Research Topics
| Juliet N BarkerSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen-matched unrelated donor bone marrow: results of a matched-pair analysisJ N Barker
Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota School of Medicine, Minneapolis, MN, USA
Blood 97:2957-61. 2001..Therefore, UCB should be considered an acceptable alternative to HLA-matched BM for pediatric patients...- Low incidence of Epstein-Barr virus-associated posttransplantation lymphoproliferative disorders in 272 unrelated-donor umbilical cord blood transplant recipientsJ N Barker
University of Minnesota Medical School, Minneapolis, USA
Biol Blood Marrow Transplant 7:395-9. 2001..Because adoptive immunotherapy with donor lymphocytes is not an available option for recipients of unrelated-donor UCBT, new therapeutic strategies are needed, and rituximab appears promising... - Umbilical cord blood transplantation: current state of the artJuliet N Barker
Department of Medicine, Blood and Marrow Transplant Program, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA
Curr Opin Oncol 14:160-4. 2002.... - Searching for unrelated donor hematopoietic stem cells: availability and speed of umbilical cord blood versus bone marrowJuliet N Barker
Department of Medicine, University of Minnesota School of Medicine, Minneapolis, USA
Biol Blood Marrow Transplant 8:257-60. 2002..These unique features of UCB transplantation must be considered in comparisons of the outcomes of UCB versus BM transplant recipients and in the design of prospective trials comparing URD sources... - Determinants of survival after human leucocyte antigen-matched unrelated donor bone marrow transplantation in adultsJuliet N Barker
The University of Minnesota Blood and Marrow Transplant Program, Minneapolis, MN 55455, USA
Br J Haematol 118:101-7. 2002..Future efforts should focus on improving the outcome for older BMT recipients, especially those with diagnoses other than CML... - Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced-intensity conditioningJuliet N Barker
Divisions of Medical and Pediatric Hematology, Oncology and Transplantation, University of Minnesota Blood and Marrow Transplant Program, Minneapolis, MN, USA
Blood 102:1915-9. 2003..These data demonstrate that 0-2 antigen mismatched UCB is sufficient to engraft most adults after reduced-intensity conditioning and is associated with a low incidence of severe acute GVHD... 
Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic diseaseClaudio G Brunstein
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis MN, USA
Blood 110:3064-70. 2007..01) and use of 2 UCB units (P = .07). These findings support the use of UCB after a nonmyeloablative conditioning as a strategy for extending the availability of transplantation therapy, particularly for older patients...- Reduced intensity compared with high dose conditioning for allotransplantation in acute myeloid leukemia and myelodysplastic syndrome: a comparative clinical analysisCatherine M Flynn
Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Am J Hematol 82:867-72. 2007..Advances in GVHD management and new approaches for relapsed or refractory disease are necessary to improve these outcomes... - Chronic graft-versus-host disease (cGVHD) following unrelated donor hematopoietic stem cell transplantation (HSCT): higher response rate in recipients of unrelated donor (URD) umbilical cord blood (UCB)Mukta Arora
Blood and Marrow Transplant Program, Departments of Medicine and Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
Biol Blood Marrow Transplant 13:1145-52. 2007..In addition, progressive onset of cGVHD was a significant predictor of increased mortality in URD cohort. These data suggest that cGVHD following UCB transplant may be more responsive to therapy and also lead to a lower NRM... - Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensityClaudio G Brunstein
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
Blood 113:5628-34. 2009..8; 95% CI, 1.0-3.1; P = .05). Our results do not support the selection of UCB units based on KIR-L status and suggest that KIR-L mismatching should be avoided in reduced intensity UCB transplantation... - Serious infection risk and immune recovery after double-unit cord blood transplantation without antithymocyte globulinCraig Sauter
Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Biol Blood Marrow Transplant 17:1460-71. 2011.... 
Availability of cord blood extends allogeneic hematopoietic stem cell transplant access to racial and ethnic minoritiesJuliet N Barker
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Biol Blood Marrow Transplant 16:1541-8. 2010..Minority patients in need of allografts, but without suitable matched sibling donors, should be referred for combined URD and CB searches to optimize transplant access...- Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allograftsSharon Avery
Department of Medicine, Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Blood 117:3277-85; quiz 3478. 2011..0001). Our findings have important implications for unit selection and provide further insight into double-unit biology... - Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancyJuliet N Barker
Blood and Marrow Transplant Program, Division of Medical and Pediatric Oncology, University of Minnesota, Box 480, 420 Delaware St SE, Minneapolis, MN 55455, USA
Blood 105:1343-7. 2005..Therefore, transplantation of 2 partially HLA-matched UCB units is safe, and may overcome the cell-dose barrier that limits the use of UCB in many adults and adolescents... - Reduced late mortality risk contributes to similar survival after double-unit cord blood transplantation compared with related and unrelated donor hematopoietic stem cell transplantationDoris M Ponce
Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Biol Blood Marrow Transplant 17:1316-26. 2011..482). These data provide strong support for the further investigation of double-unit CB grafts as an alternative hematopoietic stem cell source... - Allogeneic hematopoietic stem cell transplantation in adult acute lymphocytic leukemia: impact of donor source on survivalPriya Kumar
Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
Biol Blood Marrow Transplant 14:1394-400. 2008..4, 95% CI, 0.2-0.6, P < .01). When compared with URD:M, OS with UCB was better (RR 0.3, 95% CI, 0.1-0.7, P = .01), supporting the use of UCB as an alternative stem cell source for adults with ALL... - Serious infections after unrelated donor transplantation in 136 children: impact of stem cell sourceJuliet N Barker
Division of Medical Hematology, Oncology, and Transplantation, University of Minnesota Blood and Marrow Transplant Program, Minneapolis, Minnesota, USA
Biol Blood Marrow Transplant 11:362-70. 2005..These data suggest that the risk of serious infection after pediatric UCB transplantation is comparable to that with unmanipulated BM... - Long-term follow-up after autologous hematopoietic stem cell transplantation for low-grade non-Hodgkin lymphomaNoel Laudi
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
Biol Blood Marrow Transplant 11:129-35. 2005.... - Marked increased risk of Epstein-Barr virus-related complications with the addition of antithymocyte globulin to a nonmyeloablative conditioning prior to unrelated umbilical cord blood transplantationClaudio G Brunstein
Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Blood 108:2874-80. 2006..Use of ATG in recipients of an NMA preparative regimen warrants close monitoring for evidence of EBV reactivation and potentially preemptive therapy with rituximab... - Unrelated donor hematopoietic cell transplantation: marrow or umbilical cord blood?Satkiran S Grewal
University of Minnesota, 420 Delaware St SE, MMC 477, Minneapolis, MN 55455, USA
Blood 101:4233-44. 2003 - The use of back-up units to enhance the safety of unrelated donor cord blood transplantationDoris M Ponce
Adult Bone Marrow Transplantation, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Biol Blood Marrow Transplant 18:648-51. 2012..We demonstrate that back-up units are emergently required in a significant minority of patients, supporting the incorporation of at least 1 back-up unit in cord blood (CB) selection algorithms to enhance CBT safety... - Randomized comparison of granulocyte colony-stimulating factor versus granulocyte-macrophage colony-stimulating factor plus intensive chemotherapy for peripheral blood stem cell mobilization and autologous transplantation in multiple myelomaMukta Arora
Department of Medicine, University of Minnesota, Minneapolis 55455, USA
Biol Blood Marrow Transplant 10:395-404. 2004..Two cycles of priming chemotherapy plus autologous transplantation yields survival rates similar to those in published reports, including those using tandem transplantation... - Fludarabine vs cladribine plus busulfan and low-dose TBI as reduced intensity conditioning for allogeneic hematopoietic stem cell transplantation: a prospective randomized trialM Markova
Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis, MN, USA
Bone Marrow Transplant 39:193-9. 2007..6 (95% CI 0.2-1.3) P=0.16) and with URD RR 0.4 (0.2-1.0) P=0.04). Older patients with advanced hematologic malignancies achieve satisfactory outcomes using either of these reduced intensity conditioning regimens... - Umbilical-cord blood transplantation for the treatment of cancerJuliet N Barker
Department of Medicine, Blood and Marrow Transplant Program of the University of Minnesota School of Medicine, 420 Delaware Street, S E, Minneapolis, Minnesota 55455, USA
Nat Rev Cancer 3:526-32. 2003..These studies have identified several advantages to umbilical-cord cell transplantation, including a lower incidence of GVHD. Umbilical-cord blood is therefore a promising alternative to bone-marrow-derived stem cells... - Umbilical cord blood transplantation: current practice and future innovationsJuliet N Barker
Department of Medicine, Blood and Marrow Transplant Program of the University of Minnesota School of Medicine, University of Minnesota, MMC 480 UMHC, 420 Delaware Street, SE, Minneapolis, MN 55455, USA
Crit Rev Oncol Hematol 48:35-43. 2003..This review outlines the current status of UCBT with emphasis on current and future innovations... - Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survivalJohn E Wagner
Blood and Marrow Transplant Program of the Department of Pediatrics, University of Minnesota Cancer Center and School of Medicine, Minneapolis 55455, USA
Blood 100:1611-8. 2002..7 x 10(5) CD34(+) cells per kilogram of recipient's body weight. Therefore, graft selection should be based principally on CD34 cell dose when multiple UCB units exist with an HLA disparity of 2 or less... - Intra-BM injection to enhance engraftment after myeloablative umbilical cord blood transplantation with two partially HLA-matched unitsC G Brunstein
University of Minnesota Blood and Marrow Transplant Program, Minneapolis, MN 55455, USA
Bone Marrow Transplant 43:935-40. 2009..Survival was 47% at 1 year. Despite safety of administration, IBMI of one of two UCB units did not shorten the time to neutrophil engraftment and offers no advantage over conventional double unit transplantation... - Relationship of mycophenolic acid exposure to clinical outcome after hematopoietic cell transplantationPamala Jacobson
Department of Experimental and Clinical Pharmacology, WDH 7 189, College of Pharmacy, University of Minnesota, 308 Harvard Street SE, Minneapolis, MN 55455, USA
Clin Pharmacol Ther 78:486-500. 2005..Therapeutic monitoring of MPA concentrations with dose adjustment into the therapeutic target appears to be necessary for the most effective use of mycophenolate mofetil... - Successful treatment of EBV-associated posttransplantation lymphoma after cord blood transplantation using third-party EBV-specific cytotoxic T lymphocytesJuliet N Barker
Department of Medicine, Allogeneic Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Blood 116:5045-9. 2010..Such therapy may also be applicable to the treatment of other infections and residual or recurrent malignancy after CBT... - Cord blood transplants: one, two or more units?Sharon Avery
Department of Medicine, Allogeneic Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Curr Opin Hematol 17:531-7. 2010..This review summarizes the current status of double-unit cord blood transplantation (CBT) to improve engraftment, reduce transplant-related mortality, and improve disease-free survival... - A "no-wash" albumin-dextran dilution strategy for cord blood unit thaw: high rate of engraftment and a low incidence of serious infusion reactionsJuliet N Barker
Department of Medicine, Allogeneic Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Biol Blood Marrow Transplant 15:1596-602. 2009.... - Collection and preservation of cord blood for personal useKaren K Ballen
Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Blood Marrow Transplant 14:356-63. 2008.... - Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemiaMary J Laughlin
Case Comprehensive Cancer Center and University Hospitals of Cleveland Ireland Cancer Center, Cleveland, USA
N Engl J Med 351:2265-75. 2004..CONCLUSIONS: HLA-mismatched cord blood should be considered an acceptable source of hematopoietic stem-cell grafts for adults in the absence of an HLA-matched adult donor... - State of the art review: HLA matching and outcome of unrelated donor umbilical cord blood transplantsNaynesh Kamani
Biol Blood Marrow Transplant 14:1-6. 2008