Jason David Barbour

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Turning up the volume on mutational pressure: is more of a good thing always better? (A case study of HIV-1 Vif and APOBEC3)
    Satish K Pillai
    Department of Medicine, University of California, San Francisco, CA 94121, USA
    Retrovirology 5:26. 2008
  2. pmc Synergy or independence? Deciphering the interaction of HLA Class I and NK cell KIR alleles in early HIV-1 disease progression
    Jason D Barbour
    HIV AIDS Division, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 3:e43. 2007
  3. pmc High CD8+ T cell activation marks a less differentiated HIV-1 specific CD8+ T cell response that is not altered by suppression of viral replication
    Jason D Barbour
    Department of Medicine, HIV AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 4:e4408. 2009
  4. pmc Evolution of phenotypic drug susceptibility and viral replication capacity during long-term virologic failure of protease inhibitor therapy in human immunodeficiency virus-infected adults
    Jason D Barbour
    Gladstone Institute of Virology and Immunology, Department of Medicine, University of California, San Francisco, California, USA
    J Virol 76:11104-12. 2002
  5. pmc HIV-1/HSV-2 co-infected adults in early HIV-1 infection have elevated CD4+ T cell counts
    Jason D Barbour
    HIV AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e1080. 2007
  6. pmc Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection
    Brian R Long
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, USA
    J Virol 82:4785-92. 2008
  7. ncbi request reprint Greater CD4 T-cell gains after one year of antiretroviral therapy are associated with lower HIV-1 pol replication capacity
    Jason D Barbour
    Positive Health Program, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
    AIDS 20:2123-5. 2006
  8. pmc Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection
    David Favre
    Department of Medicine, Division of Experimental Medicine, University of California, San Francisco, California, United States of America
    PLoS Pathog 5:e1000295. 2009
  9. pmc Increased number and function of natural killer cells in human immunodeficiency virus 1-positive subjects co-infected with herpes simplex virus 2
    Brian R Long
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94110, USA
    Immunology 129:186-96. 2010
  10. pmc A novel human CD4+ T-cell inducer subset with potent immunostimulatory properties
    Lishomwa C Ndhlovu
    Division of Experimental Medicine, Department of Medicine, University of California San Francisco, and HIV AIDS Division, San Francisco General Hospital, San Francisco, CA 94110, USA
    Eur J Immunol 40:134-41. 2010

Detail Information

Publications26

  1. pmc Turning up the volume on mutational pressure: is more of a good thing always better? (A case study of HIV-1 Vif and APOBEC3)
    Satish K Pillai
    Department of Medicine, University of California, San Francisco, CA 94121, USA
    Retrovirology 5:26. 2008
    ..Rigorous testing of this hypothesis will have timely and critical implications for the therapeutic management of HIV/AIDS, and delve into the complexities underlying the induction of lethal mutagenesis in a viral pathogen...
  2. pmc Synergy or independence? Deciphering the interaction of HLA Class I and NK cell KIR alleles in early HIV-1 disease progression
    Jason D Barbour
    HIV AIDS Division, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 3:e43. 2007
  3. pmc High CD8+ T cell activation marks a less differentiated HIV-1 specific CD8+ T cell response that is not altered by suppression of viral replication
    Jason D Barbour
    Department of Medicine, HIV AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 4:e4408. 2009
    ..We hypothesized that anti-retroviral suppression of T cell activation levels would lead to alterations in the T cell differentiation of total and HIV-1 specific CD8+ T cell responses among recently HIV-1 infected adults...
  4. pmc Evolution of phenotypic drug susceptibility and viral replication capacity during long-term virologic failure of protease inhibitor therapy in human immunodeficiency virus-infected adults
    Jason D Barbour
    Gladstone Institute of Virology and Immunology, Department of Medicine, University of California, San Francisco, California, USA
    J Virol 76:11104-12. 2002
    ....
  5. pmc HIV-1/HSV-2 co-infected adults in early HIV-1 infection have elevated CD4+ T cell counts
    Jason D Barbour
    HIV AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e1080. 2007
    ..We examined the impact of HSV-2 status at the time of HIV-1 acquisition for its impact on subsequent clinical course, and total CD4+ T cell phenotypes...
  6. pmc Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection
    Brian R Long
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, USA
    J Virol 82:4785-92. 2008
    ....
  7. ncbi request reprint Greater CD4 T-cell gains after one year of antiretroviral therapy are associated with lower HIV-1 pol replication capacity
    Jason D Barbour
    Positive Health Program, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
    AIDS 20:2123-5. 2006
    ..Viral polRC was measured before starting ART in all subjects. We examined 243 individuals for a median 260 days after initiating ART. Low baseline polRC was associated with greater CD4 T-cell gains independent of virological responses...
  8. pmc Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection
    David Favre
    Department of Medicine, Division of Experimental Medicine, University of California, San Francisco, California, United States of America
    PLoS Pathog 5:e1000295. 2009
    ..The loss of Th17 cells was found to be predictive of systemic and sustained T cell activation. Collectively, these data indicate that loss of the Th17 to Treg balance is related to SIV disease progression...
  9. pmc Increased number and function of natural killer cells in human immunodeficiency virus 1-positive subjects co-infected with herpes simplex virus 2
    Brian R Long
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94110, USA
    Immunology 129:186-96. 2010
    ..This suggests that HSV-2 infection mediates changes within the NK cell population that may affect immunity in HIV-1 infection...
  10. pmc A novel human CD4+ T-cell inducer subset with potent immunostimulatory properties
    Lishomwa C Ndhlovu
    Division of Experimental Medicine, Department of Medicine, University of California San Francisco, and HIV AIDS Division, San Francisco General Hospital, San Francisco, CA 94110, USA
    Eur J Immunol 40:134-41. 2010
    ..We propose that this novel CD4+ T-cell population counterbalances the suppressive activity of suppressor Treg in peripheral blood and serves as a calibrator of immunoregulation...
  11. pmc IL-2 immunotherapy to recently HIV-1 infected adults maintains the numbers of IL-17 expressing CD4+ T (T(H)17) cells in the periphery
    Lishomwa C Ndhlovu
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA, USA
    J Clin Immunol 30:681-92. 2010
    ..However, IL-2-mediated T-reg expansions may selectively reduce responses to certain antigen-specific populations, such as HIV-1 Gag...
  12. ncbi request reprint Duration and predictors of CD4 T-cell gains in patients who continue combination therapy despite detectable plasma viremia
    Steven G Deeks
    UCSF AIDS Program, University of California and San Francisco General Hospital, San Francisco, California 94110, USA
    AIDS 16:201-7. 2002
    ..Sustained elevations in CD4 cell counts commonly occur despite incomplete viral suppression with protease inhibitor-based antiretroviral therapy...
  13. ncbi request reprint Higher frequency of HIV-1-specific T cell immune responses in African American children vertically infected with HIV-1
    Elizabeth R Sharp
    Gladstone Institute of Virology and Immunology, San Francisco General Hospital, University of California, 94158, USA
    J Infect Dis 192:1772-80. 2005
    ..01) than Hispanic children; this was significantly driven by robust responses in African American girls near the age of puberty, many of whom carried the human leukocyte antigen class I B*58 allele...
  14. ncbi request reprint CD4+ T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment with protease inhibitor-based therapy
    Steven G Deeks
    Department of Medicine, University of California at San Francisco and San Francisco General Hospital, San Francisco, CA 94110, USA
    J Infect Dis 185:315-23. 2002
    ..These data indicate that partial virus suppression reduces CD4(+) cell turnover and activation, thereby resulting in sustained CD4(+) cell gains, and that measurements of T cell dynamics may provide an in vivo marker of viral virulence...
  15. pmc Dual pressure from antiretroviral therapy and cell-mediated immune response on the human immunodeficiency virus type 1 protease gene
    Annika C Karlsson
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94141, USA
    J Virol 77:6743-52. 2003
    ..Our results indicate that both HIV type 1-specific CD8(+) T cells and antiretroviral drugs provide complex pressures on the same amino acid sequence of the HIV protease gene and, thus, can influence viral sequence evolution...
  16. pmc Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease
    David Favre
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94110, USA
    Sci Transl Med 2:32ra36. 2010
    ..We postulate that induction of IDO may represent a critical initiating event that results in inversion of the T(H)17/T(reg) balance and in the consequent maintenance of a chronic inflammatory state in progressive HIV disease...
  17. ncbi request reprint The relation between symptoms, viral load, and viral load set point in primary HIV infection
    Colleen F Kelley
    Department of Medicine, San Francisco General Hospital, University of California at San Francisco, 995 Potrero Avenue, San Francisco, CA 94110, USA
    J Acquir Immune Defic Syndr 45:445-8. 2007
    ..To examine the relation between symptoms, initial viral load, and viral load set point in primary HIV infection (PHI)...
  18. ncbi request reprint Natural killer cells in perinatally HIV-1-infected children exhibit less degranulation compared to HIV-1-exposed uninfected children and their expression of KIR2DL3, NKG2C, and NKp46 correlates with disease severity
    Wassim M Ballan
    Division of Experimental Medicine, Department of Medicine, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    J Immunol 179:3362-70. 2007
    ..This finding suggests that NK cells may have an important role in HIV-1 disease pathogenesis in HIV-1-infected children...
  19. pmc Human immunodeficiency virus type 1 superinfection was not detected following 215 years of injection drug user exposure
    Rose Tsui
    Blood Systems Research Institute, University of California, San Francisco, San Francisco, California, USA
    J Virol 78:94-103. 2004
    ..00, 0.79; P = 0.02), indicating that existing infection conferred a statistically significant level of protection against superinfection with an HIV-1 strain of the same subtype, which was between 21 and 100%...
  20. ncbi request reprint HIV-specific CD8+ T cell function in children with vertically acquired HIV-1 infection is critically influenced by age and the state of the CD4+ T cell compartment
    Johan K Sandberg
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141, USA
    J Immunol 170:4403-10. 2003
    ..The results are discussed in relation to differences between the neonatal and adult immune systems in the ability to respond to HIV infection...
  21. pmc Human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T(EMRA) cells in early infection are linked to control of HIV-1 viremia and predict the subsequent viral load set point
    John W Northfield
    Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom
    J Virol 81:5759-65. 2007
    ....
  22. ncbi request reprint Higher CD4+ T cell counts associated with low viral pol replication capacity among treatment-naive adults in early HIV-1 infection
    Jason D Barbour
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA
    J Infect Dis 190:251-6. 2004
    ....
  23. ncbi request reprint Persistence of primary drug resistance among recently HIV-1 infected adults
    Jason D Barbour
    Gladstone Institute of Virology and Immunology, San Francisco, California 94141 9100, USA
    AIDS 18:1683-9. 2004
    ..We sought to determine if primary drug resistance would be lost at a rapid rate, and viral pol replication capacity would increase, in the absence of treatment...
  24. ncbi request reprint The role of viral fitness in HIV pathogenesis
    Jason D Barbour
    Gladstone Institute of Virology and Immunology, 1650 Owens Street, San Francisco, CA 94158, USA
    Curr HIV/AIDS Rep 2:29-34. 2005
    ..The biological basis for elevated CD4+ T-cell counts among those carrying a virus of low pol RC may be because of lowered virus infectivity, or restricted tissue replication...
  25. ncbi request reprint Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormone
    Laura A Napolitano
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, CA 94141, USA
    AIDS 16:1103-11. 2002
    ..To determine whether treatment with growth hormone (GH) enhances thymopoiesis in individuals infected with HIV-1...
  26. ncbi request reprint Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma
    Seth Rakoff-Nahoum
    J D Gladstone Institutes, Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
    AIDS Res Hum Retroviruses 22:52-6. 2006
    ..In summary, we detected T cell reactivity to HERV-K peptides in both past seminoma patients and a minority of apparently healthy controls...

Research Grants6

  1. Variation in Immune Activation in HIV-1 Infected Persons
    Jason Barbour; Fiscal Year: 2007
    ..McCune and Nixon). Their mentorship will help me achieve my goal of developing an independent career in quantitatively oriented translational research, focusing on determination of key elements of HIV-1 pathogenesis. ..
  2. Bioinformatic Mapping of HIV-1 Nef Manipulation of T-Cell Activation and Function
    Jason Barbour; Fiscal Year: 2007
    ..Variation in circulating strains of HIV-1 may account for this variation. We intend to map viral genetic determinants of T cell activation within the HIV-1 Nef protein. ..
  3. Decryption of KIR genetics and function in early HIV-1 infection
    Jason Barbour; Fiscal Year: 2009
    ..By mapping KIR genetics to NK function we hope to identify novel methods for the control of HIV-1. ..
  4. Decryption of KIR genetics and function in early HIV-1 infection
    Jason David Barbour; Fiscal Year: 2010
    ..By mapping KIR genetics to NK function we hope to identify novel methods for the control of HIV-1. ..