg 28:70-8. 1998..To determine if fast spin-echo T2 (FSE) is of equal value to flow-sensitive 2D cine phase-contrast (CPC) to assess patency of endoscopic third ventriculocisternostomies (VC)...
Pontine tegmental cap dysplasia: MR imaging and diffusion tensor imaging features of impaired axonal navigationP Jissendi-Tchofo
Department of Radiology, University of California, San Francisco, CA, USA
AJNR Am J Neuroradiol 30:113-9. 2009....
The dorsal cyst in holoprosencephaly and the role of the thalamus in its formationE M Simon
Department of Radiology, The Children s Hospital of Philadelphia, Pennsylvania 19104 4399, USA
Neuroradiology 43:787-91. 2001..07). We speculate that the unseparated thalamus physically blocks egress of cerebrospinal fluid from the third ventricle, resulting in expansion of the posterodorsal portion of the ventricle to form the cyst...
Imaging of ependymomas: MRI and CTE L Yuh
Neuroradiology Section, Department of Radiology, University of California, San Francisco, San Francisco, USA
Childs Nerv Syst 25:1203-13. 2009..Finally, salient imaging features obtained in the postoperative period to evaluate completeness of surgical resection, and thereafter for long-term surveillance for disease recurrence, are reviewed...
Complex fetal disorders: effect of MR imaging on management--preliminary clinical experienceF V Coakley
Department of Radiology, University of California, San Francisco 94143 0628, USA
Radiology 213:691-6. 1999..To determine the effect of magnetic resonance (MR) imaging findings on management of complex fetal disorders...
MR artifact mimicking a temporal lobe lesion in an epilepsy patientP V Mummaneni
Department of Neurosurgery, University of California, San Francisco, Calif 94143 0112, USA
Pediatr Neurosurg 30:203-5. 1999..This case illustrates MR 'wrap around' artifact that mimicked a temporal lobe abnormality in an epilepsy patient. The physics of MR are reviewed as they pertain to this artifact...
MR imaging, MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathyA J Barkovich
Department of Radiology, University of California at San Francisco, San Francisco, Calif 94143-0628, USA
AJNR Am J Neuroradiol 27:533-47. 2006..Awareness of these evolving patterns is essential if studies are performed and interpreted during this critical period of time...
Location of periventricular nodular heterotopia is related to the malformation phenotype on MRIG Gonzalez
Department of Radiology and Biomedical Imaging, University of California, San Francisco, California
AJNR Am J Neuroradiol 34:877-83. 2013..The purpose of this study was to determine whether specific malformation phenotypes may be related to location, side, or number of PNH as assessed by MR imaging...
Visualization of nonstructural changes in early white matter development on diffusion-weighted MR images: evidence supporting premyelination anisotropyD Prayer
Department of Radiology, Section of Neuroradiology, University of Vienna, Austria
AJNR Am J Neuroradiol 22:1572-6. 2001..Visualization of nonstructural "premyelination" consequences with diffusion-weighted imaging emphasizes its sensitivity and potential in studying early processes of brain development...
Developmental differences of the major forebrain commissures in lissencephaliesS Kara
Department of Radiology and Biomedical Imaging, Section of Neuroradiology, University of California at San Francisco, CA, USA
AJNR Am J Neuroradiol 31:1602-7. 2010..We investigated the developmental differences of the commissures in patients with varying types of lissencephaly to determine whether specific commissural features may help in distinguishing lissencephaly phenotypes...
Congenital microcephaly with a simplified gyral pattern: associated findings and their significanceY Adachi
Department of Radiology and Biomedical Imaging, University of California, San Francisco, 94143, USA
AJNR Am J Neuroradiol 32:1123-9. 2011....
Giant congenital melanocytic nevi: the significance of neurocutaneous melanosis in neurologically asymptomatic childrenR D Foster
Division of Plastic and Reconstructive Surgery, Department of Dermatology, University of California, San Francisco, USA
Plast Reconstr Surg 107:933-41. 2001..Although these findings suggest an increased lifetime risk of central nervous system melanoma, they do not signify the eventual development of symptomatic neurocutaneous melanosis during childhood...
Cervical and intracranial arterial anomalies in 70 patients with PHACE syndromeC P Hess
Department of Radiology, University of California, San Francisco, 94143 0628, USA
AJNR Am J Neuroradiol 31:1980-6. 2010....
Seizure-associated brain injury in term newborns with perinatal asphyxiaS P Miller
Department of Neurology, University of California, San Francisco 94143-0628, USA
Neurology 58:542-8. 2002..034). CONCLUSION: The severity of seizures in human newborns with perinatal asphyxia is independently associated with brain injury and is not limited to structural damage detectable by MRI...
Maternal and infant characteristics associated with perinatal arterial stroke in the infantJanet Lee
Department of Neurology, University of California, San Francisco, CA 94117, USA
JAMA 293:723-9. 2005..How these complications, along with their potential effects on the placenta and fetus, may play a role in causing perinatal stroke deserves further study...
MRI shows abnormal white matter maturation in classical holoprosencephalyA J Barkovich
Department of Diagnostic Radiology, University of California, San Francisco 94143, USA
Neurology 59:1968-71. 2002..This study provides further evidence that the classic and MIH variants of HPE have different underlying causes...
Widening spectrum of congenital hemiplegia: Periventricular venous infarction in term neonatesJ Takanashi
Neuroradiology Section, Department of Radiology, University of California San Francisco, USA
Neurology 61:531-3. 2003..Some cases of congenital hemiplegia in term neonates may be due to clinically silent periventricular venous infarction that occurred in utero...
Expansion of the first PolyA tract of ARX causes infantile spasms and status dystonicusR Guerrini
Department of Pediatric Neurosciences, Pediatric Hospital A Meyer and University of Florence, Firenze, Italy
Neurology 69:427-33. 2007....
Diffusion MRI abnormalities after prolonged febrile seizures with encephalopathyJ Takanashi
Department of Pediatrics, Kameda Medical Center, Kamogawa, Japan
Neurology 66:1304-9; discussion 1291. 2006..Patients with encephalopathy heralded by a prolonged seizure as the initial symptom often have abnormal subcortical white matter on diffusion-weighted MRI (DWI)...
New and reliable MRI diagnosis for progressive supranuclear palsyH Oba
Department of Radiology, Teikyo University School of Medicine, Tokyo, Japan
Neurology 64:2050-5. 2005..237). Use of the ratio allowed differentiation between the PSP group and the MSA-P group. CONCLUSION: The area of the midbrain on mid-sagittal MRI can differentiate PSP from PD, MSA-P, and normal aging...
LIS1 and XLIS (DCX) mutations cause most classical lissencephaly, but different patterns of malformationD T Pilz
Department of Human Genetics, University of Chicago, 924 East 57th Street, R113, Chicago, IL 60637, USA
Hum Mol Genet 7:2029-37. 1998..The distinct LIS patterns suggest that LIS1 and XLIS may be part of overlapping, but distinct, signaling pathways that promote neuronal migration...
Clinically mild encephalitis/encephalopathy with a reversible splenial lesionH Tada
Department of Pediatrics, Graduate School of Medicine, Chiba University, Japan
Neurology 63:1854-8. 2004..CONCLUSION: The clinical features among the affected patients were nearly identical, consisting of relatively mild CNS manifestations and complete recovery within 1 month...
The molar tooth sign: a new Joubert syndrome and related cerebellar disorders classification system tested in Egyptian familiesM S Zaki
Clinical Genetics Department, National Research Centre, Neuromotor Institute, Cairo, Egypt
Neurology 70:556-65. 2008..Each family could be classified into one of the four subtypes. This classification may thus be useful in the evaluation of patients with JSRD...
Cortical liquefaction in severe human herpesvirus 6 encephalopathyJ Takanashi
Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba 296-8602, Japan
Neurology 66:452-3. 2006
Widening spectrum of a reversible splenial lesion with transiently reduced diffusionJ Takanashi
Department of Pediatrics, Kameda Medical Center, Kamogawa, Japan
AJNR Am J Neuroradiol 27:836-8. 2006..These and previous observations suggest a less severe course and outcome for patients with reversible lesions isolated to the splenium or to the splenium and peripheral frontoparietal white matter...
Bilateral generalized polymicrogyria (BGP): a distinct syndrome of cortical malformationB S Chang
Division of Neurogenetics, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Neurology 62:1722-8. 2004..The authors describe a new syndrome they have termed "bilateral generalized polymicrogyria" (BGP), in which the malformation occurs in a generalized distribution but is often most severe in the perisylvian regions...
Perinatal stroke in term infants with neonatal encephalopathyV Ramaswamy
Department of Neurology, University of California San Francisco, CA 94143-0663, USA
Neurology 62:2088-91. 2004..These findings suggest that in newborns with encephalopathy, acute focal strokes are an uncommon but serious occurrence with substantial risk for abnormal neurodevelopmental outcome...
Middle interhemispheric variant of holoprosencephaly: a distinct cliniconeuroradiologic subtypeA J Lewis
Stanford University School of Medicine and Lucile Packard Children's Hospital, CA, USA
Neurology 59:1860-5. 2002..CONCLUSION: MIH is a recognizable variant of HPE with differing clinical prognosis. Similar to the lobar subtype by functional measures, MIH differs from classic HPE by the absence of endocrine dysfunction and choreoathetosis...
Polymicrogyria without porencephaly/schizencephaly. MRI analysis of the spectrum and the prevalence of macroscopic findings in the clinical populationN Hayashi
Department of Radiology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Neuroradiology 44:647-55. 2002....
