Nicholas Barbaro

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint A multicenter, prospective pilot study of gamma knife radiosurgery for mesial temporal lobe epilepsy: seizure response, adverse events, and verbal memory
    Nicholas M Barbaro
    Department of Neurological Surgery, University of California at San Francisco, 94143, USA
    Ann Neurol 65:167-75. 2009
  2. ncbi request reprint Focal cooling suppresses spontaneous epileptiform activity without changing the cortical motor threshold
    Kameel M Karkar
    Department of Neurology University of California, San Francisco, San Francisco, California, U S A
    Epilepsia 43:932-5. 2002
  3. doi request reprint Seizure characteristics and control after microsurgical resection of supratentorial cerebral cavernous malformations
    Edward F Chang
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Neurosurgery 65:31-7; discussion 37-8. 2009
  4. ncbi request reprint Coexpression of angiogenic factors in brain arteriovenous malformations
    Tomoki Hashimoto
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California 94110, USA
    Neurosurgery 56:1058-65; discussion 1058-65. 2005
  5. ncbi request reprint Spontaneous spinal subdural hematoma associated with low-molecular-weight heparin. Case report
    Yoon Hee Cha
    Department of Neurology, University of California at San Francisco, California 94143, USA
    J Neurosurg Spine 2:612-3. 2005
  6. ncbi request reprint Frame-based stereotactic biopsy remains an important diagnostic tool with distinct advantages over frameless stereotactic biopsy
    Justin S Smith
    Department of Neurological Surgery, Brain Tumor Research Center, University of California at San Francisco, 505 Parnassus Avenue, 94143 0112 San Francisco, California, USA
    J Neurooncol 73:173-9. 2005
  7. ncbi request reprint Chronic stimulation of the posterior hypothalamic region for cluster headache: technique and 1-year results in four patients
    Philip A Starr
    Departments of Neurosurgery, University of California at San Francisco, California 94143, USA
    J Neurosurg 106:999-1005. 2007
  8. doi request reprint Preoperative prognostic classification system for hemispheric low-grade gliomas in adults
    Edward F Chang
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 109:817-24. 2008
  9. ncbi request reprint Complications of lumboperitoneal shunts
    Vincent Y Wang
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Neurosurgery 60:1045-8; discussion 1049. 2007
  10. doi request reprint Developing cell transplantation for temporal lobe epilepsy
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143 0112, USA
    Neurosurg Focus 24:E17. 2008

Research Grants

  1. RADIOSURGICAL TREATMENT OF TEMPORAL LOBE EPILEPSY
    Nicholas Barbaro; Fiscal Year: 2002

Detail Information

Publications50

  1. doi request reprint A multicenter, prospective pilot study of gamma knife radiosurgery for mesial temporal lobe epilepsy: seizure response, adverse events, and verbal memory
    Nicholas M Barbaro
    Department of Neurological Surgery, University of California at San Francisco, 94143, USA
    Ann Neurol 65:167-75. 2009
    ..We report the 3-year outcomes of a multicenter, prospective pilot study of RS...
  2. ncbi request reprint Focal cooling suppresses spontaneous epileptiform activity without changing the cortical motor threshold
    Kameel M Karkar
    Department of Neurology University of California, San Francisco, San Francisco, California, U S A
    Epilepsia 43:932-5. 2002
    ..Focal cerebral cooling has been shown to reduce epileptiform activity in animals. There are, however, few reports of this phenomenon in humans...
  3. doi request reprint Seizure characteristics and control after microsurgical resection of supratentorial cerebral cavernous malformations
    Edward F Chang
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Neurosurgery 65:31-7; discussion 37-8. 2009
    ..The optimal management of seizures associated with cerebral cavernous malformations (CCMs) is unclear. The aim of this study was to determine the efficacy of surgery in the management of CCM-associated seizures...
  4. ncbi request reprint Coexpression of angiogenic factors in brain arteriovenous malformations
    Tomoki Hashimoto
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California 94110, USA
    Neurosurgery 56:1058-65; discussion 1058-65. 2005
    ..Therefore, we hypothesized that there are close correlations among key angiogenic factors in BAVMs and that levels of key angiogenic factors are associated with BAVM clinical characteristics that are linked with vascular instability...
  5. ncbi request reprint Spontaneous spinal subdural hematoma associated with low-molecular-weight heparin. Case report
    Yoon Hee Cha
    Department of Neurology, University of California at San Francisco, California 94143, USA
    J Neurosurg Spine 2:612-3. 2005
    ..The authors report the first case of a spontaneous spinal SDH occurring in conjunction with low-molecular-weight heparin use in a patient with a history of spinal radiotherapy...
  6. ncbi request reprint Frame-based stereotactic biopsy remains an important diagnostic tool with distinct advantages over frameless stereotactic biopsy
    Justin S Smith
    Department of Neurological Surgery, Brain Tumor Research Center, University of California at San Francisco, 505 Parnassus Avenue, 94143 0112 San Francisco, California, USA
    J Neurooncol 73:173-9. 2005
    ..We retrospectively reviewed the UCSF experience with stereotactic brain biopsy from a 9 year period...
  7. ncbi request reprint Chronic stimulation of the posterior hypothalamic region for cluster headache: technique and 1-year results in four patients
    Philip A Starr
    Departments of Neurosurgery, University of California at San Francisco, California 94143, USA
    J Neurosurg 106:999-1005. 2007
    ..Two small case series have been described. Here, the authors report their technical approach, intraoperative physiological observations, and 1-year outcomes after hypothalamic DBS in four patients with medically intractable CHs...
  8. doi request reprint Preoperative prognostic classification system for hemispheric low-grade gliomas in adults
    Edward F Chang
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 109:817-24. 2008
    ..As a result, the objective in the present study was to design a preoperative scoring system to prognosticate long-term outcomes in patients with LGGs...
  9. ncbi request reprint Complications of lumboperitoneal shunts
    Vincent Y Wang
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Neurosurgery 60:1045-8; discussion 1049. 2007
    ..These shunts can be placed with or without valves. We sought to review the complications associated with the use of LP shunts with the increasing use of horizontal-vertical (HV) valve systems...
  10. doi request reprint Developing cell transplantation for temporal lobe epilepsy
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143 0112, USA
    Neurosurg Focus 24:E17. 2008
    ..These issues are reviewed, with a focus on those factors most likely to influence clinically applicable results...
  11. pmc Magnetic source imaging for the surgical evaluation of electroencephalography-confirmed secondary bilateral synchrony in intractable epilepsy
    Edward F Chang
    Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Room M779, San Francisco, California 94143, USA
    J Neurosurg 111:1248-56. 2009
    ..Whole-head magnetoencephalography (MEG) has superior spatial resolution compared with traditional EEG, and can potentially elucidate seizure foci in challenging epilepsy cases in which patients are undergoing evaluation for surgery...
  12. doi request reprint Seizure control outcomes after resection of dysembryoplastic neuroepithelial tumor in 50 patients
    Edward F Chang
    Northern California Comprehensive Epilepsy Center, Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg Pediatr 5:123-30. 2010
    ..The authors' aim was to identify factors that predict seizure control following excision...
  13. pmc Categorical speech representation in human superior temporal gyrus
    Edward F Chang
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA
    Nat Neurosci 13:1428-32. 2010
    ..Our results provide direct evidence for acoustic-to-higher order phonetic level encoding of speech sounds in human language receptive cortex...
  14. ncbi request reprint Challenging the clinical utility of the 14-3-3 protein for the diagnosis of sporadic Creutzfeldt-Jakob disease
    Michael D Geschwind
    Department of Neurology, University of California, San Francisco Medical Center, San Francisco, CA 94143, USA
    Arch Neurol 60:813-6. 2003
    ..Previous studies have suggested that, in the proper clinical context, the 14-3-3 protein in cerebrospinal fluid is a reliable marker for sporadic CJD...
  15. doi request reprint Seizure characteristics and control following resection in 332 patients with low-grade gliomas
    Edward F Chang
    Department of Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, California 94143, USA
    J Neurosurg 108:227-35. 2008
    ..The aim of this study was to identify factors that influenced perioperative seizure characteristics and postoperative seizure control...
  16. ncbi request reprint Trigeminal neuralgia in a patient with a dural arteriovenous fistula in Meckel's cave: case report
    Rose Du
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Neurosurgery 53:216-21; discussion 221. 2003
    ..We report a case of trigeminal neuralgia in a patient with a dural arteriovenous fistula in Meckel's cave. Endovascular closure of the fistula resulted in elimination of the patient's pain at the gasserian ganglion level...
  17. ncbi request reprint A dosimetric comparison between Gamma Knife and CyberKnife treatment plans for trigeminal neuralgia
    Martina Descovich
    Department of Radiation Oncology, University of California, San Francisco, California, USA
    J Neurosurg 113:199-206. 2010
    ..A comparison between Gamma Knife and CyberKnife treatment plans obtained with this method is presented...
  18. ncbi request reprint Gene microarray analysis of human brain arteriovenous malformations
    Tomoki Hashimoto
    Department of Anesthesia and Perioperative Care, and Center for Cerebrovascular Research, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Neurosurgery 54:410-23; discussion 423-5. 2004
    ..Human brain arteriovenous malformations (BAVMs) display abnormal expression of various angiogenesis-related genes and their products. We examined gene expression patterns in BAVMs by the gene microarray technique...
  19. ncbi request reprint Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
    Nader Sanai
    Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143, USA
    Nature 427:740-4. 2004
    ..Unexpectedly, we find no evidence of chains of migrating neuroblasts in the SVZ or in the pathway to the olfactory bulb. Our work identifies SVZ astrocytes as neural stem cells in a niche of unique organization in the adult human brain...
  20. ncbi request reprint Consistency of interictal and ictal onset localization using magnetoencephalography in patients with partial epilepsy
    Lilly Tang
    Department of Radiology, University of California at San Francisco, California, USA
    J Neurosurg 98:837-45. 2003
    ....
  21. ncbi request reprint Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia
    Matthew D Smyth
    Department of Neurological Surgery, Epilepsy Research Laboratory, University of California at San Francisco, 94143 0112, USA
    Epilepsy Res 50:251-64. 2002
    ..p.). Pre-treatment with VPA prolonged seizure latency in control rats, but had no effect in MAM-exposed animals. These results suggest MAM-exposed rats exhibit a dramatically reduced sensitivity to commonly prescribed AEDs...
  22. ncbi request reprint Abnormal cortical cells and astrocytomas in the Eker rat model of tuberous sclerosis complex
    D Koji Takahashi
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
    Epilepsia 45:1525-30. 2004
    ..Anatomic studies, including standard histologic stains and immunocytochemistry, were performed on young Eker rats exposed to a carcinogen in utero or aged untreated Eker rats (18-24 months old)...
  23. ncbi request reprint Recurrent or refractory trigeminal neuralgia after microvascular decompression, radiofrequency ablation, or radiosurgery
    Rene O Sanchez-Mejia
    Department of Neurological Surgery, University of California, San Francisco 94143 0112, USA
    Neurosurg Focus 18:e12. 2005
    ..The purpose of this study was to determine what factors are associated with the need for retreatment and which modality is most effective...
  24. doi request reprint Characteristics of auras in patients undergoing temporal lobectomy
    Devin K Binder
    Department of Neurological Surgery, University of California, Irvine, 101 The City Drive South, Building 56, Suite 400, ZOT 5397 Orange, California 92868 3298, USA
    J Neurosurg 111:1283-9. 2009
    ..Prior studies suggest that aura semiology may have localizing value. However, temporal lobe aura characteristics and response to surgery have not been studied in large patient series...
  25. ncbi request reprint Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1
    Yanling Wang
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Ann Neurol 61:139-52. 2007
    ..These studies were designed to assess whether TSC gene inactivation alters excitability...
  26. doi request reprint Fundamental skills for entering neurosurgery residents: report of a Pacific region "boot camp" pilot course, 2009
    Nathan R Selden
    Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    Neurosurgery 68:759-64; discussion 764. 2011
    ..A "boot camp" course was held in August 2009 to introduce first year neurosurgical trainees to various fundamental cognitive and practical skills...
  27. pmc Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study
    Daniel A Lim
    Department of Neurological Surgery, University of California, San Francisco, 94143, USA
    J Neurooncol 93:349-54. 2009
    ..A large-scale, double-blinded, randomized control trial of LEV versus PHT is required to determine seizure control equivalence and better assess differences in SEs...
  28. ncbi request reprint Focal cortical dysplasia: a review of pathological features, genetics, and surgical outcome
    Vincent Y Wang
    Department of Neurological Surgery, University of California, San Francisco, California 94130, USA
    Neurosurg Focus 20:E7. 2006
    ..Data from surgical series have shown that surgery often results in significant reduction or cessation of seizures, especially if the entire lesion is resected...
  29. ncbi request reprint Ronald Tasker Award: retreatment of medically refractory trigeminal neuralgia
    Rene O Sanchez-Mejia
    Department of Neurological Surgery, University of California, San Francisco, USA
    Clin Neurosurg 53:313-5. 2006
  30. doi request reprint Fluctuating response of a cystic vestibular schwannoma to radiosurgery: case report
    Amy R de Ipolyi
    Department of Neurological Surgery, Brain Tumor Research Center, University of California at San Francisco, San Francisco, California, USA
    Neurosurgery 62:E1164-5; discussion E1165. 2008
    ..In this article, we report an atypical fluctuating course of a cystic VS after GKS, ultimately requiring surgical intervention...
  31. ncbi request reprint Management of medically refractory trigeminal neuralgia in patients with multiple sclerosis
    Jason S Cheng
    Department of Neurological Surgery, University of California, San Francisco, USA
    Neurosurg Focus 18:e13. 2005
    ....
  32. ncbi request reprint Dysfunction of synaptic inhibition in epilepsy associated with focal cortical dysplasia
    Maria Elisa Calcagnotto
    Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosci 25:9649-57. 2005
    ..Together, these results suggest that profound alterations in GABA-mediated synaptic inhibition play an essential role in the process of epileptogenesis in patients with FCD...
  33. pmc Localization of neurosurgically implanted electrodes via photograph-MRI-radiograph coregistration
    Sarang S Dalal
    Biomagnetic Imaging Laboratory, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143 0628, USA
    J Neurosci Methods 174:106-15. 2008
    ..We demonstrate the results of our method in eight epilepsy patients implanted with electrode grids spanning the left hemisphere...
  34. pmc Five-dimensional neuroimaging: localization of the time-frequency dynamics of cortical activity
    Sarang S Dalal
    Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
    Neuroimage 40:1686-700. 2008
    ..This method enables the ultimate promise of MEG and EEG for five-dimensional imaging of space, time, and frequency activity in the brain and renders it applicable for widespread studies of human cortical dynamics during cognition...
  35. ncbi request reprint Magnetoencephalography source localization and surgical outcome in temporal lobe epilepsy
    Bassam A Assaf
    Department of Neurology, The University of Illinois Peoria, 530 N Glen Oak Ave, Peoria, IL 61637, USA
    Clin Neurophysiol 115:2066-76. 2004
    ..We prospectively investigated the role of magnetoencephalography (MEG) in localizing the seizure focus and in predicting outcome to surgical resections for intractable temporal lobe epilepsy (TLE)...
  36. ncbi request reprint MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations
    Yongmei Chen
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Front Biosci 11:3121-8. 2006
    ..MPO co-localized with majority of MMP-9 signal by immunohistochemistry. Our data suggest that inflammation is a prominent feature of BAVM lesional phenotype, and neutrophils appear to be a major source of MMP-9 in these lesions...
  37. ncbi request reprint Spatial localization of cortical time-frequency dynamics
    Sarang S Dalal
    Mental Processes and Brain Activation Lab, INSERM U821, 69675 Bron, France
    Conf Proc IEEE Eng Med Biol Soc 2007:4941-4. 2007
    ..This method enables non-invasive five-dimensional imaging of space, time, and frequency activity in the brain and renders it applicable for widespread studies of human cortical dynamics...
  38. ncbi request reprint Speech preservation during language-dominant, left temporal lobe seizures: report of a rare, potentially misleading finding
    Kitti Kaiboriboon
    Department of Neurology, University of California, San Francisco, California 94143 0138, USA
    Epilepsia 47:1343-6. 2006
    ..To evaluate the prevalence and mechanism of ictal speech in patients with language-dominant, left temporal lobe seizures...
  39. ncbi request reprint Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, 4412 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0585, USA
    Ann Neurol 59:81-91. 2006
    ....
  40. ncbi request reprint Stereoelectroencephalography using computerized tomography- or magnetic resonance imaging-guided electrode implantation
    Nicholas M Barbaro
    J Neurosurg 104:480-1; discussion 481-2. 2006
  41. ncbi request reprint Ictal magnetoencephalography in temporal and extratemporal lobe epilepsy
    Bassam A Assaf
    Department of Neurology, The University of Illinois Peoria, Peoria, Illinois, USA
    Epilepsia 44:1320-7. 2003
    ..We evaluated visual patterns and source localization of ictal magnetoencephalography (MEG) in patients with intractable temporal lobe epilepsy (TLE) and extratemporal epilepsy (ETE)...
  42. ncbi request reprint Thalamic deep brain stimulation for essential tremor: relation of lead location to outcome
    Efstathios Papavassiliou
    Department of Neurosurgery, University of California, San Francisco, California 94143, USA
    Neurosurgery 54:1120-29; discussion 1129-30. 2004
    ..We examined the relation of lead location to clinical outcome in a series of essential tremor patients treated by thalamic DBS...
  43. ncbi request reprint "Tectonic" hippocampal malformations in patients with temporal lobe epilepsy
    Robert S Sloviter
    Departments of Pharmacology and Neurology, University of Arizona College of Medicine, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    Epilepsy Res 59:123-53. 2004
    ..Thus, these presumably developmental hippocampal anomalies may serve as substrates for early febrile seizures and subsequent epilepsy...
  44. ncbi request reprint Motor cortex stimulation for central and neuropathic pain: current status
    Jeffrey A Brown
    Department of Neurosurgery, Wayne State University, School of Medicine, 4160 John R 930, Detroit, MI 48201, USA
    Pain 104:431-5. 2003
  45. ncbi request reprint Significance of source and size in the mechanical response of human cerebral blood vessels
    Kenneth L Monson
    Department of Mechanical Engineering, University of California, San Francisco, Berkeley, CA 94720, USA
    J Biomech 38:737-44. 2005
    ..These effects are, however, secondary to differences identified between arteries and veins in the previous study...
  46. doi request reprint Stereotactic radiosurgery for treatment of epilepsy
    Mark Quigg
    Department of Neurology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Arch Neurol 65:177-83. 2008
    ..Further studies will be required to determine whether efficacy attains that of traditional surgery while offering a noninvasive technique with potentially lower morbidity...
  47. ncbi request reprint The diagnostic utility of brain biopsy procedures in patients with rapidly deteriorating neurological conditions or dementia
    S Andrew Josephson
    Department of Neurology, University of California, San Francisco, California, USA
    J Neurosurg 106:72-5. 2007
    ....
  48. ncbi request reprint Interleukin-6 upregulates expression of KDR and stimulates proliferation of human cerebrovascular smooth muscle cells
    Jianhua S Yao
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, CA 94110, USA
    J Cereb Blood Flow Metab 27:510-20. 2007
    ..A novel role of IL-6 during HCSMC proliferation is upregulating KDR expression and phosphorylation. The results may contribute to the angiogenic phenotype of human brain vascular diseases, such as brain AVM...
  49. pmc Fast oscillations associated with interictal spikes localize the epileptogenic zone in patients with partial epilepsy
    Adrian G Guggisberg
    Biomagnetic Imaging Laboratory, Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
    Neuroimage 39:661-8. 2008
    ..Imaging of spike-locked beta/gamma power changes therefore seems to be a reliable and fast alternative to conventional MEG techniques for localizing epileptogenic tissue, in particular, if more than 50 interictal spikes can be recorded...
  50. ncbi request reprint Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformations
    Tomoki Hashimoto
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94110, USA
    Stroke 34:925-31. 2003
    ..In this study we examined the expression of MMPs and tissue inhibitors of metalloproteinases (TIMPs) in brain arteriovenous malformations (BAVMs)...

Research Grants5

  1. RADIOSURGICAL TREATMENT OF TEMPORAL LOBE EPILEPSY
    Nicholas Barbaro; Fiscal Year: 2002
    ..If radiosurgery can be shown to reduce or eliminate seizures in patients with medically refractory temporal lobe epilepsy, patients could be offered this minimally invasive technique, avoiding the morbidity of open cranial surgery. ..