Glen Barber

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
    Hiroki Ishikawa
    Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    Nature 455:674-8. 2008
  2. pmc DDX24 negatively regulates cytosolic RNA-mediated innate immune signaling
    Zhe Ma
    Sheila and David Fuente Graduate Program in Cancer Biology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS Pathog 9:e1003721. 2013
  3. doi request reprint STING-dependent cytosolic DNA sensing pathways
    Glen N Barber
    Department of Cell Biology and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA Electronic address
    Trends Immunol 35:88-93. 2014
  4. pmc The STING pathway and regulation of innate immune signaling in response to DNA pathogens
    Hiroki Ishikawa
    Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Rm 511 Papanicolaou Building M700, 1550 NW 10th Ave, Miami, FL 33136, USA
    Cell Mol Life Sci 68:1157-65. 2011
  5. ncbi request reprint Host defense, viruses and apoptosis
    G N Barber
    Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, FL 33136, USA
    Cell Death Differ 8:113-26. 2001
  6. ncbi request reprint Vesicular stomatitis virus as an oncolytic vector
    Glen N Barber
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    Viral Immunol 17:516-27. 2004
  7. ncbi request reprint The NFAR's (nuclear factors associated with dsRNA): evolutionarily conserved members of the dsRNA binding protein family
    Glen N Barber
    Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    RNA Biol 6:35-9. 2009
  8. pmc Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses
    Glen N Barber
    Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, United States
    Curr Opin Immunol 23:10-20. 2011
  9. ncbi request reprint VSV-tumor selective replication and protein translation
    Glen N Barber
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, FL 33136, USA
    Oncogene 24:7710-9. 2005
  10. doi request reprint Cytoplasmic DNA innate immune pathways
    Glen N Barber
    Department of Cell Biology and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Immunol Rev 243:99-108. 2011

Collaborators

  • Hiroki Ishikawa
  • STEPHEN POLYAK
  • A Mayeda
  • Scott E Hensley
  • Eric Greidinger
  • Paul B Fisher
  • Abujiang Pataer
  • Kelly K Hunt
  • Y Iwakura
  • Jack Roth
  • J Yewdell
  • Robert W Hoffman
  • S Chada
  • Stephen G Swisher
  • Siddharth Balachandran
  • Joshua F Heiber
  • Rachel Elsby
  • S Balachandran
  • Marilyn Fernandez
  • Timothy Kottke
  • Thiagarajan Venkataraman
  • Paula A Faria
  • Zhe Ma
  • L R Saunders
  • Heather J Ezelle
  • Mercedes Porosnicu
  • Jill Thompson
  • Kevin Harrington
  • Peter Selby
  • Phonphimon Wongthida
  • Richard G Vile
  • Feorillo Galivo
  • John Chester
  • Heather D Hickman
  • Alan Melcher
  • Jian Qiao
  • Rosa Maria Diaz
  • Ingrid Pfeifer
  • Nicolas P Andrews
  • Alan G Goodman
  • Andrea L Radtke
  • Beatriz M A Fontoura
  • Ayaz M Majid
  • Darren J Perkins
  • Masatsugu Obuchi
  • Dubravka Markovic
  • Xiangxi Xu
  • Robert Moore
  • N L Toomey
  • H J Ezelle
  • Scot R Kimball
  • Graham D Pavitt
  • Xiang Xi Xu
  • Peter Reid
  • Izidor S Lossos
  • Kazuyo Takeda
  • Faith R Murray
  • Cara N Skon
  • Pamela Ryno
  • W David Martin
  • Geoff Hall
  • Joshua Loomis
  • Jack R Bennink
  • Dragan Jevremovic
  • Candice Willmon
  • Daniel R Nussenzveig
  • Marcus J Korth
  • Mary X D O'Riordan
  • Shinobu Saijo
  • Sean C Proll
  • Gisela Caceres
  • Christopher D Pack
  • Shigeru Kakuta
  • Michael G Katze
  • Olivia Perwitasari
  • Laura M Delbridge
  • Matthew J Thomas
  • Vaiva Vezys
  • Maikel Valdes
  • Leslie A Schiff
  • Jennifer A Smith
  • Aron E Lukacher
  • Sangeeta Shah
  • Heather Ezelle
  • Papia Chakraborty
  • Carlos Arana
  • Jan van Deursen
  • Agata Levay
  • Jost Enninga
  • Emmanuel Thomas

Detail Information

Publications42

  1. pmc STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
    Hiroki Ishikawa
    Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    Nature 455:674-8. 2008
    ..Thus, as well as identifying a regulator of innate immune signalling, our results imply a potential role for the translocon in innate signalling pathways activated by select viruses as well as intracellular DNA...
  2. pmc DDX24 negatively regulates cytosolic RNA-mediated innate immune signaling
    Zhe Ma
    Sheila and David Fuente Graduate Program in Cancer Biology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS Pathog 9:e1003721. 2013
    ..Our data provide a new function for DDX24 and help explain innate immune gene regulation, mechanisms that may additionally provide insight into the causes of inflammatory disease. ..
  3. doi request reprint STING-dependent cytosolic DNA sensing pathways
    Glen N Barber
    Department of Cell Biology and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA Electronic address
    Trends Immunol 35:88-93. 2014
    ....
  4. pmc The STING pathway and regulation of innate immune signaling in response to DNA pathogens
    Hiroki Ishikawa
    Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Rm 511 Papanicolaou Building M700, 1550 NW 10th Ave, Miami, FL 33136, USA
    Cell Mol Life Sci 68:1157-65. 2011
    ..Here, we review recent discoveries relating to the detection of foreign DNA, including the importance of the STING and inflammasome pathways and the triggering of innate signaling processes...
  5. ncbi request reprint Host defense, viruses and apoptosis
    G N Barber
    Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, FL 33136, USA
    Cell Death Differ 8:113-26. 2001
    ..This likelihood is additionally underlined by the elaborate strategies developed by viruses to inhibit IFN-antiviral function and the mechanisms of cell death...
  6. ncbi request reprint Vesicular stomatitis virus as an oncolytic vector
    Glen N Barber
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    Viral Immunol 17:516-27. 2004
    ..Collectively, our data and others demonstrate that VSV as well as other RNA viruses could provide a promising and exciting approach to cancer therapy...
  7. ncbi request reprint The NFAR's (nuclear factors associated with dsRNA): evolutionarily conserved members of the dsRNA binding protein family
    Glen N Barber
    Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    RNA Biol 6:35-9. 2009
    ..Evidence indicates that the NFAR proteins play crucial roles in mRNA post-transcriptional regulation, including mRNA stability, export and translation and may also have an important function in host defense...
  8. pmc Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses
    Glen N Barber
    Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, United States
    Curr Opin Immunol 23:10-20. 2011
    ..Here, we review recent discoveries relating to the detection of foreign DNA, including the importance of the STING and AIM2 and the activation of innate signaling pathways...
  9. ncbi request reprint VSV-tumor selective replication and protein translation
    Glen N Barber
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, FL 33136, USA
    Oncogene 24:7710-9. 2005
    ..Using VSV as a model, this review will discuss some of the recent developments in the fields of innate immunity and translational regulation that may help explain mechanisms of viral oncolysis...
  10. doi request reprint Cytoplasmic DNA innate immune pathways
    Glen N Barber
    Department of Cell Biology and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Immunol Rev 243:99-108. 2011
    ....
  11. pmc Potential of vesicular stomatitis virus as an oncolytic therapy for recurrent and drug-resistant ovarian cancer
    Joshua F Heiber
    University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Chin J Cancer 30:805-14. 2011
    ..In this article, we review the development of VSV as a potential therapeutic approach for recurrent or drug-resistant ovarian cancer...
  12. ncbi request reprint The interferons and cell death: guardians of the cell or accomplices of apoptosis?
    G N Barber
    Department of Microbiology and Immunology and the Sylvester Comprehensive Cancer Center, The University of Miami School of Medicine, FL 33136, USA
    Semin Cancer Biol 10:103-11. 2000
    ..Here, we review some of what is known about IFN's ability to invoke programmed cell death as part of an intricate arsenal intended to prevent viral infection and malignant disease...
  13. ncbi request reprint Analyzing the mechanisms of interferon-induced apoptosis using CrmA and hepatitis C virus NS5A
    H J Ezelle
    Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, Florida 33136, USA
    Virology 281:124-37. 2001
    ....
  14. ncbi request reprint Induction of a TRAIL-mediated suicide program by interferon alpha in primary effusion lymphoma
    N L Toomey
    Department of Medicine, University of Miami School of Medicine, Miami, Florida, FL 33136, USA
    Oncogene 20:7029-40. 2001
    ..This novel antiviral approach to Primary Effusion lymphomas is targeted and may represent a highly effective and relatively non-toxic therapy...
  15. ncbi request reprint The 90- and 110-kDa human NFAR proteins are translated from two differentially spliced mRNAs encoded on chromosome 19p13
    L R Saunders
    Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, Florida 33136, USA
    Genomics 71:256-9. 2001
    ..Our studies, the first to elucidate the gene structure and chromosomal assignment of NFAR, establish the genetic basis for future NFAR research in humans...
  16. pmc The alpha subunit of eukaryotic initiation factor 2B (eIF2B) is required for eIF2-mediated translational suppression of vesicular stomatitis virus
    Rachel Elsby
    Department of Cell Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Virol 85:9716-25. 2011
    ..Our data emphasize the importance of eIF2Bα in mediating the eIF2 kinase translation-inhibitory activity and may provide insight into the complex nature of viral oncolysis...
  17. pmc Vesicular stomatitis virus expressing tumor suppressor p53 is a highly attenuated, potent oncolytic agent
    Joshua F Heiber
    Department of Cell Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Virol 85:10440-50. 2011
    ..Our data indicate that VSV incorporating p53 could provide a safe, effective strategy for the design of VSV oncolytic therapeutics and VSV-based vaccines...
  18. ncbi request reprint Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection
    S Balachandran
    Department of Microbiology and Immunology, University of Miami School of Medicine, Florida 33136, USA
    Immunity 13:129-41. 2000
    ..These results show that PKR is an essential component of innate immunity that acts early in host defense prior to the onset of IFN counteraction and the acquired immune response...
  19. pmc Oncolytic activity of vesicular stomatitis virus is effective against tumors exhibiting aberrant p53, Ras, or myc function and involves the induction of apoptosis
    S Balachandran
    Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Virol 75:3474-9. 2001
    ..Our data indicate that VSV shows significant promise as an effective oncolytic agent against a wide variety of malignant diseases that harbor a diversity of genetic defects...
  20. ncbi request reprint Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR
    L R Saunders
    Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 276:32300-12. 2001
    ..Collectively, our data indicate that the NFARs may facilitate double-stranded RNA-regulated gene expression at the level of post-transcription and possibly contribute to host defense-related mechanisms in the cell...
  21. pmc Treg depletion-enhanced IL-2 treatment facilitates therapy of established tumors using systemically delivered oncolytic virus
    Timothy Kottke
    Department of Molecular Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Mol Ther 16:1217-26. 2008
    ..These data demonstrate that it is possible to combine biological therapy with oncolytic virotherapy to generate systemic therapy against established tumors...
  22. ncbi request reprint A FADD-dependent innate immune mechanism in mammalian cells
    Siddharth Balachandran
    Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    Nature 432:401-5. 2004
    ..These data therefore suggest the existence of a conserved pathogen recognition pathway in mammalian cells that is essential for the optimal induction of type I interferons and other genes important for host defence...
  23. ncbi request reprint The oncolytic effect of recombinant vesicular stomatitis virus is enhanced by expression of the fusion cytosine deaminase/uracil phosphoribosyltransferase suicide gene
    Mercedes Porosnicu
    Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    Cancer Res 63:8366-76. 2003
    ....
  24. ncbi request reprint PKR in innate immunity, cancer, and viral oncolysis
    Siddharth Balachandran
    University of Miami School of Medicine, FL, USA
    Methods Mol Biol 383:277-301. 2007
    ..In this chapter, we describe some of the techniques commonly used in our laboratory to examine PKR activity and eIF2 regulation. Protocols for the generation and use of recombinant vesicular stomatitis virus variants are also described...
  25. pmc Development of recombinant vesicular stomatitis viruses that exploit defects in host defense to augment specific oncolytic activity
    Masatsugu Obuchi
    Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Virol 77:8843-56. 2003
    ..Our data indicate that rVSV designed to exploit defects in mechanisms of host defense can provide the basis for new generations of effective, specific, and safer viral vectors for the treatment of malignant and other disease...
  26. pmc The cellular protein P58IPK regulates influenza virus mRNA translation and replication through a PKR-mediated mechanism
    Alan G Goodman
    Department of Microbiology, University of Washington, Box 358070, Seattle, WA 98195 8070, USA
    J Virol 81:2221-30. 2007
    ..Taken together, our results support a model in which P58(IPK) regulates influenza virus mRNA translation and infection through a PKR-mediated mechanism which is independent of PERK...
  27. pmc Generation of hepatitis C virus-like particles by use of a recombinant vesicular stomatitis virus vector
    Heather J Ezelle
    Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Virol 76:12325-34. 2002
    ..Our data collectively indicate that engineered VSVs expressing HCV Core, E1, and E2 and/or HCV-LPs represent useful tools in vaccine and immunotherapeutic strategies designed to address HCV infection...
  28. ncbi request reprint Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses
    Thiagarajan Venkataraman
    Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA
    J Immunol 178:6444-55. 2007
    ..Collectively, our data indicate a disparate regulatory role for LGP2 in the triggering of innate immune signaling pathways following RNA virus infection...
  29. ncbi request reprint Differential tissue targeting of autoimmunity manifestations by autoantigen-associated Y RNAs
    Eric L Greidinger
    Veterans Affairs Medical Center, and the University of Miami Miller School of Medicine, Miami, Florida USA
    Arthritis Rheum 56:1589-97. 2007
    ..To assess the Y RNAs, a family of homologous RNAs that bind to the Ro autoantigen, for the ability to contribute to autoimmune disease by activating RNA-responsive Toll-like receptors (TLRs)...
  30. pmc Genetically engineered vesicular stomatitis virus in gene therapy: application for treatment of malignant disease
    Marilyn Fernandez
    Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Virol 76:895-904. 2002
    ..Our data demonstrate the validity of developing novel types of engineered VSV for recombinant protein production and as a gene therapy vector for the treatment of malignant and other disease...
  31. pmc Evaluating replication-defective vesicular stomatitis virus as a vaccine vehicle
    Ayaz M Majid
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33136, USA
    J Virol 80:6993-7008. 2006
    ..In addition, this strategy may therefore serve in effective vaccine and immunotherapy-based approaches to the treatment of HCV-related disease...
  32. ncbi request reprint A murine model of mixed connective tissue disease induced with U1 small nuclear RNP autoantigen
    Eric L Greidinger
    Division of Rheumatology and Immunology, University of Miami, Miami, Florida 33136, USA
    Arthritis Rheum 54:661-9. 2006
    ..To test whether immunizing mice with autoantigens closely linked to mixed connective tissue disease (MCTD) could induce an MCTD-like clinical syndrome distinguishable from systemic lupus erythematosus (SLE)...
  33. ncbi request reprint Defective translational control facilitates vesicular stomatitis virus oncolysis
    Siddharth Balachandran
    Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA
    Cancer Cell 5:51-65. 2004
    ..Thus, defects in translational regulation can cooperate with impaired IFN signaling to facilitate VSV replication, and may represent a common hallmark of tumorigenesis...
  34. pmc Defects in translational regulation mediated by the alpha subunit of eukaryotic initiation factor 2 inhibit antiviral activity and facilitate the malignant transformation of human fibroblasts
    Darren J Perkins
    Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    Mol Cell Biol 24:2025-40. 2004
    ..Thus, dysregulation of translation initiation is indeed sufficient to cooperate with defined oncogenic elements and participate in the tumorigenesis of human tissue...
  35. pmc NFAR-1 and -2 modulate translation and are required for efficient host defense
    Ingrid Pfeifer
    Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 105:4173-8. 2008
    ....
  36. doi request reprint Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes
    Heather D Hickman
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Nat Immunol 9:155-65. 2008
    ..Thus, antigen presentation at the lymph node periphery, not at lymphocyte exit sites in deeper lymph node venules, as dogma dictates, has a dominant function in antiviral CD8+ T cell activation...
  37. ncbi request reprint Purging metastases in lymphoid organs using a combination of antigen-nonspecific adoptive T cell therapy, oncolytic virotherapy and immunotherapy
    Jian Qiao
    Molecular Medicine Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    Nat Med 14:37-44. 2008
    ..As such, this adoptive transfer could have a great therapeutic impact, in the adjuvant setting, on many different cancer types...
  38. ncbi request reprint Early virus-associated bystander events affect the fitness of the CD8 T cell response to persistent virus infection
    Nicolas P Andrews
    Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 178:7267-75. 2007
    ....
  39. pmc TBK1 protects vacuolar integrity during intracellular bacterial infection
    Andrea L Radtke
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS Pathog 3:e29. 2007
    ..Taken together, these data demonstrate a requirement for TBK1 in control of bacterial infection distinct from its established role in antiviral immunity...
  40. ncbi request reprint Fas-associated death domain-containing protein-mediated antiviral innate immune signaling involves the regulation of Irf7
    Siddharth Balachandran
    Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA
    J Immunol 178:2429-39. 2007
    ..These data indicate that FADD's antiviral activity involves regulation of IRF-7-dependent production of IFN-alpha subtypes and consequent induction of secondary antiviral genes...
  41. ncbi request reprint VSV disrupts the Rae1/mrnp41 mRNA nuclear export pathway
    Paula A Faria
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, FL 33136, USA
    Mol Cell 17:93-102. 2005
    ..Thus, these results demonstrate that VSV M protein blocks mRNA export by disrupting Rae1 function, which can be reverted by induction of Rae1 expression...
  42. ncbi request reprint Melanoma differentiation-associated gene-7 protein physically associates with the double-stranded RNA-activated protein kinase PKR
    Abujiang Pataer
    Department of Thoracic and Cardiovascular Surgery, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 445, Houston, TX 77030, USA
    Mol Ther 11:717-23. 2005
    ....

Research Grants37

  1. A FADD-Associated Helicase Essential for Host Defense
    Glen Barber; Fiscal Year: 2007
    ..We anticipate that these studies will improve our knowledge of pathogenesis and provide new concepts for the rational design of novel therapeutic and vaccine strategies. ..
  2. Mechanisms of VSV-mediated Oncolysis
    Glen N Barber; Fiscal Year: 2010
    ..Understanding how these pathways function has significant impact on understanding pathogenesis and for developing novel therapeutics and vaccines to combat disease. ..
  3. Immunogenicity of Hepatitis C Virus (HCV) like particles
    Glen Barber; Fiscal Year: 2005
    ..abstract_text> ..
  4. Mechanisms of VSV-mediated Oncolysis
    Glen Barber; Fiscal Year: 2004
    ..Our novel data should provide information on the ability of rVSVs to function as a safe therapy for the potential treatment of Cancer. ..
  5. Mechanisms of VSV-mediated Oncolysis
    Glen Barber; Fiscal Year: 2003
    ..Our novel data should provide information on the ability of rVSVs to function as a safe therapy for the potential treatment of Cancer. ..
  6. Targeted Therapy for Burkitt Lymphoma in Resource Poor Settings
    Glen Barber; Fiscal Year: 2009
    ..Our long term goal is to develop a targeted, efficacious, antiviral-based therapy for EBV (HIV) associated lymphoma that is applicable in developing nations. ..
  7. FUNCTION ANALYSIS OF THE DSRNA REGULATED NUCLEAR FACTORS
    Glen Barber; Fiscal Year: 2002
    ..abstract_text> ..
  8. Host Defense and the Regulation of Interferon Production
    Glen N Barber; Fiscal Year: 2010
    ....
  9. Immunogenicity of Hepatitis C Virus (HCV) like particles
    Glen Barber; Fiscal Year: 2007
    ..abstract_text> ..
  10. Role of PKR in Growth Regulation
    Glen Barber; Fiscal Year: 2007
    ..We propose that these aims will lend insight into mechanisms of cell signaling, tumorigenesis and interferon-mediated actions in the cell. ..
  11. Targeted Therapy for Burkitt Lymphoma in Resource Poor Settings
    Glen N Barber; Fiscal Year: 2010
    ..Our long term goal is to develop a targeted, efficacious, antiviral-based therapy for EBV (HIV) associated lymphoma that is applicable in developing nations. ..
  12. Mechanisms of Vesicular Stomatitis Virus-mediated Oncolysis
    Glen Barber; Fiscal Year: 2007
    ..Our novel data should provide information on the ability of rVSVs to function as a safe therapy for the potential treatment of Cancer. ..
  13. Innate Intracellular Mechanisms
    Glen Barber; Fiscal Year: 2009
    ..The importance of STING in innate signaling will be determined. Understanding how these pathways function has significant impact on understanding pathogenesis and for developing novel therapeutics and vaccines to combat disease. ..
  14. Mechanisms of VSV-mediated Oncolysis
    Glen Barber; Fiscal Year: 2009
    ..Understanding how these pathways function has significant impact on understanding pathogenesis and for developing novel therapeutics and vaccines to combat disease. ..
  15. Host Defense and the Regulation of Interferon Production
    Glen Barber; Fiscal Year: 2009
    ....
  16. Mechanisms of VSV-mediated Oncolysis
    Glen Barber; Fiscal Year: 2006
    ..Our novel data should provide information on the ability of rVSVs to function as a safe therapy for the potential treatment of Cancer. ..
  17. ROLE OF PKR IN GROWTH REGULATION AND APOPTOSIS
    Glen Barber; Fiscal Year: 1999
    ..As in the above aims, embryonic fibroblasts and the animals themselves will be examined for their sensitivity or resistance to apoptosis, malignant transformation and viral disease. ..
  18. ROLE OF PKR IN GROWTH REGULATION AND APOPTOSIS
    Glen Barber; Fiscal Year: 2001
    ..As in the above aims, embryonic fibroblasts and the animals themselves will be examined for their sensitivity or resistance to apoptosis, malignant transformation and viral disease. ..
  19. ROLE OF PKR IN GROWTH REGULATION AND APOPTOSIS
    Glen Barber; Fiscal Year: 2002
    ..As in the above aims, embryonic fibroblasts and the animals themselves will be examined for their sensitivity or resistance to apoptosis, malignant transformation and viral disease. ..
  20. ROLE OF PKR IN GROWTH REGULATION AND APOPTOSIS
    Glen Barber; Fiscal Year: 2003
    ..As in the above aims, embryonic fibroblasts and the animals themselves will be examined for their sensitivity or resistance to apoptosis, malignant transformation and viral disease. ..
  21. ROLE OF PKR IN GROWTH REGULATION AND APOPTOSIS
    Glen Barber; Fiscal Year: 2000
    ..As in the above aims, embryonic fibroblasts and the animals themselves will be examined for their sensitivity or resistance to apoptosis, malignant transformation and viral disease. ..
  22. Immunogenicity of Hepatitis C Virus (HCV) like particles
    Glen Barber; Fiscal Year: 2003
    ..abstract_text> ..
  23. FUNCTION ANALYSIS OF THE DSRNA REGULATED NUCLEAR FACTORS
    Glen Barber; Fiscal Year: 2000
    ..abstract_text> ..
  24. Immunogenicity of Hepatitis C Virus (HCV) like particles
    Glen Barber; Fiscal Year: 2004
    ..abstract_text> ..
  25. Role of PKR in Growth Regulation
    Glen Barber; Fiscal Year: 2004
    ..We propose that these aims will lend insight into mechanisms of cell signaling, tumorigenesis and interferon-mediated actions in the cell. ..
  26. Mechanisms of VSV-mediated Oncolysis
    Glen Barber; Fiscal Year: 2005
    ..Our novel data should provide information on the ability of rVSVs to function as a safe therapy for the potential treatment of Cancer. ..
  27. Role of PKR in Growth Regulation
    Glen Barber; Fiscal Year: 2005
    ..We propose that these aims will lend insight into mechanisms of cell signaling, tumorigenesis and interferon-mediated actions in the cell. ..
  28. Immunogenicity of Hepatitis C Virus (HCV) like particles
    Glen Barber; Fiscal Year: 2006
    ..abstract_text> ..
  29. FUNCTION ANALYSIS OF THE DSRNA REGULATED NUCLEAR FACTORS
    Glen Barber; Fiscal Year: 2001
    ..abstract_text> ..
  30. Innate Intracellular Mechanisms
    Glen N Barber; Fiscal Year: 2010
    ..The importance of STING in innate signaling will be determined. Understanding how these pathways function has significant impact on understanding pathogenesis and for developing novel therapeutics and vaccines to combat disease. ..
  31. FUNCTION ANALYSIS OF THE DSRNA REGULATED NUCLEAR FACTORS
    Glen Barber; Fiscal Year: 2003
    ..abstract_text> ..
  32. FUNCTION ANALYSIS OF THE DSRNA REGULATED NUCLEAR FACTORS
    Glen Barber; Fiscal Year: 2004
    ..abstract_text> ..
  33. Role of PKR in Growth Regulation
    Glen Barber; Fiscal Year: 2006
    ..We propose that these aims will lend insight into mechanisms of cell signaling, tumorigenesis and interferon-mediated actions in the cell. ..