Research Topics
Species | J M BarkerSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Detail Information
Publications
Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-upJennifer M Barker
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Box B140, Denver, CO 80262
Diabetes Care 27:1399-404. 2004..The objective of this study was to determine whether earlier diagnosis of diabetes in prospectively followed autoantibody-positive children lowered onset morbidity and improved the clinical course after diagnosis...- Celiac disease: pathophysiology, clinical manifestations, and associated autoimmune conditionsJennifer M Barker
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 N Ursula Street, PO Box 6511 A140, Aurora, CO 80045 6511, USA
Adv Pediatr 55:349-65. 2008..Practitioners can identify groups of subjects at high risk for celiac disease and perform screening with celiac disease-related antibodies... - Two single nucleotide polymorphisms identify the highest-risk diabetes HLA genotype: potential for rapid screeningJennifer M Barker
Barbara Davis Center for Childhood Diabetes, University of Coloradoat Denver, Colorado, USA
Diabetes 57:3152-5. 2008..We sought to find an inexpensive, rapid test to identify DR3/4-DQ8 subjects using two single nucleotide polymorphisms (SNPs)... - Effect of oral insulin on insulin autoantibody levels in the Diabetes Prevention Trial Type 1 oral insulin studyJ M Barker
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA
Diabetologia 50:1603-6. 2007..Our aim was to evaluate insulin autoantibody (IAA) levels over time in the Diabetes Prevention Trial Type 1 (DPT-1) oral insulin study to determine the effect of oral insulin compared with placebo on IAA levels... - Pre-type 1 diabetes dysmetabolism: maximal sensitivity achieved with both oral and intravenous glucose tolerance testingJennifer M Barker
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Pediatr 150:31-36.e6. 2007.... - Clinical review: Type 1 diabetes-associated autoimmunity: natural history, genetic associations, and screeningJennifer M Barker
The Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver Health Sciences Center, P O Box 6511 A 140, Aurora, CO 80010, USA
J Clin Endocrinol Metab 91:1210-7. 2006.... - Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)Jennifer M Barker
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Clin Endocrinol Metab 89:3896-902. 2004..Predictive value of autoantibodies increases with blinded duplicate and independent sample retesting and incorporation of the level of autoantibody in the predictive algorithm... - Polyendocrine autoimmunityJennifer M Barker
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 E 9th Avenue Box B140, Denver, CO 80262, USA
Curr Diab Rep 5:84-90. 2005..Care for individuals with these diseases requires monitoring for additional autoimmune disorders and aggressive treatment of identified diseases to prevent morbidity and mortality in affected individuals... - Endocrine and immunogenetic testing in individuals with type 1 diabetes and 21-hydroxylase autoantibodies: Addison's disease in a high-risk populationJennifer M Barker
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B 140, Denver, Colorado 80262, USA
J Clin Endocrinol Metab 90:128-34. 2005..1 had AD-free survival of 60% compared with 100% AD-free survival in those who were not homozygous for MICA5.1. Homozygosity for MICA5.1 may increase progression to overt AD among 21-OHAA-positive individuals... - Autoantibody "subspecificity" in type 1 diabetes: risk for organ-specific autoimmunity clusters in distinct groupsJennifer M Barker
Barbara Davis Center, University of Colorado Health Sciences Center, 4200 E 9th Ave, B140, Denver, CO 80262, USA
Diabetes Care 28:850-5. 2005..The objective of this study was to define the prevalence of these autoantibodies and clinical disease in a population with type 1 diabetes... - Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetesTaylor M Triolo
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Health Science Center, Aurora, CO 80045, USA
J Clin Endocrinol Metab 94:4517-23. 2009..Subjects with type 1 diabetes (T1D) are at increased risk for AD. Genetic factors including HLA-DRB1*0404 and MICA have been associated with AD in populations with and without T1D... - Autoantibodies in type 1 diabetesCraig E Taplin
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045 6511, USA
Autoimmunity 41:11-8. 2008..The number of antibodies, rather than the individual antibody, is thought to be most predictive of progression to overt diabetes... - Haplotype analysis discriminates genetic risk for DR3-associated endocrine autoimmunity and helps define extreme risk for Addison's diseasePeter R Baker
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045 6511, USA
J Clin Endocrinol Metab 95:E263-70. 2010..Multiple autoimmune disorders (e.g. Addison's disease, type 1 diabetes, celiac disease) are associated with HLA-DR3, but it is likely that alleles of additional genes in linkage disequilibrium with HLA-DRB1 contribute to disease... - Diabetic subjects diagnosed through the Diabetes Prevention Trial-Type 1 (DPT-1) are often asymptomatic with normal A1C at diabetes onsetTaylor M Triolo
University of Colorado Denver, Barbara Davis Center for Childhood Diabetes, Aurora, Colorado, USA
Diabetes Care 32:769-73. 2009..Metabolic tests and the presence of symptoms were described at diabetes onset during the Diabetes Prevention Trial-Type 1 (DPT-1)... - Genetic prediction of autoimmunity: initial oligogenic prediction of anti-islet autoimmunity amongst DR3/DR4-DQ8 relatives of patients with type 1A diabetesTheresa A Aly
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue B 140, Denver, CO 80262, USA
J Autoimmun 25:40-5. 2005..These results highlight the multiplicative risk of combined high-risk genotypes at different loci in terms of time to autoantibody and autoimmune disease development... - Prevention strategies for type 1 diabetesChristopher M Kishiyama
The Barbara Davis Center for Childhood Diabetes, Denver, CO, USA
Rev Endocr Metab Disord 7:215-24. 2006..This review article describes the past, current and upcoming strategies for diabetes prevention for patients at risk for developing autoimmunity, after antibody production, and patients with new onset diabetes... - Extreme genetic risk for type 1A diabetesTheresa A Aly
Barbara Davis Center for Childhood Diabetes and Human Medical Genetics Program, University Colorado Health Sciences Center, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 103:14074-9. 2006..A subset of siblings at extremely high risk for T1D can now be identified at birth for trials to prevent islet autoimmunity... - Comparison of insulin autoantibody: polyethylene glycol and micro-IAA 1-day and 7-day assaysNaru Babaya
Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045 6511, USA
Diabetes Metab Res Rev 25:665-70. 2009..Our standard micro-IAA assay (mIAA) utilizes precipitation with proteins A/G and 1-day incubation (1-day mIAA), but is less sensitive compared to the CIAA assay... - A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1Li Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140 Building M20, 1775 N Ursula Street, Aurora, CO 80045 6511, USA
Clin Immunol 125:131-7. 2007..This simple high throughput competitive europium time resolved fluorescence assay had a sensitivity of > or =86% or greater and a specificity of >99.5%... - Primary prevention of type 1A diabetes: are we there yet?Jennifer M Barker
Pediatr Diabetes 8:115-6. 2007 - Preparing for winter: divergence in the summer-autumn hematological profiles from representative species of the squirrel familyJennifer M Barker
Centre for the Neurobiology of Stress, Department of Life Sciences, University of Toronto at Scarborough, Ontario, Canada
Comp Biochem Physiol A Mol Integr Physiol 142:32-42. 2005..We also found species differences in white blood cell counts that remain unexplained by any single simple explanation and may be more useful for comparison of individuals within a given species than for interspecies comparisons...