A G Barbour


Affiliation: University of California
Country: USA


  1. Barbour A, Restrepo B. Antigenic variation in vector-borne pathogens. Emerg Infect Dis. 2000;6:449-57 pubmed
    ..Antigenic variation poses a challenge in the development of vaccines against vector-borne pathogens. ..
  2. Barbour A, Bundoc V. In vitro and in vivo neutralization of the relapsing fever agent Borrelia hermsii with serotype-specific immunoglobulin M antibodies. Infect Immun. 2001;69:1009-15 pubmed
    ..The study established that a Vlp protein was the target of a neutralizing antibody response, and it also indicated that the conformation and/or the native topology of Vlp were important for eliciting that immunity. ..
  3. Barbour A, Bunikis J, Fish D, Hanincová K. Association between body size and reservoir competence of mammals bearing Borrelia burgdorferi at an endemic site in the northeastern United States. Parasit Vectors. 2015;8:299 pubmed publisher
    ..These empirical findings as well as inferences from modeling suggest that small mammals on the basis of their sizes are more competent as reservoirs of B. burgdorferi in this environment than medium-to large-sized mammals. ..
  4. Barbour A, Jasinskas A, Kayala M, Davies D, Steere A, Baldi P, et al. A genome-wide proteome array reveals a limited set of immunogens in natural infections of humans and white-footed mice with Borrelia burgdorferi. Infect Immun. 2008;76:3374-89 pubmed publisher
    ..These results indicate that the majority of deduced proteins of B. burgdorferi do not elicit antibody responses during infection and that the limited sets of immunogens are similar for two different host species. ..
  5. Cook V, Barbour A. Broad diversity of host responses of the white-footed mouse Peromyscus leucopus to Borrelia infection and antigens. Ticks Tick Borne Dis. 2015;6:549-58 pubmed publisher
    ..The study demonstrated the diversity of host responses to infection and immunization in this species and identified quantitative traits that may be suitable for forward genetics approaches to reservoir-pathogen interactions. ..
  6. Krause P, Fish D, Narasimhan S, Barbour A. Borrelia miyamotoi infection in nature and in humans. Clin Microbiol Infect. 2015;21:631-9 pubmed publisher
    ..Antibiotics that have been used effectively include doxycycline for uncomplicated B. miyamotoi infection in adults and ceftriaxone or penicillin G for meningoencephalitis. ..
  7. Norris S, Barbour A, Fish D, Diuk Wasser M. Response to Esteve-Gassent et al.: flaB sequences obtained from Texas PCR products are identical to the positive control strain Borrelia burgdorferi B31. Parasit Vectors. 2015;8:310 pubmed publisher
    ..burgdorferi B31 positive control strain. ..
  8. Barbour A, Travinsky B. Evolution and distribution of the ospC Gene, a transferable serotype determinant of Borrelia burgdorferi. MBio. 2010;1: pubmed publisher
  9. Barbour A, Putteet Driver A, Bunikis J. Horizontally acquired genes for purine salvage in Borrelia spp. causing relapsing fever. Infect Immun. 2005;73:6165-8 pubmed
    ..These were located among the rRNA genes. Phylogenetic analysis indicated that these genes had a different evolutionary history than those of orthologs in other spirochetes. ..

More Information


  1. Barbour A. Chromosome and Plasmids of the Tick-Borne Relapsing Fever Agent Borrelia hermsii. Genome Announc. 2016;4: pubmed publisher
    ..Application of combined long-read and short-read next-generation sequencing provided complete sequences for antigen-encoding plasmids as well as other linear and circular plasmids and the linear chromosome of the genome. ..
  2. Barbour A. Infection resistance and tolerance in Peromyscus spp., natural reservoirs of microbes that are virulent for humans. Semin Cell Dev Biol. 2017;61:115-122 pubmed publisher
  3. Elbir H, Sitlani P, Bergstrom S, Barbour A. Chromosome and Megaplasmid Sequences of Borrelia anserina (Sakharoff 1891), the Agent of Avian Spirochetosis and Type Species of the Genus. Genome Announc. 2017;5: pubmed publisher
    ..transmitted by argasid ticks. Missing or disrupted genes included a dam methylase and those in the pathway for synthesis of phospholipids from glycerol. ..
  4. Barbour A, Hirsch C, Ghalyanchi Langeroudi A, Meinardi S, Lewis E, Estabragh A, et al. Elevated carbon monoxide in the exhaled breath of mice during a systemic bacterial infection. PLoS ONE. 2013;8:e69802 pubmed publisher
  5. Barbour A, Carter C, Bundoc V, Hinnebusch J. The nucleotide sequence of a linear plasmid of Borrelia burgdorferi reveals similarities to those of circular plasmids of other prokaryotes. J Bacteriol. 1996;178:6635-9 pubmed
    ..The OrfC and OrfE proteins were similar to hypothetical proteins encoded by circular plasmids of B. burgdorferi. The OrfM and OrfN proteins were similar to replication proteins of circular plasmids of other bacteria. ..
  6. Barbour A, Bunikis J, Travinsky B, Hoen A, Diuk Wasser M, Fish D, et al. Niche partitioning of Borrelia burgdorferi and Borrelia miyamotoi in the same tick vector and mammalian reservoir species. Am J Trop Med Hyg. 2009;81:1120-31 pubmed publisher
    ..miyamotoi averaged approximately 0.20 and approximately 0.02, respectively. Co-infections of P. leucopus or I. scapularis with both B. burgdorferi and B. miyamotoi were neither more nor less common than random expectations...
  7. Barbour A, Carter C, Sohaskey C. Surface protein variation by expression site switching in the relapsing fever agent Borrelia hermsii. Infect Immun. 2000;68:7114-21 pubmed
    ..The study confirmed that serotype 33 is distinct from other serotypes of B. hermsii in its biology and demonstrated that B. hermsii can change its major surface protein through switching between two expression sites...
  8. Barbour A, Cook V. Genotyping Strains of Lyme Disease Agents Directly From Ticks, Blood, or Tissue. Methods Mol Biol. 2018;1690:1-11 pubmed publisher
    ..The methods presented here are meant for genotyping directly from ticks and from blood and tissue samples from vertebrates. ..
  9. Crowder C, Ghalyanchi Langeroudi A, Shojaee Estabragh A, Lewis E, Marcsisin R, Barbour A. Pathogen and Host Response Dynamics in a Mouse Model of Borrelia hermsii Relapsing Fever. Vet Sci. 2016;3: pubmed publisher
    ..Immunodeficient mice had higher spirochete burdens and severe anemia, which was accounted for by aggregation of erythrocytes by spirochetes and their partially reversible sequestration in greatly enlarged spleens and elsewhere. ..