J M Barker

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-up
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Box B140, Denver, CO 80262
    Diabetes Care 27:1399-404. 2004
  2. pmc Celiac disease: pathophysiology, clinical manifestations, and associated autoimmune conditions
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 N Ursula Street, PO Box 6511 A140, Aurora, CO 80045 6511, USA
    Adv Pediatr 55:349-65. 2008
  3. pmc Two single nucleotide polymorphisms identify the highest-risk diabetes HLA genotype: potential for rapid screening
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Coloradoat Denver, Colorado, USA
    Diabetes 57:3152-5. 2008
  4. ncbi request reprint Effect of oral insulin on insulin autoantibody levels in the Diabetes Prevention Trial Type 1 oral insulin study
    J M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA
    Diabetologia 50:1603-6. 2007
  5. pmc Pre-type 1 diabetes dysmetabolism: maximal sensitivity achieved with both oral and intravenous glucose tolerance testing
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Pediatr 150:31-36.e6. 2007
  6. ncbi request reprint Clinical review: Type 1 diabetes-associated autoimmunity: natural history, genetic associations, and screening
    Jennifer M Barker
    The Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver Health Sciences Center, P O Box 6511 A 140, Aurora, CO 80010, USA
    J Clin Endocrinol Metab 91:1210-7. 2006
  7. ncbi request reprint Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Endocrinol Metab 89:3896-902. 2004
  8. ncbi request reprint Polyendocrine autoimmunity
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 E 9th Avenue Box B140, Denver, CO 80262, USA
    Curr Diab Rep 5:84-90. 2005
  9. ncbi request reprint Endocrine and immunogenetic testing in individuals with type 1 diabetes and 21-hydroxylase autoantibodies: Addison's disease in a high-risk population
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B 140, Denver, Colorado 80262, USA
    J Clin Endocrinol Metab 90:128-34. 2005
  10. ncbi request reprint Autoantibody "subspecificity" in type 1 diabetes: risk for organ-specific autoimmunity clusters in distinct groups
    Jennifer M Barker
    Barbara Davis Center, University of Colorado Health Sciences Center, 4200 E 9th Ave, B140, Denver, CO 80262, USA
    Diabetes Care 28:850-5. 2005

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-up
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Box B140, Denver, CO 80262
    Diabetes Care 27:1399-404. 2004
    ..The objective of this study was to determine whether earlier diagnosis of diabetes in prospectively followed autoantibody-positive children lowered onset morbidity and improved the clinical course after diagnosis...
  2. pmc Celiac disease: pathophysiology, clinical manifestations, and associated autoimmune conditions
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 N Ursula Street, PO Box 6511 A140, Aurora, CO 80045 6511, USA
    Adv Pediatr 55:349-65. 2008
    ..Practitioners can identify groups of subjects at high risk for celiac disease and perform screening with celiac disease-related antibodies...
  3. pmc Two single nucleotide polymorphisms identify the highest-risk diabetes HLA genotype: potential for rapid screening
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Coloradoat Denver, Colorado, USA
    Diabetes 57:3152-5. 2008
    ..We sought to find an inexpensive, rapid test to identify DR3/4-DQ8 subjects using two single nucleotide polymorphisms (SNPs)...
  4. ncbi request reprint Effect of oral insulin on insulin autoantibody levels in the Diabetes Prevention Trial Type 1 oral insulin study
    J M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA
    Diabetologia 50:1603-6. 2007
    ..Our aim was to evaluate insulin autoantibody (IAA) levels over time in the Diabetes Prevention Trial Type 1 (DPT-1) oral insulin study to determine the effect of oral insulin compared with placebo on IAA levels...
  5. pmc Pre-type 1 diabetes dysmetabolism: maximal sensitivity achieved with both oral and intravenous glucose tolerance testing
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Pediatr 150:31-36.e6. 2007
    ....
  6. ncbi request reprint Clinical review: Type 1 diabetes-associated autoimmunity: natural history, genetic associations, and screening
    Jennifer M Barker
    The Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver Health Sciences Center, P O Box 6511 A 140, Aurora, CO 80010, USA
    J Clin Endocrinol Metab 91:1210-7. 2006
    ....
  7. ncbi request reprint Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Endocrinol Metab 89:3896-902. 2004
    ..Predictive value of autoantibodies increases with blinded duplicate and independent sample retesting and incorporation of the level of autoantibody in the predictive algorithm...
  8. ncbi request reprint Polyendocrine autoimmunity
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 E 9th Avenue Box B140, Denver, CO 80262, USA
    Curr Diab Rep 5:84-90. 2005
    ..Care for individuals with these diseases requires monitoring for additional autoimmune disorders and aggressive treatment of identified diseases to prevent morbidity and mortality in affected individuals...
  9. ncbi request reprint Endocrine and immunogenetic testing in individuals with type 1 diabetes and 21-hydroxylase autoantibodies: Addison's disease in a high-risk population
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B 140, Denver, Colorado 80262, USA
    J Clin Endocrinol Metab 90:128-34. 2005
    ..1 had AD-free survival of 60% compared with 100% AD-free survival in those who were not homozygous for MICA5.1. Homozygosity for MICA5.1 may increase progression to overt AD among 21-OHAA-positive individuals...
  10. ncbi request reprint Autoantibody "subspecificity" in type 1 diabetes: risk for organ-specific autoimmunity clusters in distinct groups
    Jennifer M Barker
    Barbara Davis Center, University of Colorado Health Sciences Center, 4200 E 9th Ave, B140, Denver, CO 80262, USA
    Diabetes Care 28:850-5. 2005
    ..The objective of this study was to define the prevalence of these autoantibodies and clinical disease in a population with type 1 diabetes...
  11. pmc Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetes
    Taylor M Triolo
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Health Science Center, Aurora, CO 80045, USA
    J Clin Endocrinol Metab 94:4517-23. 2009
    ..Subjects with type 1 diabetes (T1D) are at increased risk for AD. Genetic factors including HLA-DRB1*0404 and MICA have been associated with AD in populations with and without T1D...
  12. doi request reprint Autoantibodies in type 1 diabetes
    Craig E Taplin
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045 6511, USA
    Autoimmunity 41:11-8. 2008
    ..The number of antibodies, rather than the individual antibody, is thought to be most predictive of progression to overt diabetes...
  13. pmc Haplotype analysis discriminates genetic risk for DR3-associated endocrine autoimmunity and helps define extreme risk for Addison's disease
    Peter R Baker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045 6511, USA
    J Clin Endocrinol Metab 95:E263-70. 2010
    ..Multiple autoimmune disorders (e.g. Addison's disease, type 1 diabetes, celiac disease) are associated with HLA-DR3, but it is likely that alleles of additional genes in linkage disequilibrium with HLA-DRB1 contribute to disease...
  14. pmc Diabetic subjects diagnosed through the Diabetes Prevention Trial-Type 1 (DPT-1) are often asymptomatic with normal A1C at diabetes onset
    Taylor M Triolo
    University of Colorado Denver, Barbara Davis Center for Childhood Diabetes, Aurora, Colorado, USA
    Diabetes Care 32:769-73. 2009
    ..Metabolic tests and the presence of symptoms were described at diabetes onset during the Diabetes Prevention Trial-Type 1 (DPT-1)...
  15. ncbi request reprint Genetic prediction of autoimmunity: initial oligogenic prediction of anti-islet autoimmunity amongst DR3/DR4-DQ8 relatives of patients with type 1A diabetes
    Theresa A Aly
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue B 140, Denver, CO 80262, USA
    J Autoimmun 25:40-5. 2005
    ..These results highlight the multiplicative risk of combined high-risk genotypes at different loci in terms of time to autoantibody and autoimmune disease development...
  16. ncbi request reprint Prevention strategies for type 1 diabetes
    Christopher M Kishiyama
    The Barbara Davis Center for Childhood Diabetes, Denver, CO, USA
    Rev Endocr Metab Disord 7:215-24. 2006
    ..This review article describes the past, current and upcoming strategies for diabetes prevention for patients at risk for developing autoimmunity, after antibody production, and patients with new onset diabetes...
  17. pmc Extreme genetic risk for type 1A diabetes
    Theresa A Aly
    Barbara Davis Center for Childhood Diabetes and Human Medical Genetics Program, University Colorado Health Sciences Center, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 103:14074-9. 2006
    ..A subset of siblings at extremely high risk for T1D can now be identified at birth for trials to prevent islet autoimmunity...
  18. doi request reprint Comparison of insulin autoantibody: polyethylene glycol and micro-IAA 1-day and 7-day assays
    Naru Babaya
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045 6511, USA
    Diabetes Metab Res Rev 25:665-70. 2009
    ..Our standard micro-IAA assay (mIAA) utilizes precipitation with proteins A/G and 1-day incubation (1-day mIAA), but is less sensitive compared to the CIAA assay...
  19. pmc A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140 Building M20, 1775 N Ursula Street, Aurora, CO 80045 6511, USA
    Clin Immunol 125:131-7. 2007
    ..This simple high throughput competitive europium time resolved fluorescence assay had a sensitivity of > or =86% or greater and a specificity of >99.5%...
  20. ncbi request reprint Primary prevention of type 1A diabetes: are we there yet?
    Jennifer M Barker
    Pediatr Diabetes 8:115-6. 2007
  21. ncbi request reprint Preparing for winter: divergence in the summer-autumn hematological profiles from representative species of the squirrel family
    Jennifer M Barker
    Centre for the Neurobiology of Stress, Department of Life Sciences, University of Toronto at Scarborough, Ontario, Canada
    Comp Biochem Physiol A Mol Integr Physiol 142:32-42. 2005
    ..We also found species differences in white blood cell counts that remain unexplained by any single simple explanation and may be more useful for comparison of individuals within a given species than for interspecies comparisons...