Research Topics
| Nicholas BarbaroSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
A multicenter, prospective pilot study of gamma knife radiosurgery for mesial temporal lobe epilepsy: seizure response, adverse events, and verbal memoryNicholas M Barbaro
Department of Neurological Surgery, University of California at San Francisco, 94143, USA
Ann Neurol 65:167-75. 2009..We report the 3-year outcomes of a multicenter, prospective pilot study of RS...
Focal cooling suppresses spontaneous epileptiform activity without changing the cortical motor thresholdKameel M Karkar
Department of Neurology University of California, San Francisco, San Francisco, California, U S A
Epilepsia 43:932-5. 2002..Focal cerebral cooling has been shown to reduce epileptiform activity in animals. There are, however, few reports of this phenomenon in humans...- Seizure characteristics and control after microsurgical resection of supratentorial cerebral cavernous malformationsEdward F Chang
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
Neurosurgery 65:31-7; discussion 37-8. 2009..The optimal management of seizures associated with cerebral cavernous malformations (CCMs) is unclear. The aim of this study was to determine the efficacy of surgery in the management of CCM-associated seizures... - Coexpression of angiogenic factors in brain arteriovenous malformationsTomoki Hashimoto
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California 94110, USA
Neurosurgery 56:1058-65; discussion 1058-65. 2005..Therefore, we hypothesized that there are close correlations among key angiogenic factors in BAVMs and that levels of key angiogenic factors are associated with BAVM clinical characteristics that are linked with vascular instability... - Spontaneous spinal subdural hematoma associated with low-molecular-weight heparin. Case reportYoon Hee Cha
Department of Neurology, University of California at San Francisco, California 94143, USA
J Neurosurg Spine 2:612-3. 2005..The authors report the first case of a spontaneous spinal SDH occurring in conjunction with low-molecular-weight heparin use in a patient with a history of spinal radiotherapy... - Frame-based stereotactic biopsy remains an important diagnostic tool with distinct advantages over frameless stereotactic biopsyJustin S Smith
Department of Neurological Surgery, Brain Tumor Research Center, University of California at San Francisco, 505 Parnassus Avenue, 94143 0112 San Francisco, California, USA
J Neurooncol 73:173-9. 2005..We retrospectively reviewed the UCSF experience with stereotactic brain biopsy from a 9 year period... - Chronic stimulation of the posterior hypothalamic region for cluster headache: technique and 1-year results in four patientsPhilip A Starr
Departments of Neurosurgery, University of California at San Francisco, California 94143, USA
J Neurosurg 106:999-1005. 2007..Two small case series have been described. Here, the authors report their technical approach, intraoperative physiological observations, and 1-year outcomes after hypothalamic DBS in four patients with medically intractable CHs... - Preoperative prognostic classification system for hemispheric low-grade gliomas in adultsEdward F Chang
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurosurg 109:817-24. 2008..As a result, the objective in the present study was to design a preoperative scoring system to prognosticate long-term outcomes in patients with LGGs... - Complications of lumboperitoneal shuntsVincent Y Wang
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
Neurosurgery 60:1045-8; discussion 1049. 2007..These shunts can be placed with or without valves. We sought to review the complications associated with the use of LP shunts with the increasing use of horizontal-vertical (HV) valve systems... - Developing cell transplantation for temporal lobe epilepsyR Mark Richardson
Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143 0112, USA
Neurosurg Focus 24:E17. 2008..These issues are reviewed, with a focus on those factors most likely to influence clinically applicable results... 
Magnetic source imaging for the surgical evaluation of electroencephalography-confirmed secondary bilateral synchrony in intractable epilepsyEdward F Chang
Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Room M779, San Francisco, California 94143, USA
J Neurosurg 111:1248-56. 2009..Whole-head magnetoencephalography (MEG) has superior spatial resolution compared with traditional EEG, and can potentially elucidate seizure foci in challenging epilepsy cases in which patients are undergoing evaluation for surgery...- Seizure control outcomes after resection of dysembryoplastic neuroepithelial tumor in 50 patientsEdward F Chang
Northern California Comprehensive Epilepsy Center, Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurosurg Pediatr 5:123-30. 2010..The authors' aim was to identify factors that predict seizure control following excision... - Categorical speech representation in human superior temporal gyrusEdward F Chang
Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA
Nat Neurosci 13:1428-32. 2010..Our results provide direct evidence for acoustic-to-higher order phonetic level encoding of speech sounds in human language receptive cortex... - Challenging the clinical utility of the 14-3-3 protein for the diagnosis of sporadic Creutzfeldt-Jakob diseaseMichael D Geschwind
Department of Neurology, University of California, San Francisco Medical Center, San Francisco, CA 94143, USA
Arch Neurol 60:813-6. 2003..Previous studies have suggested that, in the proper clinical context, the 14-3-3 protein in cerebrospinal fluid is a reliable marker for sporadic CJD... - Seizure characteristics and control following resection in 332 patients with low-grade gliomasEdward F Chang
Department of Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, California 94143, USA
J Neurosurg 108:227-35. 2008..The aim of this study was to identify factors that influenced perioperative seizure characteristics and postoperative seizure control... - Trigeminal neuralgia in a patient with a dural arteriovenous fistula in Meckel's cave: case reportRose Du
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
Neurosurgery 53:216-21; discussion 221. 2003..We report a case of trigeminal neuralgia in a patient with a dural arteriovenous fistula in Meckel's cave. Endovascular closure of the fistula resulted in elimination of the patient's pain at the gasserian ganglion level... - A dosimetric comparison between Gamma Knife and CyberKnife treatment plans for trigeminal neuralgiaMartina Descovich
Department of Radiation Oncology, University of California, San Francisco, California, USA
J Neurosurg 113:199-206. 2010..A comparison between Gamma Knife and CyberKnife treatment plans obtained with this method is presented... - Gene microarray analysis of human brain arteriovenous malformationsTomoki Hashimoto
Department of Anesthesia and Perioperative Care, and Center for Cerebrovascular Research, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Neurosurgery 54:410-23; discussion 423-5. 2004..Human brain arteriovenous malformations (BAVMs) display abnormal expression of various angiogenesis-related genes and their products. We examined gene expression patterns in BAVMs by the gene microarray technique... - Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migrationNader Sanai
Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143, USA
Nature 427:740-4. 2004..Unexpectedly, we find no evidence of chains of migrating neuroblasts in the SVZ or in the pathway to the olfactory bulb. Our work identifies SVZ astrocytes as neural stem cells in a niche of unique organization in the adult human brain... - Consistency of interictal and ictal onset localization using magnetoencephalography in patients with partial epilepsyLilly Tang
Department of Radiology, University of California at San Francisco, California, USA
J Neurosurg 98:837-45. 2003..These findings support the interpretation of interictal spikes on MEG as a useful and effective noninvasive method for localizing primary seizure foci... - Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasiaMatthew D Smyth
Department of Neurological Surgery, Epilepsy Research Laboratory, University of California at San Francisco, 94143-0112, USA
Epilepsy Res 50:251-64. 2002..p.). Pre-treatment with VPA prolonged seizure latency in control rats, but had no effect in MAM-exposed animals. These results suggest MAM-exposed rats exhibit a dramatically reduced sensitivity to commonly prescribed AEDs... - Abnormal cortical cells and astrocytomas in the Eker rat model of tuberous sclerosis complexD Koji Takahashi
Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
Epilepsia 45:1525-30. 2004..Further analysis of this rodent model may be warranted... - Recurrent or refractory trigeminal neuralgia after microvascular decompression, radiofrequency ablation, or radiosurgeryRene O Sanchez-Mejia
Department of Neurological Surgery, University of California, San Francisco 94143-0112, USA
Neurosurg Focus 18:e12. 2005..After retreatment, the majority of patients attained complete or very good pain relief. Pain relief after retreatment correlates with postoperative facial numbness... - Characteristics of auras in patients undergoing temporal lobectomyDevin K Binder
Department of Neurological Surgery, University of California, Irvine, 101 The City Drive South, Building 56, Suite 400, ZOT 5397 Orange, California 92868 3298, USA
J Neurosurg 111:1283-9. 2009..Prior studies suggest that aura semiology may have localizing value. However, temporal lobe aura characteristics and response to surgery have not been studied in large patient series... - Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1Yanling Wang
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
Ann Neurol 61:139-52. 2007..These studies were designed to assess whether TSC gene inactivation alters excitability... - Fundamental skills for entering neurosurgery residents: report of a Pacific region "boot camp" pilot course, 2009Nathan R Selden
Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
Neurosurgery 68:759-64; discussion 764. 2011..A "boot camp" course was held in August 2009 to introduce first year neurosurgical trainees to various fundamental cognitive and practical skills... - Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot studyDaniel A Lim
Department of Neurological Surgery, University of California, San Francisco, 94143, USA
J Neurooncol 93:349-54. 2009..A large-scale, double-blinded, randomized control trial of LEV versus PHT is required to determine seizure control equivalence and better assess differences in SEs... - Focal cortical dysplasia: a review of pathological features, genetics, and surgical outcomeVincent Y Wang
Department of Neurological Surgery, University of California, San Francisco, California 94130, USA
Neurosurg Focus 20:E7. 2006..Data from surgical series have shown that surgery often results in significant reduction or cessation of seizures, especially if the entire lesion is resected... - Ronald Tasker Award: retreatment of medically refractory trigeminal neuralgiaRene O Sanchez-Mejia
Department of Neurological Surgery, University of California, San Francisco, USA
Clin Neurosurg 53:313-5. 2006 - Fluctuating response of a cystic vestibular schwannoma to radiosurgery: case reportAmy R de Ipolyi
Department of Neurological Surgery, Brain Tumor Research Center, University of California at San Francisco, San Francisco, California, USA
Neurosurgery 62:E1164-5; discussion E1165. 2008..In this article, we report an atypical fluctuating course of a cystic VS after GKS, ultimately requiring surgical intervention... - Management of medically refractory trigeminal neuralgia in patients with multiple sclerosisJason S Cheng
Department of Neurological Surgery, University of California, San Francisco, USA
Neurosurg Focus 18:e13. 2005..05). Radiosurgery proved to be an effective procedure and resulted in fewer retreatments and longer pain-free intervals compared with MVD or radiofrequency ablation... - Dysfunction of synaptic inhibition in epilepsy associated with focal cortical dysplasiaMaria Elisa Calcagnotto
Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurosci 25:9649-57. 2005..Together, these results suggest that profound alterations in GABA-mediated synaptic inhibition play an essential role in the process of epileptogenesis in patients with FCD... - Localization of neurosurgically implanted electrodes via photograph-MRI-radiograph coregistrationSarang S Dalal
Biomagnetic Imaging Laboratory, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143 0628, USA
J Neurosci Methods 174:106-15. 2008..We demonstrate the results of our method in eight epilepsy patients implanted with electrode grids spanning the left hemisphere... - Five-dimensional neuroimaging: localization of the time-frequency dynamics of cortical activitySarang S Dalal
Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
Neuroimage 40:1686-700. 2008..This method enables the ultimate promise of MEG and EEG for five-dimensional imaging of space, time, and frequency activity in the brain and renders it applicable for widespread studies of human cortical dynamics during cognition... - Magnetoencephalography source localization and surgical outcome in temporal lobe epilepsyBassam A Assaf
Department of Neurology, The University of Illinois Peoria, 530 N Glen Oak Ave, Peoria, IL 61637, USA
Clin Neurophysiol 115:2066-76. 2004..We prospectively investigated the role of magnetoencephalography (MEG) in localizing the seizure focus and in predicting outcome to surgical resections for intractable temporal lobe epilepsy (TLE)... - MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformationsYongmei Chen
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
Front Biosci 11:3121-8. 2006..MPO co-localized with majority of MMP-9 signal by immunohistochemistry. Our data suggest that inflammation is a prominent feature of BAVM lesional phenotype, and neutrophils appear to be a major source of MMP-9 in these lesions... - Spatial localization of cortical time-frequency dynamicsSarang S Dalal
Mental Processes and Brain Activation Lab, INSERM U821, 69675 Bron, France
Conf Proc IEEE Eng Med Biol Soc 2007:4941-4. 2007..This method enables non-invasive five-dimensional imaging of space, time, and frequency activity in the brain and renders it applicable for widespread studies of human cortical dynamics... - Speech preservation during language-dominant, left temporal lobe seizures: report of a rare, potentially misleading findingKitti Kaiboriboon
Department of Neurology, University of California, San Francisco, California 94143-0138, USA
Epilepsia 47:1343-6. 2006..Based on intracranial EEG recordings, the likely mechanism underlying this potentially misleading clinical finding is the preservation of language areas due to limited seizure-propagation patterns... - Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsyJack M Parent
Department of Neurology, University of Michigan Medical Center, 4412 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0585, USA
Ann Neurol 59:81-91. 2006.... - Stereoelectroencephalography using computerized tomography- or magnetic resonance imaging-guided electrode implantationNicholas M Barbaro
J Neurosurg 104:480-1; discussion 481-2. 2006 - Ictal magnetoencephalography in temporal and extratemporal lobe epilepsyBassam A Assaf
Department of Neurology, The University of Illinois Peoria, Peoria, Illinois, USA
Epilepsia 44:1320-7. 2003..We evaluated visual patterns and source localization of ictal magnetoencephalography (MEG) in patients with intractable temporal lobe epilepsy (TLE) and extratemporal epilepsy (ETE)... - Thalamic deep brain stimulation for essential tremor: relation of lead location to outcomeEfstathios Papavassiliou
Department of Neurosurgery, University of California, San Francisco, California 94143, USA
Neurosurgery 54:1120-29; discussion 1129-30. 2004..The incidence of true physiological tolerance to the antitremor effect of thalamic DBS (defined as poor tremor control in spite of lead location within 2 mm of the optimal site) was found to be 9%... - "Tectonic" hippocampal malformations in patients with temporal lobe epilepsyRobert S Sloviter
Departments of Pharmacology and Neurology, University of Arizona College of Medicine, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
Epilepsy Res 59:123-53. 2004..Thus, these presumably developmental hippocampal anomalies may serve as substrates for early febrile seizures and subsequent epilepsy... - Motor cortex stimulation for central and neuropathic pain: current statusJeffrey A Brown
Department of Neurosurgery, Wayne State University, School of Medicine, 4160 John R #930, Detroit, MI 48201, USA
Pain 104:431-5. 2003 - Significance of source and size in the mechanical response of human cerebral blood vesselsKenneth L Monson
Department of Mechanical Engineering, University of California, San Francisco, Berkeley, CA 94720, USA
J Biomech 38:737-44. 2005..These effects are, however, secondary to differences identified between arteries and veins in the previous study... - Stereotactic radiosurgery for treatment of epilepsyMark Quigg
Department of Neurology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
Arch Neurol 65:177-83. 2008..Further studies will be required to determine whether efficacy attains that of traditional surgery while offering a noninvasive technique with potentially lower morbidity... - The diagnostic utility of brain biopsy procedures in patients with rapidly deteriorating neurological conditions or dementiaS Andrew Josephson
Department of Neurology, University of California, San Francisco, California, USA
J Neurosurg 106:72-5. 2007.... - Interleukin-6 upregulates expression of KDR and stimulates proliferation of human cerebrovascular smooth muscle cellsJianhua S Yao
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, CA 94110, USA
J Cereb Blood Flow Metab 27:510-20. 2007..A novel role of IL-6 during HCSMC proliferation is upregulating KDR expression and phosphorylation. The results may contribute to the angiogenic phenotype of human brain vascular diseases, such as brain AVM... - Fast oscillations associated with interictal spikes localize the epileptogenic zone in patients with partial epilepsyAdrian G Guggisberg
Biomagnetic Imaging Laboratory, Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
Neuroimage 39:661-8. 2008..Imaging of spike-locked beta/gamma power changes therefore seems to be a reliable and fast alternative to conventional MEG techniques for localizing epileptogenic tissue, in particular, if more than 50 interictal spikes can be recorded... - Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformationsTomoki Hashimoto
Department of Anesthesia and Perioperative Care, University of California, San Francisco 94110, USA
Stroke 34:925-31. 2003..CONCLUSIONS: We found increased levels of MMP-9 and TIMPs in BAVMs. Abnormal balance of MMP-9 and TIMPs may contribute to vascular instability of BAVMs...
Research Grants
- RADIOSURGICAL TREATMENT OF TEMPORAL LOBE EPILEPSYNicholas Barbaro; Fiscal Year: 2002..If radiosurgery can be shown to reduce or eliminate seizures in patients with medically refractory temporal lobe epilepsy, patients could be offered this minimally invasive technique, avoiding the morbidity of open cranial surgery. ..