Research Topics
Species | Jason David BarbourSummaryAffiliation: University of California Country: USA Publications
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Publications
Turning up the volume on mutational pressure: is more of a good thing always better? (A case study of HIV-1 Vif and APOBEC3)Satish K Pillai
Department of Medicine, University of California, San Francisco, CA 94121, USA
Retrovirology 5:26. 2008..Rigorous testing of this hypothesis will have timely and critical implications for the therapeutic management of HIV/AIDS, and delve into the complexities underlying the induction of lethal mutagenesis in a viral pathogen...- Synergy or independence? Deciphering the interaction of HLA Class I and NK cell KIR alleles in early HIV-1 disease progressionJason D Barbour
HIV AIDS Division, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
PLoS Pathog 3:e43. 2007 - High CD8+ T cell activation marks a less differentiated HIV-1 specific CD8+ T cell response that is not altered by suppression of viral replicationJason D Barbour
Department of Medicine, HIV AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 4:e4408. 2009..We hypothesized that anti-retroviral suppression of T cell activation levels would lead to alterations in the T cell differentiation of total and HIV-1 specific CD8+ T cell responses among recently HIV-1 infected adults... - Evolution of phenotypic drug susceptibility and viral replication capacity during long-term virologic failure of protease inhibitor therapy in human immunodeficiency virus-infected adultsJason D Barbour
Gladstone Institute of Virology and Immunology, Department of Medicine, University of California, San Francisco, California, USA
J Virol 76:11104-12. 2002.... - HIV-1/HSV-2 co-infected adults in early HIV-1 infection have elevated CD4+ T cell countsJason D Barbour
HIV AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 2:e1080. 2007..We examined the impact of HSV-2 status at the time of HIV-1 acquisition for its impact on subsequent clinical course, and total CD4+ T cell phenotypes... - Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infectionBrian R Long
Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, USA
J Virol 82:4785-92. 2008.... 
Greater CD4 T-cell gains after one year of antiretroviral therapy are associated with lower HIV-1 pol replication capacityJason D Barbour
Positive Health Program, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
AIDS 20:2123-5. 2006..Viral polRC was measured before starting ART in all subjects. We examined 243 individuals for a median 260 days after initiating ART. Low baseline polRC was associated with greater CD4 T-cell gains independent of virological responses...- Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infectionDavid Favre
Department of Medicine, Division of Experimental Medicine, University of California, San Francisco, California, United States of America
PLoS Pathog 5:e1000295. 2009..The loss of Th17 cells was found to be predictive of systemic and sustained T cell activation. Collectively, these data indicate that loss of the Th17 to Treg balance is related to SIV disease progression... - Increased number and function of natural killer cells in human immunodeficiency virus 1-positive subjects co-infected with herpes simplex virus 2Brian R Long
Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94110, USA
Immunology 129:186-96. 2010..This suggests that HSV-2 infection mediates changes within the NK cell population that may affect immunity in HIV-1 infection... - A novel human CD4+ T-cell inducer subset with potent immunostimulatory propertiesLishomwa C Ndhlovu
Division of Experimental Medicine, Department of Medicine, University of California San Francisco, and HIV AIDS Division, San Francisco General Hospital, San Francisco, CA 94110, USA
Eur J Immunol 40:134-41. 2010..We propose that this novel CD4+ T-cell population counterbalances the suppressive activity of suppressor Treg in peripheral blood and serves as a calibrator of immunoregulation... - IL-2 immunotherapy to recently HIV-1 infected adults maintains the numbers of IL-17 expressing CD4+ T (T(H)17) cells in the peripheryLishomwa C Ndhlovu
Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA, USA
J Clin Immunol 30:681-92. 2010..However, IL-2-mediated T-reg expansions may selectively reduce responses to certain antigen-specific populations, such as HIV-1 Gag... - Duration and predictors of CD4 T-cell gains in patients who continue combination therapy despite detectable plasma viremiaSteven G Deeks
UCSF AIDS Program, University of California and San Francisco General Hospital, San Francisco, California 94110, USA
AIDS 16:201-7. 2002..Sustained elevations in CD4 cell counts commonly occur despite incomplete viral suppression with protease inhibitor-based antiretroviral therapy... - Higher frequency of HIV-1-specific T cell immune responses in African American children vertically infected with HIV-1Elizabeth R Sharp
Gladstone Institute of Virology and Immunology, San Francisco General Hospital, University of California, 94158, USA
J Infect Dis 192:1772-80. 2005..01) than Hispanic children; this was significantly driven by robust responses in African American girls near the age of puberty, many of whom carried the human leukocyte antigen class I B*58 allele... - CD4+ T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment with protease inhibitor-based therapySteven G Deeks
Department of Medicine, University of California at San Francisco and San Francisco General Hospital, San Francisco, CA 94110, USA
J Infect Dis 185:315-23. 2002..These data indicate that partial virus suppression reduces CD4(+) cell turnover and activation, thereby resulting in sustained CD4(+) cell gains, and that measurements of T cell dynamics may provide an in vivo marker of viral virulence... - Dual pressure from antiretroviral therapy and cell-mediated immune response on the human immunodeficiency virus type 1 protease geneAnnika C Karlsson
Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94141, USA
J Virol 77:6743-52. 2003..Our results indicate that both HIV type 1-specific CD8(+) T cells and antiretroviral drugs provide complex pressures on the same amino acid sequence of the HIV protease gene and, thus, can influence viral sequence evolution... - Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV diseaseDavid Favre
Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94110, USA
Sci Transl Med 2:32ra36. 2010..We postulate that induction of IDO may represent a critical initiating event that results in inversion of the T(H)17/T(reg) balance and in the consequent maintenance of a chronic inflammatory state in progressive HIV disease... - The relation between symptoms, viral load, and viral load set point in primary HIV infectionColleen F Kelley
Department of Medicine, San Francisco General Hospital, University of California at San Francisco, 995 Potrero Avenue, San Francisco, CA 94110, USA
J Acquir Immune Defic Syndr 45:445-8. 2007..To examine the relation between symptoms, initial viral load, and viral load set point in primary HIV infection (PHI)... - Natural killer cells in perinatally HIV-1-infected children exhibit less degranulation compared to HIV-1-exposed uninfected children and their expression of KIR2DL3, NKG2C, and NKp46 correlates with disease severityWassim M Ballan
Division of Experimental Medicine, Department of Medicine, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
J Immunol 179:3362-70. 2007..This finding suggests that NK cells may have an important role in HIV-1 disease pathogenesis in HIV-1-infected children... - Human immunodeficiency virus type 1 superinfection was not detected following 215 years of injection drug user exposureRose Tsui
Blood Systems Research Institute, University of California, San Francisco, San Francisco, California, USA
J Virol 78:94-103. 2004..00, 0.79; P = 0.02), indicating that existing infection conferred a statistically significant level of protection against superinfection with an HIV-1 strain of the same subtype, which was between 21 and 100%... - HIV-specific CD8+ T cell function in children with vertically acquired HIV-1 infection is critically influenced by age and the state of the CD4+ T cell compartmentJohan K Sandberg
Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141, USA
J Immunol 170:4403-10. 2003..The results are discussed in relation to differences between the neonatal and adult immune systems in the ability to respond to HIV infection... - Human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T(EMRA) cells in early infection are linked to control of HIV-1 viremia and predict the subsequent viral load set pointJohn W Northfield
Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom
J Virol 81:5759-65. 2007.... - Higher CD4+ T cell counts associated with low viral pol replication capacity among treatment-naive adults in early HIV-1 infectionJason D Barbour
Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA
J Infect Dis 190:251-6. 2004..The pol RC value of 43% may represent a threshold below which HIV-1 has lowered virulence and is less able to deplete CD4(+) T cell counts... - Persistence of primary drug resistance among recently HIV-1 infected adultsJason D Barbour
Gladstone Institute of Virology and Immunology, San Francisco, California 94141-9100, USA
AIDS 18:1683-9. 2004..Surveillance and clinical detection of primary resistance is feasible in the first year of infection... - The role of viral fitness in HIV pathogenesisJason D Barbour
Gladstone Institute of Virology and Immunology, 1650 Owens Street, San Francisco, CA 94158, USA
Curr HIV/AIDS Rep 2:29-34. 2005..The biological basis for elevated CD4+ T-cell counts among those carrying a virus of low pol RC may be because of lowered virus infectivity, or restricted tissue replication... - Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormoneLaura A Napolitano
Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, CA 94141, USA
AIDS 16:1103-11. 2002..CONCLUSION: GH has significant effects on the human immune system, including the reversal of thymic atrophy in HIV-1-infected adults. De-novo T cell production may thus be inducible in immunodeficient adults... - Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminomaSeth Rakoff-Nahoum
J.D. Gladstone Institutes, Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
AIDS Res Hum Retroviruses 22:52-6. 2006..In summary, we detected T cell reactivity to HERV-K peptides in both past seminoma patients and a minority of apparently healthy controls...
Research Grants
- Variation in Immune Activation in HIV-1 Infected PersonsJason Barbour; Fiscal Year: 2007..McCune and Nixon). Their mentorship will help me achieve my goal of developing an independent career in quantitatively oriented translational research, focusing on determination of key elements of HIV-1 pathogenesis. ..
- Bioinformatic Mapping of HIV-1 Nef Manipulation of T-Cell Activation and FunctionJason Barbour; Fiscal Year: 2007..Variation in circulating strains of HIV-1 may account for this variation. We intend to map viral genetic determinants of T cell activation within the HIV-1 Nef protein. ..
- Decryption of KIR genetics and function in early HIV-1 infectionJason Barbour; Fiscal Year: 2009..By mapping KIR genetics to NK function we hope to identify novel methods for the control of HIV-1. ..
- Decryption of KIR genetics and function in early HIV-1 infectionJason David Barbour; Fiscal Year: 2010..By mapping KIR genetics to NK function we hope to identify novel methods for the control of HIV-1. ..